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Minkyung Bae,Sungil Jang,Joo Weon Lim,Jieun Kang,Eun Jung Bak,Jeong-Heon Cha,Hyeyoung Kim 고려인삼학회 2014 Journal of Ginseng Research Vol.38 No.1
Helicobacter pylori-induced gastric inflammation includes induction of inflammatory mediators interleukin (IL)-8 and inducible nitric oxide synthase (iNOS), which are mediated by oxidant-sensitive transcription factor NF-kB. High levels of lipid peroxide (LPO) and increased activity of myeloperoxidase (MPO), a biomarker of neutrophil infiltration, are observed in H. pylori-infected gastric mucosa. Panax ginseng Meyer, a Korean herb medicine, is widely used in Asian countries for its biological activities including anti-inflammatory efficacy. The present study aims to investigate whether Korean Red Ginseng extract (RGE) inhibits H. pylori-induced gastric inflammation in Mongolian gerbils. One wk after intragastric inoculation with H. pylori, Mongolian gerbils were fed with either the control diet or the diet containing RGE (200 mg RGE/gerbil) for 6 wk. The following were determined in gastric mucosa: the number of viable H. pylori in stomach; MPO activity; LPO level; mRNA and protein levels of keratinocyte chemoattractant factor (KC, a rodent IL-8 homolog), IL-1b, and iNOS; protein level of phospho-IkBa (which reflects the activation of NF-kB); and histology. As a result, RGE suppressed H. pylori-induced mRNA and protein levels of KC, IL-1b, and iNOS in gastric mucosa. RGE also inhibited H. pylori-induced phosphorylation of IkBa and increases in LPO level and MPO activity of gastric mucosa. RGE did not affect viable H. pylori colonization in the stomach, but improved the histological grade of infiltration of polymorphonuclear neutrophils, intestinal metaplasia, and hyperplasia. In conclusion, RGE inhibits H. pyloriinduced gastric inflammation by suppressing induction of inflammatory mediators (KC, IL-1b, iNOS), MPO activity, and LPO level in H. pylori-infected gastric mucosa.
Minkyung Bae,Yongsik Kim,Dongsik Kong,Hyun Kwang Jeong,Woojoon Kim,Jaehyeong Kim,Inseok Hur,Dong Myong Kim,Dae Hwan Kim IEEE 2011 IEEE electron device letters Vol.32 No.11
<P>Analytical drain current and gate capacitance models for amorphous InGaZnO (a-IGZO) thin-film transistors (TFTs) over sub- and above-threshold regions are proposed by adopting an effective carrier density for the dominant carrier density. The effective carrier density fully considers the free carriers in the conduction band, the localized subgap deep states, and tail states over the bandgap for analytical <I>I</I>-<I>V</I> and <I>C</I>-<I>V</I> characteristics. The proposed analytical models are verified by comparing the measured <I>I</I>-<I>V</I> and <I>C</I>-<I>V</I> characteristics. The proposed models make a time-efficient simulation of a-IGZO TFT-based circuits possible due to their analytical form.</P>
Extraction of Subgap Donor States in a-IGZO TFTs by Generation–Recombination Current Spectroscopy
Minkyung Bae,Yongsik Kim,Sungchul Kim,Dong Myong Kim,Dae Hwan Kim IEEE 2011 IEEE electron device letters Vol.32 No.9
<P>A physics-based generation-recombination current (JG r) spectroscopy is proposed for the extraction of the sub gap donorlike density of states (DOS) of amorphous InGaZnO thin-film transistors. Physics-based Shockley-Read-Hall recombination through the subgap DOS over the bandgap is fully considered, and the potential for the carrier concentration is calculated through the DeAOTS model. The extracted parameters for the exponential deep donorlike states are N<SUB>DD</SUB> = 5.5 × 10<SUP>21</SUP> [cm<SUP>-3</SUP> · eV<SUP>-1</SUP>] and kT<SUB>DD</SUB> = 0.115 [eV].</P>
Bae, Minkyung,Jang, Sungil,Lim, Joo Weon,Kang, Jieun,Bak, Eun Jung,Cha, Jeong-Heon,Kim, Hyeyoung The Korean Society of Ginseng 2014 Journal of Ginseng Research Vol.38 No.1
Helicobacter pylori-induced gastric inflammation includes induction of inflammatory mediators interleukin (IL)-8 and inducible nitric oxide synthase (iNOS), which are mediated by oxidant-sensitive transcription factor NF-${\kappa}B$. High levels of lipid peroxide (LPO) and increased activity of myeloperoxidase (MPO), a biomarker of neutrophil infiltration, are observed in H. pylori-infected gastric mucosa. Panax ginseng Meyer, a Korean herb medicine, is widely used in Asian countries for its biological activities including anti-inflammatory efficacy. The present study aims to investigate whether Korean Red Ginseng extract (RGE) inhibits H. pylori-induced gastric inflammation in Mongolian gerbils. One wk after intragastric inoculation with H. pylori, Mongolian gerbils were fed with either the control diet or the diet containing RGE (200 mg RGE/gerbil) for 6 wk. The following were determined in gastric mucosa: the number of viable H. pylori in stomach; MPO activity; LPO level; mRNA and protein levels of keratinocyte chemoattractant factor (KC, a rodent IL-8 homolog), IL-$1{\beta}$, and iNOS; protein level of phospho-$I{\kappa}B{\alpha}$(which reflects the activation of NF-${\kappa}B$); and histology. As a result, RGE suppressed H. pylori-induced mRNA and protein levels of KC, IL-$1{\beta}$, and iNOS in gastric mucosa. RGE also inhibited H. pylori-induced phosphorylation of $I{\kappa}B{\alpha}$ and increases in LPO level and MPO activity of gastric mucosa. RGE did not affect viable H. pylori colonization in the stomach, but improved the histological grade of infiltration of poly-morphonuclear neutrophils, intestinal metaplasia, and hyperplasia. In conclusion, RGE inhibits H. pyloriinduced gastric inflammation by suppressing induction of inflammatory mediators (KC, IL-$1{\beta}$, iNOS), MPO activity, and LPO level in H. pylori-infected gastric mucosa.
Hagyoul Bae,Sungchul Kim,Minkyung Bae,Ja Sun Shin,Dongsik Kong,Hyunkwang Jung,Jaeman Jang,Jieun Lee,Dae Hwan Kim,Dong Myong Kim IEEE 2011 IEEE electron device letters Vol.32 No.6
<P>Considering asymmetry caused by layout, process, and device degradation, separate extraction of the source and drain resistances, i.e., <I>RS</I> and <I>RD</I>, respectively, from the total resistance <I>R</I><SUB>TOT</SUB> is very important in the design, modeling, and characterization of amorphous indium-gallium-zinc oxide (a-IGZO) thin-film transistors (TFTs). Due to the insulated gate structure, however, separate extraction is difficult through direct-current <I>I</I>-<I>V</I> characterization. In this letter, we propose a simple and useful technique for separate extraction of <I>RS</I> from <I>RD</I> in a-IGZO TFTs through a two-terminal parallel-mode <I>C</I> -<I>V</I> technique. We experimentally verified the validity of the proposed technique by comparing the result with the source-to-drain resistance from the <I>I</I>-<I>V</I> characteristics.</P>
배민경(Bae, MinKyung),박승훈(Park, SeungHoon) 한국지역개발학회 2018 韓國地域開發學會誌 Vol.30 No.2
Jaywalking, which is an illegal act crossing a road without a crosswalk, has been considered as a serious urban safety problem for a long time. 40.1% of traffic accidents causing death took place while walking. However, There are less studies that pay attention to the relationship between jaywalking and pedestrian collisions. Therefore, in this study, this study tries to analyze the street physical environments affecting traffic accidents occurred around the jaywalking hot spot. The data of pedestrian crashes was based on the TAAS data of the Road Traffic Corporation from 2010 to 2015. In addition, a spatial regression analysis was performed by constructing variables such as road structure, landscaping facilities, and walking-causing facilities. The OLS, SEM and SLM models were compared and the SEM model had the strongest explanatory power. As a result of the analysis, crosswalks with traffic lights increased the jaywalking accidents. Also, so-ro, dae-ro, underground sidewalks, bus stop density, and development density had a statistical significance with the pedestrian collisions. This study suggests the necessity of intensive and empirical study of jaywalking accidents for better pedestrian safety. It is possible to make an effective policy development to reduce the jaywalking, which is a urban safety problem, and to plan a pedestrian-safety city out of the vehicle-centered city.
김용식,Minkyung Bae,Dongsik Kong,Hyun Kwang Jung,Jaehyeong Kim,Woojoon Kim,Inseok Hur,김동명,김대환 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.21
The physical origins of the negative bias illumination stress (NBIS)-induced threshold voltage shift (VT ) in amorphous InGaZnO (a-IGZO) thin-film transistors (TFTs) under ambient light from a backlight unit are quantitatively and systematically investigated. Furthermore, a methodology for extracting the instability parameters is proposed and demonstrated. For the quantitative analysis, the subgap density-of-states (DOS)-based DC I-V model is intensively used. The NBIS time-evolution of the measured IDS-VGS characteristics is reproduced very well via the proposed methodology and instability parameters. Consequently, photo-excited electron detrapping, followed by ionization of oxygen vacancies (VO^(+2)) and field-enhanced VO^(+2) diffusion, followed by hole trapping into the gate insulator, are found to be the dominant mechanisms in NBIS-induced instability of a-IGZO TFTs.