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PRI: A Practical Reputation-based Incentive Scheme for Delay Tolerant Networks
( Xi Zhang ),( Xiaofei Wang ),( Anna Liu ),( Quan Zhang ),( Chaojing Tang ) 한국인터넷정보학회 2012 KSII Transactions on Internet and Information Syst Vol.6 No.4
Delay tolerant networks (DTNs) characterized by the lack of guaranteed end-to-end paths exploit opportunistic data forwarding mechanism, which depends on the hypothesis that nodes are willing to store, carry, and forward the in-transit messages in an opportunistic way. However, this hypothesis might easily be violated by the presence of selfish nodes constrained with energy, bandwidth, and processing power. To address this problem, we propose a practical reputation-based incentive scheme, named PRI, to stimulate honest forwarding and discipline selfish behavior. A novel concept of successful forwarding credential and an observation protocol are presented to cope with the detection of nodes` behavior, and a reputation model is proposed to determine egoistic individuals. The simulation results demonstrate the effectiveness and practicality of our proposal.
Mesenchymal Stem Cells on a Decellularized Cartilage Matrix for Cartilage Tissue Engineering
Xi-Fu Zheng,Shi-Bi Lu,Wei-Guo Zhang,Shu-Yun Liu,Jing-Xiang Huang,Quan-Yi Guo 한국생물공학회 2011 Biotechnology and Bioprocess Engineering Vol.16 No.3
An ideal scaffold for cartilage tissue engineering should be biomimetic in not only its biochemical composition, but also in the morphological structure of the scaffold. In this study, we fabricated a scaffold with an oriented structure using a nanofibrous articular cartilage extracellular matrix (ACECM), in which the ACECM was used to mimic the biochemical composition and oriented structure of articular cartilage. Histology analysis showed that the scaffold contained cartilage ECM (GAGs and collagen II). Scanning electron microscopy (SEM) indicated that the scaffolds were composed of nanofibers and possessed vertical microtubules. Chondrogenic differentiation-induced mesenchymal stem cells (MSCs) were seeded on the scaffold in vitro. SEM showed that MSCs proliferated well and aligned along the vertical microtubules,which mimicked the orientation of deep zone articular cartilage. A cell proliferation assay and live/dead cell staining demonstrated that the ACECM possessed good cell affinity, which favored cell adherence and proliferation. The MSCs that had been labeled with the fluorescent dye PKH26 and seeded on scaffolds were implanted into nude mice. The differentiated cells/ACECM implants formed cartilage-like tissue 4 weeks after implantation, and stained positive for collagen type II and toluidine blue. In addition,the in vivo fluorescent images verified that the MSCs in the implants were the labeled MSCs. These results demonstrated that the oriented ACECM scaffolds hold great promise for use in cartilage tissue engineering applications.
Zhang, Shao-Kai,Guo, Lan-Wei,Chen, Qiong,Zhang, Meng,Liu, Shu-Zheng,Quan, Pei-Liang,Lu, Jian-Bang,Sun, Xi-Bin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23
Background and Aim: No firm evidence of HPV infection in esophageal cancer has been established to date. The aim of this meta-analysis was to investigate the prevalence of HPV 16 in esophageal cancer in China, which had a high burden of the disease. Materials and Methods: Studies on HPV infection and esophageal cancer were identified and a random-effects model was used to pool the summary prevalence and corresponding 95% confidence intervals (CIs). Results: A total of 3,429 esophageal cancer cases were evaluated from 26 eligible studies in this meta-analysis. The summary estimate for HPV16 prevalence was 0.381 (95% CI: 0.283, 0.479). The prevalence varied by geographical areas of the study, publication year, HPV detection method and types of specimen. In sensitivity analysis, HPV 16 prevalence ranged from 0.368 (95% CI: 0.276, 0.460) to 0.397 (95% CI: 0.286, 0.508). Conclusions: The results indicate a relatively high level of HPV 16 prevalence in esophageal cancer among Chinese population, although there was variation between different variables. Further studies are needed to elucidate the role of HPV in esophageal carcinogenesis with careful consideration of study design and laboratory detection method, providing more accurate assessment of the HPV status in esophageal cancer.
Sheng Zou,Hong Zhang,Xi-yuan Chen,Wei Quan 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.66 No.6
The method to produce spin-polarized xenon-129 gas was based on the method of spin-exchangeoptical pumping (SEOP). The magnetizations produced by the hyperpolarized (HP) xenon-129gas were analyzed from the perspective of theoretical and experimental research. The theoreticalsimulation was based on the conventional Bloch equation. The experimental research was based onmeasurements made by using an all-optical atomic magnetometer. The experimental results agreedwith the theoretical simulated results, which proved that an all-optical atomic magnetometer hadthe ability to measure the magnetic field produced by xenon-129 nuclei in a low external magneticfield. Because the frequency of the nuclear spin precession could be detected precisely, the resultsshowed that the mean measurement error of the gyromagnetic ratio was 1.1 × 10−4 Hz/nT.
A Highly Stereoselective Synthesis and Crystal Structure of (E)-4'-Amino-3,4,5- trimethoxystilbene
Li, Xia-Bing,Zhang, Xi-Quan,Gu, Hong-Mei,Li, Bao-Lin Korean Chemical Society 2011 대한화학회지 Vol.55 No.2
3,4,5-Trimethoxybenzaldehyde과 p-nitrotoluene을 출발물질로 하여 두 단계 반응으로 (E)-4'-amino-3,4,5-trimethoxystilbene을 합성할 수 있는 합성 방법을 개발하였으며, 이 화합물에 대한 결정 구조를 X-ray 회절분석법으로 결정하였다. A new and highly stereoselective synthesis of (E)-4'-amino-3,4,5-trimethoxystilbene was achieved by using 3,4,5-trimethoxybenzaldehyde and p-nitrotoluene as starting materials through condensation under solvent-free condition and followed by the reducing of nitro group with the system of $NH_2NH_2/FeCl_3$/C in ethanol. The crystal structure of (E)-4'-amino-3,4,5-trimethoxystilbene was also determined by X-ray diffraction analysis.
Liu, Shu-Zheng,Zhang, Fang,Quan, Pei-Liang,Lu, Jian-Bang,Liu, Zhi-Cai,Sun, Xi-Bin Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9
In recent decades, decreasing trends in esophageal cancer mortality have been observed across China. We here describe esophageal cancer mortality trends in Linzhou city, a high-incidence region of esophageal cancer in China, during 1988-2010 and make a esophageal cancer mortality projection in the period 2011-2020 using a Bayesian approach. Age standardized mortality rates were estimated by direct standardization to the World population structure in 1985. A Bayesian age-period-cohort (BAPC) analysis was carried out in order to investigate the effect of the age, period and birth cohort on esophageal cancer mortality in Linzhou during 1988-2010 and to estimate future trends for the period 2011-2020. Age-adjusted rates for men and women decreased from 1988 to 2005 and changed little thereafter. Risk increased from 30 years of age until the very elderly. Period effects showed little variation in risk throughout 1988-2010. In contrast, a cohort effect showed risk decreased greatly in later cohorts. Forecasting, based on BAPC modeling, resulted in a increasing burden of mortality and a decreasing age standardized mortality rate of esophageal cancer in Linzhou city. The decrease of esophageal cancer mortality risk since the 1930 cohort could be attributable to the improvements of socialeconomic environment and lifestyle. The standardized mortality rates of esophageal cancer should decrease continually. The effect of aging on the population could explain the increase in esophageal mortality projected for 2020.
Determination of Thermal Equilibrium in a Sealed Cell Based on Optical Depth
Sheng Zou,Hong Zhang,Xi-Yuan Chen,Guang-cun Shan,Wei Quan 한국물리학회 2017 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.70 No.2
An effective method based on optical depth (OD) is presented to measure thermal equilibrium in a cell. First, the principle of determining the temperature distribution in the cell by using the OD is demonstrated. Subsequently, relevant experiments are carried out. Original experimental results showed that some gradients of OD distributions in the cell at different wavelengths and variations of the OD increased slowly along the direction of motion of the beam at a fixed wavelength. At a wavelength of 766.6839 nm, which is about 7 GHz blue shifted with respect to the potassium resonance, the average value of the OD was about 0.764 and the maximal and the minimum inhomogeneity biases among all location points were about 6.07% and 0.56%, respectively. As for the corresponding wavelengths of 766.67785 nm and 766.73004 nm, some deviations from previous results, which were caused by different absorptions of the alkali-metal atoms at different frequencies of the laser beam, were observed. The nonuniform OD values along the direction of motion of the beam reflected an inhomogeneous distribution of the temperature in the cell, which may have been caused by layout of the oven. When the layout of the oven was modified, comparative experiments comparable to these with the previous layout of the oven demonstrated that the uniformity of the temperature distribution in the cell was improved and that thermal equilibrium time was shorter by about 10 minutes. This method played an important role in determining the thermal equilibrium time in the cell.
( Zhong Wen Chen ),( Yin Bing Zhang ),( Xaing Jun Chen ),( Xiao Liu ),( Zhen Wang ),( Xi Kun Zhou ),( Ji Qiu ),( Nan Nan Zhang ),( Xiu Teng ),( Yong Qiu Mao ),( Chang Yong Liu ),( Yu Quan Wei ),( Jion 대한피부과학회 2015 Annals of Dermatology Vol.27 No.2
Background: Psoriasis is an autoimmune disease that is caused by a shift in the Th1/Th2 balance toward Th1- dominant immunity. It has been established as an effective treatment to counteract psoriasis by subcutaneous injection of recombinant interleukin (IL)-4, and IL-4 gene therapy by topical transdermal penetration has shown its antipsoriatic effect in mice. Retinoic acid (RA) and dimethylsulfoxide can increase the efficiency of gene transfection in the topical transdermal delivery system. Objective: We investigated whether RA could improve anti-psoriasis efficiency using IL-4 expression plasmid pORF-mIL-4 (pIL-4) via transdermal delivery system in K14-vascular endothelial growth (K14- VEGF) factor transgenic mice. Methods: After pretreatment with RA, plasmid pIL-4 in 10% dimethylsulfoxide was applied to the ear skin by topical transdermal penetration. Hematoxylin- eosin staining and immunohistochemistry were performed with ear samples to evaluate anti-psoriasis efficiency in mice. Results: The psoriasis pathological features were relieved and psoriasis-associated factors were significantly reduced. Conclusion: Our results reveal that topical application of pIL-4 in dimethylsulfoxide by transdermal delivery with RA pretreatment can improve psoriasis significantly.(Ann Dermatol 27(2) 121∼127, 2015)