3차원 전산화단층촬영 영상을 이용한 안면 연조직 두께 계측의 임상적 유용성

정호걸,김기덕,한승호,허경석,이제범,박혁,최성호,김종관,박창서 대한구강악안면방사선학회 2006 Imaging Science in Dentistry Vol.36 No.2

Purpose : To evaluate clinical usefulness of facial soft tissue thickness measurement using 3D computed tomographic images. Materials and Methods : One cadaver that had sound facial soft tissues was chosen for the study. The cadaver was scanned with a Helical CT under following scanning protocols about slice thickness and table speed; 3 mm and 3 mm/sec, 5 mm and 5 mm/sec, 7 mm and 7 mm/sec. The acquired data were reconstructed 1.5, 2.5, 3.5 mm reconstruction interval respectively and the images were transferred to a personal computer. Using a program developed to measure facial soft tissue thickness in 3D image, the facial soft tissue thickness was measured. After the ten-time repeation of the measurement for ten times, repeated measure analysis of variance (ANOVA) was adopted to compare and analyze the measurements using the three scanning protocols. Comparison according to the areas was analyzed by Mann-Whitney test. Results : There were no statistically significant intraobserver differences in the measurements of the facial soft tissue thickness using the three scanning protocols (p>0.05). There were no statistically significant differences between measurements in the 3 mm slice thickness and those in the 5 mm, 7 mm slice thickness (p>0.05). There were statistical differences in the 14 of the total 30 measured points in the 5 mm slice thickness and 22 in the 7mm slice thickness. Conclusion : The facial soft tissue thickness measurement using 3D images of 7 mm slice thickness is acceptable clinically, but those of 5 mm slice thickness is recommended for the more accurate measurement.

Upregulation of heme oxygenase-1 by ginsenoside Ro attenuates lipopolysaccharide-induced inflammation in macrophage cells

Kim, Sokho,Oh, Myung-Hoon,Kim, Bum-Seok,Kim, Won-Il,Cho, Ho-Seong,Park, Byoung-Yong,Park, Chul,Shin, Gee-Wook,Kwon, Jungkee The Korean Society of Ginseng 2015 Journal of Ginseng Research Vol.39 No.4

Background: The beneficial effects of ginsenoside species have been well demonstrated in a number of studies. However, the function of ginsenoside Ro (GRo), an oleanane-type saponin, has not been sufficiently investigated. Thus, the aim of the present study was to investigate the anti-inflammatory effects of GRo in vitro using the Raw 264.7 mouse macrophage cell line treated with lipopolysaccharide (LPS), and to clarify the possible mechanism of GRo involving heme oxygenase-1 (HO-1), which itself plays a critical role in self-defense in the presence of inflammatory stress. Methods: Raw 264.7 cells were pretreated with GRo (up to $200{\mu}M$) for 1 h before treatment with 1 mg/mL LPS, and both cell viability and inflammatory markers involving HO-1 were evaluated. Results: GRo significantly increased cell viability in a dose dependent manner following treatment with LPS, and decreased levels of reactive oxygen species and nitric oxide. GRo decreased inflammatory cytokines such as nitric oxide synthase and cyclooxygenase-2 induced by LPS. Moreover, GRo increased the expression of HO-1 in a dose dependent manner. Cotreatment of GRo with tin protoporphyrin IX, a selective inhibitor of HO-1, not only inhibited upregulation of HO-1 induced by GRo, but also reversed the anti-inflammatory effect of GRo in LPS treated Raw 264.7 cells. Conclusion: GRo induces anti-inflammatory effects following treatment with LPS via upregulation of HO-1.

Upregulation of heme oxygenase-1 by ginsenoside Ro attenuates lipopolysaccharide-induced inflammation in macrophage cells

Sokho Kim,Myung-Hoon Oh,Bum-Seok Kim,Won-Il Kim,Ho-Seong Cho,Byoung-Yong Park,Chul Park,Gee-Wook Shin,Jungkee Kwon 고려인삼학회 2015 Journal of Ginseng Research Vol.39 No.4

Background: The beneficial effects of ginsenoside species have been well demonstrated in a number of studies. However, the function of ginsenoside Ro (GRo), an oleanane-type saponin, has not been suffi- ciently investigated. Thus, the aim of the present study was to investigate the anti-inflammatory effects of GRo in vitro using the Raw 264.7 mouse macrophage cell line treated with lipopolysaccharide (LPS), and to clarify the possible mechanism of GRo involving heme oxygenase-1 (HO-1), which itself plays a critical role in self-defense in the presence of inflammatory stress. Methods: Raw 264.7 cells were pretreated with GRo (up to 200mM) for 1 h before treatment with 1 mg/ mL LPS, and both cell viability and inflammatory markers involving HO-1 were evaluated. Results: GRo significantly increased cell viability in a dose dependent manner following treatment with LPS, and decreased levels of reactive oxygen species and nitric oxide. GRo decreased inflammatory cytokines such as nitric oxide synthase and cyclooxygenase-2 induced by LPS. Moreover, GRo increased the expression of HO-1 in a dose dependent manner. Cotreatment of GRo with tin protoporphyrin IX, a selective inhibitor of HO-1, not only inhibited upregulation of HO-1 induced by GRo, but also reversed the anti-inflammatory effect of GRo in LPS treated Raw 264.7 cells. Conclusion: GRo induces anti-inflammatory effects following treatment with LPS via upregulation of HO-1.

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

한국판 해밀턴 우울증평가척도(K-HDRS)의 확인적 요인 분석

박혜원,이은호,김도관,유범희,이동수,김지혜 大韓神經精神醫學會 2009 신경정신의학 Vol.48 No.1

Objectives The present study was conducted to examine the factor structure of a Korean version of the Hamilton Depression Rating Scale (K-HDRS), and we did so by performing a confirmatory factor analysis (CFA). Methods The data from the 17-item K-HDRS data was obtained from 319 South Koreans who met the DSM-IV Criteria of Major Depressive Disorder. We examined the fit of ten competing models. The CFAs were evaluated in their original first-order structures and in their hierarchically related counterparts. Results The alternative models obtained unsatisfactory fit indices, although the five-factor inter-correlated model (model 5a) demonstrated a relatively good fit to the data. The model 5a also performed better than its hierarchically related counterpart (model 5b). The Modification Indices (MIs) were used to provide a more satisfactory account of the data. The Mls suggested correlations between the unique variances of items (item 1 & 3, item 10 & 15), and these parameters were added to the model 5a. After introducing minor modifications, the 'final' model (5m) yielded an improved model fit. Conclusion This study suggests that the symptoms of depression, as assessed by the K-HDRS, cluster into five factors : anhedonia/retardation, guilt/agitation, bodily symptoms, insomnia and appetite. This study provides evidence for the cross-cultural generalizability of the HDRS, although some refinement of the scale is still required.

會計上 資産의 本質에 대한 硏究

朴範鎬 홍익대학교 경영연구소 1985 경영연구 Vol.9 No.-

In every branch of studies, it is very important to form a clear concept, and to understand the true nature of the branch. Without the formation of a clear concept, we cannot build up a hypothesis to a theorem or induce principles and rules. The discussion of the true nature of assets is as old as the history of accounting itself. And the concept of assets has varied according to accounting principles derived from accounting situation. This study examines concepts of assets in static theory, in dynamic theory, and as service potential. Then discussion is concentrated on the concept of assets as service potential. because in the current accounting theory assets are thought to have the same attributes as service potential. This study asserts that an asset has the following three requisite attributes, and it presents the theoretical support of such an assertion. The three requisite attributes are: 1) an asset should be an economic resource, 2) an asset should provide a service or benefit for the attainment of a business purpose, and 3) an asset is that which a business has obtained from present or past transactions and now has under its control. This study also discusses the theoretical background or the asset quality of research and development expenditures and human resources, in order to expand the above mentioned asset concept.

Polyphosphate가 함유된 근관충전재가 구강세균의 성장에 미치는 영향

박석범,최기운,최호영 대한치과보존학회 2001 Restorative Dentistry & Endodontics Vol.26 No.2

Eliminating the infecting bacteria of the root canal system and preventing reinfection must be the main objectives of all endodontic works. None of commercially available root canal sealers have the properties of desirable tissue compatibility and strong antibacterial activity. The purpose of this study is to develope an ideal root canal sealer using commercially available polyphosphate (polyP), Calgon, which is known to be antibacterial and safe. For the study, resin-type AH26, zinc oxide eugenol-type Tubli-Seal, Ca(OH)2-type Apexit as base sealers for polyp (0∼3%) and para formaldehyde-containing N2 as a control base were selected. Specimens (3×4mm) of the sealers were prepared in a 37℃ incubator far 3 and 10 days and their antibacterial activity against streptococci and black-pigmented anaerobic rods was observed using an agar diffusion method. The result were as follows : 1.Among 3-day-old root canal sealers, N2 as a positive control showed the strongest antibacterial effect, followed by AH26, Tubli-Seal and, Apexit which barely showed antibacterial activity against the test bacteria. In contrast, 10-day-old AH26 showed a greater antibacterial activital than 10-day-old N2. 2.All sealer specimens showed a greater antibacterial activity against black-pigmented anaerobic rods than streptococci. Three-day-old ones appeared to be more antibacterial than 10-day-old ones except for Apexit. 3.As compared to N2, 3-day-old AH26 demonstrated a similar antibacterial activity against black-pig-mented anaerobic rods but to a lesser extent to streptococci. Ten-day-old AH26 showed a greater antibacterial activity against black-pigmented anaerobic rods than 10-day-old N2. 4.As compared to AH26, Tubli-Seal generally revealed a lower antibacterial activity but it showed a greater antibacterial activity aginst S. gordonii Challis. 5.Enhancement of antibacterial activity by polyp was more clearly observed when it was added to Ca(OH)2-based root canal sealers, Tubli-Seal and N2. 6.The addition of polyP enhanced the antibacterial activity of 3-day-old AH26 against S. gordonii G9B (16%) and Challis (29%), and P. gingivalis 2561 (24%) only. Moreover, polyp failed to increase antibacterial activity of 10-day-old AH26 against the test strains but P. gingivalis A7A1-28 (13%). 7.The addition of polyp increased the antibacterial effect of 3-day-old Tubli-Seal on several test bacteria including S. mutans GS-5 (50%), S. gordonii G9B (47%) and Challis (122%), and all the test strains of P. gingivalis (13∼35%) except for 9-14K-1. The addition of polyp to 10-day-old Tubli-Seal increased antibacterial activity of the root canal sealer against most test strains. 8.3-day-old Apexit failed to show antibacterial activity, if any very little against S. mutans GS-5 and Pr. intermedia ATCC 49046. However, polyP increased its antibacterial activity by 50 and 69%, respectively. Increase of antibacterial activity of 10-day-old Apexit by polyP was more clearly observed than that of 3-day-old one. The overall results suggest that polyP may be used in clinic as an antibacterial agent in root canal sealers. However, in order to maximize its antibacterial effect, the composition of sealers should be considered.

회계이익정보의 유용성에 관한 연구 : 장외등록법인에 있어 재무정보의 유용성

朴範鎬,尹勢憲 홍익대학교 경영연구소 2001 경영연구 Vol.26 No.-

걷기운동과 걷기운동 후 진동운동 병행 방법이 중년 비만 여성의 신체조성에 미치는 영향

박순호,류범선 龍仁大學校 體育科學硏究所 2008 體育科學硏究論叢 Vol.17 No.1

In the present study, the effects of walking exercise applying whole body vibration exercise on a body composition(Weight, %Fat, Fat, Body Mass Index; BMI, Soft Lean Mass, and Waist-Hip Ratio; WHR) change in a middle-aged obese female, and to figure out which method are more effective on those variables was investigated. Subjects were divided into two groups: the walking group(A, n=9) and the walking+whole vibration group(B, n=8). In an intensity of walking treadmill exercise was same in each group(HRmax60%), however A group has treated just walking on the treadmill with 40min and B group has 30min walking and applied 10min of whole vibration exercise. The results are as follows; 1. After 8 weeks training, there were no significant changed on weight, BMI, %Fat and Soft Lean Mass in A group, however, it have shown to decrease at Fat(kg) and WHR. And B group have appeared to have decreased at weight, BMI, %Fat, Fat(kg) and WHR, 8 weeks of training, respectably, except Soft Lean Mass. 2. After 8 weeks training, there were no significant reduction showed between groups. Overall, its applying whole vibration exercise with walking seemed to be effect on a decomposition of body fat, and these results suggested to apply those kind methods should include aerobic exercise, such as walking and running etc, for increasing the its effects.

團體交涉을 위한 會計情報시스템에 관한 硏究

朴範鎬,金東出 홍익대학교 경영연구소 1991 경영연구 Vol.15 No.-