Effects of Serum Vitamin D and Efficacy of Subcutaneous Immunotherapy in Adult Patients With Allergic Rhinitis

Maryam Joudi,Reza Farid Hosseini,Maryam Khoshkhui,Maryam Salehi,Samaneh Kouzegaran,Mansur Ahoon,Farahzad Jabbari Azad 대한천식알레르기학회 2019 Allergy, Asthma & Immunology Research Vol.11 No.6

Immunotherapy is the standard of treatment for long-life relief of symptoms of allergic rhinitis. Vitamin D may affect the outcomes of treatment. This study evaluated the clinical efficacy of subcutaneous allergen immunotherapy in adult patients with allergic rhinitis based on the serum level of vitamin D. Patients with persistent allergic rhinitis and positivity for skin prick test were evaluated by Sino-nasal Outcome Test (SNOT-22) and Mini Rhinoconjunctivitis Quality of Life Questionnaire (MiniRQLQ) before subcutaneous allergen immunotherapy and during the maintenance phase to assess the relation of the serum level of vitamin D and the clinical efficacy of immunotherapy. After immunotherapy, the greatest reduction in SNOT-22 scores were reported in patients with vitamin D sufficiency (39.0 ± 9.2), followed by vitamin D suboptimal provision (35.1 ± 12.1), insufficiency (25.0 ± 7.5), and deficiency (18.3 ± 6.0) (P < 0.001). The MiniRQLQ reduction in patients with vitamin D sufficiency, suboptimal provision, insufficiency, or deficiency was 30.7 ± 8.7, 27.1 ± 8.7, 20.0 ± 8.6, or 17.4 ± 7.1, respectively (P < 0.001). Both of SNOT-22 and MiniRQLQ scores decreased significantly following immunotherapy in patients with different levels of vitamin D. However, these effects were more pronounced when the level of vitamin D was sufficient.

Effects of Herbal combination (Melissa officinalis L. and Nepeta menthoides Boiss. & Buhse) on insomnia severity, anxiety and depression in insomniacs: Randomized placebo controlled trial

Maryam Ranjbar,Ali Firoozabadi,Alireza Salehi,Zahra Ghorbanifar,Mohammad M. Zarshenas,Khosro Sadeghniiat-Haghighi,Hossein Rezaeizadeh 한국한의학연구원 2018 Integrative Medicine Research Vol.7 No.4

Background: Insomnia is a prevalent disorder leading to psychological problems such as anxiety and depression. Methods: This study investigates the effect of a combination of herbs (Melissa officinalis L. and Nepeta menthoides Boiss. & Buhse) on anxiety and depression for insomniacs and on insomnia severity. This study is a double-blind randomized placebo-controlled clinical trial. A total number of 67 participants met the inclusion criteria who were diagnosed as cases of insomnia. The patients were randomized into the herbal treatment or placebo groups. The herbal treatment group received a combination of Melissa officinalis and Nepeta menthoides Boiss. & Buhse. The primary outcomes were insomnia, depression and anxiety. We used per-protocol analysis. Results: The all outcomes of herbal treatment were significantly improved compared with placebo in the ISI, BAI and BDI scores after four weeks’ treatment (p value: 0.008, 0.005 and <0.001 respectively). Conclusion: A combination of Melissa officinalis L. and Nepeta menthoides Boiss. & Buhse may improve insomnia and its comorbid depression and anxiety.

Porous electrospun poly(e-caprolactone)/gelatin nanofi brous mat containing cinnamon for wound healing application: in vitro and in vivo study

Majid Salehi,Maryam Niyakan,Arian Ehterami,Saeed Haghi-Daredeh,Simin Nazarnezhad,Ghasem Abbaszadeh-Goudarzi,Ahmad Vaez,Seyedeh Fatemeh Hashemi,Nariman Rezaei,Seyed Reza Mousavi 대한의용생체공학회 2020 Biomedical Engineering Letters (BMEL) Vol.10 No.1

In this study, cinnamon (cin) was loaded into poly(ε-caprolactone)/gelatin (PCL/Gel) nanofi brous matrices in order to fabricatean appropriate mat to improve wound healing. Mats were fabricated from PCL/COLL [1:1 (w/w)] solution with 1, 5and 25% (w/v) of cinnamon. Prepared mats were characterized with regard to their microstructure, mechanical properties,porosity, surface wettability, water-uptake capacity, water vapor permeability, blood compatibility, microbial penetration andcellular response. The fabricated mats with and without cinnamon were used to treat the full-thickness excisional wounds inWistar rats. The results indicated that the amount of cinnamon had a direct eff ect on porosity, mechanical properties, wateruptake capacity, water contact angle, water vapor transmission rate and cell proliferation. In addition, the results of in vivostudy indicated that after 14 days, the wounds which were treated with PCL/Gel 5%cin had better wound closure (98%)among other groups. Our results suggest that the cinnamon can be used as a suitable material for wound healing.

Association between Mismatch Repair Gene MSH3 codons 1036 and 222 Polymorphisms and Sporadic Prostate Cancer in the Iranian Population

Jafary, Fariba,Salehi, Mansoor,Sedghi, Maryam,Nouri, Nayereh,Jafary, Farzaneh,Sadeghi, Farzaneh,Motamedi, Shima,Talebi, Maede Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12

The mismatch repair system (MMR) is a post-replicative DNA repair mechanism whose defects can lead to cancer. The MSH3 protein is an essential component of the system. We postulated that MSH3 gene polymorphisms might therefore be associated with prostate cancer (PC). We studied MSH3 codon 222 and MSH3 codon 1036 polymorphisms in a group of Iranian sporadic PC patients. A total of 60 controls and 18 patients were assessed using the polymerase chain reaction and single strand conformational polymorphism. For comparing the genotype frequencies of patients and controls the chi-square test was applied. The obtained result indicated that there was significantly association between G/A genotype of MSH3 codon 222 and G/G genotype of MSH3 codon 1036 with an increased PC risk (P=0.012 and P=0.02 respectively). Our results demonstrated that MSH3 codon 222 and MSH3 codon 1036 polymorphisms may be risk factors for sporadic prostate cancer in the Iranian population.

Demographic Survey of Four Thousand Patients with 10 Common Cancers in North Eastern Iran over the Past Three Decades

Nikfarjam, Zahra,Massoudi, Toktam,Salehi, Maryam,Salehi, Mahta,Khoshroo, Fahimeh Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23

Background: Cancer is a major cause of mortality in developing countries and correct and valid information about the epidemiology of this disease is the first step in the planning of health care in each region. The aim of this study was to determine the relative frequency, mean age and sex ratio of the most 10 common non-skin cancers in the world and Iran, among patients referred to an oncology clinic. Materials and Methods: This descriptive study was conducted in Mashhad, north east of Iran. The data obtained from the records of patients referred to the private oncology center between the years of 1985-2012". According to the latest report of GLOBOCAN study commonest malignancies included were lung, breast, colorectal, prostate, stomach, liver, cervix, esophageal, bladder cancers and Non-Hodgkin lymphoma. Results: A total of 4,606 cases were analyzed. The mean age was $55.5{\pm}13.8years$ (male: $59.5{\pm}13.9$, female: $52.6{\pm}12.9$). Overall, breast cancer (1,264 cases, relative frequency of 27.4%) was the most prevalent cancer; however the mean ages of diagnosis were not significantly different between 5-year time period divisions (p=0.290). The most common cancer in men was esophageal cancer (26.3%).The lowest mean age was related to women diagnosed with breast cancer ($48.5{\pm}11.8$) and men with non-Hodgkins lymphoma ($48.4{\pm}17.8$). There were statistically significant differences between the mean age of men and women with gastric (p=0.003) and esophageal cancers (p<0.001). Male to female sex ratios in our study for bladder, lung and stomach cancers were 6.57, 2.60 and 2.50 respectively. Conclusions: The results showed that breast cancer tends to be found in younger female patients and bladder cancer appears more often in men. Screening in target population in addition to early diagnosis may reduce death and disability.

A novel hydrogel containing 4-methylcatechol for skin regeneration: in vitro and in vivo study

Jilla Majidi Ghatar,Arian Ehterami,Simin Nazarnezhad,Maryam Sadat Hassani,Nariman Rezaei Kolarijani,Solmaz Mahami,Majid Salehi 대한의용생체공학회 2023 Biomedical Engineering Letters (BMEL) Vol.13 No.3

Skin damages are usual physical injuries and different studies have been done to improve wound healing. Hydrogel dueto its properties like a moist environment and cooling wound site is a good option for wound treatment. In this study, weevaluated the consequence of using alginate/chitosan hydrogel contained various dosages of 4-Methylcatechol (0, 0.1, 1%(W/W)) on wound healing. After hydrogel fabrication, different tests like SEM, swelling, release, weight loss, and hemoandcytocompatibility were done to characterize fabricated hydrogels. Finally, the rat model was used to assess Alginate/Chitosan hydrogel's therapeutic function containing 0.1 and 1% of 4-Methylcatechol. The pore size of hydrogel was between24.5 ± 9 and 62.1 ± 11.63 μm and about 90% of hydrogel was lost after 14 days in the weight loss test. Blood compatibilityand MTT assay showed that hydrogels were nontoxic and improved cell proliferation. In vivo test showed that Alginate/Chitosan/0.1%4-Methylcatechol improved wound healing and the results were significantly better than the gauze-treatedwound. Our results showed dose depending effect of 4-Methylcatechol on wound healing. This study shows the treatmenteffect of 4-Methylcatechol on wound healing and the possibility of using it for treating skin injuries.

Disorders of Gastrointestinal Motility & Sensation : Subjective Lactose Intolerance In Apparently Healthy Adults In Southern Iran: Is It Related To IBS?

( Mehdi Saberi Firouzi ),( Famaz Khademolhosseini ),( Davood Mehrabani ),( Maryam Yousefi ),( Moosa Salehi ),( Seyyed Taghi Heidary ) 대한소화기학회 2007 SIDDS Vol.9 No.-

Background/Alms: Lactase deficiency leads to maldigestion and malabsorption of lactose. The symptoms of this deficiency in some individuals are abdominal pain and distension, flatulence, and the passage of loose watery stools. This study aimed to investigate the prevalence of subjective lactose intolerance and its relation to Irritable Bowel Syndrome (IBS), demographic factors and living habits. Methods: A survey of 1978 individuals aged above 35 years was conducted in Shiraz, Southern Iran, using a questionnaire that consisted of items regarding demographic data, life style and gastrointestinal symptoms including those experienced after consumption of dairy products. Diagnosis of IBS was made on the basis of Rome II criteria. Results: A total of 562 subjects reported lactose intolerance (28.41%). The prevalence was significantly higher in females, in subjects taking NSAIDs or acetaminophen, and in patients with irritable bowel syndrome. Subjective lactose intolerance was also associated with health-seeking behavior such as restricting diet, using herbal medicine, taking over-the-counter drugs and visiting a physician. On the other hand, no relation was found between lactose intolerance and age, smoking or the number of meals per day. Conclusions: Lactose intolerance has a relatively high prevalence in our region and is associated with irritable bowel syndrome. A test for lactose malabsorption should, therefore, be included in the work-up of patients with this syndrome.

Tissues toxicity attenuation by vitamin E on oxidative damage induced by diazinon

Kavoos Tahmasebi,Mahvash Jafari,Javad Heydari,Alireza Asgari,Maryam Salehi,Saeed Khazaie,Mohammad Saleh Abedini 5 환경독성보건학회 2022 환경독성보건학회지 Vol.37 No.4

Organophosphorus insecticides such as diazinon (DZN) are used worldwide in industry, veterinary practice, and agriculture. They may induce oxidative stress in different tissues. The use of antioxidants can protect tissues against oxidative stress. The aim of this study was to investigate the prophylactic and therapeutic roles of vitamin E against DZN–induced oxidative damage and biochemical alterations in various tissues of male Wistar rats. Thirty rats were divided into five groups: Control group received only corn oil as DZN solvent, DZN group received 100 mg/kg of DZN, E group received 150 mg/kg of vitamin E, E-DZN group received vitamin E and then dosed with DZN and DZN-E group received DZN and then dosed with vitamin E. All injections were carried out intraperitoneally. Plasma and various tissues were prepared and evaluated. Results showed that acute administration of DZN caused a significant induction of oxidative damage in the tested tissues via increased malondialdehyde level and some plasma biochemical indices, depletion of glutathione (GSH), reduced cholinesterase activity and change in the activities of superoxide dismutase, catalase and glutathione-S transferase. Treatment of rats with vitamin E resulted in an elevation in the level of GSH, normalizing the antioxidant enzymes activities and decreasing lipid peroxidation, although all these tests did not return to the normal level in certain tissues. The findings of this study suggest that both prophylactic and therapeutic treatments of rats with vitamin E provide a protective role against DZN-induced oxidative stress and cholinergic hyperactivity through free radicals scavenging and membrane stabilizing.

Therapeutic Outcomes of Pectoralis Major Muscle Turnover Flap in Mediastinitis

Reza Bagheri,Mohammad Abbasi Tashnizi,Seyed Ziaollah Haghi,Maryam Salehi,Ata’ollah Rajabnejad,Mohsen Hatami Ghale Safa,Mohammad Vejdani 대한흉부외과학회 2015 Journal of Chest Surgery (J Chest Surg) Vol.48 No.4

Background: This study aimed to evaluate the therapeutic results and safety of pectoralis major muscle turnover flaps in the treatment of mediastinitis after coronary artery bypass grafting (CABG) procedures. Methods: Data regarding 33 patients with post-CABG deep sternal wound infections (DSWIs) who underwent pectoralis major muscle turnover flap procedures in the Emam Reza and Ghaem Hospitals of Mashhad, Iran were reviewed in this study. For each patient, age, sex, hospital stay duration, remission, recurrence, and associated morbidity and mortality were evaluated. Results: Of the 2,447 CABG procedures that were carried out during the time period encompassed by our study, DSWIs occurred in 61 patients (2.5%). Of these 61 patients, 33 patients (nine females [27.3%] and 24 males [72.7%]) with an average age of 63±4.54 years underwent pectoralis major muscle turnover flap placement. Symptoms of infection mainly occurred within the first 10 days after surgery (mean, 10.24±13.62 days). The most common risk factor for DSWIs was obesity (n=16, 48.4%) followed by diabetes mellitus (n=13, 39.4%). Bilateral and unilateral pectoralis major muscle turnover flaps were performed in 20 patients (60.6%) and 13 patients (39.4%), respectively. Complete remission was achieved in 25 patients (75.7%), with no recurrence in the follow-up period. Four patients (12.1%) needed reoperation. The mean hospitalization time was 11.69±6.516 days. Four patients (12.1%) died during the course of the study: three due to the postoperative complication of respiratory failure and one due to pulmonary thromboembolism. Conclusion: Pectoralis major muscle turnover flaps are an optimal technique in the treatment of post-CABG mediastinitis. In addition to leading to favorable therapeutic results, this flap is associated with minimal morbidity and mortality, as well as a short hospitalization time.

Right Atrial Strain in the Assessment of Right Heart Mechanics in Patients with Heart Failure with Reduced Ejection Fraction

Farveh Vakilian,Alireza Tavallaie,Hedieh Alimi,Hoorak Poorzand,Maryam Salehi 한국심초음파학회 2021 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.29 No.2

BACKGROUND: Cardiac catheterization is the gold standard for cardiopulmonary hemodynamic assessment, although its widespread use could be restricted due to its invasive nature. The aim of this study is to compare multiple echocardiography parameters, including right atrial (RA) strain, with right heart catheterization (RHC) data in patients with heart failure reduced ejection fraction (HFrEF) in the assessment of right heart hemodynamics. METHODS: Patients with HFrEF (defined by left ventricular ejection fraction [LVEF] ≤ 35%) were enrolled prospectively in this study. All patients underwent echocardiography and RHC. RA pressure (RAP), right ventricular end diastolic pressure (RVEDP), systolic pulmonary artery pressure (sPAP) and pulmonary vascular resistance (PVR) were calculated in RHC. Right ventricular (RV) diastolic and systolic function, RAP, RA size, sPAP and PVR were also measured by echocardiography. RESULTS: Fifty patients (36 men) aged 13–51 years with LVEF ≤ 35% were enrolled in this study. There was a significant correlation between echocardiography and catheterization data (r > 0.6, p < 0.001). The RV diastolic grading had significant relation with RA volume (p < 0.001) and RA strain (p < 0.001) in echocardiography, and with RVEDP (p = 0.01) and RAP (p < 0.001) in RHC. There were significant relations between the New York Heart Association classification and RV diastolic function grading (p < 0.001), with RA strain (p = 0.019), and size (p = 0.04). CONCLUSIONS: RA function, as assessed by strain imaging, correlates with right heart hemodynamics in patients with HFrEF.