Olibanum Extract Inhibits Vascular Smooth Muscle Cell Migration and Proliferation in Response to Platelet-Derived Growth Factor

최옥병,박주훈,이예진,이창권,원경종,김정환,이환명,김보경 대한약리학회 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.2

Olibanum (Boswellia serrata) has been shown to have anti-inflammatory, anti-arthritic and anti- cancer effects. This study determined the role of a water extract of olibanum in platelet-derived growth factor (PDGF)-stimulated proliferation and migration of rat aortic smooth muscle cells (RASMCs). PDGF-BB induced the migration and proliferation of RASMCs that were inhibited by olibanum extract in a dose-dependent manner. The PDGF-BB-increased phosphorylation of p38 mitogen-activated protein kinase (MAPK); the heat shock protein (Hsp) 27 was significantly inhibited by the olibanum extract. The effects of PDGF-BB-induced extracellular signal-regulated kinase1/2 was not altered by the olibanum extract. Treatment with olibanum extract inhibited PDGF-BB-stimulated sprout out growth of aortic rings. These results suggest that the water extract of olibanum inhibits PDGF-BB-stimulated migration and proliferation in RASMCs as well as sprout out growth, which may be mediated by the inhibition of the p38 MAPK and Hsp27 pathways.

아로마테라피를 이용하여 생리통 및 생리전증후군의 개선에 대한 효과검증에 관한 실험

최옥병,정영미,박주훈 호서대학교 기초과학연구소 2000 기초과학연구 논문집 Vol.8 No.1

Women has hindered every day by premenstrual syndrom. The symptom treated with 10%. It was many trials that premenstrual syndrom treated. The method was drugs, self-control, nutrition, play. We had aromatherapy. Aromatherapy obtained oil with medicinal herb, it is treated massage and smell. Oil is massage with fixed geranium, bergamot, neroil etc. After treatment, premenstrual syndrom decreased that attention, memory, intelligence disorder, impulse, attack, vigilance, breast pain, abdominal pain, waist pain.

기능성식품을 이용한 비만여성에 신체계측 및 혈액성분의 변화

최옥병,박주훈,신주철 호서대학교 기초과학연구소 2004 기초과학연구 논문집 Vol.12 No.1

The study was designed to investigate the effects of w eight control and change in serum components using antifat diets w ith function food on 10 obese women over a period of 6 weeks. The subjects had antifat diets w ith function food(7g) twice a day. Our results show that antifat diets w ith function food are effective in the diet therapy of obese women.

아로마테라피를 이용한 비만여자대학생의 체중조절 효과 평가에 관한 연구

최옥병,정영미,박주훈 호서대학교 기초과학연구소 2000 기초과학연구 논문집 Vol.8 No.1

This study is a clinic demonstration about Body Fit and Lifting & Cellulite make using of Essential oil. The method of demonstration have used the massage with a eating treatment and exercise-treatment at the same time. The subject persons of study were fifteen and operated for 4 weeks. We have done a body- instrumentation and serum lipids analysis for make firm the result of study. We divided in to A , B group of eight. A group goes abreast a eating and exercise and B group dosent anything else. After 4 weeks w e analyze a body instruments and serum lipids. The result of analysis, A , B groups were appeared a reducing tendency. B group is not so reduce as A group. But the goods is know n to the effect on obese-treatment because B group had only a massage as a reducing reason.

동종요법의 임상적 의미와 한의학적 응용 가능성에 관한 고찰

최옥병,Choi, Ok-Byung 대한약침학회 2007 Journal of pharmacopuncture Vol.10 No.1

Objectives : The purpose of this study is to analyze the practical implications of homeopathic medicines, their status, their preparation systems and registration rules, recognized by the European Union and other countries. Contents : This paper covers the background of homeopathic medical principle, homeopathy throughout the world, the medicine status and clinical research, increases of the drug potency, the practical regulation of treatment, preparation techniques of homeopathic drugs and registration rules and the clinical practice. Homeopathy has been currently practised in over eighty countries throughout the world, especially in Europe. It had attracted considerable attentions in South and North America (notably in USA, Brazil, and Argentina), India and Pakistan. Although it is not dominantly popular in North America, constant growth has been nevertheless noted. Over the last thirty years, homeopathy has also developed or appeared in South Africa, Tunisia, Morocco, Venezuela, Israel, and Australia, etc. Result & suggestion : As over 300 million patients have put their trust in homeopathy, the study of the integration of homeopathy to oriental medicine, its development and feasibility in Korea are urgently needed. The products, substances, compositions of Homeopathic drugs are very similar to those of oriental medicine theory. Therefore their preparations and applications should prescribed and practised exclusively by oriental doctors. Applying the homeopathic theory and its preparation techniques to oriental medicine, the herbal acupuncture preparation should be modernized and various oriental products are to be developed. To this end, government and herbal acupuncture society need to interact each other for the development of oriental medicine.

마르지 않는 샘처럼

崔玉丙 세계평화교수협의회 1983 廣場 Vol.123 No.-

겨우살이 암치료제의 임상의학적 중요성과 한의학적 겨우살이 약침제제 개발 및 적용 가능성에 관한 고찰

최옥병,Choi, Ok-Byung 대한약침학회 2009 Journal of pharmacopuncture Vol.12 No.1

Objectives : Mistletoe extracts have been in use for around 85 years, predominantly in the area of cancer therapy. Today mistletoe preparations are among the most prescribed drugs in cancer medicine, thus constituting a standard biological therapy in the area of oncology. The purpose of this study is to analyze the practical implications of mistletoe cancer therapy, their clinical status, their preparation techniques and companies. Contents : Mistletoe therapy for cancer has been developed within the context of anthroposophical medicine. One major effect of mistletoe extract is that it stimulates the immune system and cancer defences. In Germany, a total of eight different mistletoe preparations are available, five developed by Anthroposophic Medicine and three evolved from research in phytotherapy. Therapy always consists of an introductory phase in order to test the patient's tolerance, find the right dosage and choose the most suitable preparation. This paper covers the background of mistletoe medical plant materials, mistletoe therapy for cancer, the anthroposophical medicine and clinical research, the practical regulation of treatment, preparation of mistletoe drugs. Result & suggestion : Mistletoe extracts are a complementary teratment of cancer, widely used in intergrative cancer care. The study of the integration of korean mistletoe extracts to oriental cancer medicine, its development and feasibility in Korea are urgently needed. The products, substances, compositions of european mistletoe drugs are very similar to those of oriental medicine theory. Applying the mistletoe cancer therapy and its preparation techniques to oriental medicine, the herbal acupuncture preparation should be modernized and korean mistletoe products are to be developed. To this end, government and herbal acupuncture society need to interact each other for the development of oriental mistletoe cancer medicine.

어성초 추출물의 혈관 평활근 세포 이주 및 증식 억제 활성에 관한 연구

최옥병,한정호,박선남,윤미소 한국생약학회 2011 생약학회지 Vol.42 No.2

Houttuynia cordata Thunb.[H.cordata]belonging to Saururaceae, is a wild medicinal herb of perennial plants, and grows well in a place with a lot of shade and moisture. The medical action of H.cordata is reported to have an antitumer effect, toxicity-suppressive effect, antifungal effect, diuretic effect , and antioxidative action, but its effect hasn't been reported on cardiovascular diseases, such as ateriosclerosis and hypertension yet. This study intended to confirm the effect of the water extract of H.cordata on the migration and proliferation of rat aortic smooth muscle cells. Such results show that the water extract of H.cordata suppresses the migration and proliferation of rat aortic smooth muscle cells. It is believed that a useful clue will be offered later to the prevention of cardiovascular diseases such as ateriosclerosis and hypertension, and the development of their medicines on the basis of the fact.

한국산 겨우살이 (Viscum album L. ssp. coloratum)주줄물이 Human Tumor Xenograft에 미치는 직접적 항암효과 연구

최옥병 호서대학교 기초과학연구소 1998 기초과학연구 논문집 Vol.6 No.1

운동종류에 따른 비만 체중감량 효과의 상관성

최옥병(Ok-Byung Choi) 호서대학교 기초과학연구소 2006 기초과학연구 논문집 Vol.14 No.1

운동의 종류에 따라 체중감량, 지방대사 및 체지방 분해, 근육기능에 미치는 효과가 각각 다르게 나타남을 보여준다. 많은 사람들이 살을 빼기위해 땀을 흘리는 유산소 운동을 선호하고 근육에 저항력을 키워주는 운동은 비만에 크게 도움이 안 된다고 인식하고 있다. 그러나 근육 저항력을 키우는 근육 저항성 운동이 오히려 체내의 탄수화물, 지방대사 효율성을 증대 시키고 체지방을 분해시켜 체중 감량에도 효과적이다. 비만의 경우 대부분 대사증후군을 수반하여 고혈압 , 제 2 형 당뇨병, 심혈관질환, 암등을 야기 시키는데 이러한 대사증후군이 나타나는 비만인의 경우 체중감소효과 및 대사증후군 개선 효과 면에서 근육 저항성이 약한 유산소운동(strenuous exercise )보다 저항력을 주는 근육저항운동(resistance exercise) 이 현저하게 높게 나타나고 있다 . 특히 여성들의 경우 운동의 종류와 강도에 따라 여성 호르몬 에스트로겐의 생성과 분비에 커다란 영향을 미치게 되고 그에 따라 여성 생리주기, 골밀도, 조직성장, 임신, 출산 등에 커다란 변화가 관찰되어 진다. 이러한 여성 호르몬의 변화는 비만여성의 경우 체중 감량에도 크게 영향을 주는 것으로 밝히고 있다 The adipositas is associated with a metabolic syndrom. This metabolic syndrom is characterized by obesity, increased Triglyceride, VLDL and decreased HDL cholesterol concentrations as well as elevated concentrations of blood glucose and insuline. A large number of investigations has proven that resistance exercise is effective in the treatment and prevention of the metabolic syndrome and the associated body weight reductions. Resistance exercise has been shown to be associated with higher HDL cholesterol and lower triglycerides as well as a reduction of small dense LDL cholesterol. This effect can be explained by a reduction in body fat, improvement of the fat metabolic function of the adipocyte, increased fatty acid turnover in muscular metabolism. Hardtraining activity in females induces menstrual cycle irregularities. Menstrual cycle disorders caused by hardtraining, body over weight, low body weight, malnutrition and stress with persisting amenorrhea may lead to infertility and osteoporotic problems in advanced ages. Resistance exercise is very important to avoid serious damage to the females ovar funtion and body weight control. It is the responsibility of trainers to recognize these factors and provide for the necessary body over weight.