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IL-1 수용체를 통한 T세포 활성화에 Genistein 과 Staurosporin이 미치는 영향
한미영,윤도영,오은숙,고우석,윤선영,정태화 大韓免疫學會 1996 大韓免疫學會誌 Vol.18 No.4
Stimulation of T-cells through TCR/CD3 complex alone is known to be not enough but also require a costimulatory signal, such as IL-1 stimulation. to induce IL-2 production. In this report, we studied the differential effects of staurosporin (a PKC inhibitor) and genistein (a PTK inhibitor) on the IL-2 production by EL-4 and A2.5 cells, to determine which pathway is responsible for IL-1 receptor signal transduction. While staurosporin suppressed the IL-2 production induced in EL-4 cells upon PMA stimulation but not upon PHA plus IL-1, genistein inhibited the IL-2 production induced by PHA plus IL-1 but not by PMA. Genistein also completey abrogated the IL-2 production by A2.5 cell when stimulated with PHA and IL-1. These results suggest that the costimulatory signal by IL-1, which leads to IL-2 production and proliferation, is closely linked to the PTK activity in T cells.
Sweep Co-Distillation법에 의한 산화방지제의 추출법
김재관,황혜정,오문헌,도영숙,윤미혜 한국식품영양학회 1999 韓國食品營養學會誌 Vol.12 No.4
식용유지 중의 산화방지제를 효율적으로 분석하기 위하여 일반적인 용매추출법과 SCD법으로 전처리하여 HPLC법으로 비교 분석하였다. SCD법의 최적조건은 florisil의 활성도와 UNITREX의 온도와 추출시간에 따른 회수율로 분석하였다. 식용유지에 산화방지제를 농도별로 가하여 용매추출법과 SCD법의 회수율을 비교한 결과 용매추출법은 80.4∼102.1%, SCD법은 89.8∼106.4%로 나타났다. Florisil의 활성화에 따르면 2% 수분 첨가시 TBHQ, BHA, BHT는 89.8∼106.4%로 회수율이 가장 높았고, PG는 5% 수분 첨가시 53.9±7.3%의 회수율을 보였다. 회수율은 UNITREX의 210℃에서 20분간 추출하였을 때 가장 높았다. This study was conducted to evaluate the extraction methods for the determination of antioxidants in soybean oil. Recovery rates of various antioxidants in soybean oil showed similar rates as 80.4∼102.1% by solvent/solvent extraction method and 89.8∼106.4% by sweep co-distillation method except 46.6∼61.2% of PG at corresponding spiked concentractions. The maximum recovery rates of antioxidants were obtained when extraction time and extraction temperature used in UNITREX were 20min and 210℃ respectively. In the recovery rates with the activation of florisil, when 2% of water was added to florisil, the highest recovery rates for TBHQ, BHA, BHT were obtained by sweep co-distillation method. Therefore, sweep co-distillation method showed less solvent, simple operation and high recovery rate compared with solvent/solvent extraction method.
Mi-Sook Do,Ria-Ann R. Lomeda,Young-Eun Cho,In-Sook Kwun 한국영양학회 2007 Nutrition Research and Practice Vol.1 No.4
For the assessment of representative and longitudinal Zn nutriture in South Koreans, Zn, phytate and Ca intakes were determined using four consecutive years of food consumption data taken from Korean National Nutrition Survey Report (KNNSR) every 10 years during 1969-1998. The nutrient intake data are presented for large city and rural areas. Zn intake of South Koreans in both large city and rural areas was low during 1969-1988 having values between 4.5-5.6 ㎎/d, after then increased to 7.4 (91% Estimated Average Requirements for Koreans, EAR = 8.1 ㎎/d) and 6.7 ㎎/d (74% EAR) in 1998 in large city and rural areas, respectively. In 1968, Zn intake was unexpectedly higher in rural areas due to higher grain consumption, but since then until 1988 Zn intake was decreased and increased back in 1998. Food sources for Zn have shifted from plants to a variety of animal products. Phytate intake of South Koreans during 1969-1978 was high mainly due to the consumption of grains and soy products which are major phytate sources, but decreased in 1998. The molar ratios of phytate:Zn and millimmolar ratio of phytate×Ca:Zn were decreased due to the decreased phytate intake in South Koreans, which implies higher zinc bioavailability. The study results suggest that Zn nutriture has improved by increased dietary Zn intakes and the decreased molar ratio of phytate:Zn in South Koreans in both large city and rural areas.
윤미혜(Mi-Hye Yoon),엄미나(Mi-Na Eom),도영숙(Young-Sook Do),정홍래(Hong-Rae Jung),정일형(Il-Heoung Jeong),고환욱(Hoan-Uck Ko),손진석(Jin-Seok Son) 대한환경위생공학회 2005 대한환경위생공학회지 Vol.20 No.2
This study was performed to survey and evaluate the contents of plasticizers such as DEP(diethyl phthalate), DPrP(di-n-propyl phthalate), DBP(di-n-butyl phthalate), DPP(di-n-pentyl phthalate), DCHP(dicyclohexyl phthalate), BBP (butylbenzyl phthalate), DEHP (di-(2-ethylhexyl) phthalate) and DEHA(di-(2-ethylhexyl) adipate), which are suspected as endocrine disruptors, in food and drug PVC packaging. Tested samples were 5 food wraps, 35 food containers, 40 food and drug packages(type of tablet and capsule) in Gyeonggi-Do area. The contents of DEHA in wrap were 188.9g/㎏, 203.1g/㎏, 238.4g/㎏, 290.9g/㎏ and 308.3g/㎏, respectively, while the other plasticizers were not detected. DEHP was used in 4 samples of food containers and DEHP contents were 4.7g/㎏, 30.7g/㎏, 35.8g/㎏ and 53.4g/㎏, respectively. In food and drug packaging materials(type of tablet and capsule), the plasticizers were not detected.
아이들이 주인공이 되는 즐거운 바깥놀이 프로그램 적용 연구
김순숙(Kim, Soon Sook),도미향(Do, Mi Hyang),구승희(Koo, Seung Hee),최정은(Choi, Jung Eun) 한국부모교육학회 2021 부모교육연구 Vol.18 No.3
본연구의 목적은 영유아들이 중심이 되고, 놀이가 중심이 되는 어린이집의 바깥놀이 활성화를 위한 방안을 모색하고자 한다. 본 연구의 대상은 충남 홍성군에 위치한 충청남도청어린이집 영아 97명과 유아 126명을 포함한 영유아 213명과 영아반교사 19명과 유아반 교사 9명을 포함한 교사 28명을 대상으로 참여적 실행연구를 하였다. 연구방법은 참여관찰, 현지자료 조사, 기타자료조사 등을 수집하여 이를 바탕으로 심층적 분석과 고찰이 이루어졌다. 본 연구의 결과는 첫째, 영유아 중심의 바깥놀이 활성화를 저해하는 요인을 분석하여 영유아 중심의 바깥놀이를 활성화하는 프로그램을 구성하였다. 둘째, 구성한 프로그램 적용을 통해 긍정적이고 주도적인 영유아의 변화와 영유아 중심의 바깥놀이 중요성 및 바깥놀이를 연구하는 등 교사의 변화가 나타났다. 따라서 본 연구의 결과를 바탕으로 자유롭게 바깥놀이에 참여하는 과정을 통해 영유아 주도의 바깥놀이가 활성화되고, 교사의 바깥놀이에 대한 적극적인 태도와 상호작용을 통해 영유아가 바깥놀이에 대한 인식에 긍정적 영향을 미치게 되어 어린이집의 바깥놀이 활성화에 기여할 수 있음을 논의하였다. The purpose of this study is to find ways to revitalize outdoor play in daycare centers where infants and toddlers are centered and play is centered. The subjects of this study were 213 infants and toddlers, including 97 infants and 126 toddlers at the Chungcheongnam-do Provincial Government Daycare Center in Hongseong-gun, Chungcheongnam-do, and 28 teachers, including 20 infant class teachers and 8 toddler class teachers. As for the research method, participatory observation, field data survey, and other data survey were collected, and in-depth analysis and consideration were conducted based on this. The results of this study first constructed a program to activate infant-centered outdoor play by analyzing the factors that hinder the activation of infant-centered outdoor play. Second, through the application of the organized program, positive and leading changes in infants and toddlers, the importance of playing outside centered on infants, and changes in teachers appeared. Therefore, based on the results of this study, it was discussed that infant-led outdoor play can be activated through the process of freely participating in outdoor play, and infants and toddlers can have a positive effect on their perception of outdoor play.