Relation between the local structure and solid solubility of the layered material LiMO2 (M=Co, Ni, Fe) in Li2MnO3

Chen Hou,Xiang Xiao,Yi-Ran Xing,Le-Le Yu,Yong-Heng Si,Han Lu,Yu-Juan Zhao 대한금속·재료학회 2022 ELECTRONIC MATERIALS LETTERS Vol.18 No.1

Although low solid solubility and activity of LiFeO2in xLi2MnO3·(1–x)LiFeO2 limit its practical application, it still has thepotential to become a new-generation cathode material without cobalt or nickel for Li-ion batteries. In order to understand theeffects of the local structures of different LiMO2(M = Co, Ni, Fe) layered materials on their solid solubility in Li2MnO3,partialdensities of states are calculated to determine the Jahn–Teller distortion in the layered cathode material, and the first-principlescalculation method based on density functional theory is used to optimize and compare the local structures of LiCoO2,LiNiO2,LiFeO2,LiMnO2,and Li2MnO3. The degrees of distortion of the transition metal–oxygen (M–O) and lithium–oxygen (Li–O)octahedra in the crystal structure of the material are evaluated. It is clear that the solid solubility of layered materials is relatedto the bond lengths and degrees of distortion of the M–O and Li–O octahedra. Among them, the similar bond length of LiNiO2and Li2MnO3and the high distortion of NiO6enhance the solid solubility of LiNiO2in Li2MnO3. Owing to the absence ofJahn–Teller distortion in LiFeO2and LiCoO2,the FeO6and CoO6octahedra are slightly distorted, thereby decreasing thesolid solubility of LiMO2(M = Fe, Co) in Li2MnO3. Understanding the relation between intra-octahedral distortion and solidsolubility provides simple and efficient evidence for comparing the solid solubilities of different LiMO2layered materials inthe Li2MnO3of Li-rich cathode materials. This study can be used as a reference for component design in Li-rich materials.

Amorphous copper tungsten oxide with tunable band gaps

Chen, Le,Shet, Sudhakar,Tang, Houwen,Ahn, Kwang-soon,Wang, Heli,Yan, Yanfa,Turner, John,Al-Jassim, Mowafak American Institute of Physics 2010 JOURNAL OF APPLIED PHYSICS - Vol.108 No.4

Prediction of Chemotherapeutic Response in Unresectable Non-small-cell Lung Cancer (NSCLC) Patients by 3-(4,5-Dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) Assay

Chen, Juan,Cheng, Guo-Hua,Chen, Li-Pai,Pang, Ting-Yuan,Wang, Xiao-Le Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5

Background: Selecting chemotherapy regimens guided by chemosensitivity tests can provide individualized therapies for cancer patients. The 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2Htetrazolium, inner salt (MTS) assay is one in vitro assay which has become widely used to evaluate the sensitivity to anticancer agents. The aim of this study was to evaluate the clinical applicability and accuracy of MTS assay for predicting chemotherapeutic response in unresectable NSCLC patients. Methods: Cancer cells were isolated from malignant pleural effusions of patients by density gradient centrifugation, and their sensitivity to eight chemotherapeutic agents was examined by MTS assay and compared with clinical response. Results: A total of 37 patients participated in this study, and MTS assay produced results successfully in 34 patients (91.9%). The sensitivity rates ranged from 8.8% to 88.2%. Twenty-four of 34 patients who received chemotherapy were evaluated for in vitro-in vivo response analysis. The correlation between in vitro chemosensitivity result and in vivo response was highly significant (P=0.003), and the total predictive accuracy, sensitivity, specificity, positive predictive value, and negative predictive value for MTS assay were 87.5%, 94.1%, 71.4%, 88.9%, and 83.3%, respectively. The in vitro sensitivity for CDDP also showed a significant correlation with in vivo response (P=0.018, r=0.522). Conclusion: MTS assay is a preferable in vitro chemosensitivity assay that could be use to predict the response to chemotherapy and select the appropriate chemotherapy regimens for unresectable NSCLC patients, which could greatly improve therapeutic efficacy and reduce unnecessary adverse effects.

Effect of fiber type and content on properties of high-strength fiber reinforced self-consolidating concrete

Bui Le Anh Tuan,Mewael Gebregirogis Tesfamariam,Chao-Lung Hwang,Chun-Tsun Chen,Yuan-Yuan Chen,Kae-Long Lin 사단법인 한국계산역학회 2014 Computers and Concrete, An International Journal Vol.14 No.3

Effects of polypropylene (PP) fibers, steel fibers (SF) and hybrid on the properties of high-strength fiber reinforced self-consolidating concrete (HSFR-SCC) under different volume contents are investigated in this study. Comprehensive laboratory tests were conducted in order to evaluate both fresh and hardened properties of HSFR-SCC. Test results indicated that the fiber types and fiber contents greatly influenced concrete workability but it is possible to achieve self consolidating properties while adding the fiber types in concrete mixtures. Compressive strength, dynamic modulus of elasticity, and rigidity of concrete were affected by the addition as well as volume fraction of PP fibers. However, the properties of concrete were improved by the incorporation of SF. Splitting tensile and flexural strengths of concrete became increasingly less influenced by the inclusion of PP fibers and increasingly more influenced by the addition of SF. Besides, the inclusion of PP fibers resulted in the better efficiency in the improvement of toughness than SF. Furthermore, the inclusion of fibers did not have significant effect on the durability of the concrete. Results of electrical resistivity, chloride ion penetration and ultrasonic pulse velocity tests confirmed that HSFR-SCC had enough endurance against deterioration, lower chloride ion penetrability and minimum reinforcement corrosion rate.

Meta-Analysis of the Association between the rs8034191 Polymorphism in AGPHD1 and Lung Cancer Risk

Zhang, Le,Jin, Tian-Bo,Gao, Ya,Wang, Hui-Juan,Yang, Hua,Feng, Tian,Chen, Chen,Kang, Long-Li,Chen, Chao Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.7

Background: Possible associations between the single nucleotide polymorphism (SNP) rs8034191 in the aminoglycosidephosphotransferase domain containing 1 (AGPHD1) gene and lung cancer risk have been studied by many researchers but the results have been contradictory. Materials and Methods: A computerized search for publications on rs8034191 and lung cancer risk was performed. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the association between rs8034191 and lung cancer risk with 13 selected case-control studies. Sensitivity analysis, test of heterogeneity, cumulative meta-analysis, and assessment of bias were also performed. Results: A significant association between rs8034191 and lung cancer susceptibility was found using the dominant genetic model (OR=1.344, 95% CI: 1.285-1.406), the additive genetic model (OR=1.613, 95% CI: 1.503-1.730), and the recessive genetic model (OR=1.408, 95% CI: 1.319-1.503). Moreover, an increased lung cancer risk was found with all genetic models after stratification of ethnicity. Conclusions: The association between rs8034191 and lung cancer risk was significant using multiple genetic models, suggesting that rs8034191 is a risk factor for lung cancer. Further functional studies of this polymorphism and lung cancer risk are warranted.

Sodium tanshinone IIA sulfonate depresses angiotensin IIinducedcardiomyocyte hypertrophy through MEK/ERKpathway

Le Yang,Xiaojing Zou,Qiansheng Liang,Hao Chen,Jun Feng,Li Yan,Zhaohua Wang,Daixing Zhou,Shusheng Li,Shanglong Yao,Zhi Zheng 생화학분자생물학회 2007 Experimental and molecular medicine Vol.39 No.1

Cardiomyocyte hypertrophy is a major cause of morbidity and mortality worldwide. The aim of this study is to determine the effects of sodium tans - hinone IIA sulfonate (STS) on cardiomyocyte hypertrophy induced by angiotensin II (Ang II) in vivo and in vitro. In long-term treatment, adult Wistar rats were infused with Ang II for three weeks via osmotic mini-pumps and some of them were given intragas - trically of STS. Left ventricle was isolated; the ratio of left ventricular weight to body weight and systolic blood pressure (SBP) were determined and heart morphometry was assessed after hematoxylin and eosin staining. Results indicated STS inhibited Ang II-induced increases in myocyte diameter and decreased the LVW/BW ratio independent of decreasing systolic blood pressure. In vitro, treatment of cultured cardiomyocytes with STS inhibited Ang II-induced increase in cell size, protein synthesis, ANP expression, activation of extracellular signalregulated kinase (ERK) and ERK kinase (MEK). Then we reexamined the mechanism of STS-induced antihypertrophic effects. Results revealed MEK inhibitor U0126 (20 µM) markedly enhanced STS-induced depressions in [3H]leucine incorporation and ANP expression. In conclusion, MEK/ERK pathway plays a significant role in the anti-hypertrophic effects of STS.

Guaranteed-performance Consensualization for High-order Multi-agent Systems with Intermittent Communications

Le Wang,Qing Chen,Jianxiang Xi,Guangbin Liu 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.5

The current paper studies the guaranteed-performance consensualization for general high-order multiagentsystems with intermittent communications. Firstly, a new consensus protocol is constructed by using only intermittentlocal information, and the corresponding performance function is given to guarantee the consensus regulationperformance among neighboring agents. Then, linear matrix inequality conditions for guaranteed-performanceconsensus and consensualization are respectively provided and a guaranteed-performance cost of multi-agent systemsis determined meanwhile. Furthermore, the whole motion mode of the multi-agent system can be described byderiving a precise expression of the consensus function. If the nominal converge rate is larger than a positive threshold,then multi-agent systems can achieve guaranteed-performance consensus by determining the gain matrix whenintermittent communications are involved, and the performance function is less than the guaranteed-performancecost. Finally, a simulation example is shown to demonstrate the effectiveness of the proposed theorems.

Exploring the Impact of Surface Roughness on Tribological Properties at Micro and Macro Scales

Chen Wang,Wenli Wang,Kai Le,Shusheng Xu,Weimin Liu 한국표면공학회 2023 한국표면공학회 학술발표회 초록집 Vol.2023 No.11-1

Positive enhancement of Lactobacillus fermentum HY01 on intestinal movements of mice having constipation

Chen, Xiaoyong,Song, Jia-Le,Hu, Qiang,Wang, Hongwei,Zhao, Xin,Suo, Huayi The Korean Society for Applied Biological Chemistr 2018 Applied Biological Chemistry (Appl Biol Chem) Vol.61 No.1

Lactobacilli have been used to treat many gastrointestinal disorders. But the outcome of Lactobacilli are strain specific. The strain Lactobacillus Fermentum, HY01, (LF-HY01) has a good performance in the environment of gastrointestinal tract. In this study, the aim is to investigate the preventive effects of LF-HY01 against activated-carbon-induced constipation in mice. Mice are randomized into four groups. Normal group was fed a normal diet, model group also has the same with activated carbon treatment, and low and high concentration groups are treated with LF-HY01. We have determined many indexes such as body weight, water content in faeces, defecation conditions, the level of small intestinal villi damages and levels of various neurotransmitters in serum, including motilin (MTL), gastrin (GT), endothelin (ET), somatostatin (SST), acetylcholinesterase (AchE), substance P (SP), and vasoactive intestinal peptide (VIP). LF-HY01 has no significant difference in each group, but it can significantly improve water content of faeces, defecation time of first black stool and activated carbon propelling rate in small intestine as compared of model group. Furthermore, LF-HY01 can effectively prevent small intestinal villi damages, which is less than that of model group. Moreover, LF-HY01 has the consistency to increase the levels of MTL, GT, ET, AchE, SP and VIP, and LF-HY01 can also have the ability to reduce the level of SST. These results suggest that Lactobacillus Fermentum, HY01, has a great impact in enhancing intestinal peristalsis ability and has the ability to prevent from activated-carbon-induced constipation in mice.

Experimental Investigation on Fatigue Behavior of Steel Reinforced Concrete Composite Beam-to-Girder Joints

Le-Wei Tong,Qingjun Xian,Liying Zhou,Yiyi Chen,Yunfeng Zhang 한국강구조학회 2012 International Journal of Steel Structures Vol.12 No.4

Fatigue behavior and failure mechanism of steel reinforced concrete (SRC) beam-to-girder joints is discussed in this paper,which is intended for use in high-speed railway station structures due to their high stiffness and load capacity. Three identical SRC beam-to-girder joint specimens were designed and tested under static loading and two stages of fatigue loading. In the first stage of fatigue loading, the specimens were subjected to design fatigue load for 2 million cycles, while during the second stage, the specimens were loaded to failure under increased fatigue loading amplitude in order to know its fatigue strength and failure mechanism. The constructional details of SRC beam-to-girder joint specimen and the method of loading and testing are presented. The comparison in structural behavior of the joint is made between under static and fatigue loading. Fatigue failure characteristics of the joint are described in detail. It is found that the SRC beam-to-girder joints remained in their elastic range and the concrete surface crack did not exceed 0.1 mm when subjected to design static loading and 2 million cycles of design fatigue loading. There was no significant difference in structural behavior of each component of SRC composite beam between static and fatigue loading. Fatigue failure occurred after these joints were applied higher-level fatigue loading for another 0.70to 0.91 million cycles. Fatigue crack was initiated at the tension flange of I-shape steel of beam connected by welding to the flange of I-shape steel of girder or at the hole in tension flange of I-shape steel of beam, and then the crack propagated along flange width and web height of the I-shape steel in beam until the I-shape steel lost loading capacity due to lack of enough cross section. The fatigue behavior of constructional detail of the I-shape steel played a key role in the fatigue strength of the SRC beam-to-girder joints. Discussions on improving the fatigue strength of SRC beam-to-girder joints and future research aspects are presented finally.