폐경 후 여성에서 체성분과 골밀도와의 관계

채진욱,김일희,권우성,이근미,정승필,문용 영남대학교 의과대학 2003 Yeungnam University Journal of Medicine Vol.20 No.1

Background: Body weight is an important factor that influence the bone density in postmenopausal women except estrogen dificiency. However, different results are reported about the relationship between body composition and bone density in the postmenopausal women. We have studied the relationship between age, body weight, body mass index (BMI), waist hip ratio (WHR), muscle mass, fat mass, fat free mass and bone density. Materials and Methods: We have studied 127 persons of postmenopausal women who visited university medical center and examined the inbody 3.0 and Dual Energy X-ray Absorptiometry (DEXA) from Jan, 2001 to Jun, 2002. they didn't have any disease and didn't received homone therapy, osteoprosis therapy or other medication that influence the bone density. Results: The numbers of study subjects is total 127 persons. Mean age is 56.9±5.14, mean weight is 59.3±8.7 kg, mean BMI is 25.37±3.16 (kg/㎡), mean fat mass is 20.02±5.05 kg, mean muscle mass is 37.49±4.50 kg, mean fat free mass is 39.80±4.70, mean BMD is 0.828±0.148 (g/㎠). In the result of linear regression analysis, age, height, weight, muscle mass, fat free mass, fat mass, BMI are significant determinants of BMD. In stepwise multiple regression analysis, age is the most significant determinant of BMD and besides age, fat mass is the most significant determinant of BMD among body composition. Conclusion: In postmenopausal women, age, height, weight, BMI, muscle mass, fat free mass, fat mass are significant determinants of BMD and besides age, fat free mass is the most significant determinant of BMD among the body composition. So, diet and exercise that increase fat free mass will contribute to bone density increment.

노인의 영적 간호요구

최미혜,김경희,김귀옥,김기숙,김수강,김정신,김춘숙,노흥진,박지연,성혜연,오명선,이선희,이원옥,이윤영,이현수,장명재,차혜경,채정선,홍상희 중앙대학교 의과대학 간호학과 간호과학연구소 2001 중앙간호논문집 Vol.5 No.1

This study was designed to exam the aged's needs for spiritual nursing care. The purpose was to serve as a basis for the development of spiritual nursing practice. The major findings are as follows : 1. The degree of needs for spiritual nursing care as area was that needs of love and relationship mean 22.0, needs of meaning and object mean 28.2, needs of forgiving mean 13.5. Total needs for spiritual nursing care mean 63.7, which was on the upper middle level. The needs of meaning and object was rated highest. 2. Among the general characteristics of the subjects, needs of love and relatiohship wasn't significanlty different. 3. Among the general characteristics of the subjects, needs of meaning and object was significantly different according to two factors : age(F=7.260, p=0.001), religion(F=5.275, p=0.001). Higher needs of meaning and object was possessed by the older than the younger, by the one who have religion than the other. 4. Among the general characteristics of the subjects, four factors made a significantly difference to needs of forgiving : sex(t=-2.851, p=0.006), age(F=8.201, p=0.001), religion(F=6.928, p=0.000), disease(t=2.327, p=0.024). Higher needs of forgiving was possessed by man than woman, by the older than the younger, by the one who have religion than the other, by the one who have disease than the other.

정상 체중인 성인 남성에서 지방과다와 심혈관질환의 위험요인간의 관련성

권우성,김준수,채진욱,이근미,정승필,문용 영남대학교 의과대학 2003 Yeungnam University Journal of Medicine Vol.20 No.1

정상체중을 가진 성인 남성에서 지방과다(adiposity)와 심혈관계 질환의 위험요인과의 관련성을 알아보고자 하였다. 2001년 1월 3일부터 12월 31일까지 영남대 학교의료원에서 종합검진을 받은 만 28∼69세 성인 남성 129명을 대상으로 연령, 신체계측, 혈압, 공복 혈당, 혈청 지질대사치와 체성분 검사를 실시하였다. 체질량지수(BMI)가 18.5∼23 kg/㎡(76명)인 정상체중군과 23∼25 kg/㎡(53명)인 과체중군으로 분류하고, 체비방률, 체지방량과 위험인자들(수축기혈압, 이완기혈압, 공복시 혈당, 중성지방, 저밀도지단백, 고밀도지단백)의 상관관계를 분석하고, 정상체중군을 지방과다에 따라 3군으로 나누고, 각 군과 과체중군에서 심혈과 질환의 위험인자를 평가하였다. 정상체중의 제1군을 기준으로 제2, 3군과 과체중군의 위험인자 존재에 대한 비차비(odds ratio)를 조사하였다. 정상체중군에서 지방과다 변수들(adiposity variables: 체지방량, 체지방률)과 수축기 및 이완기 혈압, 저밀도지단백, 중성지방에서 유의한 상관관계가 있었다. (P<0.01). 나이를 보정하고 난 뒤 제1군을 기준으로 제3군(체지방율: 3.7, 체지방양: 4.7)과 과체중군(체지방율: 6.6, 체지방양 11.5)에서 위험인자에 대해 더 높은 비차비를 가졌다. 지방이 많은 정상체중의 성인남성은 적은 지방을 가진 성인 남성보다 심혈관 질환에서 더 높은 유병 위험도를 가졌다. 지방 측정은 정상체중군에서 심혈관계 질환의 위험인자외에 추가적인 정보를 제공할 수 있었다. Background: Most of all studies about the relation between the health risk and obesity are based on the European and American data. The purpose of this study is to examine the relation between adiposity and factors for cardio vacular disease (CVD) in normal weight individuals. Materials and Methods: Normal weight subjects with a body mass index (BMI) between 18.5 and 23 kg/㎡(76 subjects) and overweight subjects with a BMI between 23 and 25 kg/㎡ (53 subjects) were retained for this study. Normal weight subjects were divided into three group of each adiposity variable, then three group and the overweight group were evaluated for the presence of CVD risk factors and analyze the correlation coefficients between adiposity variables and risk factors controlled for age in normal weight, overweight groups. Using logistic regression analysis, the odds ratio (OR) for the prevalence of risk factors for each group of adiposity variables and the overweight group was estimated relative to the first group in normal weight subjects. Results: Systolic BP, diastolic BP, LDL cholestrol, HDL cholesterol, triglycerides in normal weight subjects were significantly correlated with all adiposity variables (P<0.01). Third group (3.7 for %fat and 4.7 for fat mass) of adiposity variables in the normal weight group and the overweight group (6.6 for %fat and 11.5 for fat mass) tended to have higher ORs compared to first group for risk factor variables. Conclusion: Normal weight subjects with elevated adiposity had higher prevalence of risk factors than normal weights subjects with less adiposity. Measuring of adiposity added additional information of cardiovascular disease risk factors in normal weight subjects.

SPSS 통계프로그램을 이용한 상호작용의 사후검정방법

정미미(Mi Mi Jung),윤승호(Seung Ho Yun),엄한주(Han Joo Eom),강성기(Seong Ki Kang),김도진(Do Jin Kim),장채욱(Chae Ouk Jang),조은형(Eun Hyung Cho) 한국체육측정평가학회 2005 한국체육측정평가학회지 Vol.7 No.1

Alcohol, NAFLD, Other : Clinical Features and Diagnostic Accuarcy of Drug Induced Hepatotoxicity with Anti-Tuberculous Agents

( Seung Ho Lee ),( Kyung Sook Kim ),( Mi Kyung Kim ),( Hee Bok Chae ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1

Background: Drug induced liver injury with anti-tuberculous agents (DILI-T) is approximately 10% of patients, and elevated serum aminotransferase levels develop during the first few weeks of therapy. When starting anti-tuberculous treatment, patients` next appointment is usually made in one month. But most DILI-T symptom was developed within the first two weeks. The aims of study are to find out the incidence, clinical course and prognostic factors of DILI-T. Method: Inclusion criteria were 1) temporal relationship 2) >2*ULN of aminotransferase, 3) the persistent elevation of AST/ALT elevation 4) > 5 ROUCAM score. Results: We screened total 1,246 patients who took anti-tuberculous agents from January 2007 to December 2011. Final number of eligible patients were 28. M: F ratio was 15:13, the age(mean±SD) was 49±18, ADR was developed within 22±17 days from the administration. The level of AST in symptom onset 189±146 IU/L; ALT, 229±142 IU/L; ALP, 232±134 IU/L; and total bilirubin 0.8±0.4 mg/dL. The drug was withdrawn in 21 patients, but anti-tuberculous agents were taken without stop in remaining 7 patients. In drug-withdrawal group, twelve patients experienced full regression of liver enzyme within 8 days, 8 patients within a month, only 1 patient after 1 month. Relapse was observed in 7 out of 19 patients who tried the medication again. Four patients were classified as a definite group, 13 to highly probable group, 11 to probable group. The tuberculosis diagnosis was classified according to their affected organ, like followings, lung (20 patients), meninges (4), lymph node (2), intestine (1), bone (1). Conclusion: The incidence of DILI-T was 2.2%. Mean time of the symptom onset from drug intake was 22 days. All patients recovered without any fatal case. In summary, the incidence of DILI-T is rare, but the next appointment should be within two weeks especially in the early treatment period.

HBV : PE-016 ; Antiviral efficacy of currently available combination therapies for multi-drug resistant chronic hepatitis B: A real life study

( Mi Sung Park ),( Seung Up Kim ),( Jun Yong Park ),( Do Young Kim ),( Kwang Hyub Han ),( Chae Yoon Chon ),( Sang Hoon Ahn ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1

Background: Multidrug resistant (MDR) chronic hepatitis B (CHB) during sequential lamivudine (LAM) and adefovir dipivoxil (ADV) treatment has been increased. This study compared the antiviral efficacy of current combination therapies in patients who have failed to sequential LAM and ADV treatment with confirmed both genotypic resistances. Methods: A total of 48 patients (83.3 % HBeAg-positive) with confirmed genotypic resistance to both LAM and ADV were switched to each of 3 different treatment regimens. Of these, 16 patients were treated with ETV monotherapy, 20 with a combination of LAM plus ADV and the remained 12 were treated with a combination of ETV plus ADV. The virological and biochemical parameters were compared every 3 months between the three groups. All patients were treated and regularly followed up at least for 48 weeks. Results: There was no significant difference in baseline characteristics and treatment duration among 3 treatment groups. The median antiviral treatment duration of all patients was 23.3 months. Serum HBV DNA changes from baseline were greatest in the ETV+ADV arm at all time points (Week 48: -2.79, Week 96: -4.27 log10IU/ml). The rate of complete virological response at 96 weeks was greater in the ETV+ADV arm than that in the ETV monotherapy and the LAM+ADV arms (40.0% vs. 30.0% / 30.0%, p = 0.909). Virological breakthrough was less common in the ETV+ADV arm than that in the ETV monotherapy and the LAM+ADV arm (8.3% vs. 43.8% / 35.0%, p = 0.126). HBeAg loss occurred in one patient in the ETV+ADV, two in the ETV mono arm and none in the LAM+ADV arm. Safety profiles were similar between arms. Conclusions: The combination of ETV plus ADV had the greatest antiviral effect than the LAM plus ADV or ETV monotherapy in MDR CHB in Korea, where tenofovir is not available.

전신성 홍반성 낭창 환자에서 발병된 골 Cryptococcosis 1예

채양석,김우주,김준미,신상원,우흥정,강세용,최윤상,임채승,박승철 대한감염학회 1991 감염 Vol.23 No.3

Cryptococcosis is a systemic fungal infection by Crytococcus neoformans. This mycosis most commonly involves central nervous system, but bone involvement may occur as many as 5-10% of the patients. We experienced a case of bone cryptococcosis in a patient with SLE. The patient was a 28-year old woman, who diagnosed as SLE 3 years ago. She had been treated with immune suppressants such as steroid and cyclophosphamide. She noticed painful erythematous swelling on her left forearm and skin of left breast. X-ray findings showed sclerotic changes on her posterior aspect of left proximal ulnar. Pathologic and microbiologic examination revealed characteristic findings compatible with bone cryptococcosis. The patient was treated with bone curettage and systemic amphotericin B. The clincal symptoms and bone lesion were improved significantly without sequellae.

Solid-state nanopore analysis on conformation change of p53TAD-MDM2 fusion protein induced by protein-protein interaction

Chae, Hongsik,Kwak, Dong-Kyu,Lee, Mi-Kyung,Chi, Seung-Wook,Kim, Ki-Bum The Royal Society of Chemistry 2018 Nanoscale Vol.10 No.36

<P>Although protein-protein interactions (PPIs) are emerging therapeutic targets for human diseases, development of high-throughput screening (HTS) technologies against PPI targets remains challenging. In this study, we propose a protein complex structure to effectively detect conformational changes of protein resulting from PPI using solid-state nanopore for a novel, widely-applicable drug screening method against various PPI targets. To effectively detect conformational changes resulting from PPI, we designed a fusion protein MLP (MDM2-linker-p53TAD), where p53TAD and MDM2 are connected by a 16 amino acid linker. The globular conformation of MLP exhibited a single-peak translocation event, whereas the dumbbell-like conformation of nutlin-3-bound MLP revealed as a double-peak signal. The proportion of double-peak to single-peak signals increased from 9.3% to 23.0% as nutlin-3 concentration increased. The translocation kinetics of the two different MLP conformations with varied applied voltage were analyzed. Further, the fractional current of the intra-peak of the double-peak signal was analyzed, probing the structure of our designed protein complex. This approach of nanopore sensing may be extendedly employed in screening of PPI inhibitors and protein conformation studies.</P>

HBV : PE-016 ; Antiviral efficacy of currently available combination therapies for multi-drug resistant chronic hepatitis B: A real life study

( Mi Sung Park ),( Seung Up Kim ),( Jun Yong Park ),( Do Young Kim ),( Kwang Hyub Han ),( Chae Yoon Chon ),( Sang Hoon Ahn ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

Background: Multidrug resistant (MDR) chronic hepatitis B (CHB) during sequential lamivudine (LAM) and adefovir dipivoxil (ADV) treatment has been increased. This study compared the antiviral efficacy of current combination therapies in patients who have failed to sequential LAM and ADV treatment with confirmed both genotypic resistances. Methods: A total of 48 patients (83.3 % HBeAg-positive) with confirmed genotypic resistance to both LAM and ADV were switched to each of 3 different treatment regimens. Of these, 16 patients were treated with ETV monotherapy, 20 with a combination of LAM plus ADV and the remained 12 were treated with a combination of ETV plus ADV. The virological and biochemical parameters were compared every 3 months between the three groups. All patients were treated and regularly followed up at least for 48 weeks. Results: There was no significant difference in baseline characteristics and treatment duration among 3 treatment groups. The median antiviral treatment duration of all patients was 23.3 months. Serum HBV DNA changes from baseline were greatest in the ETV+ADV arm at all time points (Week 48: -2.79, Week 96: -4.27 log10IU/ml). The rate of complete virological response at 96 weeks was greater in the ETV+ADV arm than that in the ETV monotherapy and the LAM+ADV arms (40.0% vs. 30.0% / 30.0%, p = 0.909). Virological breakthrough was less common in the ETV+ADV arm than that in the ETV monotherapy and the LAM+ADV arm (8.3% vs. 43.8% / 35.0%, p = 0.126). HBeAg loss occurred in one patient in the ETV+ADV, two in the ETV mono arm and none in the LAM+ADV arm. Safety profiles were similar between arms. Conclusions: The combination of ETV plus ADV had the greatest antiviral effect than the LAM plus ADV or ETV monotherapy in MDR CHB in Korea, where tenofovir is not available.

Examination and Quantification of Preservatives in Body Cleaning Cosmetics

Mi-sun Kim,Chae-man Choi,Ae-sook Park,Yun-hee Kim,Ji-young Kim,Su-un Kim,Myung-sook Lee,In-sook Hwang,Yong-seung Shin 한국분석과학회 2022 학술대회논문집 Vol.2022 No.5