항갑상선제로 치료한 그레이브스병 환자의 관해예측인자

남일송,윤여일,김선규,김용현,이주영,목지오,윤석기,김철희,김영선,변동원,서교일,유명희 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background: Most cases of Graves' disease have been treated by antithyroid drugs in Korea. The major drawbacks of antithyroid drugs are the relative high rate of relapse and the inconvinience of long term therapy. Measurement of TBII and TRH stimulation test have been considered as the most reliable tests predicting relapse, but the predictive power is not high enough to use in clinical situation. This study was performed to find good prognostic indicators in Graves' disease patients after the discontinuation of antithyroid drug therapy. Subjects and methods : We restrospectively evaluated 96 patients with Graves' disease who showed normal TRH test at the end of antithyroid drug therapy and were followed for more than one year. Serum T3, T4, T3/T4 ratio, TBII, Anti-TPO Ab and TGAb levels were measured at the time of diagnosis and at the end of therapy. Two to three months after withdrawal of antithyroid medication, serum TSH and free T3 responses to TRH were examined. These parameters were compared between the relapse group and the remission group. Results : Among the 96 patients, 22 patients(22.9%) relapsed(Group Ⅱ) and 74 patients(77.1%) remained in remmision(Group Ⅰ). No significant difference was observed between the relapse and the remission group in clinical parameters, serum T3, T4, TSH, T3/T4 ratio, TBⅡ and Anti-TPO Ab determined before and after treatment. Serum TSH and free T3 levels measured after TRH stimulation were also similar in both groups. Serum TGAb levels determined at the end of treatment were significantly higher in the remission group(p<0.05). Relapse following the discontinuation of therapy occured within 24 months in 72.7% of the relapsed cases. After 24 months, relapse rate was reduced significantly. Conclusion : These results suggest that high serum TGAb levels could be a favorable prognostic indicator for the long term remission of Graves' disease treated with antithyroid drugs, and may suggest that Hashimoto's thyroiditis is combined with Graves' disease in those patients.

양전자 소멸 분광학에 대한 플라스틱 섬광검출기의 시간 분해능 측정

남기용;김도현;김종국;주관식 명지대학교 자연과학연구소 2004 자연과학논문집 Vol.23 No.-

We have measured the time resolution of the system for Positron Annihilation Spectroscopy(PAS). Time resolution means a measure to response to time intervals between start and stop signals. We used ^(22)Na positron source to obtain start and stop signals, that is, 1.27 MeV γ-ray is as a start signal, and 511 keV γ-ray as a stop signals resulted from annihilation with electron in material. The system composed of two plastic scintillation detertors with a size of diameter 2". After calibrating TAC, We obtained that the time resolution of PAS system has about 300 ps for ^(60)Co window. In addition to that, we recognized that the resolution was dependent of the length of delay line on the CFD panel, except of the size of scintillators and the geometry of Photo Multiplier Tube. 본 연구에서는 양전사 소멸 분광학(PSA)의 시스템의 시간 분해능을 측정하였다. 시간 분해능은 시작과 정지신호 사이의 시간 차이의 반응 정도를 측정하는 것이다. ^(22)Na 양전자 동위원소를 사용하여 금속안에서 전자의 소멸로 인한 1.27 MeV의 감마선 시작 신호와, 511 keV의 정지신호를 얻을 수 있었다. 측정장비는 지름이 2인치인 두 개의 플라스틱 섬광검출기로 구성하였다. TAC를 보정한 후에 ^(60)Co 창에서 PAS 시스템의 시간 분해능은 300ps임을 얻을 수 있었다. 이번 연구에서 분해능은 CFD 패널의 시간 지연선의 길이에 의존적임을 알 수가 있었으며, 섬광체의 크기와 광전자증배판(PM Tube)의 구조와는 연관이 없음을 알 수 있다.

마우스 종양발생에서 Nitric Oxide의 역할에 관한 연구 Ⅲ : Helicobacter pylori에 의해 유발된 마우스 위암에서 염증매개인자의 역할 The role of inducible nitric oxide synthase and cyclooxygenase-2 in H. Pylori-associated gastric carcinogenesis

남기택,오상연,조현무,이국경,강진석,제정환,최미나,한상욱,김대용,장동덕,양기화,안병우 식품의약품안전청 2001 식품의약품안전청 연보 Vol.5 No.-

feficotorfer fyf☞ri(Hp)가 위암파 관련이 있다는 역학적인 증거는 많이 있지만 이에 대한 정확한 기전에 대해선 밝혀져 있지 않고 있으며 실험동물 모델도 적절하지 못한 것으로 알려져있다. 본 실험에서는 위암의 원인으로 알려져 있는 f, fyforf'(Hp)를 이용하여 마우스에서 위암 모델을 확립하고 만성염증과정 중에 생성되는 리0와 COX-2 등의 발현이 위암발생에 미치는 명향을 통하여 예방과 치료를 위한 점근을 시도하고자 하였다. 마우스를 7군으로 나누어서 1, 2, 3, 4군의 등물은 MNU를 증류수에 200ppm 농도로 음수병득 이용하띤 10주간 격주로 투여하였으며 MHU 음술 투여 1주 휴씩 후 배양한 f. fyrofi 를 약 109cru/rfll 로 맞춰 한 마리당 0.1ml 씩 이틀 간격으로 세 번에 걸쳐 하룻방 금식시킨 1, 2, 3, 5, 6, 7군기 마우스의 위장에 투입하떴다. 균 투입을 마친 후 다응 날부터 2군쏙 6군은 iNOS 억제제인 aminoguanidine(AG)을 음수병으로 툰여하였으며 3군과 7군은 COX-2 척제제인 nimesulide(NSD)를 투여하였다. 위의 종양발생양상을 샅최보면 bfNU와 Hp만을 투여한 1 관 ; (hfNU +Hp), 2군 : iNO을 inhibitor 투여군(MNU+HP+AG'1. 3군 ;CO딘-2 Inilibitor 투여군(MNU누Hp누 NSD), 4군 ,MNlf 단독투여군, 5군 ;Hp 단독투여춘, 6군 ; 러p 단독에 AG투여군, 7군 , Hp 단독에 NSD투여군의 종양발샐을은 각각 쁜.Bff(l1/16), 70.6%f12/ti), 했.9ff(7/18), 10%(1/10), Off(O/IS)0%(O/S), 0%(O/5)의 발쟁율을 보여 iNOS 억제제인 AC은 좁양발생을 억계하지 못하였으며, COX-2억제제인 NSD 는 종양발생을 유의적으로 감소시켰다. 콩양발생개수에서는 2.62±0.36, 1.41츠0.14, 0.44 르0.12, 0.10±0.10을 보여 AC와 NSD에서 유의성 있게 발생개수를 줄였다. Hp 단독투여에 의해즌는 종양발생이 나타나지 않았으며 HP+AG, Hp+ IfSD 추여군에콕 시험증료 시점에 약물에 의해 Hp의 제균효과가 있는지의 여부를 확인끓기 위하여 PCR을 이용하여 확인한 결과 모두 양성인 것으로 나타나 Hp의 제균효과에 의한 촐양발생 억제가 일어나지는 않았다. 위의 결과로 볼 때 Hp는 위암발생을 촉진하는 것으로 나타났고 딘p 감염시 매개되는 염증인자를 억제하였을 때 종양발생을 억제하는 것으로 위암 발생에서 염증매개인자는 종양을 촉진하는 것으로 나타났으며 it,705 억제제쓱 COX-』 억제제의 위알 예밭효과fl는 효과적일 것으로 사료된다 In spite of a large volume of epidemiological evidence indicating significant relationship between H. pylori infection and gastric adenocarcinoma, a doubt still exists on an elevated risk of stomach cancer by H. pylori infection due to lack of direct evidence of their exact mechanistic link. It is, therefore, essential to have an appropriate animal model for detailed analysis of the role of H. pylori played in gastric carcinogenesis. There is a wealth of evidence to support that over production of inducible nitric oxide synthase(iNOS) and cyclooxygenase-2(COX-2) is involved in the pathogensis of various cancer in both rodents and humans. The aim of this study was to establish a mouse model for H. pylori-associated gastric carcinogenesis and to identify the role of inducible nitric oxide synthase(iNOS) and cyclooxygenase-2(COX-2) played during the gastric carcinogenesis in mice. Eighty-three specific pathogen free, six-week-old male C57BL/6 mice were randomly divided into seven groups. Animals of the group 1, 2, 3, 4 were given MNU in their drinking water at the concentration of 200 p.p.m. for total five cycles of one-week regimen with one-week pause. After completion of MNU administration, they were given autoclaved distilled water for one weeks, and groups 1, 2, 3, 5, 6, 7 were inoculated with H. pylori. After completion of H. pylori. inoculation, groups 2 and 6 were given aminoguanidine in their drinking water at concentration of 1000p.p.m. and animals of group 3 and 7 were given the diet containing 200 ppm nimesulide at 12 weeks of age. All animals were killed at 50 weeks of age. The incidences of the glandular stomach tumors in the group 1, 2, 3 and 4 were 87.5%(14/16), 76.4%(13/17), 44.4(8/18), 10.0%(1/10), respectively and the tumor incidence of group 3(MNU→Hp+nimesulide) was significantly lower than those of group 1(MNU→Hp) at the value of P<0.01. The average numbers of tumors of group 2(MNU→Hp+AG : 1.41±0.24) and group 3(MNU→Hp+nimesulide : 0.44±0.12) were significantly lower than those of group 1(MNU→Hp : 2.62±0.36) at the value of P<0.05. Therefore, overproduced iNOS and COX-2 plays an important role in mice gastric carcinogenesis. We concluded iNOS and COX-2 inhibitor have good effects on gastric carcinogenesis.

주사전자현미경을 이용한 무당벌레에 기생하는 무당벌레기생파리(Degeeria separata)의 외부형태적 특징

윤영남,김남성,김기덕,박수진,서미자,채순용 충남대학교 농업과학연구소 2000 농업과학연구 Vol.27 No.1

External morphological characteristics of male and female of Degeeria separata, which was endoparasited in adult of the Asian ladybird, were studied by using the scanning electron microscopy(SEM). The antenna of Degeeria separata was consisted of three segment and arista. Anstae were about 750㎛ length and 30㎛ in diameter. The surface of antennae was covered with many sensilla. They were long or short, slender or thick, and straight or curved. Each three morphological types of sensilla were observed on the second and third segment of antennae. The mouthpart was sponging type. It was consisted with clypeus, labellum, labium, labrum, and maxillary palp. The labellum is 400㎛ width and double folded vertically. The leg consist of tarsus, tarsus claw, pulvilli, and empodium.

폐석재와 석분을 사용한 식생블럭 제품 개발

성찬용,류능환,연규석,윤준노,김영익,남기성,노경희,박일순 강원대학교 부설 석재복합신소재 제품연구센터 2002 석재연 논문집 Vol.7 No.-

본 연구는 폐석재와 석분을 사용하여 친환경적인 식생블럭 제품을 개발하기 위하여 폐석재의 입경과 석분의 첨가량을 각각 3종류씩 총 9종류의 식생블럭에 대하여 단위중량, 공극율, 투수량, 압축강도, 쪼갬인장강도, 휨강도, 내산성, 알카리농도에 대하여 구명하였다. 단위중량, 강도, 내산성은 골재의 입경이 작을수록 석분의 혼입량이 많을수록 크게 나타났으며, 공극율과 투수량은 작게 나타났다. 강도는 중성화 처리 유무에 따라 4∼5% 정도의 미소한 차이가 나타났다. 알카리 농도는 중성화 약품처리, 수중용출, 야외폭로 순으로 효과가 크게 나타났으며, 이는 식생블럭의 중성화 방법 선택에 매우 중요한 내용이라 할 수 있다. 또한, 식생상태는 공극율과 골재의 입경이 큰 식생블럭이 생육에 유리한 것으로 나타났다. This study was performed to develop the environment-friendly plantable block and to evaluate unit weight, void ratio, permeability, strength, acid-resistance and value of pH by the change of the grading of waste stone and the addition amount of stone dust. The unit weight, strength, acid-resistance is increased with small size of waste stone with increase of the addition amount of stone dust. But, the void ratio and permeability is decreased. The strength of neutral plantable block is decreased approximately 4-5% than that of the normal plantable block. The decreased effect of pH increased in order to neutral treatment, underwater leaching and field exposure. It is very important contents in neutral method selection of plantable block. Also, the planting state is grown rapidly with increase of the void ratio and of the waste stone size, approximately.

폴리에틸렌 필름 被覆과 摘心 및 遮光程度가 柴胡의 生育과 根收量에 미치는 影響

玄英權,宋昌吉,趙南棋 濟州大學校 亞熱帶農業硏究所 1998 亞熱帶農業硏究 Vol.15 No.-

This experiment was conducted to examine effects of different polyethylene film mulching, pinching methods, and shading level on growth and root yield of Bupleurum falcatum L. Plant height, leaf length, leaf width, stem diameter, root length, number of lateral roots and number of branches were fewer in a polyethylene film mulching than in a non-mulching. In a non-mulching, plant height was highest at a non-pinching and leaf length, leaf width, root length, root diameter, number of lateral roots, number of branches were greatest at the third pinching (25 Aug.) among the pinching treatments. In a polyethylene film mulching, plant height was highest at a non-mulching and leaf length, leaf width, stem diameter, root length, root diameter were greatest at the third pinching (25 Aug.) among the pinching treatments. Characteristics such as fresh aboveground weight, fresh root weight, dry aboveground weight, dry root weight were greatest in a polyethylene film mulching and total yield per 3.3㎡ was greatest in a non-mulching between polyethylene film mulching and non-mulching. Root yield in a non-mulching was two fold greater than in a polyethylene film mulching, and in a non-mulching, was much greater at the third-pinching (25 Aug.) among the pinching treatments. As the shading level was increased from 0 to 90%, plant height was increased from 83.4 to 100.3cm. Stem diameter, root length, and root diameter were decreased with the increased shading level. Fresh aboveground and root weights were decreased as shading level was increased.

Butyl Acetate를 이용한 Ethyl Alcohol의 추출

이용철,강원만,김남기 成均館大學校 科學技術硏究所 1989 論文集 Vol.40 No.2

Iso-butyl acetate and sec-butyl acetate were used in this experiment as solvents for the extraction of ethyl alcohol from the range of 5% to 50% ethyl alcohol-water mixture at 50℃ and 80℃. 100%∼400% of them to pure ethyl alcohol(g-solvent/g-ethyl alcohol), were added into ethyl alcohol solution At 50℃, the best effect of iso-butyl acetate and sec-butyl acetate was shown on at 10% ethyl alcohol solution and about 300% of solvent and 20% ethyl alcohol solution and about 300% of solvent respectively. But at 80℃, the best effect of them was shown on at 35% solution and about 400% of iso-butyl acetate and 25% solution and about 400% of sec-butyl acetate more than ethyl alcohol. At higher temperature and ethyl alcohol concentration, iso-butyl acetate was more useful solvent for the extraction cf ethyl alcohol than sec-butyl acetate. Extraction rate was increased with increasing the amount of solvent added into ethyl alcohol solution in the range of 100%∼400% to net ethyl alcohol.

주사전자현미경을 이용한 토마토에 발생하는 아메리카잎굴파리(Liriomyza trifolii)의 외부형태적 특징

윤영남,김기덕,박수진,김남성,서미자,채순용 충남대학교 농업과학연구소 2000 농업과학연구 Vol.27 No.1

SEM을 이용하여 아메리카잎굴파리(Liriomyza trifolii)의 암 ·수컷 성충의 외부형태적 특징을 살펴보았다. 더듬이에 있어 감각모의 3가지 형태는 더듬이가는마디(funicle)에서 관찰되었으며, 모상감각기(trlchold sensillum)는 말단 부위가 뽀족한 특징적인 형태를 하고 있고 감각기들 중에서 가장 많이 분포하고 있다. 원추상 감각기(basiconic sensillum)는 길이가 13㎛, 지름이 1.4㎛에서 1.2㎛인 원형곡선형이다. 홈형 감각기(grooved sensillum)는 간상(peg) 끝에서 나온 손 모양을 하고 있으며, 이 모든 감각기들은 후각과 연관되어져 있는것으로 추정된다. 구기는 홉즙형으로 작고 펼쳐진 윗입술(labrum)과 합쳐져서 하나의 연결된 주둥이(rostrum)을 형성하고 있다. 가느다란 한 쌍의 작은턱수염(maxillary palp)은 긴 관 모양으로 각각의 세로로 이어져 있다. 발마디는 5마디로 이루어져 있으며 그 한가운데에는 패드모양의 흡착반(pulvillus)과 가시모양의 발톱사이돌기(empodium)가 있다. 아메리카잎굴파리는 흡착반과 발톱사이돌기에서 미끄러운 표면에 부착할 수 있는 물질을 분비한다. 수컷의 생식기는 매우 복잡하며 삽입구(aedeagus)는 생식기관으로서 가장 일반적인모양이다. 반면에 암컷의 생식기는 상대적으로 간단한데 이 구조는 외부로 돌출된 관모양이었다. 또한 이러한 결과를 이미 발표된 다른 여러 종의파리와 비교하였다. The external morphology of male and female of Liriomyza trifolii (Burgess) was studied using the scanning electron microscopy (SEM). Three types of sensilla were identified on the funicle of antennae. The trichoid sensilla were most conspicious and distributed with a characteristic sharp structure at the apical end. Basiconic sensilla were showed distal curvature about 13㎛ long and 1.2㎛ to 1.4㎛ in diameter. Grooved sensilla were showed a finger-like projections at the peg apex. The function of these sensilla likely to be olfactory. The mouthparts were adapted for sucking food, and formed a elongate rostrum which was incorporated with labrum. The labrum was a small and flap-like shape. The slender and paired maxillary palp seemed to combine with each other lengthwise to long tube. The tarsus typically consisted of 5 segments, which might be variously modified, principally by thickening or flattening. The segment healed a pair of claws. Beneath the claws, there was a pair of pad-like pulvillia and a bristle-like median empodium. L. trifolii secreted on the pulvillus and empodium an adhesive substance that enable them to cling to smooth surfaces. Male terminalia was complicated. The name 'aedeagus' seemed the best available general term for the copulatory organ, otherwise, female terminalia was usually relatively simple. This structure was reduced and formed a telescopic, eversible, and tubular ovipositor.

신장의 사춘기 성장 동안 초경 발생 시기와 성장 곡선의 형태에 관한 연구

안용수,이기수,남종현,강윤구 대한치과교정학회 2009 대한치과교정학회지 Vol.39 No.3

이 연구는 만 7세부터 17세까지의 신장의 누년적 변화를 통해서 사춘기 최대 성장기와 초경 발생 시기와의 관계를 평가하고, 성장 곡선의 형태에 따라 성장 곡선을 분류하여 각 형태별 특징을 파악하고자 시행하였다. 경기도 화성에 있는 삼괴 고등학교에서 1학년부터 3학년까지 96명의 생활기록부에 기재되어 있는 신장의 누년적인 자료가 이용되었으며, 초경 시기와 전신적 질환 유무는 설문지를 통해 조사되었다. 사춘기 성장 가속기는 9.9세에 시작하여 11.6세에 최대 성장기를 이루고 14.1세경에 끝났다. 초경은 12.6세에 일어나며 76.1%는 최대 성장기 이후에 나타나고 최대 성장기와는 1년의 차이를 보인다. 10.4%에서 최대 성장기 전에 초경이 나타났고 13.5%에서는 최대 성장기와 동일한 시점에 나타났다. 초경 시기와 관계없이 사춘기 성장 가속 기간은 4.2년으로 일정하게 나타난다. 성장 곡선을 4가지 형태로 분류하였으며, A형은 51.1%, B형은 21.9%, C형은 20.8%, D형은 6.2%의 분포를 보인다. C형의 성장 가속 기간이 가장 길게 나타난다. B형과 C형에서 PHV가 두 개인 경우는 B형과 C형의 58.5%인 24명에서 나타났다. 이상의 연구 결과에서 개개인의 성장 양상은 개인차가 크며 초경뿐만 아니라 누년적인 성장을 참고로 하여 onset의 정확한 시기와 성장 곡선 형태를 파악할 수 있다면 남은 성장 기간 예측에 도움을 줄 것으로 생각된다. Objective: This study investigated the onset, peak height velocity (PHV) and end of adolescent growth spurt as well as menarcheal timing deduced from surveying accumulative height growth over many years. Methods: Ninety six students of Samgoe high school between 1st and 3rd grade that were in good health participated in the research. A survey questionnaire was distributed to examine the students’ health status and menarche timing. Results: Adolescent growth spurt typically began at the age of 9.9 and reached a PHV at the age of 11.6. The growth spurt ended at the age of 14.1 on average. The average age of menarche was 12.6 years, which was about one year after the PHV of adolescent growth spurt. In most cases, menarche came after PHV. But in 24% of the students, menarche and PHV was nearly coincident or menarche preceded PHV. The growth curves were classified into four types. A typical adolescent growth spurt showed one PHV on graph that drastically drops after the PHV. However, there were cases with two PHVs. Conclusions: The results indicate that individual growth patterns show large individual differences, however the categorization into the various growth curves may aid in predicting individual growth patterns.

링형 초음파모터의 고정자 진동 해석 및 구동회로 개발

박기준,백수현,김용,윤신용,김일남 동국대학교 산업기술연구원 1999 산업기술논문집 Vol.14 No.-

본 논문에서는 링형 초음파 모터의 고정자의 굽힘진동에 대한 일반적인 해석에 대해 기술하였다. 전기-기계 결합효과를 고려하여 일반화 응력과 변형의 개념을 정립하였고, 일반화 압전방정식, 일반화 응력과 변형의 관계, 미분운동방정식에 대해 기술하였다. 또한 고정자의 진동모드 계산과 공진주파수를 계산하기 위해 유한요소법을 적용하였으며, 유한요소법을 이용한 진동해석 프로그램인 ATILA를 사용하여 고정자의 공진주파수와 변위를 계산하였다. 초음파 모터의 구동을 위해 20kHz 이상의 고주파 전원이 필요하기 때문에 2상 병렬 공진형 인버터를 제작하여 구동전압의 주파수 및 크기를 측정하여 고정자 해석과 구동회로 시뮬레이션과 비교하였다. In this paper, the bending vibration analysis of the stator for a ring type ultrasonic motor is described. Considering the electromechanical coupling effect, the concepts of generalized stress and strain are explained in detail using the generalized piezoelectric equations, which is the relationship between generalized stress and strain, the differential motion equation were derived. The vibration modes and resonance frequencies of the stator were calculated using the finite element code ATILA. For driving of ultrasonic motor, a two-phase parallel-resonant inverter was made. The stator analysis results and driving circuit simulation results are compared with measured frequencies and amplitudes.