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RISS 인기검색어
- 검색키워드
- 저자 : ( Mehdi Saberi Firouzi ) (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
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Disorders of Small and Large Intestine : Prevalence of Celiac Disease In Shiraz, Southern Iran
( Mehdi Saberi Firouzi ),( Marzieh Nejabat ),( Gholamreza Omrani ),( Davood Mehrabani ),( Farnaz Khademolhosseini ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Aims: Celiac disease (CD) is an auto immune type of gastrointestinal (GI) disorder, in genetically susceptible persons. Recent reports from Middle East and from our country revealed a high prevalence of disease as high as Europe. However, in our daily practice celiac disease is not a prominent diagnosis, and is considered as a sub-clinical or latent form. This study was performed to evaluate the prevalence of celiac disease in Shiraz, southern Iran. Methods: Serum samples were collected from 1,440 persons (age range=20-83 years, mean age=45.4 years) and screened for endomysial and tissue transglutaminase antibodies. A questionnaire was completed for all subjects in relation to GI symptoms and cases with positive serology were requested to undergo small-bowel biopsy. Results: Five subjects were positive for anti-tTG antibody assay, 4 agreed to undergo biopsy, and three cases were reported with March I histologic findings. In two cases with positive serologic anti-EMA, more advanced forms of CD were present. Conclusions: The prevalence of celiac disease in apparently healthy adults was lower than reported series form northern parts of the country. Therefore, we suggest a more long term follow up study in high risk groups especially in apparently healthy subjects in our region.
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Plenary Session : Experiences With Helicobacter Pylori Treatment in Iran
( Mehdi Saberi Firouzi ),( Marzieh Nejabat ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Aims: Helicobacter pylori (HP) infection is currently recognized as the major canse of chronic active gastritis, peptic ulcer disease and MALT lymphoma of the stomach. Eradication of the infection will prevent the recurrence of the majority of such diseases. Different combined treatments have been tried in Iran for eradication of HP, but the optimal HP eradication needs further evaluation. Methods: Herein we have reviewed the eradication regimens of HP used by Iranian scientists during 1990-2004 and compared them with published clinical trials from other countries regarding the number, the type of drugs used, the duration, eradication rate, and their side effects. Results: From 26 articles retrieved, 22 drug regimens were evaluated. Triple drug therapy was favored in our country, as it consisted of 63% of the regimens. But it could not achieve an optimal eradication rate. Of 8 quadruple drug regimens, 2 led to an optimal eradication rate, whereas, the highest eradication rate was 92% based on furazolidone quadruple regimen. But this regimen had significant side effects in more than 62% of the patients. Conclusions: The best first line treatment regimen for eradication of HP in Iran would be a type of furazolidone or clarithromycine based quadruple therapy for a minimum duration of two weeks. However, the patients should be monitored for furazolidone side effects. On the other hand, in metronidazole based quadruple therapy drug resistance is a major problem, even with doses of more than I gm/day. In patients with treatment failure, medication should be adjusted according to antibiotic sensitivity and newer antibiotic therapies, such as levofloxacin based therapies should be studied in well designed clinical trials.
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( Mehdi Saberi Firouzi ),( Famaz Khademolhosseini ),( Maryam Yousefi ),( Davood Mehrabani ),( Najaf Zare ),( Seyed Taghi Heydari ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Aim: Symptoms of gastroesophageal reflux disease (GERD) represent one of the most common problems in the western world. The aim of this study was to determine the prevalence and symptoms of GEFD in a healthy general population in relation to demographic, lifestyle and health-seeking behaviors in Shiraz, southern Iran. Methods: 1978 subjects of >35 years old who referred to Gastroenterohepatology Research Center and completed a questionnaire consisting of 53 questions for GERD in relation to demographic, lifestyle and health-seeking behavior were enrolled in our study during a period of five months. The validity and reliability of the questionnaire were determined. Results: The prevalence of GERD was 15.4%, which was more in females (17.3%), in rural areas (19.8%), in illiterate subjects (21.5%) and in the mean age of 50.25 years. There was significantly a lower prevalence in subjects having fried foods (14.8%), and fruit and vegetables (14.6%). We noticed more symptoms in subject consuming pickles (22.1%), taking Aspirin (21%) and in subjects with psychological distresses. (27.2%) and headaches (22%). The correlation between GERD and halitosis (18.3%), dyspepsia (30.6%), anxiety (19.5%), nightmares (23.9%) and restlessness (18.5%) was statistically significant. Their health seeking behavior showed that there was a significant restriction of diet (20%), consumption of herbal medicine (19%), using over-the-counter drugs (29.9%), and visiting a physician (24.8%). Presence of GERD symptoms was also significantly related to previous family history of the disease (22.3%). Conclusion: GERD was significantly more in females, rural and illiterate subjects and had a correlation with consumption of pickles, headache, psychological distress, dyspepsia, halitosis, anxiety, nightmare, restlessness and pervious history of GERD in the family and aspirin intake but the correlation was inverse with consumption of fat and fiber intake.
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( Mehdi Saberi Firouzi ),( Famaz Khademolhosseini ),( Davood Mehrabani ),( Maryam Yousefi ),( Moosa Salehi ),( Seyyed Taghi Heidary ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Alms: Lactase deficiency leads to maldigestion and malabsorption of lactose. The symptoms of this deficiency in some individuals are abdominal pain and distension, flatulence, and the passage of loose watery stools. This study aimed to investigate the prevalence of subjective lactose intolerance and its relation to Irritable Bowel Syndrome (IBS), demographic factors and living habits. Methods: A survey of 1978 individuals aged above 35 years was conducted in Shiraz, Southern Iran, using a questionnaire that consisted of items regarding demographic data, life style and gastrointestinal symptoms including those experienced after consumption of dairy products. Diagnosis of IBS was made on the basis of Rome II criteria. Results: A total of 562 subjects reported lactose intolerance (28.41%). The prevalence was significantly higher in females, in subjects taking NSAIDs or acetaminophen, and in patients with irritable bowel syndrome. Subjective lactose intolerance was also associated with health-seeking behavior such as restricting diet, using herbal medicine, taking over-the-counter drugs and visiting a physician. On the other hand, no relation was found between lactose intolerance and age, smoking or the number of meals per day. Conclusions: Lactose intolerance has a relatively high prevalence in our region and is associated with irritable bowel syndrome. A test for lactose malabsorption should, therefore, be included in the work-up of patients with this syndrome.
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