Slide Session : OS-IFD-07 ; Infectious Disease : In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus

( Myung Jin Lee ),( Kye Hyung Kim ),( Jong Youn Yi ),( Su Jin Choi ),( Chung Jong Kim ),( Nak Hyun Kim ),( Kyoung Ho Song ),( Pyoeng Gyun Choi ),( Ji Hwan Bang ),( Wan Beom Park ),( Eu Suk Kim ),( San 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus Myung Jin LEE1, Kye-Hyung KIM1, Jongyoun YI2, SuJin CHOI1, Chung-Jong KIM1, Nak- Hyun KIM1, Kyoung-Ho SONG1, Pyoeng Gyun CHOI1, Ji-Hwan BANG1, Wan Beom PARK1, Eu Suk KIM1, Sang-Won PARK1, Hong Bin KIM1, Nam Joong KIM1, Myoung- Don OH1 Seoul National University College of Medicine, Korea1, Pusan National University School of Medicine, Korea2 Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel Bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV). No effective antiviral therapy is proven yet, but clinical use of ribavirin (RBV) has been tried. We investigated the antiviral effect of RBV against SFTSV in vitro. Methods: To test for cytotoxicity of RBV, Vero cells were treated with different concentrations of RBV (3.90 to 500 μg/mL, two-fold dilution) and analyzed by cell viability MTS assay 48h post-infection. To determine antiviral activity of RBV against SFTSV, Vero cells were infected with SFTSV strain Gangwon/Korea/2012 at 100 TCID50 (50% tissue culture infective dose) per well in a 96-well plate, and RBV was added at the concentrations showing no or minimal cytotoxicity. Viral RNAs were extracted from the culture supernatants and quantifi ed using one-step real-time reverse transcription- PCR to amplify the partial large segment of SFTSV. Statistical analysis was done by one-way ANOVA with Tukey`s post hoc test. Results: Cytotoxicity due to RBV was not observed at RBV concentration =31.3 μg/ mL. Viral RNAs at 24h post-RBV treatment were reduced with increasing RBV concentrations (1-32 μg/mL), compared with those of mock-treated cells (P <0.01, Figure). Half maximal inhibitory concentration (IC50) of RBV was 3.69 μg/mL at 24h post-RBV treatment. Conclusions: Our study shows that RBV has antiviral effect against SFTSV in a dose-dependent manner. Further studies are required to evaluate the effi cacy of RBV in SFTS.

Goretex를 이용한 융비술

최진영,민철기,명훈,황순정,서병무,이종호,정필순,김명진 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.4

융비술시 실리콘 고무는 다루기 쉽고 조직 반응이 적어 현대 많이 돌출의 합병증이 생길 수 있다. 저자등은 이러한 실리콘의 단점을 보완할 수 있는 goretex를 사용하여 융비술을 시행하고 비첨에 대해서 자가연골을 이식하여 만족할 만한 결과를 얻었기에 goretex가 안면부 연조직의 증강을 위한 이식재료로 적합하다고 생각되어 문헌고찰과 함께 보고하는 바이다. Many different materials have been used to provide augmentation of the nasal dorsum. this include both autogenous and homogenous materials,as well as allografts. Silicone among the artificial materials has been most widely used. The silicone has some advantages and disadvantages. Goretex(expanded polytetra-fluoroethylene) which has widely used in vascular surgery and abdominal surgery can be used for facial soft tissue augmentation. The author presemts 2 cases of nasal augmentaion using goretex with literature review.

이동 컴퓨팅 환경에서 단절 연산을 지원하기 위한 선인출 메커니즘

최창호,김명일,김성조 중앙대학교정보통신연구소 2000 정보통신연구소논문집 Vol.2 No.1

이동 컴퓨팅 환경에서 이동 호스트(클라이언트)는 네트워크가 연결되어 있는 동안 단절에 대비하여 중요한 파일들을 자신의 로컬 캐쉬에 저장하여야 한다. 본 논문에서는 클라이언트가 네트워크 단절시 가까운 미래에 사용하게 될 파일을 캐쉬에 저장하는 선인출 메커니즘을 제안한다. 이 메커니즘은 분서기, 선인출 목록 생성기, 그리고 선인출 관리기로 구성된다. 분석기는 클라이언트의 파일참조 기록을 FAP(File Access Pattern), 프로파일에 저장한다. 선인출 목록 생성기는 이 프로파일을 이용하여 선인출 목록을 만들며, 선인출 관리기는 이 선인출 목록을 파일 서버에게 요청한다. 본 논문에서는 제시된 선인출 메커니즘의 성능을 평가하기 위해, 우리는 캐쉬적중률, 단절 후 클라이언트의 참조 파일 수, 적재 크기를 측정하였다. 시뮬레이션 결과, 선인출 메커니즘의 성능이 LRU 캐슁 메커니즘 보다 우수함을 알 수 있었다. In the mobile computing environment, the mobile host(client) must store copies of important files in its local cache while being well-connected in order to make them avilable when being disconnected. In this paper, we propose the prefetching mechanism for the client so that it can save the files which may be accessed in the near future. Our prefetching mechanism consists of analyser, prefetch-list producer, and prefetch manager. The analyser records file access patterns of the user in a FAP(File Access Patterns) profile. Using the profile, the prefetch-list producer creates the prefetch-list. The prefetch manager requests a file server to return this list. In order to evaluate the performance of our prefetching mechanism, we measure the metrics such as the cache hit ratio, the number of files referenced by the client after disconnection and hoarding size. The simulation results show that the performance of our mechanism becomes superior to that of the LRU caching mechanism.

증기발생기 전열관의 내면 축방향 균열에 대한 ECT 특성 평가

최명식,허도행,이덕현,박중암,한정호 한국비파괴검사학회 2001 한국비파괴검사학회지 Vol.21 No.5

증기발생기 전열관에서 1차측 응력부식균열의 발생빈도가 증가하고 있으므로 이의 정확한 탐지와 평가를 위해서는 균열 형상에 따른 와전류 신호특성을 규명하고 적합한 탐촉자를 선정하는 것이 매우 중요하다. 본 연구에서는 증기발생기 전열관의 내면 축방향 균열에 대한 와전류 검사의 검출능과 크기예측에 대한 신뢰도를 정량적으로 평가하고 pancake coil과 plus coil과의 신호특성 차이를 비교하였다. 이를 위하여 전열관 내면에 EDM으로 노치를 가공한 시편과 실제 증기발생기에서 1차측 응력부식균열이 발생하여 인출한 전열관을 시험편으로 사용하였다. 본 연구에서 얻어진 결과를 토대로 내면 축방향 균열에 대한 와전류 검사 신뢰도 향상을 위한 방안을 제시하였다. For the enhancement of ECT reliability on the primary water stress corrosion cracks of unclear steam generator tubes, of which the occurrence is on the increase, it is important to comprehend the signal characteristics on crack morphology and to select an appropriate probe type. In this paper, the sizing accuracy and the detectability for the inner wall axial cracks of tubes were quantitatively evaluated using the following specimens: the electric discharge machined notches and the corrosion cracks which were developed on the operating steam generator tubes. The difference of eddy current signal characteristics between pancake and axial coil were also investigated. The results obtained from this study provide a useful information for more precise evaluation on the inner wall axial cracks of steam generator tubes.

고관절 외전근의 원심성 운동이 보행시 균형에 미치는 효과

최원호,김명종 대한정형물리치료학회 2003 대한정형도수물리치료학회지 Vol.9 No.2

The purpose of this study was to identify the effects of eccentric exercise of affected help abductor muscles on Gait balance in patient with hemiplegia. 30 patients with hemiplegia were recruited among in and out patients of Gil Hospital(age x=50.5, SD=10.1, range 37-80. post stroke days x=383.2, SD=309.3, range 57-1165). These patients were divided into eccentric and control groups by random sampling. TUG were used for this study. Paired t- test was used to identify the effects of eccentric exercise of hip. The results were stastically significantly differences in the effect of exercise between experimental and control groups by TUG(p<0.05). The results indicate that the eccentric exercise of affected hip abductor muscles is effects on gait balance in patient with hemiplegia.

피더부하 균등화지수를 이용한 배전계통의 긴급정전복구 및 부하균등화

崔相烈,鄭澔聖,申明澈 성균관대학교 2003 학술회의지원논문목록집 Vol.2003 No.-

This paper presents an algorithm to obtain an approximate optimal solution for the service restoration and load balancing of large scale radial distribution system in a real-time operation environment. Since the problem is formulated as a combinatorial optimization problem, it is difficult to solve a large-scale combinatorial optimization problem accurately within the reasonable computation time. Therefore, in order to find an approximate optimal solution quickly, the authors proposed an algorithm which combines optimization technique called cyclic best-first search with heuristic based feeder loadings balance index for computational efficiency and robust performance. To demonstrate the validity of the proposed algorithm. numerical calculations are carried out the KEPCO's 108 bus distribution system.

주의력결핍 과잉행동장애 아동에서 틱 장애 동반 여부에 따른 확산 텐서 영상 비교 연구

최지욱,임명호,이창화,박진균,손정우,심세훈,유인규,강현수,정범석 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.5

Objectives : Diffuse tensor imaging (DTI) was applied to explore the difference in regional distribution and extent of white matter (WM) abnormalities in boys with Attention-deficit/hyperactivity disorder (ADHD) versus boys with comorbid ADHD and tic disorders. Methods : Fifteen boys with ADHD (mean age 9.3 +1.8), 24 ADHD boys with chronic tic disorder or Tourette's disorder(9.9 =b 1.2) and 9 age-, gender-matched controls (9.2 d= 1.8) received DTI assessments. Fractional Anisotropy (FA) maps of WM were compared between groups with a voxel-wise analysis after intersubject registration to MNI space. Results : Bo groups, ADHD group and ADHD with tic disorder group, commonly showed decreased FA than healthy control group in left cerebellar middle peduncle and right frontal lobe, increased FA in right middle occipital WM. In the common areas of left cerebellar middle peduncle and right middle occipital WM, comorbid group showed broader areas of significant FA. The comorbid group also showed increased FA in right cerebellar peduncle, additionally. Conclusion : The findings in ADHD group support previous ADHD hypothesis of the functional abnormalities in corticocerebellar circuit, and suggest that ADHD might have more complicated pathology of neuronal circuit including occipital visual system. The comorbid group showed common areas of overlapping but more extensive abnormalities and also had additional WM abnormalities. ADHD with chronic tic disorders may represent a severe form of ADHD with additional regions of abnormal connectivity.

급속응고된 Al-Zr 합금의 시효현상에 미치는 Si첨가의 영향

최상욱,박홍일,김명호 울산대학교 1987 연구논문집 Vol.18 No.2

본 연구에서는 급속응고된 Al-Zr 합금의 과포화 고용도에 미치는 제3첨가 원소 Si의 영향 및 급속응고된 Al-Zr-Si 합금계의 시효특성에 관하여 실험적으로 조사하였다. Twin-roller 장치에 의하여 급속응고시킨 시편의 응고속도는 10?? K/s 정도였으며, 이때 Al기지내에 Zr은 약 1 wt.% 정도만이 과포화 고용되었다. 그러나 Si의 첨가량이 증가됨에 따라 Zr의 과포화 고용도는 증대되어 Si의 첨가량이 1 wt.% 일때 Zr은 1.7 wt.% 정도 Al기지내에 완전 과포화 고용되었다. 그리고 Si의 첨가량이 증가됨에 따라 Al-Zr 합금의 미소경도는 증대되었다. Al -1.7wt.%Zr -1.0wt.%Si 합금을 시효처리하면 Si이 우선 미세한 구상석출물을 형성하며 초기 시효경화를 일으킨 후, 잇따라 Zr의 준안정 석출물이 불연속 석출되어 성장하며 최대 시효경화를 나타냄을 알 수 있었다. An experimental investigation has been made about the effects of the third alloying element silicon on the sold solubility of zirconium in the aluminium, and on the ageing phenomena of Al-Zr-Si alloys. Rapidly solidified specimens were prepared by a twin-roller quenching apparatus in the form of long, thin ribbon, whose cooling rate was estimated to be about 10?? K/s. Under such a cooling rate, the maximum solubility of zirconium in solid aluminum was extended to about 1.0wt.%. However, it was extended up to 1.7wt.% by addition of 1.0wt.% silicon. With the increase of silicon content, the microhardness of Al-Zr alloys were increased as well. Ageing of supersaturated Al-1.7wt.% Zr-1.0wt.% Si solid solution appeared to occur in three sequential stages; Ⅰ. precipitation of silicon as fine spherical particles which harden the alloys, followed by Ⅱ. discontinuous precipitation of metastable zirconium phases which produce remarkable age hardening of the alloys, and finally Ⅲ. formation of coarse equilibrium zirconium phases.

호텔기업의 로열티 프로그램이 몰입과 고객 애호도에 미치는 영향에 관한 연구

최우성,황명호 한국문화관광학회 2003 문화관광연구 Vol.5 No.2

In the hotel industry, the royalty (membership) program is very important because the profit or loss in their hotels income depends on it. The revenue from VIP membership takes 30~40% of total profits in the total hotel revenue. The utility value of the membership system is very powerful and hotels use this system to gain dominance over others. The hotels royalty program is a very important method in managing customers examining how to activate customer relationships, and analyzing how to affect customer loyalty. In the hotels royalty program, I researched how to influence level of commitment and loyalty.

Ba_2Ti_9O_20 유전체 재료의 저온소결 첨가제에 의한 소결 거동 및 고주파 특성

최명호,이주희,박명진,고영철,김남철 국립7개대학공동논문집간행위원회 2001 공업기술연구 Vol.1 No.-

Sintering characteristics and microwave dielectric properties of the Ba_2Ti_9O_20 ceramics added with lithium-boro-silicate glass frit were investigated. Sintering experiments showed that the densification occurred at lower firing temperatures down to 900℃ as the addition of glass frit was increased up to 10wt%. The bulk density and shrinkage of ceramics were strongly dependent on the amount of the glass frit. The microstructures of the ceramics were found to become skeletal-like structures as increase of glass frit. The monoclinic crystal structure of the Ba_2Ti_9O_20, however, was found not to be affected by the addition of glass frit up to 10wt%. Microwave dielectric constants of the glass frit added ceramics were relatively consistent of 35 with over 15% shrunk and densified ceramics. However, the quality factor (Qf) and the temperature constant (TCP) was found to be significantly affected by the additions of glass frit.