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Edward John Nevins,James Edward Dixon,Yirupaiahgari Krishnaiah Setty Viswanath 대한소화기내시경학회 2021 Clinical Endoscopy Vol.54 No.4
Background/Aims: STRETTA improves the quality of life and reduces the need for anti-reflux medication in select patients,especially those with uncomplicated gastroesophageal reflux disease (GERD). We aimed to review the outcomes of STRETTA inpatients with medically refractory GERD, who had undergone previous gastric surgery. Methods: This was a review of a prospective database in a British center. Since 2016, all GERD patients who underwent STRETTAand had a history of previous gastric surgery were studied (n=11). Anti-reflux medication pre- and post-STRETTA was evaluated. The outcomes were assessed objectively by the change in anti-reflux medication and subjectively through a pre- and post-procedureGERD-health-related quality of life (HRQL) questionnaire. Results: The median length of follow-up was 23 months. Nine patients demonstrated improved GERD-HRQL scoresfollowing STRETTA (82%). Of the 7 patients who underwent fundoplication, all reported improved symptoms, with 3 patientsdiscontinuing the medication and 3 patients on a reduced dose of proton pump inhibitor. Four patients underwent surgery otherthan fundoplication, of which 2 reported improvement and discontinued the proton pump inhibitor. Two patients reported noimprovement. Conclusions: This study demonstrates that STRETTA is successful in reducing refractory GERD in patients with previous gastricsurgery. The outcomes were comparable to published outcomes in patients with uncomplicated GERD with no previous history ofgastric surgery.
Xu, X.Q.,Belli, E.,Bodi, K.,Candy, J.,Chang, C.S.,Cohen, R.H.,Colella, P.,Dimits, A.M.,Dorr, M.R.,Gao, Z.,Hittinger, J.A.,Ko, S.,Krasheninnikov, S.,McKee, G.R.,Nevins, W.M.,Rognlien, T.D.,Snyder, P.B. International Atomic Energy Agency 2009 Nuclear fusion Vol.49 No.6
<P>We present edge gyrokinetic simulations of tokamak plasmas using the fully non-linear (full-<I>f</I>) continuum code TEMPEST. A non-linear Boltzmann model is used for the electrons. The electric field is obtained by solving the 2D gyrokinetic Poisson equation. We demonstrate the following. (1) High harmonic resonances (<I>n</I> > 2) significantly enhance geodesic-acoustic mode (GAM) damping at high <I>q</I> (tokamak safety factor), and are necessary to explain the damping observed in our TEMPEST <I>q</I>-scans and consistent with the experimental measurements of the scaling of the GAM amplitude with edge <I>q</I><SUB>95</SUB> in the absence of obvious evidence that there is a strong <I>q</I>-dependence of the turbulent drive and damping of the GAM. (2) The kinetic GAM exists in the edge for steep density and temperature gradients in the form of outgoing waves, its radial scale is set by the ion temperature profile, and ion temperature inhomogeneity is necessary for GAM radial propagation. (3) The development of the neoclassical electric field evolves through different phases of relaxation, including GAMs, their radial propagation and their long-time collisional decay. (4) Natural consequences of orbits in the pedestal and scrape-off layer region in divertor geometry are substantial non-Maxwellian ion distributions and parallel flow characteristics qualitatively like those observed in experiments.</P>
Prognostic Significance of CD24 Expression in Gastric Carcinoma
Nevine S. Darwish,Min A Kim,Mee Soo Chang,Byung Lan Lee,Woo Ho Kim,이혜승,Yong Il Kim 대한암학회 2004 Cancer Research and Treatment Vol.36 No.5
Purpose: The human CD24 antigen is a small heavily glycosylated cell surface protein, which is expressed in hematological malignancies, as well as in a large variety of solid tumors. Its expression is now known to be related to the prognosis of several kinds of tumors. This study is designed to examine the prognostic significance of CD24 in Korean gastric cancer patients. Materials and Methods: In the present study, we examined CD24 expression in 300 consecutive cases of gastric carcinoma by immunohistochemical staining using the tissue-array method. We also investigated the clinicopathological profiles related to CD24 expression. Results: One hundred and three cases out of 300 (34.3%) showed the positive expression of CD24. The altered expression of CD24 was significantly associated with differentiated cancer (p=0.003), the intestinal subtype according to the Lauren classification (p〈0.001), the advanced stage cancer (p=0.027), with lymphatic invasion (p=0.038) and with vascular invasion (p=0.006). The survival analysis revealed that the patients with CD24 positive expression showed significantly poorer survival than those without CD24 expression. Moreover, a combined evaluation revealed that PTEN /CD24 cases showed the best survival compared to other groups (p=0.01). Conclusion: Positive CD24 expression occurs in a subset of gastric carcinomas and it correlates significantly with lymphatic invasion, blood vessel invasion and poor survival. (Cancer Res Treat. 2004;36:298-302)
Nevin Gamze Karsli,Okan Gul,Taner Yilmaz 한국섬유공학회 2022 Fibers and polymers Vol.23 No.4
This study aims to investigate the effect of graphene nanoplatelet (GNP) and terpolymer addition on themechanical, adhesive wear and thermal properties of carbon fiber (CF) reinforced poly(phenylene sulphide) (PPS) matrixcomposites. In the composites the CF content was fixed at 10 wt.% and the terpolymer content at 2 wt.%, while the GNPcontent was changed to 0.1, 0.3 and 0.5 wt.%. Physical properties of composites were evaluated by using tensile test,adhesive wear test, differential scanning calorimeter analysis and scanning electron microscopy analysis. As a result, it wasconcluded that the simultaneously addition of both 0.5 wt.% GNP and 2 wt.% terpolymer to CF reinforced compositesimproved the mechanical and tribological properties of composites. Thus, a solution has been developed to increase theefficiency of use of high performance composite materials produced for use in areas requiring good mechanical andtribological performance such as the aerospace and automotive industries.
Body Hair Scores and Total Hair Diameters in Healthy Women in Kirikkale Region, of Turkey
Nevin Sagsoz,Mansur Kamaci,Zerrin Orbak 연세대학교의과대학 2004 Yonsei medical journal Vol.45 No.SUP
It was aimed to determine the normal hair scores of women of Kırıkkale region according to the Ferriman- Gallwey scale and to investigate the relationship between the hair shaft diameter and hair scores. Hair scores were calculated in 204 healthy women, and hair shaft diameters were measured from the hair samples collected from 60 patients. Body mass index, waist to hip ratio, insulin resistance and blood androgen levels were determined. Neutral, hormonal and total hair scores were 2.1±1.4, 3.1±2.7 and 5.2±3.6, respectively. The average total hair diameter and hormonal hair diameter were 191.93±90.49μm and 121.8±75.9μm respectively. The correlation between total hair diameter and total hair score was statistically significant (r=0.704 p<0.001). Also, the correlation between hormonal hair diameter and hormonal hair score was statistically significant (r=0.724 p<0.001). While hair scores and diameters show meaningful positive correlation with androgen levels, they show negative correlation with age. In our population, 95% value of total hair score was 11, and for the hormonal score, it was 9. Hair diameters increase with hair score, regardless of total or hormonal of hair scores. Hair scores and hair diameters may be affected by blood androgens in healthy women.
Prognostic Value of Prepro-Gastrin Releasing Peptide in Lung Cancer Patients; NCI-Prospective Study
Shafik, Nevine F,Rahoma, M,Elshimy, Reham AA,El kasem, Fatma M Abou Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.12
Background: Prior series investigated the expression of prepro-gastrin releasing peptide (prepro-GRP) in the peripheral blood of lung cancer patients. Our aim was to assess any prepro-GRP role as a prognostic factor for small cell lung cancer (SCLC) and NSCLC and correlations with clinical presentation and treatment outcome. Methods: A prospective study was conducted during the time period from the beginning of January 2012 till the end of January 2014. Prepro-GRP expression was analysed using a nested RT-PCR assay in peripheral blood of 62 untreated lung cancer patients attending the National Cancer Institute (NCI), Cairo University, and 30 age and sex matched healthy volunteers. Results: Among the 62 lung cancer cases, there were 24 (38.7%) SCLC, and 38 (61.3%) NSCLC (10 squamous cell carcinomas, 12 adenocarcinomas, 11 large cell carcinomas, 4 undifferentiated carcinomas, and 1 adenosquamous carcinoma). Twenty six patients (41.9%) were prepro-GRP positive. Prepro-GRP expression was higher (58.3%) among SCLC patients compared to NSCLC (squamous cell carcinoma (15.4%), large cell carcinoma (36.4%), and adenocarcinoma (25%)). Mean OS among prepro-GRP negative cases was longer than that among preprogastrin positive cases (17.6 vs 14.9 months). The mean PFS durations among preprogastrin negative versus positive cases were 7.7 vs 4.6 months (p= 0.041). No difference in response to chemotherapy was identified between the groups (p=0.983). Conclusion: Prepro-GRP is suggested to be a useful prognostic marker for lung cancer patients, especially with the fast- growing, bad prognostic SCLC type. More studies should aim at detailed understanding of the mechanisms of prepro-GRP action and its use in monitoring the response to treatment in a larger cohort.