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Man Zhang,Su‑Su Li,Qiao‑Mei Xie,Jian‑Hua Xu,Xiu‑Xiu Sun,Fa‑Ming Pan,Sheng‑Qian Xu,Sheng‑Xiu Liu,Jin‑Hui Tao,Shuang Liu,Jing Cai,Pei‑Ling Chen,Long Qian,Chun‑Huai Wang,Chun‑Mei Liang,Hai‑Liang Huang,Ha 한국유전학회 2018 Genes & Genomics Vol.40 No.10
Although the current glucocorticoids (GCs) treatment for systemic lupus erythematosus (SLE) is effective to a certain extent, the difference in therapeutic effect between patients is still a widespread problem. Some patients can have repeated attacks that greatly diminish their quality of life. This study was conducted to investigate the relationship between HSP90AA2 polymorphisms and disease susceptibility, GCs efficacy and health-related quality of life (HRQoL) in Chinese SLE patients. A case–control study was performed in 470 SLE patients and 470 normal controls. Then, 444 patients in the case group were followed up for 12 weeks to observe efficacy of GCs and improvement of HRQoL. Two single nucleotide polymorphisms (SNPs) of HSP90AA2 were selected for genotyping: rs1826330 and rs6484340. HRQoL was assessed using the SF-36 questionnaire. The minor T allele of rs1826330 and the TT haplotype formed by rs1826330 and rs6484340 showed associations with decreased SLE risk (T allele: PBH = 0.022; TT haplotype: PBH = 0.033). A significant association between rs6484340 and improvement of HRQoL was revealed in the follow-up study. Five subscales of SF-36 were appeared to be influenced by rs6484340: total score of SF-36 (additive model: PBH = 0.026), physical function (additive model: PBH = 0.026), rolephysical (recessive model: PBH = 0.041), mental health (dominant model: PBH = 0.047), and physical component summary (additive model: PBH = 0.026). No statistical significance was found between HSP90AA2 gene polymorphisms and GCs efficacy. These results revealed a genetic association between HSP90AA2 and SLE. Remarkably, HSP90AA2 has an impact on the improvement of HRQoL in Chinese population with SLE.
Man Zhang,Deyue Yu,Kai Li,Jianyu Liu 한국식물생명공학회 2012 Plant biotechnology reports Vol.6 No.4
Plant 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) were considered to be encoded by single copy. In this study, we successfully isolated two DXR isogenes, designated GmDXR1 and GmDXR2, from soybean. The multicopy nature of DXRs in soybean was supported by Southern blot. Alignment of the two GmDXRs showed the presence of the N-terminal transit peptide for plastids, the conserved cleavage site, prolinerich region, and the NADPH-binding motif. Phylogenetic analysis revealed GmDXR1 and GmDXR2 belonged to different branches of angiosperm DXRs clusters. Expression pattern analysis indicated that GmDXR1 was expressed in all analyzed organs except the pod walls, with the highest level in seeds, whereas no message was detected for GmDXR2. In response to heat stress, GmDXR1 showed declined transcript levels in the experiments; in contrast,GmDXR2 was highly responsive, with mRNA accumulation peaking at 6 h after treatment. We also demonstrated that both GmDXRs were localized in chloroplasts. Overexpression of GmDXRs induced increased contents of various isoprenoids (chlorophyll, carotenoids, and gibberellins),but with reduced level of ABA, indicating that GmDXRs participate in the control of differential isoprenoid biosynthesis of the MEP pathway. This work provides a new insight into the wide presence of multicopies of DXR enzyme in plants.
Man Zhang,강웅철,문찬일,한승환,안태훈,신익균 대한심장학회 2010 Korean Circulation Journal Vol.40 No.3
We successfully rescued a patient whose coronary artery perforated following implantation of a drug-eluting stent (DES), by deploying a stent-graft in symptomatic myocardial bridging. Our case demonstrated that coronary perforation could be handled without difficulty when perforated myocardial bridging is confined to the interventricular groove.
Zhang Qing,He Yi-Jing,Zhu Yu-Hang,Dai Min-Chen,Pan Man-Man,Wu Jia-Qi,Zhang Xian,Gu Ying-Er,Wang Fang-Fang,Xu Xiang-Rong,Qu Fan 한국한의학연구원 2020 Integrative Medicine Research Vol.9 No.3
Background: During the COVID-19 epidemic period, Traditional Chinese Medicine (TCM) course for international students of Medical Bachelor, Bachelor of Surgery (MBBS) program in Zhejiang University has shifted from traditional classroom to online environment. This study aimed to investigate MBBS international students’ perception on online TCM course, and to assess the online learning efficacy. Methods: A total of 84 MBBS international students attending course of “Basic Traditional Chinese Medicine” during 2020 academic years at Zhejiang University were enrolled in this study. A quantitative questionnaire was respectively completed before and after the TCM course using a pretest–post-test design. By means of two online learning platforms, Learning in ZJU and DingTalk, TCM course was broadcast in both live and archived format to students. Results: A total of 48 participants completed both baseline and follow-up questionnaires. The majority of participants preferred face-to-face classroom learning (26, 54.17% of total) when compared with online learning. Students felt that the course had brought in much benefits (mean 3.88, SD 0.87), and they were satisfied with the course content (mean 3.83, SD 0.95). Students’ TCM related knowledge and their behaviors of discussion and consulting were significantly improved by online TCM course (all P < 0.001). Students’ awareness of the necessity of TCM education and their feeling of difficulty in learning TCM were significantly strengthened (P = 0.042, 0.025, respectively). Conclusion: Online learning is a good alternative for TCM course of MBBS international students when classroom learning is suspended, whereas it cannot replace the need for onsite and face-to-face learning.
Effects of Face Sheet Structure on Mechanical Properties of 3D Integrated Woven Spacer Composites
Man Zhang,Xiaoxue Wang,Shuqiang Liu,Fu Li,Gaihong Wu 한국섬유공학회 2020 Fibers and polymers Vol.21 No.7
Due to the lightweight, structural integrity, superior heat and sound insulation performance, three-dimensional(3D) integrated woven spacer composites are expected to be used in many fields such as marine, automotive, electronics, andbuilding industries. This paper reports the effects of face sheet structure on the mechanical properties of 3D integrated wovenspacer composites. Three-point bending, quasi-static compression and low-velocity impact tests were conducted to comparethe mechanical responses of 3D woven spacer composites with plain and complex face sheets. The floating yarn segments incomplex face sheet could efficiently transfer the stress to neighboring areas and lead to a more balanced stress distribution. The existence of floats thus has positive effect on mechanical properties of composites. On the contrary, plain structuresurface was dense and the stress transfer was easily hindered by numerous weaving points, resulting in stress concentrationand ultimate premature failure. As a consequence, for surface-dominated properties such as warp-direction bending andimpact resistance, 3D integrated woven spacer composites with complex surface is better and should be given priority duringindustrial applications. In terms of weft-direction bending property and quasi-static compressive performance, which moredepend on the structure of core piles, show little difference between the composites with different surfaces.
Man Zhang,Yanwei Sui,Xiaofang Yuan,Jiqiu Qi,Fuxiang Wei,Qingkun Meng,Yezeng He,Yaojian Ren,Zhi Sun,Jinlong Liu 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.3
A nanoflower structure of Zn0.76Co0.24S directly grown on carbon fiber papers (CFP) was successfully designed by a mild two-step hydrothermal method. Benefiting from their fascinating structural features, Zn0.76Co0.24S/CFP electrode exhibits a maximum specific capacitance of 300 F g -1 at current density of 1 A g -1 and 84% capacitance retention after 5,000 cycles at current density of 5 Ag -1. Subsequently, Zn0.76Co0.24S/CFP//AC all-solid-state asymmetric supercapacitor (ASC) device is assembled and able to illuminate the red LEDs. ASC devices deliver a maximum energy density of 9.59 Wh kg -1 at a power density of 750 W kg -1. Therefore, this impressive result demonstrates that the nanoflower Zn0.76Co0.24S have promising applications in the development of high-performance supercapacitors.
Man Li,Yang Wang,Feng Wei,Xiumei An,Naining Zhang,Shui Cao,Baozhu Ren,Xinwei Zhang,Xiubao Ren 한국유방암학회 2018 Journal of breast cancer Vol.21 No.2
Purpose: The treatment of triple-negative breast cancer (TNBC) remains challenging, due to the absence of estrogen, progesterone, and human epidermal growth factor receptors. This study was designed to evaluate the efficiency and safety of cytokineinduced killer (CIK) cell immunotherapy, following regular chemotherapy, for patients with TNBC. Methods: A total of 340 patients with postmastectomy TNBC, from January 1, 2010 to June 30, 2014, were included in this retrospective study. Seventy-seven patients received CIK cell immunotherapy, following regular chemotherapy (arm 1), and 263 patients received regular chemotherapy alone (arm 2). The primary aim was overall survival (OS) and disease-free survival (DFS), and the treatment responses and adverse events were also evaluated. Results: The 5-year DFS and OS rates in arm 1 were 77.9% and 94.3%, compared with 69.8% and 85.6% in arm 2, respectively (p=0.159 and p=0.035, respectively). This clearly shows that there was no statistical difference in the 5-year DFS between the two groups. Multivariate analyses of arm 1 indicated that a Karnofsky performance score (KPS) ≥90 and stage I/IIA disease were significantly associated with a prolonged DFS period (hazard ratio [HR], 0.25; 95% confidence interval [CI], 0.09–0.74; p=0.012; and HR 0.21; 95% CI, 0.06–0.82; p=0.024, respectively), but a KPS ≥90 and stage I/IIA disease were not independent prognostic factors for OS. Toxicity was mild in patients who received the CIK therapy. Conclusion: The data suggested that CIK cell immunotherapy improved the efficiency of regular chemotherapy in patients with TNBC, and the side effects of CIK cell immunotherapy were mild.