항공기 소음이 지역 주민들에게 미치는 건강영향

이경종,장재연,박재범,조선미,이세휘,김종구,이순영,곽정자,정호근 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.4

Objectives : This study was conducted to reveal the health effects of aircraft noise on the residents live near the military airport. Methods : We sampled systematically 87 residents as the high exposed group, 58 residents as the low exposed group according to the geographical distance from the airport. We also sampled 67 residents as the control group lived far from the airport. Noise levels were measured for conform the exposures. Self-administered questionnaires for symptoms, air conduction hearing threshold level, blood pressure blood cholesterol with health examinations, and SCL-90-R were introduced to get the data from the residents. Results : The Ld/n at the area near the airport was 72.4 dB, however that of control area was 67.7 dB. The value of pure tone average, high pure tone average, and threshold of 4,000 Hz were decreased with exposure level significantly. Linear regression analysis showed that the noise exposure level of the airport was related to the hearing threshold at pure tone average, threshold of 4,000 Hz, and high pure tone average. The systemic and diastolic blood pressure showed dose-response relationship with noise exposure. The prevalence of hypertension was higher in exposed group, but not statistically significant. In linear regression, noise level was related to systolic and diastolic blood pressure with other variables such as age, sex, BMI(Body Mass Index), and family history of hypertension. SCL-90-R showed that exposed group had higher score significantly in neurotic and psychologic variable and felt the various somatic symptoms. Conclusions : These results suggest that aircraft noise would influence hearing loss at low frequencies as well as 4,000 Hz and higher frequencies, systolic and diastolic blood pressure, and psychological response.

조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성

김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.

고빌리루빈혈증을 동반한 자가면역성 간염 1례

서영범,김성욱,장재식,강혁주,이중현,윤병구,김욱년,이광헌,이구,유석동,양창헌,이정호,이영현,이창우,서정일 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-

자가면역성 간염은 대개 만성 경과를 가지며, 혈중 자가면역항체와 혈청 글로불린치의 상승, 그리고 조직학적으로 괴사 염증성 변화를 특징으로 하는 질환으로 아직 정확한 병인이 밝혀져 있지 않은 상태이다. 발병연령은 대개 젊은 영자(15-25세)에서 호발한다. 이 질환은 급성 간염의 임상경과를 보일 수 있으나, 심한 급성 간염이나 전격성 간염으로도 나타날 수 있는데, 이 경우 아주 나쁜 예후를 보인다고 한다. 치료는 자가면역성 간염 임상 경과의 다양성이나 병인, 병리기전의 불확실성에도 불구하고 대개 steroid 치료에 반응하는 것으로 알려져 있으며 대개 80%의 관해율을 나타내며 궁극적으로 간경변으로의 진행을 막을 수 있는 것으로 보인다. 저자들은 58세 남자에서 발생한 급성의 경과를 가지고 심한 황달을 동반한 자가면역성 간염을 경험하였기에 문헌고찰과 함께 보고하는 바이다. Autoimmune hepatitis (AIH) is a chronic necroinflammatory liver disorder of unknown cause associated with circulating autoantibodies and a high serum globulin level. The age of onset of AIH show a peak between the age of 15 and 25 years. AIH can develop and be manifested as acute hepatitis, but severe form of acute hepatitis or fulminant hepatic failure has a poor prognosis. Although AIH is likely to progress from chronic active hepatitis to cirrhosis, steroid therapy can control the disease activity, prolong survival, improve the quality of life , and defer liver transplantation. In the present report we describe a 58-year-old man who admitted because of progressive jaundice and fatigue. He was diagnosed with AIH from laboratory test result showing positivity for antinuclear antibodies, anti-smooth muscle antibodies, and negativity for hepatitis viral markers and from liver biopsy. Steroid therapy, oral administration of prednisolone, was effective in improving the liver function test. Following liver biopsy 6 months after onset shows markedly improved necroinflammatory activity.

내시경적 점막절제술로 치험한 식도 과립상 세포종 1례

강혁주,김성욱,최석진,이중현,장재식,서영범,윤병구,박건욱,김성자,김용섭,강승완,이구,양창헌,이창우,김욱년,이광헌,서정일 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-

과립상 세포종은 Schwann 세포 기원으로 생각되며 인체에 비교적 드물게 발생한다. 과립상 세포종은 전신 어느 곳에서나 발견될 수 있으나 주로 혀, 구강, 피부 혹은 유방 등에서 호발하며 드물게 위장관에서 발견된다. 위장관에서는 식도에서 가장 호발하며 다음으로 위, 대장 순이다. 과립상 세포종은 대부분, 특히 위장관에서는 양성이며 소수의 악성 병변이 보고되었다. 이러한 이유와 함께 수술 전의 진단이 어렵기 때문에 과립상 세포종에 대한 근본적인 치료는 현재까지 외과적 절제술이다. 최근에 시도되는 치료방법들로는 내시경적 레이저 치료, 용종절제술, 내시경적 점막 절제술 등이 있다. 저자들은 상부 소화관 내시경검사를 시행하여 식도 과립상 세포종을 진단하고 내시경적 점막 절제술을 시행하여 합병증 없이 퇴원하여 현재 재발없이 경과 관찰중인 1례를 경험하였기에 보고하는 바이다. Granular cell tumors, which occur infrequently, are probably of Schwann cell origin. They can occur almost anywhere in the body but usually affect the tongue, oral cavity, skin, or breasts and are rarely found in the gastrointestinal tracts. The esophagus is the most frequent gastrointestinal site, followed by the stomach and the colon. Granular cell tumors are generally benign, especially in the gastrointestinal tract, some malignant lesions have been reported. For this reason, and also because preoperative diagnosis is difficult, the standard treatment for granular cell tumor has until now been surgical excision. In recent years, other therapeutic methods is endoscopic laser therapy (ELT), polypectiomy, endoscopic mucosal resection (EMR). We report a case of esophageal granular cell tumor which was diagnosed by an endoscopy and managed using an endoscopic mucosal resection without complication.

대학 건축공학과의 실습학기제에 관한 연구

이승준,한인웅,정구용,조방현,한기원,박재호,김진원 三陟大學校 2000 論文集 Vol.33 No.2

In order to solidify the architectural education in university, we should enlarge the opportunity of field training and develop the field training course system as a part of industry-scholastic cooperation. And we should develop new educational process to bring up potent engineers adaptable to the training affairs, faithful to the educational object of the industrial university.

시민 교육의 전개 방향

이구재 公州大學校 地域開發硏究所 1996 地域開發硏究論叢 Vol.4 No.1

한 자동차 제조 사업장의 산업재해 분석

이경종,박재범,정호근,김종구 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.1

목 적 : 우리나라 자동차 산업업체의 산업재해 발생 현황을 파악하고 산재예방에 필요한 기초자료를 마련하기 위하여 한 완성 자동차 제조공장에서 1997년도에 발생한 산업재해를 분석하여 다음과 같은 결과를 얻었다. 방 법 : 1년간 산업재해보상보험에 요양 급여를 신청한 근로자들의 재해일지, 건강진단 결과등을 가지고 단면적 연구를 시행하였다. 결 과 : 연령별 재해율은 45-49세 군이 1.6 %로 가장 높았고 35-3971 군이 1.3 %, 40-44세 군, 30-34세 군이 각각 0.9 %, 25-29세 군이 0.6 %, 20-24세 군이 0.4 % 순이며, 근무경력별로는 25년 이상 근로자가 2.7 %으로 가장 높아 연령이 증가할수록, 근무경력이 길수록 재해율이 증가하였다. 작업형태별로는 숙련 작업이 2.3 %로 재해률이 가장 높았고 고정작업이 1.2 % 순 이었다. 작업시간별 발생율은 10-11시(21.4 %)와 오후 2-3시(17.9 %)에 높았다. 요일별로는 금요일(20.5 %), 수요일(17.9 %), 월요일(16.2%), 화요일(15.4 %), 토요일(12.0 %), 목요일(11.1%), 일요일(6.8 %) 순이었다. 월별 발생률은 5월(17.9 %), 3월(11.1 %), 4월(11.1 %) 순으로 봄철이 높았고 8월(10.3 %), 1월(9.4 %) 순이었다. 재해발생 부위는 허리가 41.0 %로 가장 많이 많았고, 다음으로 손가락이 17건(14.5 %), 다리(9.4 %), 손(7.7 %), 머리(6.0 %) 순이었다. 손상 종류별로는 염좌가 38.5 %로 가장 많았고 골절(22.2 %), 요추간판 탈출증(11.1 %), 타박상(9.4 %) 순이었다. 재해의 원인으로는 중량물 취급(34.2 %), 전도(17.1 %), 협착(16.2 %), 낙하비래(6.8 %) 순이었다. 결 론 : 자동차 제조업에서는 중량물 취급과 점심식사 전후나 금요일 등 피로한 시간대에 발생이 많은 근골격계 손상에 대한 주의가 필요해 보인다. Objeetives : To know the present conditions of industrial accidents in automobile facto-ries in Korea and make the basic materials essential to prevention of industrial accidents Methods : We reviewed and analyzed the records of industrial accidents occurred in an automobile factory in 1997 by time of occurrence, job categories (fixed production, skilled trades, mechanical material handling, and clerical & technical), type of injury, kind of accident, and location of injury. Results 1. By age groups, the accident rate was the highest in age 45-49(1.6 %) followed by age 35-39(1.3 %), 40-44(0.9 %), 30-34(0.9 %), 25-29(0.6 %), and 20-24(0.4 %) and by working duration, it was highest in group of experience over 25 years, and so we could see that the more age or working duration increases the more accident rate increases. 2. By work time, the accident rate was the highest in 10-11 a. m. (21.4 %) followed by 2-3 p.m. (17.9%). By the day of the week, it was as follows, Friday(20.5 %), Wednesday(17.9%), Monday(16.2 %), Thesday(15.4 %), Saturday(12.0 %), Thursday(11, 1 %), Sunday(6.8 %) in order. By the month, it was high in May(17.9%), March(11.1 %), and April(71.1 %) followed by August(10.3 %) and January(9.4%) , so we could see it was high in spring. 3. The most frequent injury was in the back by 41.0 % followed by 17 cases in fingers(14.5 %), legs(9.4 %), hands(7.7 %), head(6.0 %) In order. And by the type of Injuries, the sprain was most frequent by 38.5% followed by fracture(22.2 %), lumbar HNP(11.1 %), and contusion(9.4 %) in order. The causes of accident were handling heavy materials(34.2 %), upset(17.1 %), stenosis(16.2 %), and falling(6.8 %) in order. Conclusions : By the above results, to prevent the industrial accidents in automobile factories in Korea, preventive activities for handling heavy materials and back and continuous industrial education are necessary.

PLCM을 이용한 카오스 블록 암호화 기법

이성우,이민구,박정렬,신재호 東國大學敎 産業技術硏究院 2005 산업기술논문집 Vol.15 No.1

본 논문에서는 동력학적 특성이 좋은 PLCM을 이용한 256비트 길이의 암호 키와 32비트 데이터 블록의 카오스 블록 암호화 기법을 제안한다. 본 논문에서 제안한 기법은 256비트의 키에서 각 암호화 단계마다 사용될 32비트의 세션 키 두 개를 생성해서 PLCM의 초기 값과 반복회수를 결정하는데 사용한다. 본 제안 기법은 피드백 구조와 대치 기능의 S함수를 통해 암호 강도를 향상시켰다. 또한 실험 결과와 안전성 분석을 통해 본 제안 기법이 통계적(Statistical) 공격에 매우 강함을 보여준다. In this paper, we propose a chaotic block encryption scheme using a PLCM (Piecewise Linear Chaotic Map) having a good dynamical property. The proposed scheme has a block size of 32 bits and a key size of 256 bits. In the proposed scheme we use two 32-bit session keys generated from 256-bit key to decide the initial value and the number of iteration of PLCM. To enhance the strength of security we use a feedback structure and a S (Substitution) function. With results of test and analyses of security we show the proposed scheme is very secure against statistical attacks.

韓國의 損害保險 經營에 관한 考察

李載求 건국대학교 1980 樂圓誌 Vol.15 No.1

Prednisolone과 Prednisone의 임상약동학적 평가

신재국,윤영란,차인준,이경훈,장인진,신상구,박찬웅 大韓臨床藥理學會 1994 臨床藥理學會誌 Vol.2 No.1