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Development of a type II diabetic mellitus animal model using Micropig®
Myeong-Seop Lee,Hee-Jun Yang,Chester D. Solis,Ki-Duk Song,Soo-Hyeon Kim,Woon-Kyu Lee 한국실험동물학회 2012 Laboratory Animal Research Vol.28 No.3
Diabetes, which has shown an explosive increase in terms of its incidence, is regarded as a serious disease that must be overcome for the sake of human life. Among animal models used for testing of drug efficacy, the mini-pig model has shown a rapid upload due to its many similarities with human, particularly concerning the pharmacokinetics of compounds after subcutaneous administration, the structure and function of the gastrointestinal tract, the morphology of the pancreas, and overall metabolic status. Based on these various advantages, we sought to develop an animal model of type II diabetic mellitus using the Micro-pig, which differs from other miniature pigs. We used six male Micro-pigs for induction of a moderate insulin deficient model with nicotinamide (NIA)/streptozotocin (STZ) treatment and three animals for control. For evaluation of incidence of type II diabetes, we measured blood glucose level, and performed oral glucose tolerance test and immunohistochemistry on pancreatic tissue using insulin antibody. Compared to control animals, all animals treated with NIA/STZ showed high levels of glucose and low levels of insulin. In addition, we observed the partially destroyed beta cell population from tissue of the pancreas in treated animals. Based on these results, we report that the Micro-pig model developed in this study can be used for testing of the efficacy of therapeutic agents for treatment of Type 2 diabetic mellitus.
Comparative genomic hybridization 기법을 이용한 인체 구강암의 유전자 변화에 대한 연구
이명렬(Myeong Reoyl Lee),심광섭(Kwang Sup Shim),이영수(Young Soo Lee),우순섭(Soon Seop Woo),공구(Gu Kong) 대한구강악안면외과학회 2000 대한구강악안면외과학회지 Vol.26 No.3
The development and progression of oral cancer is associated with an accumulation of multiple genetic alterations through the multistep processes. Comparative genomic hybridization(CGH), newly developed cytogenetic and molecular biologic technique, has been widely accepted as a useful method to allow the detection of genetic imbalance in solid tumors and the screening for chromosome sites frequently affected by gains or losses in DNA copy number. The authors examined 19 primary oral squamous cell carcinomas using CGH to identify altered chromosome regions that might contain novel oncogenes and tumor suppressor genes. Interrelationship between these genetic aberrations detected and major oncogenes and tumor suppressor genes previously recognized in carcinogenesis of oral cancers was studied. 1. Changes in DNA copy number were detected in 14 of 19 oral cancers (78.9%, mean: 5.58, range: 3~13). High level amplification was present in 4 cases at 9p23, 12p21.1~q13.1, 3q and 8q24~24.3. Fourteen cases(78.9%, mean: 3.00, range: 1~8) showed gains of DNA copy number and 12 cases(70.5%, mean: 2.58, range: 1~9) revealed losses of DNA copy number. 2. The most common gains were detected on 3q(52.6%), 5p(21.0%), 8q(21.0%), 9p(21.0%), and 11q(21.0%). The losses of DNA copy number were frequently occurred at 9p(36.8%), 17q(36.8%), 13q(26.3%), 4p(21.0%) and 9p(21.0%). 3. The minimal common regions of gains were repeatedly observed at 3q24~26.7, 3q27~29, 1q22~31, 5p12~13.3, 8q23~24, and 11q13.1-13.3. The minimal common regions of losses were detected at 9q11~21.3, 17p31, 13q22~34, and 14p16. 4. In comparison of CGH results with tumor stages, the lower stage group showed more frequent gain at 3q, 5q, 9p, and 14q, whereas gains at 1q(1q22~31) and 11q(11q13.1~13.3) were mainly detected in higher stage group. The loss at 13q22~34 was exclusively detected in higher stage. The results indicate that the most frequent genetic alterations in the development of oral cancers were gains at 3q24~26.3, 1q22~31, and 5p12~13.3 and losses at 9q11~21.3, 17p31, and 13q. It is suggested that genetic alterations manifested as gains at 3q24~26.3, 3q27~29, 5p12~13.3 and 5p are associated with the early progression of oral cancer. Gains at 1q22~31 and 11q13.1~13.3 and loss at 13q22-34 could be involved in the late progression of oral cancers.
6축 협동 로봇을 이용한 CFRP 절삭 칩 제거 시스템 구상
이명희(Myeong Hui Lee),김홍민(Hong Min Kim),이현호(Hyeon Ho Lee),전현섭(Hyeon Seop Jeon),정영훈(Young Hun Jeong) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.5
최근 자동차, 항공 우주 등의 산업에서 경량 소재에 대한 관심이 높아지고 있다. 특히 탄소섬유강화플라스틱(CFRP)은 우수한 비강도와 안정성으로 인해 생산 및 가공 분야에서의 연구가 활발히 이루어지고 있다. CFRP 가공 시 절삭 칩이 발생하는데, 해당 칩의 크기는 0.25 ~ 1 ㎛로 미세하다. 이로 인해, CFRP 가공 분진이 호흡기 등을 통해 인체에 흡입되어 악영향을 미칠 수 있다. 이러한 문제를 개선하고자, 본 연구에서는 6축 협동 로봇과 산업용 진공청소기를 활용하여 가공 공간에서의 무인 절삭 칩 흡입 시스템을 구상하였다. 해당 시스템을 구축하기 위한 선행 단계로, 절삭 칩의 위치를 파악하기 위해 비전 카메라를 통해 가공 공간을 좌표화하고 절삭 칩을 대신할 분말을 가공 공간 상에서 인식할 수 있음을 보였다. Recently, lightweight materials gain a lot of attention from various industries such as automobile and aerospace. In particular, carbon fiber reinforced plastic (CFRP) has been actively studied in the production and machining fields. Dimension of CFRP chips generated in machining process ranges from 0.25 to 1 ㎛. For this reason, CFRP chips may be inhaled into the human body through a respirator and detoriorate the human health. In this study, an unmanned chip suction system based on a 6-DOF collaborative robot and an industrial vacuum cleaner was proposed. At the preliminary step, the machining space was coordinated using a camera, and then the location of the cutting chip was identified.
건설업 KOSHA 18001 인증제도의 실효성 제고에 관한 연구
이진섭 ( Jin Seop Lee ),이명구 ( Myeong Gu Lee ),이동율 ( Dong Yul Lee ),오태근 ( Tae Keun Oh ) 한국안전학회(구 한국산업안전학회) 2015 한국안전학회지 Vol.30 No.3
The industrial accidents in the construction business have decreased on the basis of the accreditation of KOSHA 18001, one of the occupational health and safety management system. However, the interest and investment into the KOSHA 18001 has grown down because of the worsened construction business so that the construction companies that maintain the system as a mere formality has begun to be displayed. In this regard, this study performed the interview with the internal and external review board as well as the question investigation from the persons concerned in order to apprehend the current problems in the KOSHA 18001. First of all, the internal reviewers in the KOSHA are lack in the comparison with the number of new and renew accreditation. Secondly, many persons concerned with the KOSHA has required the quantitative criteria for the accreditation. Consequently, the manpower supplement associated with the external reviewers, the grading evaluation would be strong solutions to improve the effectiveness of KOSHA 18001.
H-자형 이메소제닉 화합물; α,ω-Bis(2,5-bis(4-cyanophenoxy carbonyl)phenoxy)alkanes의 합성과 열방성 성질
박주훈,이환명,최옥병,이용섭,고경곤,이은상,송종혁,김기환,이은경,이창준,소봉근,이수민,Park, Ju-Hun,Lee, Hwan-Myeong,Choe, Ok-Byeong,Lee, Yong-Seop,Go, Gyeong-Gon,Lee, Eun-Sang,Song, Jong-Hyeok,Kim, Gi-Hwan,Lee, Eun-Gyeong,Lee, Chang-Jun,S 대한화학회 2006 대한화학회지 Vol.50 No.3