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      • Esophageal, Gastric and Duodenal Disorders : The Associated Factors of Gastro-Esophageal Reflux Disease (GERD) in Shiraz, Southern Iran

        ( Mehdi Saberi Firouzi ),( Famaz Khademolhosseini ),( Maryam Yousefi ),( Davood Mehrabani ),( Najaf Zare ),( Seyed Taghi Heydari ) 대한소화기학회 2007 SIDDS Vol.9 No.-

        Aim: Symptoms of gastroesophageal reflux disease (GERD) represent one of the most common problems in the western world. The aim of this study was to determine the prevalence and symptoms of GEFD in a healthy general population in relation to demographic, lifestyle and health-seeking behaviors in Shiraz, southern Iran. Methods: 1978 subjects of >35 years old who referred to Gastroenterohepatology Research Center and completed a questionnaire consisting of 53 questions for GERD in relation to demographic, lifestyle and health-seeking behavior were enrolled in our study during a period of five months. The validity and reliability of the questionnaire were determined. Results: The prevalence of GERD was 15.4%, which was more in females (17.3%), in rural areas (19.8%), in illiterate subjects (21.5%) and in the mean age of 50.25 years. There was significantly a lower prevalence in subjects having fried foods (14.8%), and fruit and vegetables (14.6%). We noticed more symptoms in subject consuming pickles (22.1%), taking Aspirin (21%) and in subjects with psychological distresses. (27.2%) and headaches (22%). The correlation between GERD and halitosis (18.3%), dyspepsia (30.6%), anxiety (19.5%), nightmares (23.9%) and restlessness (18.5%) was statistically significant. Their health seeking behavior showed that there was a significant restriction of diet (20%), consumption of herbal medicine (19%), using over-the-counter drugs (29.9%), and visiting a physician (24.8%). Presence of GERD symptoms was also significantly related to previous family history of the disease (22.3%). Conclusion: GERD was significantly more in females, rural and illiterate subjects and had a correlation with consumption of pickles, headache, psychological distress, dyspepsia, halitosis, anxiety, nightmare, restlessness and pervious history of GERD in the family and aspirin intake but the correlation was inverse with consumption of fat and fiber intake.

      • Disorders of Gastrointestinal Motility & Sensation : Subjective Lactose Intolerance In Apparently Healthy Adults In Southern Iran: Is It Related To IBS?

        ( Mehdi Saberi Firouzi ),( Famaz Khademolhosseini ),( Davood Mehrabani ),( Maryam Yousefi ),( Moosa Salehi ),( Seyyed Taghi Heidary ) 대한소화기학회 2007 SIDDS Vol.9 No.-

        Background/Alms: Lactase deficiency leads to maldigestion and malabsorption of lactose. The symptoms of this deficiency in some individuals are abdominal pain and distension, flatulence, and the passage of loose watery stools. This study aimed to investigate the prevalence of subjective lactose intolerance and its relation to Irritable Bowel Syndrome (IBS), demographic factors and living habits. Methods: A survey of 1978 individuals aged above 35 years was conducted in Shiraz, Southern Iran, using a questionnaire that consisted of items regarding demographic data, life style and gastrointestinal symptoms including those experienced after consumption of dairy products. Diagnosis of IBS was made on the basis of Rome II criteria. Results: A total of 562 subjects reported lactose intolerance (28.41%). The prevalence was significantly higher in females, in subjects taking NSAIDs or acetaminophen, and in patients with irritable bowel syndrome. Subjective lactose intolerance was also associated with health-seeking behavior such as restricting diet, using herbal medicine, taking over-the-counter drugs and visiting a physician. On the other hand, no relation was found between lactose intolerance and age, smoking or the number of meals per day. Conclusions: Lactose intolerance has a relatively high prevalence in our region and is associated with irritable bowel syndrome. A test for lactose malabsorption should, therefore, be included in the work-up of patients with this syndrome.

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