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Zheng, Long Tai,Hwang, Jaegyu,Ock, Jiyeon,Lee, Maan Gee,Lee, Won-Ha,Suk, Kyoungho Blackwell Publishing Ltd 2008 Journal of Neurochemistry Vol.107 No.5
<P>Abstract</P><P>Glial activation and neuroinflammatory processes play an important role in the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and HIV dementia. Activated glia cells can secrete various proinflammatory cytokines and neurotoxic mediators, which may influence neuronal cell survival. Recent studies have demonstrated that glia cell-mediated neuroinflammation is also related to the pathophysiology of schizophrenia. In the present study, anti-inflammatory and neuroprotective effects of antipsychotics were investigated using cultured brain cells as a model. The results showed that spiperone significantly decreased the production of nitric oxide in lipopolysaccharide-stimulated BV-2 microglia cells, primary microglia and primary astrocyte cultures. Spiperone also significantly inhibited nitric oxide production in adenosine 5′-triphosphate (ATP)-stimulated primary microglia cultures. Spiperone markedly decreased the production of tumor necrosis factor-alpha in BV-2 microglia cells. Spiperone attenuated the expression of inducible nitric oxide synthase and proinflammatory cytokines such as interleukin-1&bgr; and tumor necrosis factor-alpha at mRNA levels in BV-2 microglia cells. Spiperone inhibited nuclear translocation and DNA binding of the p65 subunit of nuclear factor kappa B (NF-&kgr;B), inhibitor of kappa B (I&kgr;B) degradation, and phosphorylation of p38 mitogen-activated protein kinase in the lipopolysaccharide-stimulated BV-2 microglia cells. Moreover, spiperone was neuroprotective, as the drug reduced microglia-mediated neuroblastoma cell death in the microglia/neuron co-culture. These results imply that the antipsychotic spiperone has anti-inflammatory and neuroprotective effects in the central nervous system by modulating glial activation.</P>
커먼레일 연료분사 시스템을 장착한 2.9 리터급 경량 DME 트럭의 연구 및 개발
정수진(Soo-Jin Jeong),오세두(Se-Doo Oh),이호길(Ho-Kil Lee),박정권(Jung-Kwon Park),이기수(Gee-Soo Lee),표영덕(Young-Dug Pyo),임옥택(Ock-Taek Lim) 한국자동차공학회 2011 한국자동차공학회 학술대회 및 전시회 Vol.2011 No.11
In this study, the trucks(2.9-liter) have been developed to use DME as fuel, and performance test of the vehicle"s DME engine, power, emissions, fuel economy and vehicle aspects was conducted. For experiments, the fuel system(common-rail injectors and high-pressure pump included) and the engine control logic was developed, and ECU mapping was performed. In this way, put the diesel fuel in the DME engine, and injection quantity at the injectors were measured. As a result, the rail pressure from 40 ㎫ to approximately 65% increase compared to the base injector has been confirmed that. Also, the Inlet IMV of DME high-pressure fuel pump opens under normal conditions, the performance of prototype was evaluated. As a result, the pump discharge flow is 15.5 ㎏/h when the fuel rail pressure is 400rpm(40 ㎫), and the pump discharge flow is 92.1 ㎏/h when the fuel rail pressure is 2,000rpm(40 ㎫). The maximum value of full-load torque capability is 25.5 ㎏fm(based on 2,000 rpm), and more than 90% compared to the level of the diesel engine were obtained. The DME vehicle was developed in this study, 110 ㎞/h can drive to the stable, and calculated in accordance with the carbon-balance method of fuel consumptions is 5.7 ㎞/L.
중국산 수입말에서 분리된 Taylorella equingenitalis의 특성
조현호,배찬의,남향미,송시욱,조남인,강두황,이기옥,김옥경,김용환,Cho Hyun-ho,Bae Chan-eui,Nam Hyang-mi,Song Si-wook,Jo Nam-in,Kang Du-hwang,Lee Gee-ock,Kim Ok-kyeong,Kim Yong-hwan 대한수의사회 1998 대한수의사회지 Vol.34 No.6
Investigation of contagious equine metritis(CFM) in 497 imported horses from several countries during 1997 was performed, and one strain of Taylorella equigenitalis was isolated from a chinese horse. To identify, we studied on the biochemical properties a