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Nguyen Thu Hien,Nguyen Duc Quan,Kim Lien Nguyen Thi,Thi Thanh Ngan Nguyen,Nguyen Thi Phuong Mai,Tran Ngoc Dung,Nguyen Huy Hoang 한국유전학회 2023 Genes & Genomics Vol.45 No.4
Background Androgens and androgen receptor (AR) are critical regulators of the masculinization process in male sexual development. The absence of a functioning AR results in the development of the androgen insensitivity syndrome (AIS), a rare disorder of sexual development (DSD) characterized by the external genitalia feminization, gynecomastia, and impaired spermatogenesis. Objective To determine the AR gene mutations associated with male DSD in four unrelated Vietnamese patients. Methods To detect the disease-causing mutations, whole exome sequencing (WES) was performed on four patients diagnosed with AIS. Sanger sequencing was then used for validation of the identified mutations. Finally, 12 web-based tools, three-dimensional protein modeling software, and the guidelines issued by the American College of Medical Genetics and Genomics were used to assess the potential pathogenicity of these mutations. Results Four distinct novel mutations, namely c.1834T > A (p.Cys612Ser), c.2122 C > G (p.Leu708Val), c.2630T > G (p.Phe877Cys), and c.2641 C > A (p.Leu881Met) in the AR gene, were identified in four AIS patients using WES. The in silico analysis results revealed that the Cys612, Leu708, Phe877, and Leu881 sites are important for an appropriate response to androgens of the AR, and mutation at these sites can have adverse effects on the AR functions, androgen–AR interaction, and AR signaling pathway. Conclusions WES and in silico analyses strongly suggested that four novel AR mutations are pathogenic and have led to the development of AIS in the four Vietnamese patients under consideration.
Nguyen Thi Thanh Ngan,TRANHONG QUANG,김관우,김혜진,손재학,강대길,이호섭,김윤철,오현철 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.3
After the chemical investigation of the ethylacetate extract of the marine-derived fungal strain Penicilliumsp. SF-5629, the isolation and structural elucidationof eight secondary metabolites, including (3R,4S)-6,8-dihydroxy-3,4,7-trimethylisocoumarin (1), (3S,4S)-sclerotininA (2), penicitrinone A (3), citrinin H1 (4), emodin (5),x-hydroxyemodin (6), 8-hydroxy-6-methyl-9-oxo-9Hxanthene-1-carboxylate (7), and 3,8-dihydroxy-6-methyl-9-oxo-9H-xanthene-1-carboxylate (8) were carried out. Evaluation of the anti-inflammatory activity of thesemetabolites showed that 4 inhibited nitric oxide and prostaglandinE2 production in lipopolysaccharide-stimulatedBV2 microglia, with IC50 values of 8.1 ± 1.9 and8.0 ± 2.8 lM, respectively. The inhibitory function of 4was confirmed based on decreases in inducible nitric oxidesynthesis and cyclooxygenase-2 gene expression. In addition,4 was found to suppress the phosphorylation ofinhibitor kappa B-a, interrupt the nuclear translocation ofnuclear factor kappa B, and decrease the activation of p38mitogen-activated protein kinase.
Nguyen Phuong Thao,Bui Thi Thuy Luyen,Nguyen Thi Thanh Ngan,Le Duc Dat,Nguyen Xuan Cuong,Nguyen Hoai Nam,Phan Van Kiem,Seok Bean Song,Chau Van Minh,김영호 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.5
Peroxisome proliferator-activated receptors(PPARs) are ligand-activated transcription factors thatregulate the expression of multiple genes involved inmetabolic, anti-inflammatory, and developmental processes. This study evaluated the PPARs transactivationaleffects of thirteen cembranoid diterpenoids 1–13 from thesoft coral Lobophytum crassum, using PPAR-responsiveelements–luciferase reporter and GAL4–PPAR chimeraassays. All isolated compounds activated the transcriptionof PPARs in a dose-dependent manner, with EC50 valuesranging from 2.07 ± 1.73 to 130.20 ± 1.85 lM. Moreover,compounds 6–9 affected the transactivation of allthree PPAR types, PPARa, c, b(d), in a dose-dependentmanner, with EC50 values in a ranging from 11.92 ± 1.23to 122.50 ± 2.12 lM. These results provide a scientificrationale for further studies on the soft coral L. crassum andits diterpenoid constituents to develop medicinal productsagainst inflammatory and metabolic diseases.
A New Sterol from the Soft Coral Lobophytum crassum
Nguyen, Phuong Thao,Nguyen, Hoai Nam,Nguyen, Xuan Cuong,Nguyen, Xuan Nhiem,Pham, The Tung,Tran, Hong Quang,Nguyen, Thi Thanh Ngan,Phan, Van Kiem,Chau, Van Minh,Kim, Young Ho Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.1
Cembranoid Diterpenes from the Soft Coral Lobophytum crassum and Their Anti-inflammatory Activities
Cuong, Nguyen Xuan,Thao, Nguyen Phuong,Luyen, Bui Thi Thuy,Ngan, Nguyen Thi Thanh,Thuy, Dinh Thi Thu,Song, Seok Bean,Nam, Nguyen Hoai,Kiem, Phan Van,Kim, Young Ho,Minh, Chau Van Pharmaceutical Society of Japan 2014 Chemical & pharmaceutical bulletin Vol.62 No.2
Cuong, Nguyen Xuan,Thao, Nguyen Phuong,Luyen, Bui Thi Thuy,Ngan, Nguyen Thi Thanh,Thuy, Dinh Thi Thu,Song, Seok Bean,Nam, Nguyen Hoai,Kiem, Phan Van,Kim, Young Ho,Minh, Chau Van WILEY‐VCH Verlag 2014 Chem Inform Vol.45 No.28
<P><B>Abstract</B></P><P>isolation, structure determination and antiinflammatory effects of nine cembranoid diterpenes including four new compounds, crassumols D—G (I)—(IV), respectively</P>
LE, Thai Thanh Dat,HO, Thi Thanh Ngan,LE, Nguyen Truc Quyen,HUYNH, Thi Khanh Tuyen,NGUYEN, Minh Tri,LUU, Thi Mai Anh,HOANG, Thi Phuong Thao,NGUYEN, Trong Luan Korea Distribution Science Association 2022 The Journal of Asian Finance, Economics and Busine Vol.9 No.6
The purpose of the study is to analyze the significant impacts of expectations, performance, complaints, and fairness that affect consumer satisfaction. The methodology involves reviewing and referencing relevant literature carefully, then proposing a model for customer satisfaction. This study is empirically based on a survey with 50 respondents who work in the field of import and export in the region stretching from the north to the south of Vietnam. The sampling method used in this study is the in-depth interview method. The results show that: (1) expectation has a specific impact on customer satisfaction, (2) performance has a positive impact on customer satisfaction, and (3) complaint which is an intermediary factor between expectation, performance, and fairness has an impact on satisfaction, (4) fairness has a positive effect on satisfaction, in addition, fairness is an extremely important feature when customers choose an import-export service. Research implies that increasing expectations, performance, and fairness results in an improved customer experience and satisfaction when they use the service. It is suggested that the complaint factor continue to be studied and looked into because it still has some effect on satisfaction and is an intermediate variable that changes how the other factors relate to each other.
Thu Hien Nguyen,Thi Thanh Ngan Nguyen,Bac Viet Le,Ngoc Minh Thanh,Thi Kim Lien Nguyen,Van Hai Nong,Huy Hoang Nguyen 한국유전학회 2017 Genes & Genomics Vol.39 No.3
Autism spectrum disorders (ASDs) are a group of neurodevelopmental disorders characterized by ritualistic- repetitive behaviors and impaired verbal and non-verbal communication. Boys are more likely to be diagnosed with ASD than girls. Genetics have been shown to play a key role in the etiology of autism. Many genes were found to be implicated in the inheritance of idiopathic autism. Analysis of mutation abnormalities associated with autism contributes significantly to the identification of autism candidate genes. Whole-exome sequencing has been shown as an application of the next generation sequencing technology used to determine the variations of all coding regions, or exons of the known genes. In the present study, we have found two novel heterozygous missense mutations (p.L111P and p.R3048C) on the RYR3 gene, which was located in the autism susceptibility region (15q14-q15) in a 9-year-old boy with ASD. Therefore, the sequence missense mutations provide the first suggestive link between a genetic abnormality in the RYR3 gene and a neurodevelopmental disorder.