푸른길 공원의 대기 환경 특성에 관한 연구

민경우,이경석,박옥현,윤관주,김도술,박세일,정원삼,이대행,조영관,Min, Kyoung-Woo,Lee, Kyoung-Soek,Park, Ok-Hyun,Yoon, Kwan-Ju,Kim, Do-Sool,Park, Se-Il,Jeung, Won-Sam,Lee, Dae-Hang,Cho, Young-Gwan 한국환경보건학회 2015 한국환경보건학회지 Vol.41 No.3

Objectives: This study aimed to survey the characteristics of air quality and meteorological conditions in a greenway park. Methods: We measured meteorological and health related factors, including noise, particulate matter ($PM_{10}$) and selected gaseous air pollutants at three locations in a greenway park and on a general roadside as comparison. The measurements were repeated four times from April to October 2014. Results: The average air temperature in the greenway park was $20.7^{\circ}C$ which was $1-2^{\circ}C$ lower than on the general roadside. The average $PM_{10}$ concentration in the greenway park was $85.0{\mu}g/m^3$, a level 2-3 times lower than that at the roadside. The noise level at the greenway site was 4.4 dB(A)- 23.0 dB(A) lower than at the roadside. The average CO, $CO_2$, $SO_2$ and NOx concentrations in the greenway park were lower than at the roadside. The average phytoncide and anions concentrations in the greenway park were higher than at the roadside. Conclusions: The urban forest of the greenway park may have some impact on air quality and meteorological conditions.

심장혈관용 약물코팅풍선카테터의 개발 동향

박정훈 ( Junghun Park ),조원일 ( Won-il Jo ),변대흥 ( Dae-heung Byeon ),강소영 ( So Young Kang ),남충현 ( Choong-hyun Nam ),서경우 ( Kyoung-woo Seo ),박준규 ( Jun-kyu Park ) 한국공업화학회 2022 공업화학 Vol.33 No.5

급격한 고령화 사회로의 진입과 서구화된 식습관에 의해 협심증, 심근경색증, 고혈압 등에 의한 심장질환자의 수가 5년간 10만명 이상 증가했다. 심장질환은 지난 8년간 꾸준히 국내 사망원인 2위를 기록 중이며, 이로 인해 연간 소모되는 의료비는 6조원에 달한다. 증가한 환자와 함께 다양한 치료법이 제시되고 있는 가운데, 현재 보편화 된 관상동맥 중재시술 중 스텐트 삽입술의 단점인 재협착이나 장기간 이중항혈소판제 복용으로 인한 출혈의 위험 증가 등의 문제점을 보완하기 위해 약물코팅풍선카테터가 개발되어 점차 상용화되고 있는데, 국내에선 2010년 ‘SeQuent Please^Ⓡ (비브라운코리아)’라는 제품이 처음 출시되면서 약물코팅풍선카테터를 사용한 시술이 시작되었고, 이후 2012년 보험급여가 적용되면서 그 사용량이 본격적으로 늘어났다. 약물코팅풍선치료는 국내뿐만 아니라 전 세계적으로 사용이 증가하고 있는데, 특히 일본을 포함한 아시아태평양 지역에서 그 사용량이 급격히 증가하고 있다. 현재까지 국산 제품의 수요가 증가하고 있는 상황이며 향후, 동물시험 및 임상시험에서의 성능이 입증된다면 위험성이 높은 스텐트 삽입술에 비해 효과적인 시술이 될 것이라 예상한다. As a result of the rapid entry into an aging society and westernized eating habits, the number of heart disease patients caused by angina pectoris, myocardial infarction, and high blood pressure has increased by more than 100,000 over five years. Heart disease has consistently ranked second in the cause of death in Korea over the past eight years, and medical expenses consumed annually reach 6 trillion won. While various treatments are being proposed for more patients, drug-coated balloon catheters have been developed and gradually commercialized to solve the disadvantages of stent implantation such as restenosis and increased risk of bleeding due to long-term double antiplatelet medication. In Korea, it began to use a drug-coated balloon catheter with the first release of it called “SeQuent Please^Ⓡ (Bibrown Korea)” in 2010. Its demand increased gradually as insurance benefits were applied in 2012. Drug-coated balloon angioplasty is increasing in use not only in Korea but also around the world, especially in the Asia-Pacific region, including Japan. Until now, the demand for domestic products is increasing, and if the efficiency in vivo and clinical trials is proven in the future, it is expected to be an effective procedure compared to high-risk stent implantation.

지역기후기능을 고려한 주거단지계획기법에 관한 연구 - 바람길을 중심으로 -

김태욱,정응호,류지원,박지혜,Kim, Dae-Wuk,Jung, Eung-Ho,Ryu, Ji-Won,Park, Ji-Hye 한국주거학회 2007 한국주거학회 논문집 Vol.18 No.2

This research has been implemented based on the area of #369 Dowon-dong, Dalseo-gu, Dae-gu which is considered as a place with satisfactory characteristics for the flow of fresh air into the city. Simulations of the target area both prior to the development plan and after apartment complex blocking were analyzed in regard to blocking planning and pilotis based on the main direction of wind, $90^{\circ}$ (east wind) and $180^{\circ}$ (south wind). In addition, congested wind corridor flow in the target place was identified through a pollution spread simulation according to the wind corridor. Therefore, the flow of wind in the one area is affected by the blocking of the complex and the main direction of the wind. Also blocking, in regard of pilotis, provides a better flow of wind. This study was implemented based on wind formation by apartment complex planning, so further study on the other factors affecting the flow of a wind corridor along with block planning and pilotis need to be carried out. Sustainable environmental factors through analysis of the environmental factors have to be analyzed. Moreover, building and complementing fundamental resources and systematic devices should be supported.

고랭지 밭 유역의 융설에 의한 수질특성

최용훈 ( Yong Hun Choi ),원철희 ( Chul Hee Won ),박운지 ( Woon Ji Park ),신민환 ( Min Hwan Shin ),신재영 ( Jea Young Shin ),이수인 ( Su In Lee ),최중대 ( Joong Dae Choi ) 한국물환경학회 ( 구 한국수질보전학회 ) 2012 한국물환경학회지 Vol.28 No.3

In this study, Song-Cheon river Basin located at Dae-kwan-lyong Meyn in Kang-Won Province was monitored to analyze characteristics of non-point source pollution during the snowmelt period. The characteristics of NPS pollution such as runoff, change in water quality and pollutant loads by snowmelt were investigated from 23th February 2010 to 27th April 2010. The results showed that The climate change effects flow, turbidity and concentration of SS and COD with showing similar trend of fluctuation. Daily pollutant loads per unit area were SS 74.43 kg/ha/day, COD 1.25 kg/ha/day, BOD 0.21 kg/ha/day, TN 0.717 kg/ha/day, TP 0.141 kg/ha/day and the flow weight mean concentration has been SS 985.97 mg/L, COD 16.28 mg/L, BOD 2.67 mg/L, TN 9.302 mg/L, TP 1.834 mg/L, respectively. The flow and pollutant loads both of SS and of COD significantly increased during the snowmelt period. Because structurally loosen soil by freezing and thawing deteriorates water quality, research and management measures will be needed.

우리나라 노인여성의 골다공증성 척추골절로 인한 경제적 부담 추계

강혜영,강대룡,장영화,박성은,최원정,문성환,양규현,Kang, Hye-Young,Kang, Dae-Ryong,Jang, Young-Hwa,Park, Sung-Eun,Choi, Won-Jung,Moon, Seong-Hwan,Yang, Kyu-Hyun 대한예방의학회 2008 예방의학회지 Vol.41 No.5

Objectives : To estimate the economic burden of osteoporotic vertebral fracture (VF) from a societal perspective. Methods : From 2002 to 2004, we identified all National Health Insurance claims records for women ${\geq}50$ years old with a diagnosis of VF. The first 6-months was defined as a "clearance period," such that patients were considered as incident cases if their first claim of fracture was recorded after June 30, 2002. We only included patients with ${\geq}$ one claim of a diagnosis of, or prescription for, osteoporosis over 3 years. For each patient, we cumulated the claims amount for the first visit and for the follow-up treatments for 1 year. The hospital charge data from 4 hospitals were investigated to measure the proportion of the non-covered services. Face-to-face interviews were conducted with 106 patients from the 4 study sites to measure the out-of-pocket spending outside of hospitals. Results : During 2.5 years, 131,453 VF patients were identified. The patients had an average of 3.38 visits, 0.40 admissions and 6.36 inpatient days. The per capita cost was 1,909,690 Won: 71.5% for direct medical costs, 20.6% for direct non-medical costs and 7.9% for indirect costs. The per capita cost increased with increasing age: 1,848,078 Won for those aged 50-64, 2,084,846 Won for 65-74, 2,129,530 Won for 75-84and 2,121,492 Won for those above 84. Conclusions : Exploring the economic burden of osteoporotic VF is expected to motivate to adopt effective treatment options for osteoporosis in order to prevent the incidence of fracture and the consequent costs.

Interaction of GAT1 with Ubiquitin-Specific Protease Usp14 in Synaptic Terminal

Dae-Hyun Seog(석대현),Sang-Jin Kim(김상진),Young-Ju Joung(정영주),Sung Su Yea(예성수),Yeong-Hong Park(박영홍),Moo Seong Kim(김무성),Il Soo Moon(문일수),Won Hee Jang(장원희) 한국생명과학회 2010 생명과학회지 Vol.20 No.7

γ-aminobutyric acid (GABA)는 중추신경계에서 억제성으로 작용하는 주요한 신경전달물질이다. GABA 수송체(GAT)는 연접간격에 존재하는 GABA를 세포 내로 재 흡수하여 GABA의 농도를 조절한다. 그런데 GABA 수송체가 어떻게 조절되는지는 아직 밝혀지지 않았다. 본 연구에서는 효모 two-hybrid system을 사용하여 뇌의 주요 GABA 수송체인 GAT1의 C-말단과 특이적으로 결합하는 ubiquitin-specific protease 14 (Usp14)를 분리하였다. Usp14는 GABA 수송체 GAT1및 GAT2와는 결합하지만, 다른 GAT isoform과는 결합하지 않았다. GAT1과의 결합에는 Usp14의 C-말단부위가 필수적으로 관여함을 확인하였다. 또한 이 단백질간의 결합을 GST pull-down assay로 확인하였으며, 생쥐 뇌 균질액의 co-immunoprecipitation을 통하여 in vivo에서도 GAT1과 Usp14가 결합함을 확인하였다. 이러한 결과들은 Usp14가 GAT1과 결합하여 세포막에 존재하는 GAT1의 수를 조절하는 역할을 할 가능성을 시사한다. γ-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system. GABA transporters (GATs) control extracellular GABA levels by reuptake of released GABA from the synaptic cleft. However, how GATs are regulated has not yet been elucidated. Here, we used the yeast two-hybrid system to identify the specific binding protein(s) that interacts with the carboxyl (C)-terminal region of GAT1, the major isoform in the brain and find a specific interaction with the ubiquitin-specific protease 14 (Usp14), a deubiquitinating enzyme. Usp14 protein bound to the tail region of GAT1 and GAT2 but not to other GAT members in the yeast two-hybrid assay. The C-terminal region of Usp14 is essential for interaction with GAT1. In addition, these proteins showed specific interactions in the glutathione S-transferase (GST) pull-down assay. An antibody to GAT1 specifically co-immunoprecipitated Usp14 from mouse brain extracts. These results suggest that Usp14 may regulate the number of GAT1 at the cell surface.

전자파 분석 및 제어기용 WIN CE 기반의 범용 임베디드 시스템 플랫폼 개발

김용대(Yong-Dae Kim),김호철(Ho-Cheol Kim),노재명(Jae-Myeong No),박혜원(Hye-Won Park),이왕헌(Wang-Heon Lee),김철수(Chul-Su Kim) 대한전기학회 2008 대한전기학회 학술대회 논문집 Vol.2008 No.10

기존 상용의 스펙트럼 분석기를 이용한 EMI 분석장비들은 고정도의 측정결과를 내고 있으나 1차 검교정기관에서 주로 사용되고 있다. EMI가 환경문제의 일환으로 간주되면서 전자제품을 생산하는 업체의 생산라인마다 EMI분석 장치의 보급은 오실로 스코프와 같이 보편적인 장비로 사용해야하는 시점에 와 있다. 본 논문에서는 WIN CE를이용한 EMI분석용 범용 Embedded System Platform의 개발은 물론 이를 산업용 제어기로의 적용할수 있는 임베디드 시스템에 관한 것이다. 특히 본 연구에서는 WIN CE기반의 임베디드 시스템 플레폼과 ATMEGA128을 Sub Mode로 하는 범용 제어 모듈의 소프트웨어 및 하드웨어 구조를 제안한다.

Synthesis and Electrochemical Performance of Polypyrrole-Coated Iron Oxide/Carbon Nanotube Composites

Dae-Won Kim,Ki-Seok Kim,Soo-Jin Park 한국탄소학회 2012 Carbon Letters Vol.13 No.3

In this work, iron oxide (Fe3O4) nanoparticles were deposited on multi-walled carbon nanotubes (MWNTs) by a simple chemical coprecipitation method and Fe3O4-decorated MWNTs (Fe-MWNTs)/polypyrrole (PPy) nanocomposites (Fe-MWNTs/PPy) were prepared by oxidation polymerization. The effect of the PPy on the electrochemical properties of the Fe-MWNTs was investigated. The structures characteristics and surface properties of MWNTs, Fe-MWNTs, and Fe-MWNTs/PPy were characterized by X-ray diffraction and X-ray photoelectron spectroscopy, respectively. The electrochemical performances of MWNTs, Fe-MWNTs, and Fe-MWNTs/PPy were determined by cyclic voltammetry and galvanostatic charge/discharge characteristics in a 1.0 M sodium sulfite electrolyte. The results showed that the Fe-MWNTs/PPy electrode had typical pseudo-capacitive behavior and a specific capacitance significantly greater than that of the Fe-MWNT electrode, indicating an enhanced electrochemical performance of the Fe-MWNTs/PPy due to their high electrical properties.

Cooperativity of E-cadherin and Smad4 Loss to Promote Diffuse-Type Gastric Adenocarcinoma and Metastasis

Park, Jun Won,Jang, Seok Hoon,Park, Dong Min,Lim, Na Jung,Deng, Chuxia,Kim, Dae Yong,Green, Jeffrey E.,Kim, Hark Kyun American Association for Cancer Research 2014 Molecular Cancer Research Vol.12 No.8

<P>Loss of E-cadherin (<I>CDH1</I>), Smad4, and p53 has been shown to play an integral role in gastric, intestinal, and breast cancer formation. Compound conditional knockout mice for Smad4, p53, and E-cadherin were generated to define and compare the roles of these genes in gastric, intestinal, and breast cancer development by crossing with <I>Pdx-1-Cre</I>, <I>Villin-Cre</I>, and <I>MMTV-Cre</I> transgenic mice. Interestingly, gastric adenocarcinoma was significantly more frequent in <I>Pdx-1-Cre;Smad4<SUP>F/F</SUP>;Trp53<SUP>F/F</SUP>;Cdh1<SUP>F</SUP></I><SUP>/+</SUP> mice than in <I>Pdx-1-Cre;Smad4<SUP>F/F</SUP>;Trp53<SUP>F/F</SUP>;Cdh1</I><SUP>+/+</SUP> mice, demonstrating that <I>Cdh1</I> heterozygosity accelerates the development and progression of gastric adenocarcinoma, in combination with loss of Smad4 and p53. <I>Pdx-1-Cre;Smad4<SUP>F/F</SUP>;Trp53<SUP>F/F</SUP>;Cdh1<SUP>F</SUP></I><SUP>/+</SUP> mice developed gastric adenocarcinomas without E-cadherin expression. However, intestinal and mammary adenocarcinomas with the same genetic background retained E-cadherin expression and were phenotypically similar to mice with both wild-type <I>Cdh1</I> alleles. Lung metastases were identified in <I>Pdx-1-Cre;Smad4<SUP>F/F</SUP>;Trp53<SUP>F/F</SUP>;Cdh1<SUP>F</SUP></I><SUP>/+</SUP> mice, but not in the other genotypes. Nuclear β-catenin accumulation was identified at the invasive tumor front of gastric adenocarcinomas arising in <I>Pdx-1-Cre;Smad4<SUP>F/F</SUP>;Trp53<SUP>F/F</SUP>;Cdh1<SUP>F</SUP></I><SUP>/+</SUP> mice. This phenotype was less prominent in mice with intact E-cadherin or Smad4, indicating that the inhibition of β-catenin signaling by E-cadherin or Smad4 downregulates signaling pathways involved in metastases in <I>Pdx-1-Cre;Smad4<SUP>F/F</SUP>;Trp53<SUP>F/F</SUP>;Cdh1<SUP>F</SUP></I><SUP>/+</SUP> mice. Knockdown of β-catenin significantly inhibited the migratory activity of <I>Pdx-1-Cre;Smad4<SUP>F/F</SUP>;Trp53<SUP>F/F</SUP>;Cdh1<SUP>F</SUP></I><SUP>/+</SUP> cell lines. Thus, loss of E-cadherin and Smad4 cooperates with p53 loss to promote the development and metastatic progression of gastric adenocarcinomas, with similarities to human gastric adenocarcinoma.</P><P><B>Implications:</B> This study demonstrates that inhibition of β-catenin is a converging node for the antimetastatic signaling pathways driven by E-cadherin and Smad4 in <I>Pdx-1-Cre;Smad4<SUP>F/F</SUP>;Trp53<SUP>F/F</SUP>;Cdh1<SUP>F</SUP></I><SUP>/+</SUP> mice, providing novel insights into mechanisms for gastric cancer metastasis. <I>Mol Cancer Res; 12(8); 1088–99. ©2014 AACR</I>.</P>

Scaffolds for bone tissue engineering fabricated from two different materials by the rapid prototyping technique: PCL versus PLGA.

Park, So Hee,Park, Dae Sung,Shin, Ji Won,Kang, Yun Gyeong,Kim, Hyung Keun,Yoon, Taek Rim,Shin, Jung-Woog Chapman and Hall ; Kluwer Academic Publishers 2012 Journal of materials science, Materials in medicin Vol.23 No.11

<P>Three dimensional tissue engineered scaffolds for the treatment of critical defect have been usually fabricated by salt leaching or gas forming technique. However, it is not easy for cells to penetrate the scaffolds due to the poor interconnectivity of pores. To overcome these current limitations we utilized a rapid prototyping (RP) technique for fabricating tissue engineered scaffolds to treat critical defects. The RP technique resulted in the uniform distribution and systematic connection of pores, which enabled cells to penetrate the scaffold. Two kinds of materials were used. They were poly(ε-caprolactone) (PCL) and poly(D, L-lactic-glycolic acid) (PLGA), where PCL is known to have longer degradation time than PLGA. In vitro tests supported the biocompatibility of the scaffolds. A 12-week animal study involving various examinations of rabbit tibias such as micro-CT and staining showed that both PCL and PLGA resulted in successful bone regeneration. As expected, PLGA degraded faster than PCL, and consequently the tissues generated in the PLGA group were less dense than those in the PCL group. We concluded that slower degradation is preferable in bone tissue engineering, especially when treating critical defects, as mechanical support is needed until full regeneration has occurred.</P>