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- 저자 : El kasem, Fatma M Abou (검색결과 2 건)
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Analytical Modeling of Nonlinear Behavior of Composite Stub-Girders
Raafat E. S. Ismail,Mohamed T. H. El-Katt,Hesham A. Zien Eldin,Younis M. Y. Kasem 한국강구조학회 2012 International Journal of Steel Structures Vol.12 No.4
This paper presents an inelastic analytical model for modeling the nonlinear behavior of partially composite stub-girder under midspan concentrated load with partially end joint stiffness. The method treats the stub-girder as a beam with three distinct layers, the top and bottom layers behave according to the normal beam bending theory, while the middle layer is a shear layer without any bending stiffness. At the interface between the steel and concrete elements, the headed stud shear connectors are modeled as linear elastic built-in cantilevers. The present method smears the effects of all the contributing shear elements, stubs and studs, along the span. The differential equation for the stub-girder is solved to obtain the general expression of elastic deflection for the case when one concentrated load is applied at the mid-span. Based on the present approach a computer program called “PZA” is developed. The program accounts for nonlinear behavior of concrete and steel materials. The accuracy and reliability of the program are demonstrated by the analysis of three stub girders and one composite beam over the entire loading range up to ultimate load and the results are compared with published experiments.. A relatively good agreements with the experimental findings are found. Then a parametric study is carried out to discuss the effect of the initial stiffness of shear connector and the stub height on the behavior of stub-girder.
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Prognostic Value of Prepro-Gastrin Releasing Peptide in Lung Cancer Patients; NCI-Prospective Study
Shafik, Nevine F,Rahoma, M,Elshimy, Reham AA,El kasem, Fatma M Abou Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.12
Background: Prior series investigated the expression of prepro-gastrin releasing peptide (prepro-GRP) in the peripheral blood of lung cancer patients. Our aim was to assess any prepro-GRP role as a prognostic factor for small cell lung cancer (SCLC) and NSCLC and correlations with clinical presentation and treatment outcome. Methods: A prospective study was conducted during the time period from the beginning of January 2012 till the end of January 2014. Prepro-GRP expression was analysed using a nested RT-PCR assay in peripheral blood of 62 untreated lung cancer patients attending the National Cancer Institute (NCI), Cairo University, and 30 age and sex matched healthy volunteers. Results: Among the 62 lung cancer cases, there were 24 (38.7%) SCLC, and 38 (61.3%) NSCLC (10 squamous cell carcinomas, 12 adenocarcinomas, 11 large cell carcinomas, 4 undifferentiated carcinomas, and 1 adenosquamous carcinoma). Twenty six patients (41.9%) were prepro-GRP positive. Prepro-GRP expression was higher (58.3%) among SCLC patients compared to NSCLC (squamous cell carcinoma (15.4%), large cell carcinoma (36.4%), and adenocarcinoma (25%)). Mean OS among prepro-GRP negative cases was longer than that among preprogastrin positive cases (17.6 vs 14.9 months). The mean PFS durations among preprogastrin negative versus positive cases were 7.7 vs 4.6 months (p= 0.041). No difference in response to chemotherapy was identified between the groups (p=0.983). Conclusion: Prepro-GRP is suggested to be a useful prognostic marker for lung cancer patients, especially with the fast- growing, bad prognostic SCLC type. More studies should aim at detailed understanding of the mechanisms of prepro-GRP action and its use in monitoring the response to treatment in a larger cohort.
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