Inositol이 白鼠唾液腺의 phosphatase 및 esterase에 미치는 影響에 關한 組織化學的硏究

朴致善 최신의학사 1968 最新醫學 Vol.11 No.6

Histochemcal observations were undertaken in respect to the influence of the administration of inositol upon the salivary glands in the normal male rats. The three major salivary glands were removed after 1, 2, 3, 4, 5,7 10 and 14 days of continuous administration (4mg of inositol was injected daily), respectively. The histochemicaI reactions for alkaline phosphatase, acid phosphatase and esterase were emploied to the paraffin sections by Coupling azo-dye method. The results were summarized as follows: 1) Alkaline phosphatase reaction tended to increase at the basal parts of the submandibular acini, the secretory and excretory ducts of each salivary glands. 2) In the acid phosphatase reactons, there was no difference between control group and inositol-administrated groups. 3) Esterase reaction also increased in the acinar cells and duct cells of the three major salivary glands.

李鶴 소장 고려불화 '수월관음도'의 保存修復에 관하여

朴智善 龍仁大學校 傳統文化硏究所 1996 丹豪文化硏究 Vol.- No.1

The restoration of this relic was performed by the Jung-Jae Conservation Center for about two years and eight months form February in 1994 until October in 1996. This has a great importance in that it was the first systematical restoration of paintings in Korea and a great deal of art historical information was gained about Koryo˘ Buddhist paintings during the work. Condition before Treatment This painting, 98.5 cm in length and 51.5 cm in width in net size, had been kept in framed panel without glass. The framed panel was originally an eastern hanging scroll and altered for convenience of exhibition and treatment as a common western type of picture frame in which the upper and lower parts of its original scroll were cut away and the back side was attached on plywood. Such an alteration was frequently found in paintings of western art galleries. Besides, the entire picture was blurry as if were covered with extraneous substance, the adhesive strength was so weakened between the painting and the lining paper that the picture screen was partly the infilling and the color was entirely worn of due to the adhesive weakness of the pigment. The painting was so much damaged that there rarely remained the blank space around the Buddhist image in it, which was ragged because any pieces of the Infilling silk had been overlaid in previous repairs. The bamboo and the Buddhist bottle for the background were overpainted in those occasions. Conversation Treatment Examination and Documentation : before Treatment-Washing the Painting-Strengthening the Pigments Adhesivenes-Removing the old Lining Paper by very little moisture-Removing the Pieces of the Infilling Silk of Previous Repairs-Investigation of the pigments from the back of the Painting - Infilling Silk from the back of the Painting - Dyeing the Lining Paper, Relining the Painting -First Toning-Selecting and Preparing the Mountings Fabrics - Second Lining - Drying - Assembling the Mountings - Final Lining - Finishing the hanging Scroll - Photographic Documentation : After Treatment - Preserving tin the Roller Clamp and the Double Storage box Paulownia wood. State after restoration After the old lining paper was removed, there remained the original painting and the pieces of the Infilling Silk in previous repairs. The Infilling Silk used for repairs were various in texture and color. When the Infilling Silk cloths were removed and the original painting remained, damaged parts were invisibly mended with handwoven silk cloths of similar intensity and texture with the original cloth materials. The color of the supplement part was chosen as similar to that of the blank space of the painting. Lost patterns were not restored in order for the painting to have a more similar form with its original form and then much more art historical value. The supplement part was only restored in unremarkable color so that the entire beauty of the painting might not be injured. The completed painting is 100.3 cm in length and 52.45 cm in width in net size by revealing the hidden part. It was made in hanging scroll and preserved in the Roller Clamp and the Double Storage box of Paulownia wood. Matters of Special Note 1. Before the restoration, some parts were observed by X-ray and found different from the views by the naked eye. .Haloes around the head are lost. .The front part of the crown is lost. .Lines observed by the naked eye are not the same as underlaid lines which are much more elaborate and excellent; expecially the lines of lips, neck and right foot suggest a possibility that they were painted by another person. .In the upper right part, two bamboo trees are observed in the X-ray picture straight upward to the end of the side, though they are not visible to the naked eye. The curved line in the middle of the bamboo was overpainted in previous repirs, which have caused a misunderstanding of the original shape of the bamboos. . In the left side, the Buddhist bottle is observed in the X-ray picture as a common Koryo˘ one with long neck, which was also altered completely different in previous repirs. 2. By Taking the Infrared Ray Picture The upper dark space proved to have been painted in different colors between the right and left sides. In other words, the white part in left means that it has less amount of carbon than that in right. The overlaid silk cloths for supplement in the left part is estimated that it had been dyed. .Outlines of a rock and a wave clearly appear in the lower part of the picture by the infrared ray. 3. After the lining paper was removed , the background painting technique of Koryo˘ Buddhist paintings was recognized. The restoration procedure provided an only chance to observe this technique and 4 x 5inch colorpictures and microscope pictures of pigment were taken. Since only a little pigment remained in the removed lining paper, its analysis was requested to the protection Laboratory of the Nara Cultural Properties Institute in Japan where the devices for performing such ananalysis were equipped. From the analysis, the red pigment proved to be HgS, that is the cinnabar the reddish ocher yellow pigment Pb_3(CO_3)_2(OH_2), that is white lead, and the green pigment a kind of chemical compound of copper. [Refer the report] 4. The above-mentioned information gained during the restoration provides a clue for studying the artistic technique of Koryo˘ Buddhist paintings and suggests that materials and techniques may be a good surce of studies in art history.

폐외소세포암

선길홍,윤찬영,정춘해,박치영 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.3

Background: Small cell carcinomas (SCC) are most commonly seen in the lung, approximately 2.5-4% of all SCC occur in extrapulmonary sites. This study aimed to review the clinical features, therapy and natural course of patients with extrapulmonary small cell carcinoma (EPSCC) in single-institution series. Methods: We retrospectively reviewed the medical records of patients with SCC between December 2002 and November 2005. Study eligibility required that patients had pathologically proven SCC in sites other than lung with normal radiological findings of the chest and normal sputum cytology or negative bronchoscopic findings. Result: Eight patients with EPSCC were identified and their primary sites were various such as esophagus (4 cases), kidney (1 case), thymus (1 case), stomach (1 case) and unknown primary supraclavicular lymph node (1 case). The 4 patients were classified as limited disease (LD) and 2 patients were as extended disease (ED) at initial staging work-up. But 2 patients were undetermined. The 3 patients with EPSCC of LD were treated with operation and adjuvant chemotherapy or chemotherapy and radiotherapy and one received only supportive care. They showed favorable clinical courses with a median overall survival of 23 months. EPSCC of ED and undetermined group received only supportive care. They had aggressive clinical courses with a median overall survival of 3 months, Conclusions: EPSCC was identified in various sites with the most common primary site being the esophagus, It was predominantly occurred in old male patients and associated with smoking like as SCC of the lung. Since EPSCC is a relalively rare disease that mimics SCC of the lung in its response to treatment and survival pattern, it would appear advisable to follow similar treatment guidelines. Although recurrence within short terms was observed, a significant survival benefit was obtained in EPSCC of LD received treatment (chemotherapy, operation and radiation therapy). Thus, EPSCC is usually a fatal disease with meidan overall survival of 18 months. 연구배경: 소세포암의 가장 흔한 발생부위는 폐이며, 폐외소세포암은 전체 소세포암의 2.5~4%를 차지하는 매우 드문질환이다. 본 연구의 목적은 단일 기관에서 진단된 폐외소세포암의 임상적 특징, 치료와 자연경과를 보고하고자 하였다. 방법: 조선대학교부속병원에서 2002년 12월 부터 2005년 11월 사이에 소세포암으로 진단된 66명의 의무기록을 검토하였다. 폐외소세포암은 흉부 단순 몇 전산화단층 촬영, 객담세포 검사, 기관지경 검사에서 폐병번이 없으면서 폐와 병변의 조직학적 생검에서 소세포암으로 증명된 경우로 하였으며, 총 8명이였다. 결과: 본 연구에서 식도가 전체 폐외소세포 암 환자의 50%(4례)로 가장 많은 원발병소를 보였으며 그 외 흉선, 신장, 위가 1례씩 있었으며 쇄곧상부 림프절에서 소세포암이 발견되었으나 원발 병소를 발견 못한 경우가 1례 관찰되었다. 4명의 환자는 제한 병기를 보였으며 2명은 광범위 병기를 보였지만 나머지 2명은 위내시경으로 식도에서 소세포암이 조직학적으로 진단되었으나 보전적 치료만을 받길 원하여 병기결정을 위한 검사는 시행할 수 없었다. 제한 병기의 폐외소세포암 환자는 4명이었다. 2명은 수술적 절제후 보조항암화학요법을 받았으며, 1명은 항암화학요법후 방사션치료를 받았고, 나머지 한명은 보전적 치료만 시행하였다. 제한 병기의 폐외소세포암 환자틀은 양호한 임상 경과를 보였으며 중앙 생존기간은 23개월이었다. 하지만 광범위 병기의 폐외소세포암 환자와 병기를 분류할 수 없던 환자에 대해서는 항암화학요법 등의 적극적 치료는 시행하지 않고 보존적 치료만 시행하였다. 그들의 임상경과는 빠르게 악화되었으며 중앙 생존 기간은 3개월이었다. 결론: 본 연구에서 폐외소세포암은 다양한 장기에서 발견될 수 있으나 가장 흔한 곳은 식도였다. 소세포폐암과 유사하게 고령, 남성 및 흡연과 관련을 보였었다. 제한 병기에서 국소 치료, 항암화학요법은 생존기간의 연장을 보였으나 쉽게 다른 장기로 전이가 되거나 재발하는 매우 치명적인 질환임을 확인할 수 있었다. 전체 중앙 생존기간은 18개월 이었고 항암 화학요법등의 치료를 받은 군이 보존적 치료를 받은 군에 비해 의미있는 생존기간 (p=0.040)의 연장을 보였다. 본 연구는 단일기관의 상대적으로 적은 수의 소규모 연구이지만 폐외소세포암의 제한 병기에서 국소치료 및 항암화학요법은 생존기간의 연장을 보였고 쉽게 다른 장기로 전이가 되거나 재발하는 매우 치명적인 질환임을 확인 할 수 있었다.

Streptomyces albulus 세정균체에 의한 polylysine의 대량생산

선흥석,김광섭,안치민,박찬영 全南大學校 觸媒硏究所 1997 觸媒硏究 論文集 Vol.19 No.-

Streptomyces albulus 세정균체를 이용하여 항세균물질인 폴리리신의 대량생산 가능성에 대하여 조사하였다. 발효기 배양에서 배양액 pH는 6.8에서 3.2로 감소하는 동안에 pH 4.0에서 4.5사이에서 폴리리신이 최대로 축적되므로 대수말기의 균체를 멸균증류수로 세척하여 마련한 세정균체를 아미노산 생산을 향상할수 있는 구연산을 2%첨가하고 pH를 최적인 4.2로 조정한 배지로 옮겨 배양하였다. 이러한 2단계공정으로 세정균체를 배양한 경우 배양액내의 폴리리신은 일반 1단계 단순 배양에 비하여 최대 6배의 축적량을 나타내었다. The feasibility of mass production of polylysine, an antibacterial substance, employing a washed mycelium of Streptomyces albulus has been investigated. Since the maximum accumulation of polylysine had appeared between 4.0 to 4.5 of pH during fermentor cultivation of which the pH of the broth has declined to 3.2 from 6.8, the strain growing in the broth on late log phase had been washed with sterilized water, then the sole mycelium had been transferred to another medium containing 2% citric acid having pH adjusted with NaOH to optimum of 4.2 to improve the production of the amino acid. The total accumulation of polylysine by washed mycelium of Streptomyces albulus from this two step procedure has exhibited 6 times more than the normal production of the simple one step fermentation.

"나한도"의 보존수복 : 국립중앙박물관 소장 고려불화

박지선 국립중앙박물관 2000 박물관보존과학 Vol.2 No.-

회화유물 보존에 있어서 가장 중요한 관점은 유물의 원형을 찾아 그대로 복원하는 것이다. 복원 방법으로는 전통적인 표장법을 쓰는데 이를 위해서는 X선 및 적외선 촬영, 현미경조사 등과 같은 과학적인 조사와 함께 재료를 선택적으로 사용하는 것이다. 이번 국립중앙박물관 소장 고려불화 ‘나한도’는 그 원형이 많이 손상되어 있었다. 따라서 보존처리 과정에 있어 그 문제점을 찾아 복원하였고, 표장 형식은 액자에서 족자로 바꾸는 방법을 택하였다. 본고에서는 ‘나한도‘의 사전조사 내용 및 보존처리 과정을 소개하고자 한다. The most important aspect in preserving ancient paintings is to return the painting to the original state and conserve it in the original state. One traditional recovering method is the use of frame, for which scientific analysis such as X-rays, infrared and microscope are used and materials are carefully selected. Arhat, a Buddhist painting of Goryeo Dynasty, one of the Korean National Museum collections has lost its original shape. With conservation treatment, the cause was found, that is to change frame scroll method to mounting method. In the main body, pre-analysis and conservation method of Arhat will be introduced.

자가면역 용혈빈혈의 임상적 분석

박치영,강지은,박상곤,김상현,김형선,정춘해 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.2

Background: Autoimmune hemolytic anemia (AIHA) is a very uncommon disorder with the incidence between one and three cases per a hundred thousans a year. There have been very few studies about AIHA in Korea because of its low incidence. Most AIHA studies in Korea were about case history. The aim of this study was to review the clinical features, therapy and outcome of AIHA patients in single institution clinic. Methods: We reviewed retrospectively the medical records of AIHA patients from December 2002 to December 2006. Results: Twelve patient with AIHA were identified, and their median age was 49 years (range 27-75). Male to female ratio is 9:3. The median hemoglobin level was 5.0 g/㎗ (range 2.5-8.2). Warm type AIHA was most common (8/12), cold type was three, and mixed type was one. There was histories of associated disease in six patients. Two patients were complicated by systemic lupus erythematosus and mycoplasma infection and one patient by idiopathic myelofibrosis and solid tumor. Oral steroid was used as the first-line treatment in nine patients. An initial response was observed in eight patients with complete response. One patient had not responded to the initial steroid treatment, and then showed complete response with rituximab. Two relapsed patients were treated with rituximab and partial splenic embolization. Conclusion: The majority of patients can be treated with steroid. Rituximab can improve the response rate in relapsed and refractory AIHA.

일본 중학교에서의 지역학습 : the Case of Japan

박선미,정치영 한국지리환경교육학회 2003 한국지리환경교육학회지 Vol.11 No.1

본 연구에서는 우리나라 중학생들이 배우고 있는 지역학습의 목적과 내용간에 정합성이 결여되었다는 문제점을 인식하고 이러한 문제 해결의 실마리를 마련하기 위하여 1998년에 개정된 일본의‘학습지도요령’과 帝國書院과 東京書籍의 중학교 지리교과서를 대상으로 학습지역을 선정하는 기준과 지역학습 내용 및 활동을 분석한다. 일본 지역학습은 우리나라와 같이 개별 지역 낱낱을 모두 학습하도록 되어 있던 종전의 틀을 과감하게 탈피하여 다양한 규모의 지역적 특색을 파악하는 관점과 방법을 체득하도록 내용을 구성하고 있다. 우리나라 교육과정과 달리, 일본의 학습지도요령은 학습해야 할 지역을 선정하는 기준과 해당 규모에서 성취해야 할 목표를 제시하고, 교과서 집필진과 출판사가 교과서에서 다루는 지역과 구체적인 내용을 선택한다. 일본의 지역학습은 학습의 넓이 대신에 깊이를 선택했다. 이러한 전환은 한 영역의 깊이 있는 학습이 학생들의 사고를 외연적으로 확대시키기 때문에 학습의 넓이를 결코 희생시키지 않으리라는 믿음을 전제로 한 것이다. This study examines criteria of selecting regions, contents, and activities for regional studies based on the revised version of Japanese national curriculum in social studies (1998) and middle school textbooks of Imperial Books and Tokyo Books. By referring to the Japanese case, the authors hope to find possible solutions to the gap between aims and contents of regional studies in the middle school level social studies in Korea. Regional studies in Japan differs from those in Korea in the sense that the contents include methods and viewpoints by which students can understand regional characteristics in different scales, which extends its scope far beyond simple poking and soaking of each specific region. Furthermore, unlike National Curriculum in Korea, instructions for learning and teaching in Japan suggest relevant criteria for selecting regions and main purposes that students should achieve in each scale. Also in Japan, selection of regions and contents for textbooks is decided by the editorial board and the publishers. Regional studies in Japan is focusing on the depth details rather than the comprehensiveness. This focus is based on the belief that in depth study on a particular are should not sacrifice the comprehensiveness because it helps students to extend their scope of reasoning.

혼합형 자가면역성용혈성빈혈과 동반된 Evans 증후군 1례

선길홍,윤찬영,박상곤,박경희,우정주,한경택,김진화,김영훈,정춘해,박치영 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

Evans syndrome is defined as a simultaneous or sequential occurrence of autoimmune hemolytic anemia and autoimmune thrombocytopenia. Autoimmune hemolytic anemia (AIHA) is usually induced by IgG warm autoantibody or cold-active IgM antibodies reacting specifically with antigens associated with a patient's RBC. AIHA is a fairly uncommon disorder, with estimates of the incidence at 1 to 3 cases per 100,000 per year. Mixed-type AIHA is a relatively uncommon form of AIHA, with studies noting the incidence of 7-8% among cases of AIHA. We experienced a patient, 46-year-old woman who was diagnosed having a very rare clinical presentation of mixed warm and cold antibody mediated Evans syndrome. She was treated with corticosteroid therapy only and has been maintaining a complete response for 15 weeks. 저자들은 혼합형의 자가면역성 용혈성 빈혈과 자가면역성 혈소판 감소증이 동시에 발생한 혼합형 Evans 증후군으로 진단하고 스테로이드 요법 후 혈액학적으로 회복된 상태로 15주가 지난 현재 steroid 5 mg/일 까지 감량한 상태에서 추적 관찰 치료중인 46세 여자 환자를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

繪畵.典籍문화재 보존의 역사와 현황

박지선 용인대학교 박물관 2007 丹豪文化硏究 Vol.- No.11

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쇄석 골재의 광물학적 및 화학적 특성과 알칼리-실리카 반응성

전쌍순,박현재,이효민,진치섭 釜山大學校生産技術硏究所 2002 生産技術硏究所論文集 Vol.61 No.-

본 연구에서는 쇄석 골재의 광물학적 및 화학적 특징과 알칼리-실리카 반응에 대한 골재의 유해 가능성을 연구하였다. 이를 위하여 알칼리-실리카 반응을 유발하는 광물들의 포함여부 및 이에 따라 잠재적으로 조기 열화현상을 유발할 수 있는 암석을 유형별(화성암, 변성암, 퇴적암 및 탄산염암)로 골재를 수집하였다. 암종 별로 선별하여 수집한 골재 내의 알칼리 반응성 유해 물질 존재 여부 확인 X선 회절분석(XRD)과 편광현미경에 의한 광물학적 방법을 사용하였다. 알칼리-실리카 반응성 유무해 판단을 ASTM C 227의 Mortar-Bar 시험방법에 의해 평가 분석하였고, 주 화학성분은 X선 형광분석기(XRF)로 실시하였다. In Korea, due to the shortcomings of natural aggregates and increasing needs of crushed stones, it is necessary to examine the alkali-silica reaction of the crushed stones. The purpose of this study is to analyze petrographic, chemical properties and alkali-silica reaction of crushed stones. This study was performed to investigate the alkali-silica reaction of crushed stones using chemical analysis, physical properties, XRD, XRF and mortar-bar method. As a result, most of test aggregates didn't show any reaction, but many test aggregates have common deleterious mineral. Therefore, there exists the possibility of chemical reaction in petrographic point of view.