A New ent-Kaurane type Diterpenoid Glycoside from Inula japonica Thunb

Jiang Jiang Qin,Jia Xian Zhu,Wei Dong Zhang1,2,Yan Zhu,Jian Jun Fu,Xiao Hua Liu,Hui Zi Jin 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.10

A new ent-kaurane type diterpenoid glycoside, 17-O-β-D-glucopyranosyl-16α-ent-kauran-19-oic acid (1), together with 17-hydroxy-16α-ent-kauran-19-oic acid (2), 16α,17-dihydroxyl-ent-kauran-19-oic acid (3), and 16α-hydroxy-17-acetoxy-ent- kauran-19-oic acid (4) were isolated from the aerial parts of Inula japonica Thunb. The structure of 1 was determined mainly by use of 1D and 2D NMR spectroscopic techniques including HSQC, 1H-1H COSY, HMBC, and NOESY. In addition, 4 exhibited significant inhibitory activity on NO production in LPS-stimulated RAW264.7 cells with IC50 value of 14.3 μg/mL.

Which Indicator Among Lumbar Vertebral Hounsfield Unit, Vertebral Bone Quality, or Dual-Energy X-Ray Absorptiometry-Measured Bone Mineral Density Is More Efficacious in Predicting Thoracolumbar Fragility Fractures?

Bo Zhang,Lu-Ping Zhou,Xian-Liang Zhang,Dui Li,Jia-Qi Wang,Chong-Yu Jia,Hua-Qing Zhang,Liang Kang,Ren-Jie Zhang,Cai-Liang Shen 대한척추신경외과학회 2023 Neurospine Vol.20 No.4

Objective: Hounsfield units (HU), vertebral bone quality (VBQ), and bone mineral density (BMD) can all serve as predictive indicators for thoracolumbar fragility fractures. This study aims to explore which indicator provides better risk prediction for thoracolumbar fragility fractures. Methods: Patients who have received medical attention from The First Affiliated Hospital of Anhui Medical University for thoracolumbar fragility fractures were selected. A total of 78 patients with thoracolumbar fragility fractures were included in the study. To establish a control group, 78 patients with degenerative spinal diseases were matched to the fracture group on the basis of gender, age, and body mass index. The lumbar vertebral HU, the VBQ, and the BMD were obtained for all the 156 patients through computed tomography, magnetic resonance imaging, and dual-energy x-ray absorptiometry (DEXA). The correlations among these parameters were analyzed. The area under curve (AUC) analysis was employed to assess the predictive efficacy and thresholds of lumbar vertebral HU, VBQ, and BMD in relation to the risk of thoracolumbar fragility fractures. Results: Among the cohort of 156 patients, lumbar vertebral HU exhibited a positive correlation with BMD (p < 0.01). Conversely, VBQ showed a negative correlation with HU, BMD (p < 0.05). HU and BMD displayed a favorable predictive efficacy for thoracolumbar fragility fractures (p < 0.01), with HU (AUC = 0.863) showcasing the highest predictive efficacy, followed by the DEXA-measured BMD (AUC = 0.813). VBQ (AUC = 0.602) ranked lowest among the 3 indicators. The thresholds for predicting thoracolumbar fragility fractures were as follows: HU (88),VBQ (3.37), and BMD (0.81). Conclusion: All 3 of these indicators, HU, VBQ, and BMD, can predict thoracolumbar fragility fractures. Notably, lumbar vertebral HU exhibits the highest predictive efficacy, followed by the BMD obtained through DEXA scanning, with VBQ demonstrating the lowest predictive efficacy.

Research of Acoustic Emission Testing Method with Application to Monitored for Wind Turbines

Qin Hongwu,Zhang Chao,Zhang Xian,Fan Qinyin 보안공학연구지원센터 2015 International Journal of Multimedia and Ubiquitous Vol.10 No.1

Acoustic Emission method of nondestructive check is based on exertion wave radiation and their registration during fast local material structure reorganization. It is used as a means of analysis of materials, constructions, productions control and diagnosis during operating time. In the article, it is applied to structural health monitoring of Wind Turbines. Acoustic emission testing is based condition monitoring system uses data already collected at the wind turbine controller. It is an effective way to monitor wind turbines for early warning of failures and performance issues. We used a number of measurements to develop anomaly detection algorithms and investigated classification techniques using clustering algorithms and principal components analysis for capturing fault signatures. When registering signal amplitude it is required to consider its frequency distribution connecting each amplitude rate with the corresponding vibration rate. The correlation and signal to noise ratio were evaluated by the algorithm based on frequency spectrum. Classical method of frequency distortion influence exclusion consists of FRF calculation with subsequent adjustment of received signals spectral characteristics.

Synthesis and characterization of nanocrystalline LiTiO₂ using a one-step hydrothermal method /

Zhang, Dong Ri,Liu, Hai Lan,Jin, Rong Hu,Zhang, Nan Zhe,Liu, Yue Xian,Kang, Young Soo The Korean Society of Industrial and Engineering C 2007 Journal of industrial and engineering chemistry Vol.13 No.1

Measurement of Lateral and Interfacial Thermal Conductivity of Single- and Bilayer MoS₂ and MoSe₂ Using Refined Optothermal Raman Technique

Zhang, Xian,Sun, Dezheng,Li, Yilei,Lee, Gwan-Hyoung,Cui, Xu,Chenet, Daniel,You, Yumeng,Heinz, Tony F.,Hone, James C. American Chemical Society 2015 ACS APPLIED MATERIALS & INTERFACES Vol.7 No.46

<P>Atomically thin materials such as graphene and semiconducting transition metal dichalcogenides (TMDCs) have attracted extensive interest in recent years, motivating investigation into multiple properties. In this work, we demonstrate a refined version of the optothermal Raman technique1,2 to measure the thermal transport properties of two TMDC materials, MoS<SUB>2</SUB> and MoSe<SUB>2</SUB>, in single-layer (1L) and bilayer (2L) forms. This new version incorporates two crucial improvements over previous implementations. First, we utilize more direct measurements of the optical absorption of the suspended samples under study and find values ∼40% lower than previously assumed. Second, by comparing the response of fully supported and suspended samples using different laser spot sizes, we are able to independently measure the interfacial thermal conductance to the substrate and the lateral thermal conductivity of the supported and suspended materials. The approach is validated by examining the response of a suspended film illuminated in different radial positions. For 1L MoS<SUB>2</SUB> and MoSe<SUB>2</SUB>, the room-temperature thermal conductivities are 84 ± 17 and 59 ± 18 W/(m·K), respectively. For 2L MoS<SUB>2</SUB> and MoSe<SUB>2</SUB>, we obtain values of 77 ± 25 W and 42 ± 13 W/(m·K). Crucially, the interfacial thermal conductance is found to be of order 0.1–1 MW/m<SUP>2</SUP> K, substantially smaller than previously assumed, a finding that has important implications for design and modeling of electronic devices.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2015/aamick.2015.7.issue-46/acsami.5b08580/production/images/medium/am-2015-085805_0004.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am5b08580'>ACS Electronic Supporting Info</A></P>

Study of the flow around a cylinder from the subcritical to supercritical regimes

Zhang, Xian-Tao,Li, Zhi-Yu,Fu, Shi-Xiao,Ong, Muk Chen,Chen, Ying Techno-Press 2014 Ocean systems engineering Vol.4 No.3

The objective of the present simulations is to evaluate the applicability of the standard $k-{\varepsilon}$ turbulence model in engineering practice in the subcritical to supercritical flow regimes. Two-dimensional numerical simulations of flow around a circular cylinder at $Re=1{\times}10^5$, $5{\times}10^5$ and $1{\times}10^6$, had been performed using Unsteady Reynolds-Averaged Navier Stokes (URANS) equations with the standard $k-{\varepsilon}$ turbulence model. Solution verification had been studied by evaluating grid and time step size convergence. For each Reynolds number, several meshes with different grid and time step size resolutions were chosen to calculate the hydrodynamic quantities such as the time-averaged drag coefficient, root-mean square value of lift coefficient, Strouhal number, the coefficient of pressure on the downstream point of the cylinder, the separation angle. By comparing the values of these quantities of adjacent grid or time step size resolutions, convergence study has been performed. Solution validation is obtained by comparing the converged results with published numerical and experimental data. The deviations of the values of present simulated quantities from those corresponding experimental data become smaller as Reynolds numbers increases from $1{\times}10^5$ to $1{\times}10^6$. This may show that the standard $k-{\varepsilon}$ model with enhanced wall treatment appears to be applicable for higher Reynolds number turbulence flow.

Multiple Smooth Support Vector Machine with FCM Clustering in Hidden Space

Xian-wei Zhang,Jinjin Liang 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.9

A multiple smooth model is proposed by smoothing technique and piecewise technique for large scale data. Mapping the training data to the hidden space with a hidden function, the proposed model divides the original data into several subclasses by Fuzzy C Means (FCM), whose initial cluster centers are selected by samples with large density indexes; derives the smooth differentiable model by utilizing the entropy function to replace the plus function of the slack vector, and introduces linking rules to combine results of subclasses. Simulations demonstrate that the obtained algorithm maintains good classification accuracies, reduces the training time and hardly varies with kernel parameters.

The evaluation of online course of Traditional Chinese Medicine for Medical Bachelor, Bachelor of Surgery international students during the COVID-19 epidemic period

Zhang Qing,He Yi-Jing,Zhu Yu-Hang,Dai Min-Chen,Pan Man-Man,Wu Jia-Qi,Zhang Xian,Gu Ying-Er,Wang Fang-Fang,Xu Xiang-Rong,Qu Fan 한국한의학연구원 2020 Integrative Medicine Research Vol.9 No.3

Background: During the COVID-19 epidemic period, Traditional Chinese Medicine (TCM) course for international students of Medical Bachelor, Bachelor of Surgery (MBBS) program in Zhejiang University has shifted from traditional classroom to online environment. This study aimed to investigate MBBS international students’ perception on online TCM course, and to assess the online learning efficacy. Methods: A total of 84 MBBS international students attending course of “Basic Traditional Chinese Medicine” during 2020 academic years at Zhejiang University were enrolled in this study. A quantitative questionnaire was respectively completed before and after the TCM course using a pretest–post-test design. By means of two online learning platforms, Learning in ZJU and DingTalk, TCM course was broadcast in both live and archived format to students. Results: A total of 48 participants completed both baseline and follow-up questionnaires. The majority of participants preferred face-to-face classroom learning (26, 54.17% of total) when compared with online learning. Students felt that the course had brought in much benefits (mean 3.88, SD 0.87), and they were satisfied with the course content (mean 3.83, SD 0.95). Students’ TCM related knowledge and their behaviors of discussion and consulting were significantly improved by online TCM course (all P < 0.001). Students’ awareness of the necessity of TCM education and their feeling of difficulty in learning TCM were significantly strengthened (P = 0.042, 0.025, respectively). Conclusion: Online learning is a good alternative for TCM course of MBBS international students when classroom learning is suspended, whereas it cannot replace the need for onsite and face-to-face learning.

Antiobesity Effect of <i> Astilbe chinensis</i> Franch. et Savet. Extract through Regulation of Adipogenesis and AMP-Activated Protein Kinase Pathways in 3T3-L1 Adipocyte and High-Fat Diet-Induced C57BL/6N Obese Mice

Zhang, Xian Hua,Wang, Zhiqiang,Kang, Bueom-Goo,Hwang, Seung Hwan,Lee, Jae-Young,Lim, Soon Sung,Huang, Bo Hindawi 2018 Evidence-based Complementary and Alternative Medic Vol.2018 No.-

<P><I>Astilbe chinensis </I>Franch. et Savat. (AC) has been used in traditional medicine for the treatment of chronic bronchitis, arthralgia, and gastralgia. In this study, we investigated the antiobesity effect of AC extract on 3T3-L1 preadipocytes and high-fat-diet-fed C57BL/6N obese mice. We found that AC extracts dramatically decreased the lipid content of 3T3-L1 cells in a concentration-dependent manner without cytotoxicity. The action mechanism of AC extract was demonstrated to be the inhibition of lipid accumulation and dose-dependent decrease in the expression of CCAAT/enhancer-binding protein <I>α</I> (C/EBP<I>α</I>), peroxisome proliferator-activated receptor-<I>γ</I> (PPAR-<I>γ</I>), and sterol regulatory element-binding protein 1 (SREBP1). Furthermore, AC extract increased the mitochondrial phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC), mitochondrial biogenesis, and lipolysis-related factors. In amice model of high-fat-diet-induced obesity, the mice administered AC extract experienced significant decrease of 64% in weight gain, 55% in insulin resistance index, 22% in plasma triglycerides (TG), 56% in total cholesterol (TC), and 21% in nonesterified fatty acid (NEFA) levels compared with those in the high-fat diet-fed control mice. Collectively, these results indicated that AC extract exerted antiobesogenic activity through the modulation of the AMPK signaling pathway, inhibition of adipogenesis, decreased lipid content, and reduced adipocyte size.</P>

The role of domestic and international festivals in promotion of artistic movies in China and around

Zhang xian min 한국영화학회 2006 한국영화학회 학술발표대회 논문집 Vol.- No.-