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Cuong, Nguyen Xuan,Thao, Nguyen Phuong,Luyen, Bui Thi Thuy,Ngan, Nguyen Thi Thanh,Thuy, Dinh Thi Thu,Song, Seok Bean,Nam, Nguyen Hoai,Kiem, Phan Van,Kim, Young Ho,Minh, Chau Van WILEY‐VCH Verlag 2014 Chem Inform Vol.45 No.28
<P><B>Abstract</B></P><P>isolation, structure determination and antiinflammatory effects of nine cembranoid diterpenes including four new compounds, crassumols D—G (I)—(IV), respectively</P>
Cembranoid Diterpenes from the Soft Coral Lobophytum crassum and Their Anti-inflammatory Activities
Cuong, Nguyen Xuan,Thao, Nguyen Phuong,Luyen, Bui Thi Thuy,Ngan, Nguyen Thi Thanh,Thuy, Dinh Thi Thu,Song, Seok Bean,Nam, Nguyen Hoai,Kiem, Phan Van,Kim, Young Ho,Minh, Chau Van Pharmaceutical Society of Japan 2014 Chemical & pharmaceutical bulletin Vol.62 No.2
Triterpenoid saponins from the roots of Rosa rugosa Thunb. as rat intestinal sucrase inhibitors
Nguyen Phuong Thao,Bui Thi Thuy Luyen,주성호,Tran Manh Hung,Nguyen Xuan Cuong,Nguyen Hoai Nam,권영인,Chau Van Minh,김영호 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.10
Medicinal plants constitute an important sourceof potential therapeutic agents for diabetes. The purpose ofpresent study is to investigate the effect of root extract ofRosa rugosa Thunb. on inhibition of sucrase related todiabetes mellitus (DM). Bioassay-guided fractionation ofthe methanol extract led to the identification of 13 triterpenoidsaponins (1–13). Their structures were elucidatedon the basis of extensive spectroscopic analysis, including1D, 2D NMR, and MS. The n-butanol fraction showedpotent rat intestinal sucrase inhibitory activity with value of87.62 ± 5.84 % inhibition compared to the positive controlacarbose (50.96 ± 2.97 % inhibition at 0.02 mM). Subsequently, compounds 11–13 (1.0 mM) exhibited significantsucrase inhibitory activity, with inhibition percentagevalues of 41.17 ± 3.52, 46.80 ± 4.00, and39.39 ± 4.19 %, respectively. Whereas, compounds 2–6,8, and 10 showed moderate sucrase inhibitory activity(ranging from 13.26 ± 7.00 to 32.08 ± 6.04 % inhibition)at a same concentration. The data provide a starting pointfor creating new sucrase inhibitors, which may be usefulfor the development of effective therapies for the treatmentof DM.
Inverse MR and Dual-AMR Phenomena in Co/CoO/Ag/Co Sandwiches
Nguyen Anh Tuan,Luong Van Su,Hoang Quoc Khanh,Nguyen Anh Tue,Nguyen Thi Luyen 한국물리학회 2018 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.72 No.7
Band-form Co/CoO/Ag/Co sandwiches were prepared using radio-frequency magnetron sputtering. The sandwiches had rather thick Co (tCO = 63 nm) and Ag (tAg = 2 ÷ 65 nm) layers and a super-thin paramagnetic cobalt monoxide (CoO) layer (< 1 nm) inserted in the Co/Ag interface. The sandwiches exhibited anomalous magnetoresistance (MR) behavior depending on the tAg value. Inverse magnetoresistance (IMR) effect was observed only at thin tAg values of 2 nm and 6 nm, whereas the dual-anisotropic MR (dual-AMR) occurred at thicker tAg values of 12 nm, 25 nm and 65 nm. A superposition of the dual-AMR and the weak IMR effects was obtained at the thickest Ag layer of 65 nm. The origin of these anomalous MR behaviors was discussed to show the prominent role of the CoO layer and large thickness of the Co and Ag layers.
Nguyen Phuong Thao,Bui Thi Thuy Luyen,Chau Ngoc Diep,Bui Huu Tai,김은지,강희경,이상현,장해동,Nguyen The Cuong,Nguyen Van Thanh,Nguyen Xuan Cuong,Nguyen Hoai Nam,Chau Van Minh,김영호 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.4
This study performed phytochemical and bioactiveassessments of the mangrove Lumnitzera racemosaWilld. leaves. Bioassay-guided fractionation of the methanolicextracts led to the identification of thirty-six compounds(1–36), their structures were elucidated using detailed NMRspectroscopic and MS analysis. The extracts, fractions, andthe isolated compounds were screened for potential antioxidantand cytotoxic activities. Antioxidant assays wereperformed using peroxyl radical-scavenging and reducingassays, whereas cytotoxicity was measured using MTTassays in HL-60 and Hel-299 cell lines. The methanolicextract, CH2Cl2 and n-BuOH fractions (10.0 lg/mL)exhibited potent antioxidant activity, with Trolox equivalent(TE) values of 24.94 ± 0.59, 28.34 ± 0.20, and27.09 ± 0.37 (lM), respectively. In addition, the isolatedcompounds exerted cytotoxic effects in a dose-dependentmanner; compounds 1 and 14 exhibited the most potentcytotoxicity in HL-60 cells, with IC50 values of 0.15 ± 0.29and 0.60 ± 0.16 lM, respectively. To clarify the mechanism(s) behind these cytotoxic effects, we measured thetime-dependent changes in apoptotic markers including thecondensation and fragmentation of nuclear chromatin, andthe downregulation of p-ERK1/2, p-AKT, and c-Myc levels.
Evaluation of Auditors' Professional Skills in Local Auditing Firms in Hanoi
NGUYEN, Thi Hanh Duyen,LE, Van Luyen,HAU, Nguyen Van,DO, Duc Tai,THAO, Nguyen Thi Thu Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.9
In recent years, the quality of auditing human resources in domestic auditing firms in Hanoi has certain limitations in which professional skills of auditors have not been given adequate attention. The number of customers at local auditing firms is forecast to increase gradually. Therefore, the quantity and quality of auditors need to be improved to meet requirements of the workload. Data for this research were collected through surveying 120 customers of domestic auditing firms in Hanoi on the 5-point Likert scale. Based on the collected data, we employ both qualitative and quantitative methodology along with some tools such as descriptive statistics, Cronbach's Alpha, T-test and ANOVA to analysis, evaluate and measure the professional skills of auditors in local auditing firms in Hanoi. The results show that the professional skills of auditors in auditing firms include 17 attributes. The majority of respondents show appreciation for the professionalism and professional competence of auditors, while, they think that critical thinking skills and creative thinking skills are still limited and need to be improved. These findings, not only help auditors to improve themselves, but also provide solutions for managers of domestic auditing firms in Hanoi to enhance quality of audited human resources.
Nguyen Phuong Thao,Bui Thi Thuy Luyen,Nguyen Thi Thanh Ngan,Le Duc Dat,Nguyen Xuan Cuong,Nguyen Hoai Nam,Phan Van Kiem,Seok Bean Song,Chau Van Minh,김영호 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.5
Peroxisome proliferator-activated receptors(PPARs) are ligand-activated transcription factors thatregulate the expression of multiple genes involved inmetabolic, anti-inflammatory, and developmental processes. This study evaluated the PPARs transactivationaleffects of thirteen cembranoid diterpenoids 1–13 from thesoft coral Lobophytum crassum, using PPAR-responsiveelements–luciferase reporter and GAL4–PPAR chimeraassays. All isolated compounds activated the transcriptionof PPARs in a dose-dependent manner, with EC50 valuesranging from 2.07 ± 1.73 to 130.20 ± 1.85 lM. Moreover,compounds 6–9 affected the transactivation of allthree PPAR types, PPARa, c, b(d), in a dose-dependentmanner, with EC50 values in a ranging from 11.92 ± 1.23to 122.50 ± 2.12 lM. These results provide a scientificrationale for further studies on the soft coral L. crassum andits diterpenoid constituents to develop medicinal productsagainst inflammatory and metabolic diseases.
Nguyen Phuong Thao,Nguyen Hoai Nam,Nguyen Xuan Cuong,Bui Thi Thuy Luyen,Bui Huu Tai,김지은,송석빈,Phan Van Kiem,Chau Van Minh,김영호 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.6
Anti-inflammatory transcriptional effects ofnineteen compounds (1–19) from the soft coral Sinulariamaxima were evaluated using NF-jB luciferase and reversetranscriptase polymerase chain reaction. Compounds 1, 2,4, 8, 15, 17, and 18 significantly inhibited TNFa-inducedNF-jB transcriptional activity in HepG2 cells in a dosedependentmanner, with IC50 values ranging from15.81 ± 2.29 to 29.10 ± 1.54 lM. Furthermore, the transcriptionalinhibitory function of these compounds wasconfirmed by a decrease in intercellular adhesion molecule-1 and inducible nitric oxide synthase gene expressionlevels in HepG2 cells. These results provide a scientificrationale for the use of the soft coral S. maxima warrantfurther studies to develop new agents for the preventionand treatment of inflammatory.