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- 저자 : Gaihong Wu (검색결과 3 건)
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Shuqiang Liu,Gaihong Wu,Xiaofang Zhang,Juanjuan Yu,Mingfang Liu,Yao Zhang,Peng Wang,Xiaolong Yin 한국섬유공학회 2019 Fibers and polymers Vol.20 No.2
The drug-release time of suture should meet with the healing time of wound, so it is needed to control the drugrelease performance of polylactic acid (PLA) suture. In this paper, two biodegradable polymers with different degradation rates, such as polycaprolactone (PCL) and polyglycolide (PGA), were applied to carry the drug of tea polyphenol (TP). The drug-loading finishing solution which is made of PCL/PGA carriers and TP, was coated on the PLA suture. The drug-release rate and time of PLA suture could be regulated by adjusting the proportion of PCL/PGA carriers. The results indicate that thesurface of drug-loaded PLA suture becomes rough. There is no obvious chemical reaction among the drug, carriers and PLA suture, just physical adhesion. With the increasing of PCL in drug-carriers, the strength of suture gradually increases. At 70/30 of PCL/PGA, the fracture elongation of suture reaches the highest point. In process of degradation, the surface of drugloaded PLA suture appears some holes after 25 weeks. The strength of sutures decreases gradually during degradation, and the effective strength time of sutures with various proportions of PCL/PGA is different. The drug-release rate of the suture isfast at early stage and slow at later stage and the higher the PGA proportion is, the faster the drug-release rate of the suture is.
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Zhichao Yang,Shuqiang Liu,Jingjing Li,Gaihong Wu,Man Zhang,Fu Li,Lu Jia,Yujing Zhang,Huimin Li,Xia Liu,Jingjing Zhao,Huiqin Zhang,Shiyu Li 한국섬유공학회 2023 Fibers and polymers Vol.24 No.12
Polylactic acid (PLA) surgical suture is considered to be one of the most ideal materials for tissue closure due to its rich raw materials and excellent biological properties. However, surgical sutures face great challenges due to problems such as wound infection and tissue reaction in practical applications. In order to improve the clinical applicability of surgical sutures, we constructed a new drug-loading system for core-spun surgical sutures. The shell was composed of nanofibrous membranes composed of polyglycolic acid (PGA) and polycaprolactone (PCL) and ciprofloxacin (CIP) antibacterial drugs, and the core layer adopts PLA filament. By adjusting the composition ratio of PGA and PCL in the shell, a new mode of regulating the release rate and release cycle of the suture was constructed. According to different wound healing time, different drug release cycles of surgical suture were selected. In the study, the structure of the core-spun yarn can be clearly observed by scanning electron microscope, the higher the shell PGA content and drug loading, the faster the drug release rate. When the carrier ratio PGA/PCL was 80/20 and the drug loading was 3%, the drug release rate was the fastest and the drug release was high; finally, antibacterial experiments showed that the suture had excellent antibacterial effect and could effectively kill Staphylococcus aureus and Escherichia coli. The successful preparation of core-spun yarn surgical suture provides a new idea for the study of new antibacterial surgical suture.
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Effects of Face Sheet Structure on Mechanical Properties of 3D Integrated Woven Spacer Composites
Man Zhang,Xiaoxue Wang,Shuqiang Liu,Fu Li,Gaihong Wu 한국섬유공학회 2020 Fibers and polymers Vol.21 No.7
Due to the lightweight, structural integrity, superior heat and sound insulation performance, three-dimensional(3D) integrated woven spacer composites are expected to be used in many fields such as marine, automotive, electronics, andbuilding industries. This paper reports the effects of face sheet structure on the mechanical properties of 3D integrated wovenspacer composites. Three-point bending, quasi-static compression and low-velocity impact tests were conducted to comparethe mechanical responses of 3D woven spacer composites with plain and complex face sheets. The floating yarn segments incomplex face sheet could efficiently transfer the stress to neighboring areas and lead to a more balanced stress distribution. The existence of floats thus has positive effect on mechanical properties of composites. On the contrary, plain structuresurface was dense and the stress transfer was easily hindered by numerous weaving points, resulting in stress concentrationand ultimate premature failure. As a consequence, for surface-dominated properties such as warp-direction bending andimpact resistance, 3D integrated woven spacer composites with complex surface is better and should be given priority duringindustrial applications. In terms of weft-direction bending property and quasi-static compressive performance, which moredepend on the structure of core piles, show little difference between the composites with different surfaces.
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