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( Mehdi Saberi Firouzi ),( Famaz Khademolhosseini ),( Davood Mehrabani ),( Maryam Yousefi ),( Moosa Salehi ),( Seyyed Taghi Heidary ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Alms: Lactase deficiency leads to maldigestion and malabsorption of lactose. The symptoms of this deficiency in some individuals are abdominal pain and distension, flatulence, and the passage of loose watery stools. This study aimed to investigate the prevalence of subjective lactose intolerance and its relation to Irritable Bowel Syndrome (IBS), demographic factors and living habits. Methods: A survey of 1978 individuals aged above 35 years was conducted in Shiraz, Southern Iran, using a questionnaire that consisted of items regarding demographic data, life style and gastrointestinal symptoms including those experienced after consumption of dairy products. Diagnosis of IBS was made on the basis of Rome II criteria. Results: A total of 562 subjects reported lactose intolerance (28.41%). The prevalence was significantly higher in females, in subjects taking NSAIDs or acetaminophen, and in patients with irritable bowel syndrome. Subjective lactose intolerance was also associated with health-seeking behavior such as restricting diet, using herbal medicine, taking over-the-counter drugs and visiting a physician. On the other hand, no relation was found between lactose intolerance and age, smoking or the number of meals per day. Conclusions: Lactose intolerance has a relatively high prevalence in our region and is associated with irritable bowel syndrome. A test for lactose malabsorption should, therefore, be included in the work-up of patients with this syndrome.