RISS 학술연구정보서비스

검색
다국어 입력

http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.

변환된 중국어를 복사하여 사용하시면 됩니다.

예시)
  • 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
  • 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
닫기
    인기검색어 순위 펼치기

    RISS 인기검색어

      검색결과 좁혀 보기

      • 좁혀본 항목

      • 좁혀본 항목 보기순서

        • 원문유무
        • 음성지원유무
          • 원문제공처
          • 등재정보
          • 학술지명
          • 주제분류
          • 발행연도
          • 작성언어
          • 저자

        오늘 본 자료

        • 오늘 본 자료가 없습니다.
        더보기
        • 무료
        • 기관 내 무료
        • 유료
        • SCIESCOPUSKCI등재

          Discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins

          Liu, Juan,Xu, Yangrong,Yang, Jingjing,Wang, Wenzhi,Zhang, Jianqiang,Zhang, Renmei,Meng, Qingguo The Korean Society of Ginseng 2017 Journal of Ginseng Research Vol.41 No.3

          Ocotillol-type saponins are one kind of tetracyclic triterpenoids, sharing a tetrahydrofuran ring. Natural ocotillol-type saponins have been discovered in Panax quinquefolius L., Panax japonicus, Hana mina, and Vietnamese ginseng. In recent years, the semisynthesis of 20(S/R)-ocotillol-type saponins has been reported. The biological activities of ocotillol-type saponins include neuroprotective effect, antimyocardial ischemia, antiinflammatory, antibacterial, and antitumor activities. Owing to their chemical structure, pharmacological actions, and the stereoselective activity on antimyocardial ischemia, ocotillol-type saponins are subjected to extensive consideration. In this review, we sum up the discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins.

        • KCI등재

          The discovery of potent immunostimulatory CpG-ODNs widely distributed in bacterial genomes

          Juan Liu,Yan Wei,Yongling Lu,Yangyuling Li,Qian Chen,Yan Li 한국미생물학회 2020 The journal of microbiology Vol.58 No.2

          Oligodeoxynucleotides containing unmethylated CpG dinucleotides (CpG-ODN) can be specifically recognized by Toll-like receptor 9 (TLR9), provoking innate immune responses. Designed according to this structural feature, many synthetic phosphorothioate CpG-ODNs successfully activate macrophages. However, it is difficult to find potent stimulatory CpG-DNA fragments in microbial genomes. Therefore, whether microbial CpG-DNA substantially contributes to infectious and immune diseases remains controversial. In this study, high-throughput scanning was carried out for thousands of bacterial genomes with bioinformatics tools to comprehensively evaluate the distribution of CpG-DNA fragments. A random sampling test was then performed to verify their immunostimulatory properties by experiments in vitro and in vivo. Natural TLR9-dependent and potent stimulatory CpG-DNA fragments were found in microbial genomes. Interestingly, highly conserved stimulatory CpG-DNA fragments were found in 16S and 23S rDNA sequences with multiple copies, while others were species-specific. Additionally, we found that the reported active motifs were mostly nonstimulatory in natural CpG fragments. This evidence indicates that the previous structural descriptions of functional CpG-ODNs are incomplete. Our study has assessed the distribution of microbial CpG-DNA fragments, and identified natural stimulatory CpG-DNA fragments. These findings provide a deeper understanding of CpG-ODN structures and new evidence for microbial DNA inflammatory function and pathogenicity.

        • KCI등재

          An Anacardic acid Analog from the Jellyfish-derived Fungus Paecilomyces variotii

          ( Juan Liu ),( Famei Li ),( Yoon Mi Lee ),( Jian Lin Li ),( Jongki Hong ),( Won Duk Yoon ),( Eui Kyung Kim ),( Jee H Jung ) 한국생약학회 2012 Natural Product Sciences Vol.18 No.1

          An anacardic acid analog (1) was isolated from the fungus Paecilomyces variotii which was derived from the giant jellyfish Nemopilema nomurai. Compound 1 was isolated from a natural source for the first time and was evaluated for antibacterial activity against human and marine pathogens, including MDR (multidrug-resistant) strains. Compound 1 exhibited mild antibacterial activity against Escherichia coli DC 2, Streptococcus iniae, and methicillin-resistant Staphylococcus aureus 3089 (MRSA).

        • SCOPUSKCI등재

          Articles : Viriditoxin, from a Jellyfish-derived Fungus, is Antibiotic to Fish Pathogens

          ( Juan Liu ),( Fa Mei Li ),( Eun La Kim ),( Jong Ki Hong ),( Jee H. Jung ) 한국생약학회 2013 Natural Product Sciences Vol.19 No.1

          A bioassay-guided fractionation of the extract of the fungus Paecilomyces variotii, which was derived from the giant jellyfish Nemopilema nomurai, led to the isolation of antibacterial compounds viriditoxin and its monomeric subunit semi-viriditoxin. Viriditoxin showed significant antibacterial activity against several marine fish and human pathogens including MDR strains. Significant potencies against resistant pathogens such as VRE Enterococcus faecium, VRE Enterococcus faecalis, and MRSA were highly interesting. Viriditoxin also showed notable antibacterial activity against the fish pathogen Streptococcus iniae. Its potency was over 100-fold higher than oxytetracycline which is employed as a general antibiotic for aquaculture.

        • SCISCIESCOPUS

          A Ringed Dwarf LINER 1 Galaxy Hosting an Intermediate-mass Black Hole with Large-scale Rotation-like ${\rm{H}}\alpha $ Emission

          Liu, Wen-Juan,Qian, Lei,Dong, Xiao-Bo,Jiang, Ning,Lira, Paulina,Cai, Zheng,Wang, Feige,Yang, Jinyi,Xiao, Ting,Kim, Minjin American Astronomical Society 2017 The Astrophysical journal Vol.837 No.2

          <P>We report the discovery of a 20 kpc sized H alpha emission in SDSS J083803.68+540642.0, a ringed dwarf galaxy (M-V = -17.89 mag) hosting an accreting intermediate-mass black hole at z = 0.02957. Analysis of the Hubble Space Telescope images indicates that it is an early-type galaxy with a featureless low-surface brightness disk (mu(0) = 20.39 mag arcsec(-2) in the V band) and a prominent, relatively red bulge (V - I = 2.03, R-e = 0.28 kpc or 0 48) that accounts for approximate to 81% of the total light in the I band. A circumgalactic ring of a diameter 16 kpc is also detected, with a disperse shape on its south side. The optical emission lines reveal the nucleus to be a broad-line LINER. Our MMT longslit observation indicates that the kinematics of the extended H alpha emission is consistent with a rotational gaseous disk, with a mean blueshifted velocity of 162 km s(-1) and mean redshifted velocity of 86 km s(-1). According to our photoionization calculations, the large-scale H alpha emission is unlikely to be powered by the central nucleus or by hot evolved (post-AGB) stars interspersed in the old stellar populations, but by in situ star formation; this is vindicated by the line-ratio diagnostic of the extended emission. We propose that both the ring and large-scale H alpha-emitting gas are created by the tidal accretion in a collision-and then merger-with a gas-rich galaxy of a comparable mass.</P>

        • KCI등재

          Study on the Recycling of Nuclear Graphite after Micro-Oxidation

          Juan Liu,Chen Wang,Limin Dong,Tongxiang Liang 한국원자력학회 2016 Nuclear Engineering and Technology Vol.48 No.1

          In this paper, a feasible strategy for the recycling of nuclear graphite is reported, based onthe formation mechanism and the removal of carbon-14 by micro-oxidation. We investigatedwhether ground micro-oxidation graphite could be used as a filler to make newrecycled graphite and which graphite/pitch coke ratio will give the recycled graphiteoutstanding properties (e.g., apparent density, flexural strength, compressive strength,and tensile strength). According to the existing properties of nuclear graphite, the ratio ofgraphite to pitch coke should not exceed 3. The recycled reactor graphite has been provensuperior in density, strength, and thermal conductivity. The micro-oxidation processenhances the strength of the recycled graphite because there are more pores andunsmooth surfaces on the oxidized graphite particles, which is beneficial for the access ofthe pitch binder and leads to efficient joint adhesion among the graphite particles.

        • Influence of Swirl Injector Diameter on the Process of Conical Sheet Breakup

          ( Juan Liu ),( Qing Lian Li ),( Wei Dong Liu ),( Zhen Guo Wang ) 한국액체미립화학회 2010 한국액체미립화학회 학술강연회 논문집 Vol.2010 No.-

          High-speed shadowgraph was used to capture the process of conical liquid sheet ejected from the central hole in coaxial swirl injector of gas generator; and the impact of injector diameter was especially analyzed. With the increasing of injector diameter, breakup length shortens and the cone angle becomes larger. For this kind of injector, the breakup lengths are around 50mm and the cone angles are less than 60 degree though the pressure drop exceeds 3.0 MPa. The experimental cone angles were far less than the therotical formula when compared with Abromvich and Lefebvre`s result, while they have the same trend that cone angle increases with injector`s characteristic parameter A. The understanding of conical sheet breakup is beneficial to master the atomization character of coaxial swirl injector.

        • Normal Estimation for Mass Point Clouds of Irregular Model in the 3D Reconstruction based on Fuzzy Inference

          Liu Yan-ju,Jiang Jin-gang,Miao Feng-juan,Tao Bai-rui,Zhang Hong-lie 보안공학연구지원센터 2014 International Journal of Grid and Distributed Comp Vol.7 No.5

          This paper presents a fuzzy normal estimate for mass point clouds of irregular models in reconstruction. The irregular model is complex object that some part is smooth and some parts are irregular including sharp features. Therefore, we put kNN and curvature of mass point clouds to fuzzy inference system to divide the kind of point clouds and the output of FIS can determine which part of tooth point clouds belong to. For different kinds point clouds, corresponding algorithm is given. Point clouds in the smooth area are estimated normal by PCA directly and ones in other regions of thin or sharp area are estimated by checker and attach points. This method is simpler than those complex methods used on the whole point clouds directly. The experiment results show that much time is saved and surface reconstruction is very fine than PCA and WLOP.

        • SCIESCOPUSKCI등재

          Study on the Recycling of Nuclear Graphite after Micro-Oxidation

          Liu, Juan,Wang, Chen,Dong, Limin,Liang, Tongxiang Korean Nuclear Society 2016 Nuclear Engineering and Technology Vol.48 No.1

          In this paper, a feasible strategy for the recycling of nuclear graphite is reported, based on the formation mechanism and the removal of carbon-14 by micro-oxidation. We investigated whether ground micro-oxidation graphite could be used as a filler to make new recycled graphite and which graphite/pitch coke ratio will give the recycled graphite outstanding properties (e.g., apparent density, flexural strength, compressive strength, and tensile strength). According to the existing properties of nuclear graphite, the ratio of graphite to pitch coke should not exceed 3. The recycled reactor graphite has been proven superior in density, strength, and thermal conductivity. The micro-oxidation process enhances the strength of the recycled graphite because there are more pores and unsmooth surfaces on the oxidized graphite particles, which is beneficial for the access of the pitch binder and leads to efficient joint adhesion among the graphite particles.

        • ST6Gal-I Predicts Postoperative Clinical Outcome for Patients with Localized Clear-cell Renal Cell Carcinoma

          Liu, Hai-Ou,Wu, Qian,Liu, Wei-Si,Liu, Yi-Dong,Fu, Qiang,Zhang, Wei-Juan,Xu, Le,Xu, Jie-Jie Asian Pacific Organization for Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23

          Hyperactivated ${\alpha}2$-6-sialylation on N-glycans due to overexpression of the Golgi enzyme ${\beta}$-galactoside: ${\alpha}2$-6-sialyltransferase (ST6Gal-I) often correlates with cancer progression, metastasis, and poor prognosis. This study was aimed to determine the association between ST6Gal-I expression and the risk of recurrence and survival of patients with localized clear-cell renal cell carcinoma (ccRCC) following surgery. We retrospectively enrolled 391 patients (265 in training cohort and 126 in validation cohort) with localized ccRCC underwent nephrectomy at a single center. Tissue microarrays were constructed for immunostaining of ST6Gal-I. Prognostic value and clinical outcomes were evaluated. High ST6Gal-I expression was associated with Fuhrman grade (p<0.001 and p=0.016, respectively) and the University of California Los-Angeles Integrated Staging System (UISS) score (p=0.004 and p=0.017, respectively) in both cohorts. Patients with high ST6Gal-I expression had significantly worse overall survival (OS) (p<0.001 and p<0.001, respectively) and recurrence free survival (RFS) (p<0.001 and p=0.002, respectively) than those with low expression in both cohorts. On multivariate analysis, ST6Gal-I expression remained associated with OS and RFS even after adjusting for the UISS score. Stratified analysis suggested that the association is more pronounced among patients with low and intermediate-risk disease defined by the UISS score. High ST6Gal-I expression is a potential independent adverse predictor of survival and recurrence in ccRCC patients, and the prognostic value is most prominent in those with low and intermediate-risk disease defined by the UISS score.

        맨 위로 스크롤 이동