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Antioxidant Flavone Glycosides from the Root of Pteroxygonum giraldii
Li, Bao-Lin,Yang, Zhan-Jun,Jiang, Lin-Ling,Zhang, Xi-Quan,Gu, Hong-Mei,Wang, Hui-Chun,Tian, Xian-Hua Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.7
Two new flavone glycosides, giraldiin A and B, together with three known compounds, annulatin, myricetin 3-O-$\alpha$- L-rhamnopyranoside and gallic acid, were isolated from the ethanol extract of the root of Pteroxygonum giraldii Damm. et Diels. The structures of giraldiin A and B are designated as 3'-($\alpha$-L-arabinopyranosyloxy)-4',5,5',7- tetrahydroxy-3-methoxyflavone and 4'-($\beta$-D-glucopyranosyloxy)-5,5',7-trihydroxy-2',3-dimethoxyflavone, respectively, on the basis of detailed spectroscopic analyses. The free radical scavenging activity of giraldiin A was evaluated by decolouring spectrophotometry of pentamethine cyanine dye (Cy5) with $Fe^{2+}-H_2O_2$ Fenton radical generating system. The results indicated the hydroxyl free radical scavenging activity of giraldiin A (E$D_{50}$ = 23.7 nmol/mL) is higher than that of some known antioxidants such as rutin, puerarin, daidzein and 2,6-di-tertbutyl-4-methylphenol.
Ling-yan Li,Shuang-lin Li,Yan Shao,Rui Dou,Bo Yin,Ming-bo Yang 한국물리학회 2018 Current Applied Physics Vol.18 No.4
In this work, Polyvinylidene Fluoride (PVDF)/polystyrene (PS)/high density polyethylene (HDPE) ternary blends displayed a core-shell structure where HDPE was the core, PS was the shell, and this core-shell system dispersed in PVDF matrix. Here, multiwall carbon nanotubes (MWCNTs) and ferroferric oxide (Fe3O4) was incorporated. F-F composites with MWCNTs was in PS shell and Fe3O4 was in PVDF matrix and E-F composites with MWCNTs was in PS shell and Fe3O4 was in HDPE core were fabricated by melt blending. It was indicated that the core-shell morphology between PS and HDPE was well retained with the incorporation of Fe3O4 and MWCNTs. Both the electrical conductivity of F-F and E-F composites were similar without no obvious change with the incorporation of Fe3O4. Composites with greater than 20 dB shielding effectiveness were easy to obtain. The highest SE we observed was for the F-F composite with 1 vol% Fe3O4 and 1 vol%MWCNTs was 25 dB at 9.5 GHz, and the SE was over 20 dB in the whole measured frequency(X-band). The E-F composites with SE greater than 20 dB in X-band was at 2 vol% Fe3O4 and 1 vol% MWNCTs. Such effective and lightweight nanocomposites were obtained, resulting from the synergetic effect of MWCNTs and Fe3O4 nanoparticles.
Weng, Ling-Ling,Xiang, Jian-Feng,Lin, Jin-Bo,Yi, Shang-Hui,Yang, Li-Tao,Li, Yi-Sheng,Zeng, Hao-Tao,Lin, Sheng-Ming,Xin, Dong-Wei,Zhao, Hai-Liang,Qiu, Shu-Qi,Chen, Tao,Zhang, Min-Guang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.24
Liver cancer is one of leading digestive malignancies with high morbidity and mortality. There is an urgent need for the development of novel therapies for this deadly disease. It has been proven that asparagus polysaccharide, one of the most active derivates from the traditional medicine asparagus, possesses notable antitumor properties. However, little is known about the efficacy of asparagus polysaccharide as an adjuvant for liver cancer chemotherapy. Herein, we reported that asparagus polysaccharide and its embolic agent form, asparagus gum, significantly inhibited liver tumor growth with transcatheter arterial chemoembolization (TACE) therapy in an orthotopic hepatocellular carcinoma (HCC) tumor model, while significantly inhibiting angiogenesis and promoting tumor cell apoptosis. Moreover, asparagine gelatinous possessed immunomodulatory functions and showed little toxicity to the host. These results highlight the chemotherapeutic potential of asparagus polysaccharide and warrant a future focus on development as novel chemotherapeutic agent for liver cancer TACE therapy.
Antioxidant Flavone Glycosides from the Root of Pteroxygonum giraldii
Bao-Lin Li,Lin-Ling Jiang,Hui-Chun Wang,Zhan-Jun Yang,Xi-Quan Zhang,Hong-Mei Gu,Xian-Hua Tian 대한화학회 2009 Bulletin of the Korean Chemical Society Vol.30 No.7
Two new flavone glycosides, giraldiin A and B, together with three known compounds, annulatin, myricetin 3-O-α-L-rhamnopyranoside and gallic acid, were isolated from the ethanol extract of the root of Pteroxygonum giraldii Damm. et Diels. The structures of giraldiin A and B are designated as 3'-(α-L-arabinopyranosyloxy)-4',5,5',7-tetrahydroxy-3-methoxyflavone and 4'-(β-D-glucopyranosyloxy)-5,5',7-trihydroxy-2',3-dimethoxyflavone, respectively,on the basis of detailed spectroscopic analyses. The free radical scavenging activity of giraldiin A was evaluated by decolouring spectrophotometry of pentamethine cyanine dye (Cy5) with Fe2+-H2O2 Fenton radical generating system. The results indicated the hydroxyl free radical scavenging activity of giraldiin A (ED50 = 23.7 nmol/mL) is higher than that of some known antioxidants such as rutin, puerarin, daidzein and 2,6-di-tertbutyl-4-methylphenol.
Chao Lin,Xue-Song Sun,Sai-Lan Liu,Xiao-Yun Li,Nian Lu,Xin-Ling Li,Lin-Quan Tang,Ling Guo 대한암학회 2020 Cancer Research and Treatment Vol.52 No.3
Purpose The prognosis of nasopharyngeal carcinoma (NPC) patients with parotid lymph node (PLN) metastasis remains unclear. This study was performed to investigate the prognostic significance and optimal staging category of PLN metastasis and develop a nomogram for estimating individual risk. Materials and Methods Clinical data of 7,084 non-metastatic NPC patients were retrospectively reviewed. Overall survival (OS) was the primary endpoint. A nomogram was established based on the Cox proportional hazards regression model. The accuracy and calibration ability of this nomogram was evaluated by C-index and calibration curves with bootstrap validation. Results Totally, 164/7,084 NPC patients (2.3%) presented with PLNs. Multivariate analyses showed that PLN metastasis was a negative prognostic factor for OS, progression-free survival (PFS), distant metastasis-free survival (DMFS), and locoregional relapse-free survival (LRFS). Patients with PLN metastasis had a worse prognosis than N3 disease. Five independent prognostic factors were included in the nomogram, which showed a C-index of 0.743. The calibration curves for probability of 3- and 5-year OS indicated satisfactory agreement between nomogram-based prediction and actual observation. All results were confirmed in the validation cohort. Conclusion NPC patient with PLN metastasis had poorer survival outcome (OS, PFS, DMFS, and LRFS) than N3 disease. We developed a nomogram to provide individual prediction of OS for patients with PLN metastasis.
The Gastrointestinal Metabolic Effects of Oat Product Based-β- glucan in Mice
Ji-Lin Dong,Wen-Li Zhang,Juan Lin,Rui-Ling Shen,Jun-Ling Si,Ying Wang 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.3
Most physiologicalstudies studies of oat beta(β)-glucan have shown positive effects on regulation ofblood glucose and lipid metabolism related to β-glucanmetabolism in the gastrointestinal tract. The effects of oatβ-glucan (OG), oat bran (OB), oat flour (OF), and oatmeal(OM) containing different levels of β-glucan on digestibilityand degradation were investigated in normal mice. Chymeviscosity, the gastric emptying rate, the gastrointestinaltransit rate, the activities of intestinal digestive enzymes,the levels of plasma cholecystokinin (CCK) and motlin(MOT), and degradation of β-glucan in oat products weredetermined. β-glucans from different oat products increasedintestinal chyme viscosity, delayed gastric emptying,promoted enterokinesia, decreased amylase, trypsin, lipase,and Na+, K+-ATPase activities, and promoted secretion ofCCK and MOT, especially for oat derived β-glucan.
( Ching-ling Lin ),( Ming-lin Tsai ),( Yu-hsin Chen ),( Wei-ni Liu ),( Chun-yu Lin ),( Kai-wen Hsu ),( Chien-yu Huang ),( Yu-jia Chang ),( Po-li Wei ),( Shu-huey Chen ),( Li-chi Huang ),( Chia-hwa Lee 한국응용약물학회 2021 Biomolecules & Therapeutics(구 응용약물학회지) Vol.29 No.5
Thyroid cancer is the most common endocrine malignancy. Patients with well-differentiated thyroid cancers, such as papillary and follicular cancers, have a favorable prognosis. However, poorly differentiated thyroid cancers, such as medullary, squamous and anaplastic advanced thyroid cancers, are very aggressive and insensitive to radioiodine treatment. Thus, novel therapies that attenuate metastasis are urgently needed. We found that both PDGFC and PDGFRA are predominantly expressed in thyroid cancers and that the survival rate is significantly lower in patients with high PDGFRA expression. This finding indicates the important role of PDGF/PDGFR signaling in thyroid cancer development. Next, we established a SW579 squamous thyroid cancer cell line with 95.6% PDGFRA gene insertion and deletions (indels) through CRISPR/Cas9. Protein and invasion analysis showed a dramatic loss in EMT marker expression and metastatic ability. Furthermore, xenograft tumors derived from PDGFRA geneedited SW579 cells exhibited a minor decrease in tumor growth. However, distant lung metastasis was completely abolished upon PDGFRA gene editing, implying that PDGFRA could be an effective target to inhibit distant metastasis in advanced thyroid cancers. To translate this finding to the clinic, we used the most relevant multikinase inhibitor, imatinib, to inhibit PDGFRA signaling. The results showed that imatinib significantly suppressed cell growth, induced cell cycle arrest and cell death in SW579 cells. Our developed noninvasive apoptosis detection sensor (NIADS) indicated that imatinib induced cell apoptosis through caspase-3 activation. In conclusion, we believe that developing a specific and selective targeted therapy for PDGFRA would effectively suppress PDGFRA-mediated cancer aggressiveness in advanced thyroid cancers.
Ya-Jun Li,Ji-Wei Li,Kai-Lin Chen,Jin Li,Mei-Zuo Zhong,Xian-Ling Liu,Ping-Yong Yi,Hui Zhou 대한혈액학회 2020 Blood Research Vol.55 No.1
BackgroundHuman immunodeficiency virus (HIV)-negative plasmablastic lymphoma (PBL) is a rare entity of diffuse large B-cell lymphoma (DLBCL). The clinicopathological features of and optimal treatment for HIV-negative PBL remain largely unknown.MethodsTo gain insight into this distinct lymphoma, we summarized the clinicopathologic charac-teristics of 8 unpublished HIV-negative PBLs and performed a comprehensive review of 394 published cases.ResultsOf the 8 unpublished PBLs, the median patient age was 53.0 years. Four patients pre-sented with stage IV disease. All 8 patients showed a plasma cell-like immunophenotype. Of the six patients who received anthracycline-based chemotherapy, including two who received bortezomib, three patients achieved a continuous complete response, two pa-tients died due to disease progression, and one patient was lost to follow-up. The other two patients achieved continuous complete response after receiving chemotherapy com-bined with radiotherapy and surgery. Of the 402 patients, the majority were male, with a mean age of 58.0 years. EBV infection was detected in 55.7% of the patients. The median survival times of the patients who received CHOP or CHOP-like regimens and intensive regimens were not reached and 23.0 months, respectively, and the intensive regimen did not improve the survival outcome (P=0.981). Multivariate analysis showed that EBER remained the only independent factor affecting overall survival (OS).ConclusionHIV-negative PBL is a distinct entity with a predilection for elderly and immunosup-pressed individuals. Intensive chemotherapy had no apparent survival benefits over the CHOP regimen in terms of OS; the prognosis of this disease is poor with current chemo-therapy methods, and treatment remains a challenge.