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RISS 인기검색어
- 검색키워드
- 저자 : Jun-Ling Si (검색결과 5 건)
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Si-Qi Tang,Ling-Long Tang,Yan-Ping Mao,Wen-Fei Li,Lei Chen,Yuan Zhang,Ying Guo,Qing Liu,Ying Sun,Cheng Xu,Jun Ma 대한암학회 2021 Cancer Research and Treatment Vol.53 No.2
Purpose The occurrence pattern of immune-related adverse events (irAEs) induced by immune checkpoint inhibitor (ICI) in cancer treatment remains unclear. Materials and Methods Phase II-III clinical trials that evaluated ICI-based treatments in cancer and were published between January 2007 and December 2019 were retrieved from public electronic databases. The pooled median time to onset (PMT-O), resolution (PMT-R), and immune-modulation resolution (PMT-IMR) of irAEs were generated using the metamedian package of R software.Results Twenty-two eligible studies involving 23 clinical trials and 8,436 patients were included. The PMT-O of all-grade irAEs ranged from 2.2 to 14.8 weeks, with the longest in renal events. The PMT-O of grade ≥ 3 irAEs was significantly longer than that of all-grade irAEs induced by programmed cell death protein 1 (PD-1) and its ligand 1 (PD-L1) inhibitors (27.5 weeks vs. 8.4 weeks, p < 0.001) and treatment of nivolumab (NIV) plus ipilimumab (IPI) (7.9 weeks vs. 6.0 weeks, p < 0.001). The PMT-R of all-grade irAEs ranged from 0.1 to 54.3 weeks, with the shortest and longest in hypersensitivity/infusion reaction and endocrine events, respectively. The PMT-IMR of grade ≥ 3 irAEs was significantly shorter than that of all-grade irAEs caused by PD-1/PD-L1 blockade (6.9 weeks vs. 40.6 weeks, p=0.002) and NIV+IPI treatment (3.1 weeks vs. 5.9 weeks, p=0.031).Conclusion This study revealed the general and specific occurrence pattern of ICI-induced irAEs in pan-cancers, which was deemed to aid the comprehensive understanding, timely detection, and effective management of ICI-induced irAEs.
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Inhibitory effect of 2,4-dichlorophenol on nitrogen removal in a sequencing batch reactor
Jun-Wei Lim,Si-Ling Ng,Siok-Moi Khor,Chye-Eng Seng 한국화학공학회 2012 Korean Journal of Chemical Engineering Vol.29 No.7
We examined the inhibitory effect of 2,4-dichlorophenol (2,4-DCP) on nitrogen removal in the sequencing batch reactor (SBR) system. The reactor was operated with FILL, REACT (nitrification: denitrification), SETTLE,DRAW and IDLE phases in the duration ratio of 2 : 12 (9 : 3) : 1 : 1 : 8 for a 24 h cycle time. The deterioration of 2,4-DCP removal efficiency from 100 to 41% was observed when the influent concentration of 2,4-DCP was increased to 30mg/L. The residual 2,4-DCP remaining in the mixed liquor was found to inhibit the nitrification process, resulting in the decrease of nitrogen removal efficiency to 25 %. For kinetic study, the result showed that the experimental data of ammoniacal nitrogen (AN) removal at every stage fitted well to the first-order kinetics equation with high R2 values. The rate constant of AN removal, kAN, decreased with increasing influent concentration of 2,4-DCP, from 0.053 to 0.0006/min when 2,4-DCP concentration increased from 0 to 30 mg/L, respectively. However, the observed gradual recovering of AN removal with respect to the removal efficiency and kinetics during the recovery stage indicated that the inhibitory effect of 2,4-DCP on the nitrification process was reversible.
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Xiong, Shang-Ling,Lim, Gyu Tae,Yin, Shang-Jun,Lee, Jinhyuk,Si, Yue-Xiu,Yang, Jun-Mo,Park, Yong-Doo,Qian, Guo-Ying Elsevier 2019 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES Vol.121 No.-
<P><B>Abstract</B></P> <P>Pyrogallol is naturally found in aquatic plant and has been proposed as a substrate of tyrosinase. In this study, we evaluated the dual effect of pyrogallol on tyrosinase as an inhibitor in the presence of L‑DOPA simultaneously via integrating methods of enzyme kinetics and computational molecular dynamics (MD) simulations. Pyrogallol was found to be a reversible inhibitor of tyrosinase in the presence of L‑DOPA and its induced mechanism was the parabolic non-competitive inhibition type (<I>IC</I> <SUB>50</SUB> = 0.772 ± 0.003 mM and <I>K</I> <SUB>i</SUB> = 0.529 ± 0.022 mM). Kinetic measurements by real-time interval assay showed that pyrogallol induced rapid inactivation process composing with slight activations at the low dose. Spectrofluorimetry studies showed that pyrogallol mainly induced regional changes in the active site of tyrosinase accompanying with hydrophobic disruption at high dose. The computational MD simulations further revealed that pyrogallol could interact with several residues near the tyrosinase active site pocket such as HIS61, HIS85, HIS259, ASN260, HIS263, VAL283, and ALA296. Our study provides insight into the mechanism by which hydroxyl group composing pyrogallol inhibit tyrosinase and pyrogallol is a potential natural anti-pigmentation agent.</P>
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The Gastrointestinal Metabolic Effects of Oat Product Based-β- glucan in Mice
Ji-Lin Dong,Wen-Li Zhang,Juan Lin,Rui-Ling Shen,Jun-Ling Si,Ying Wang 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.3
Most physiologicalstudies studies of oat beta(β)-glucan have shown positive effects on regulation ofblood glucose and lipid metabolism related to β-glucanmetabolism in the gastrointestinal tract. The effects of oatβ-glucan (OG), oat bran (OB), oat flour (OF), and oatmeal(OM) containing different levels of β-glucan on digestibilityand degradation were investigated in normal mice. Chymeviscosity, the gastric emptying rate, the gastrointestinaltransit rate, the activities of intestinal digestive enzymes,the levels of plasma cholecystokinin (CCK) and motlin(MOT), and degradation of β-glucan in oat products weredetermined. β-glucans from different oat products increasedintestinal chyme viscosity, delayed gastric emptying,promoted enterokinesia, decreased amylase, trypsin, lipase,and Na+, K+-ATPase activities, and promoted secretion ofCCK and MOT, especially for oat derived β-glucan.
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Xu, Jia,Liu, Chang,Zhou, Lei,Tian, Feng,Tai, Ming-Hui,Wei, Ji-Chao,Qu, Kai,Meng, Fan-Di,Zhang, Ling-Qiang,Wang, Zhi-Xin,Zhang, Jing-Yao,Chang, Hu-Lin,Liu, Si-Nan,Xu, Xin-Shen,Song, Yan-Zhou,Liu, Jun,Z Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.2
Serum alpha-fetoprotein (AFP) is a significant marker for clinical diagnosis and prognosis evaluation in hepatocellular carcinoma (HCC) patients. However, some proportion of liver cancer patients are AFP-negative (AFP ${\leq}$20ng/ml). In order to study the differences between clinicopathological factors and prognosis of alpha-fetoprotein negative and positive patients, a total of 114 cases (41 AFP-negative and 73 AFP-positive) were selected for our research. By systematically statistical analysis, the results demonstrated that compared with AFP-negative patients, AFP-positive examples were more likely to feature cirrhosis nodules, non-complete neoplasm capsules, and a poor Edmondson-steiner grade. Furthermore, AFP-negative patients demonstrated a favorable long-term prognosis. By univariate analysis and multivariate analysis with Cox's proportional hazards model, multiple tumors were found to be independent risk factors for worse survival of AFP negative patients; however, less tumor-free margins, multiple tumors and Edmondson-steiner grades III/IV, proved to be independent risk factors leading to a poor prognosis of AFP positive cases. Finally, we can infer that high levels of AFP signify a highly malignant tumor and unfavorable prognosis.
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