White-Matter Hyperintensities and Lacunar Infarcts Are Associated with an Increased Risk of Alzheimer’s Disease in the Elderly in China

Shuai Ye,Shuyang Dong,Jun Tan,Le Chen,Hai Yang,Yang Chen,Zeyan Peng,Yingchao Huo,Juan Liu,Mingshan Tang,Yafei Li,Huadong Zhou,Yong Tao 대한신경과학회 2019 Journal of Clinical Neurology Vol.15 No.1

Background and Purpose This study investigated the contribution of white-matter hyperintensities (WMH) and lacunar infarcts (LI) to the risk of Alzheimer’s disease (AD) in an elderly cohort in China. Methods Older adults who were initially cognitively normal were examined with MRI at baseline, and followed for 5 years. WMH were classified as mild, moderate, or severe, and LI were classified into a few LI (1 to 3) or many LI (≥4). Cognitive function was assessed using the Mini Mental State Examination and the Activities of Daily Living scale. Results Among the 2,626 subjects, 357 developed AD by the end of the 5-year follow-up period. After adjusting for age and other potential confounders, having only WMH, having only LI, and having both WMH and LI were associated with an increased risk of developing AD compared with having neither WMH nor LI. Moderate and severe WMH were associated with an increased risk of developing AD compared with no WMH. Furthermore, patients with many LI had an increased risk of developing AD compared with no LI. Conclusions Having moderate or severe WMH and many LI were associated with an increased risk of developing AD, with this being particularly striking when both WMH and LI were present.

A large-area free-standing graphene oxide multilayer membrane with high stability for nanofiltration applications

Chen, Long,Li, Yanhui,Chen, Lina,Li, Na,Dong, Chenglong,Chen, Qiong,Liu, Beibei,Ai, Qing,Si, Pengchao,Feng, Jinkui,Zhang, Lin,Suhr, Jonghwan,Lou, Jun,Ci, Lijie Elsevier 2018 CHEMICAL ENGINEERING JOURNAL -LAUSANNE- Vol.345 No.-

<P><B>Abstract</B></P> <P>A flexible and free-standing graphene oxide and nylon 6 (GO@nylon 6) multilayer nanofiltration membrane was prepared by a layer-by-layer assembly process. The combination of electrospinning and electrospraying technique was employed, which can facilely prepare large-area membrane with size of 20 × 30 cm. The mechanical stability of multilayer membrane has enhanced significantly due to the tightly locked structure achieved by nylon 6 nanofibers network. The novel GO@nylon 6–13 multilayer nanofiltration membrane demonstrated a pure water flux up to 11.15 L m<SUP>−2</SUP> h<SUP>−1</SUP> bar<SUP>−1</SUP>, while keeping high organic dye rejection rate (>95% for methylene blue, and >99% for methyl orange). The rejections rate of the Na<SUB>2</SUB>SO<SUB>4</SUB>, NaCl, CuSO<SUB>4</SUB>, and Pb(NO<SUB>3</SUB>)<SUB>2</SUB> were 56.5%, 27.6%, 36.7%, and 18.9%, respectively. Furthermore, GO@nylon 6–13 multilayer nanofiltration membrane also demonstrated a high flux of some common organic solvents (8.4, 5.3, and 0.8 L m<SUP>−2</SUP> h<SUP>−1</SUP> bar<SUP>−1</SUP> for methanol, ethanol, and NMP, respectively), showing excellent chemical stability for separation process in those solvents.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Large-area GO@nylon 6 multilayer nanofiltration membrane was prepared. </LI> <LI> The multilayer structure enhances the mechanical stability. </LI> <LI> The multilayer membrane demonstrates a high water flux. </LI> <LI> The multilayer membrane shows high rejection rate for organic dyes. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Photograph and cross-section SEM image of GO@nylon 6 multilayer nanofiltration membrane, the inset shows the water contact angle.</P> <P>[DISPLAY OMISSION]</P>

Insights into the subsurface transport of As(V) and Se(VI) in produced water from hydraulic fracturing using soil samples from Qingshankou Formation, Songliao Basin, China

Chen, Season S.,Sun, Yuqing,Tsang, Daniel C.W.,Graham, Nigel J.D.,Ok, Yong Sik,Feng, Yujie,Li, Xiang-Dong Elsevier 2017 Environmental pollution Vol.223 No.-

<P><B>Abstract</B></P> <P>Produced water is a type of wastewater generated from hydraulic fracturing, which may pose a risk to the environment and humans due to its high ionic strength and the presence of elevated concentrations of metals/metalloids that exceed maximum contamination levels. The mobilization of As(V) and Se(VI) in produced water and selected soils from Qingshankou Formation in the Songliao Basin in China were investigated using column experiments and synthetic produced water whose quality was representative of waters arising at different times after well creation. Temporal effects of produced water on metal/metalloid transport and sorption/desorption were investigated by using HYDRUS-1D transport modelling. Rapid breakthrough and long tailings of As(V) and Se(VI) transport were observed in Day 1 and Day 14 solutions, but were reduced in Day 90 solution probably due to the elevated ionic strength. The influence of produced water on the hydrogeological conditions (i.e., change between equilibrium and non-equilibrium transport) was evidenced by the change of tracer breakthrough curves before and after the leaching of produced water. This possibly resulted from the sorption of polyacrylamide (PAM (-CH<SUB>2</SUB>CHCONH<SUB>2</SUB>-)<SUB>n</SUB>) onto soil surfaces, through its use as a friction reducer in fracturing solutions. The sorption was found to be reversible in this study. Minimal amounts of sorbed As(V) were desorbed whereas the majority of sorbed Se(VI) was readily leached out, to an extent which varied with the composition of the produced water. These results showed that the mobilization of As(V) and Se(VI) in soil largely depended on the solution pH and ionic strength. Understanding the differences in metal/metalloid transport in produced water is important for proper risk management.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Earlier breakthrough of metals with increasing ionic strength of flowback solutions. </LI> <LI> Two-region physical non-equilibrium model provided a good fit of metal transport. </LI> <LI> Less non-equilibrium transport in Day 14 and Day 90 than Day 1 flowback solutions. </LI> <LI> Tracer tests indicated reversible change of transport channels due to leaching. </LI> <LI> Sorption/desorption of As(V) and Se(VI) was both pH- and ionic strength-dependent. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Potential impact of flowback water from hydraulic fracturing on agricultural soil quality: Metal/metalloid bioaccessibility, Microtox bioassay, and enzyme activities

Chen, Season S.,Sun, Yuqing,Tsang, Daniel C.W.,Graham, Nigel J.D.,Ok, Yong Sik,Feng, Yujie,Li, Xiang-Dong Elsevier 2017 The Science of the total environment Vol.579 No.-

<P><B>Abstract</B></P> <P>Hydraulic fracturing has advanced the development of shale gas extraction, while inadvertent spills of flowback water may pose a risk to the surrounding environment due to its high salt content, metals/metalloids (As, Se, Fe and Sr), and organic additives. This study investigated the potential impact of flowback water on four representative soils from shale gas regions in Northeast China using synthetic flowback solutions. The compositions of the solutions were representative of flowback water arising at different stages after fracturing well establishment. The effects of solution composition of flowback water on soil ecosystem were assessed in terms of metal mobility and bioaccessibility, as well as biological endpoints using Microtox bioassay (<I>Vibrio fischeri</I>) and enzyme activity tests. After one-month artificial aging of the soils with various flowback solutions, the mobility and bioaccessibility of As(V) and Se(VI) decreased as the ionic strength of the flowback solutions increased. The results inferred a stronger binding affinity of As(V) and Se(VI) with the soils. Nevertheless, the soil toxicity to <I>Vibrio fischeri</I> only presented a moderate increase after aging, while dehydrogenase and phosphomonoesterase activities were significantly suppressed with increasing ionic strength of flowback solutions. On the contrary, polyacrylamide in the flowback solutions led to higher dehydrogenase activity. These results indicated that soil enzyme activities were sensitive to the composition of flowback solutions. A preliminary human health risk assessment related to As(V) suggested a low level of cancer risk through exposure via ingestion, while holistic assessment of environmental implications is required.</P> <P><B>Highlights</B></P> <P> <UL> <LI> High ionic strength of flowback water reduced mobility of metalloids. </LI> <LI> Relatively high bioaccessibility of metalloids in spite of low mobility </LI> <LI> Soil toxicity moderately increased after 1-month aging with flowback water. </LI> <LI> Soil dehydrogenase activity was affected by PAM in flowback water. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Zero-valent iron for the abatement of arsenate and selenate from flowback water of hydraulic fracturing

Sun, Yuqing,Chen, Season S.,Tsang, Daniel C.W.,Graham, Nigel J.D.,Ok, Yong Sik,Feng, Yujie,Li, Xiang-Dong Elsevier 2017 CHEMOSPHERE - Vol.167 No.-

<P><B>Abstract</B></P> <P>Zero-valent iron (ZVI) was tested for the removal of 150 μg L<SUP>−1</SUP> As(V) and 350 μg L<SUP>−1</SUP> Se(VI) in high-salinity (ionic strength 0.35–4.10 M) flowback water of hydraulic fracturing. Over 90% As(V) and Se(VI) was removed by 2.5 g L<SUP>−1</SUP> ZVI in Day-14 flowback water up to 96-h reaction, with the remaining concentration below the maximum contaminant level for As(V) and criterion continuous concentration for Se(VI) recommended by US EPA. The kinetics of As(V) and Se(VI) removal followed a pseudo-second-order rate expression with the observed rates of 4.51 × 10<SUP>−2</SUP>–4.91 × 10<SUP>−1</SUP> and 3.48 × 10<SUP>−2</SUP>–6.58 × 10<SUP>−1</SUP> h<SUP>−1</SUP> (with 0.5–10 g L<SUP>−1</SUP> ZVI), respectively. The results showed that Se(VI) removal significantly decreased with increasing ionic strength, while As(V) removal showed little variation. Common competing anions (nitrate, bicarbonate, silicate, and phosphate), present in shallow groundwater and stormwater, caused marginal Se(VI) desorption (2.42 ± 0.13%) and undetectable As(V) desorption from ZVI. The competition between As(V) and Se(VI) for ZVI removal depended on the initial molar ratio and surface sites, which occurred when the Se(VI) concentration was higher than the As(V) concentration in this study. The characterization of As(V)- and Se(VI)-loaded ZVI by X-ray diffraction and Raman analysis revealed that ZVI gradually converted to magnetite/maghemite corrosion products with lepidocrocite in flowback water over 30 days. Similar corrosion compositions were confirmed in aerobic and anaerobic conditions regardless of the molar ratio of As(V) to Se(VI). The high reactivity and stability of ZVI showed its suitability for <I>in-situ</I> prevention of As(V) and Se(VI) migration due to accidental leakage, spillage, or overflow of flowback water.</P> <P><B>Highlights</B></P> <P> <UL> <LI> As(V) and Se(VI) in high-salinity flowback water was effectively removed by ZVI. </LI> <LI> As(V) removal was less susceptible to ionic strength variations than Se(V). </LI> <LI> Competing anions in groundwater and stormwater caused insignificant desorption. </LI> <LI> As(V) and Se(VI) competition depended on their molar ratio and ZVI surface sites. </LI> <LI> Surface characteristics of ZVI were unaffected by molar ratio and dissolved oxygen. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

SERS study of surface plasmon resonance induced carrier movement in Au@Cu₂O core-shell nanoparticles

Chen, Lei,Zhang, Fan,Deng, Xin-Yu,Xue, Xiangxin,Wang, Li,Sun, Yantao,Feng, Jing-Dong,Zhang, Yongjun,Wang, Yaxin,Jung, Young Mee Elsevier 2018 Spectrochimica acta. Part A, Molecular and biomole Vol.189 No.-

<P><B>Abstract</B></P> <P>A plasmon induced carrier movement enhanced mechanism of surface-enhanced Raman scattering (SERS) was investigated using a charge-transfer (CT) enhancement mechanism. Here, we designed a strategy to study SERS in Au@Cu<SUB>2</SUB>O nanoshell nanoparticles with different shell thicknesses. Among the plasmonically coupled nanostructures, Au spheres with Cu<SUB>2</SUB>O shells have been of special interest due to their ultrastrong electromagnetic fields and controllable carrier transfer properties, which are useful for SERS. Au@Cu<SUB>2</SUB>O nanoshell nanoparticles (NPs) with shell thicknesses of 48–56nm are synthesized that exhibit high SERS activity. This high activity originates from plasmonic-induced carrier transfer from Au@Cu<SUB>2</SUB>O to 4-mercaptobenzoic acid (MBA). The CT transition from the valence band (VB) of Cu<SUB>2</SUB>O to the second excited π-π* transition of MBA, and is of b<SUB>2</SUB> electronic symmetry, which was enhanced significantly. The Herzberg-Teller selection rules were employed to predict the observed enhanced b<SUB>2</SUB> symmetry modes. The system constructed in this study combines the long-range electromagnetic effect of Au NPs, localized surface plasmon resonance (LSPR) of the Au@Cu<SUB>2</SUB>O nanoshell, and the CT contribution to assist in understanding the SERS mechanism based on LSPR-induced carrier movement in metal/semiconductor nanocomposites.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We designed a shell-dependent Au@Cu<SUB>2</SUB>O nanoshell for SERS study. </LI> <LI> SERS contribution enables us to understand the possible enhancement of hybrid nanostructures. </LI> <LI> LSPR-induced carrier movement in Au@Cu<SUB>2</SUB>O nanocomposites. </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>We designed the shell-dependent Au@Cu<SUB>2</SUB>O core-shell nanoparticles (NPs) for SERS study. For the electron-hole pairs in the Cu<SUB>2</SUB>O, the plasmon induced resonant energy transfer from Au to the Cu<SUB>2</SUB>O and the direct electron transfer simultaneously which can be observed from the SERS intensity.</P> <P>[DISPLAY OMISSION]</P>

Cordblood-Based High-Throughput Screening for Deafness Gene of 646 Newborns in Jinan Area of China

Shou-Xia Li,Ding-Li Chen,Su-Bin Zhao,Li-Li Guo,Hai-Qin Feng,Xiao-Fang Zhang,Li-Li Ping,Zhi-Ming Yang,Cai-Xia Sun,Gen-Dong Yao 대한이비인후과학회 2015 Clinical and Experimental Otorhinolaryngology Vol.8 No.3

Objectives. Infants with slight/mild or late-onset hearing impairment might be missed in universal newborn hearing screening (UNHS). We identified the mutation hot spot of common deaf gene in the newborns in Jinan area population by screening the mutation spot with neonate cord blood, in order to make clear whether the neonate cord blood for screening is feasible. Methods. Six hundred and forty-six newborns were subjected to both UNHS and genetic screening for deafness by using neonate cord blood. The newborn genetic screening targeted four deafness-associated genes, which were commonly found in the Chinese population including gap junction beta-2 protein (GJB2), gap junction beta-3 protein (GJB3), solute carrier family 26 member 4 (SLC26A4), and mtDNA 12S rRNA. The most common 20 spot mutations in 4 deaf genes were detected by MassARRAY iPLEX platform and mitochondrial 12S rRNA A1555G and C1494T mutations were sequenced using Sanger sequencing. Results. Among the 646 newborns, 635 cases passed the UNHS and the other 11 cases (1.7%) did not. Of the 11 failures, two cases were found to carry homozygous GJB2 p.R143W pathogenic mutation, one case was found to have heterozygous GJB2 235delC mutation, and another one case carried heterozygous GJB3 p.R180X pathogenic mutation. Six hundred and thirty-five babies passed the newborn hearing screening, in which 25 babies were identified to carry pathogenic mutations, including 12 heterozygotes (1.9%) for GJB2 235delC, eight heterozygotes (1.3%) for SLC26A4 IVS7-2A>G, one heterozygote (0.2%) for p.R409H, two homozygotes (0.3%) for m.1494C>T, and two homozygotes (0.3%) for m.1555A>G. Conclusion. Newborn genetic screening through the umbilical cord blood for common deafness-associated mutations may identify carriers sensitive to aminoglycoside antibiotic, and can effectively prevent or delay hearing loss occurs.

Aging effects on chemical transformation and metal(loid) removal by entrapped nanoscale zero-valent iron for hydraulic fracturing wastewater treatment

Sun, Yuqing,Lei, Cheng,Khan, Eakalak,Chen, Season S.,Tsang, Daniel C.W.,Ok, Yong Sik,Lin, Daohui,Feng, Yujie,Li, Xiang-dong Elsevier 2018 Science of the Total Environment Vol.615 No.-

<P><B>Abstract</B></P> <P>In this study, alginate and polyvinyl alcohol (PVA)-alginate entrapped nanoscale zero-valent iron (nZVI) was tested for structural evolution, chemical transformation, and metals/metalloids removal (Cu(II), Cr(VI), Zn(II), and As(V)) after 1–2month passivation in model saline wastewaters from hydraulic fracturing. X-ray diffraction analysis confirmed successful prevention of Fe<SUP>0</SUP> corrosion by polymeric entrapment. Increasing ionic strength (<I>I</I>) from 0 to 4.10M (deionized water to Day-90 fracturing wastewater (FWW)) with prolonged aging time induced chemical instability of alginate due to dissociation of carboxyl groups and competition for hydrogen bonding with nZVI, which caused high Na (7.17%) and total organic carbon (24.6%) dissolution from PVA-alginate entrapped nZVI after 2-month immersion in Day-90 FWW. Compared to freshly-made beads, 2-month aging of PVA-alginate entrapped nZVI in Day-90 FWW promoted Cu(II) and Cr(VI) uptake in terms of the highest removal efficiency (84.2% and 70.8%), pseudo-second-order surface area-normalized rate coefficient <I>k</I> <SUB> <I>sa</I> </SUB> (2.09×10<SUP>−1</SUP> Lm<SUP>−2</SUP> h<SUP>−1</SUP> and 1.84×10<SUP>−1</SUP> Lm<SUP>−2</SUP> h<SUP>−1</SUP>), and Fe dissolution after 8-h reaction (13.9% and 8.45%). However, the same conditions inhibited Zn(II) and As(V) sequestration in terms of the lowest removal efficiency (31.2% and 39.8%) by PVA-alginate nZVI and <I>k</I> <SUB> <I>sa</I> </SUB> (4.74×10<SUP>−2</SUP> Lm<SUP>−2</SUP> h<SUP>−1</SUP> and 6.15×10<SUP>−2</SUP> Lm<SUP>−2</SUP> h<SUP>−1</SUP>) by alginate nZVI. The X-ray spectroscopic analysis and chemical speciation modelling demonstrated that the difference in metals/metalloids removal by entrapped nZVI after aging was attributed to distinctive removal mechanisms: (i) enhanced Cu(II) and Cr(VI) removal by nZVI reduction with accelerated electron transfer after pronounced dissolution of non-conductive polymeric immobilization matrix; (ii) suppressed Zn(II) and As(V) removal by nZVI adsorption due to restrained mass transfer after blockage of surface-active micropores. Entrapped nZVI was chemically fragile and should be properly stored and regularly replaced for good performance.</P> <P><B>Highlights</B></P> <P> <UL> <LI> nZVI entrapment successfully prevented Fe<SUP>0</SUP> corrosion in fracturing wastewaters. </LI> <LI> Entrapped nZVI was chemically fragile due to dissolution of Na and TOC. </LI> <LI> nZVI passivation promoted Cu(II) and Cr(VI) but inhibited Zn(II) and As(V) removal. </LI> <LI> Effects of nZVI aging on removal efficiency depended on interaction mechanisms. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Reconsidering the Hierarchy and Translation of “Physical Education/Sports” Related Terms: Taiwan Perspective

Jeffrey Yu,Jun Lian,Ruei-Hong Li,Chen-Sin Hung,Dong-Tai Chen,Yu-Kai Chang 대한운동학회 2024 아시아 운동학 학술지 Vol.26 No.1

Objectives In the past centuries, the concept of “physical education” has changed from a more general concepts including physical activities and sports, to specifically inferring “instruction of physical activity”. Instead, “sports” has become the comprehensive concept of sports, exercise, and physical education. Given to the inconsistent terminologies and English translations of “體育 (ti-yu)” (physical education) and “運 動 (yun-dong)” (sports or exercise) in Mandarin, the purpose of this study was to investigate in the current terminology usage, hierarchy, and the English translation of “體育 (ti-yu)” and “運動 (yun-dong)” in Taiwan. Met hods Three government authorities, two sport related universities, eight top sport and exercise journals, and nighty-six college departments in Taiwan were analyzed. Results “運動 (yun-dong)” was the most widely used terminology as “體育 (ti-yu)” occupied the majority usage among government authorities, sport related universities, and title of top sport and exercise journals. Regarding English translation, despite of “department of physical education”, “sports” remained the most common terminology. Moreover, “體育 (ti-yu)” and “sports” are the highest hierarchy among government authorities, and sport related university; “體育 (ti-yu)” and “physical education” are the highest hierarchy among traditional sport and exercise journals; “運動 (yun-dong)” and “sports” are the highest hierarchy among college departments also the mainstream of current translation and hierarchy. Conclusions “體育 (ti-yu)” was the highest hierarchy in the past. However, “運動 (yun-dong)” has been the mainstream of the highest hierarchy in Mandarin according to college departments. In English, “sport(s)” is the main term in Taiwan when translating “體育 (ti-yu)” and 運動 (yun-dong)”, also being the highest hierarchy. On the other hand, “體育 (ti-yu)” and “physical education” are utilized regarding those departments focusing on educating PE teachers. This study expects the terminology, English translations, and hierarchy being align with the mainstream of current translation and hierarchy in the future.

Nanoscale zero-valent iron for metal/metalloid removal from model hydraulic fracturing wastewater

Sun, Yuqing,Lei, Cheng,Khan, Eakalak,Chen, Season S.,Tsang, Daniel C.W.,Ok, Yong Sik,Lin, Daohui,Feng, Yujie,Li, Xiang-dong Elsevier 2017 CHEMOSPHERE - Vol.176 No.-

<P><B>Abstract</B></P> <P>Nanoscale zero-valent iron (nZVI) was tested for the removal of Cu(II), Zn(II), Cr(VI), and As(V) in model saline wastewaters from hydraulic fracturing. Increasing ionic strength (<I>I</I>) from 0.35 to 4.10 M (Day-1 to Day-90 wastewaters) increased Cu(II) removal (25.4–80.0%), inhibited Zn(II) removal (58.7–42.9%), slightly increased and then reduced Cr(VI) removal (65.7–44.1%), and almost unaffected As(V) removal (66.7–75.1%) by 8-h reaction with nZVI at 1–2 g L<SUP>−1</SUP>. The removal kinetics conformed to pseudo-second-order model, and increasing <I>I</I> decreased the surface area-normalized rate coefficient (<I>k</I> <SUB> <I>sa</I> </SUB>) of Cu(II) and Cr(VI), probably because agglomeration of nZVI in saline wastewaters restricted diffusion of metal(loid)s to active surface sites. Increasing <I>I</I> induced severe Fe dissolution from 0.37 to 0.77% in DIW to 4.87–13.0% in Day-90 wastewater; and Fe dissolution showed a significant positive correlation with Cu(II) removal. With surface stabilization by alginate and polyvinyl alcohol, the performance of entrapped nZVI in Day-90 wastewater was improved for Zn(II) and Cr(VI), and Fe dissolution was restrained (3.20–7.36%). The X-ray spectroscopic analysis and chemical speciation modelling demonstrated that the difference in removal trends from Day-1 to Day-90 wastewaters was attributed to: (i) distinctive removal mechanisms of Cu(II) and Cr(VI) (adsorption, (co-)precipitation, and reduction), compared to Zn(II) (adsorption) and As(V) (bidentate inner-sphere complexation); and (ii) changes in solution speciation (e.g., from Zn<SUP>2+</SUP> to ZnCl<SUB>3</SUB> <SUP>−</SUP> and ZnCl<SUB>4</SUB> <SUP>2−</SUP>; from CrO<SUB>4</SUB> <SUP>2−</SUP> to CaCrO<SUB>4</SUB> complex). Bare nZVI was susceptible to variations in wastewater chemistry while entrapped nZVI was more stable and environmentally benign, which could be used to remove metals/metalloids before subsequent treatment for reuse/disposal.</P> <P><B>Highlights</B></P> <P> <UL> <LI> nZVI could remove Cu(II), Zn(II), Cr(VI), and As(V) from fracturing wastewaters. </LI> <LI> High salinity enhanced Fe dissolution and reduced removal rates except Cu(II). </LI> <LI> nZVI entrapment mitigated Fe dissolution and improved metal(loid) removal. </LI> <LI> Removal efficiency varied with interaction mechanisms and solution speciation. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>