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( Hyun Chang Ko ),( Jeong Min Kim ),( Hyun Ho Cho1 ),( Won Jeong Kim ),( Je Ho Mun ),( Margaret Song ),( Hoon Soo Kim ),( Byung Soo Kim ),( Moon Bum Kim ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Conventional destructive modalities for warts like cryotherapy or laser ablation have some limitations that are excruciating pain during procedure, in especially pediatric patients. Imiquimod is a topical immune response modifier that was approved for treating genital and perianal warts. But, thick stratum corneum of common warts may act as a barrier against drug permeation via the skin. Objectives: To evaluate efficacy and safety of above treatment. Methods: Eleven pediatric patients (6 female and 5 male, mean age 12.5 years) were included in this study. The lesions were treated by fractional 2940 nm Er:YAG laser for achieving the penetration of stratum corneum with 1 or 2 weeks intervals. Then, imiquimod 5% cream was self-applied once daily for 5 days a week. Assessment of response and adverse effects was performed every 2 weeks until complete clearance or up to maximum of 48 weeks. Pain during procedure was checked by VAS (0-10). Results: 8 out of 11 (72.7%) patients experienced complete clearance of all warts lesions. Mean duration of total treatment was 29.7 (16-48) weeks. Mean number of fractional laser treatment was 17.5 (8-37) times. No significant adverse effect was observed. VAS score of the pain during fractional laser treatment was 2.4 (1-4), comparing with 6.2 (5-8) during cryotherapy. Conclusion: Fractional ErYAG laser-assisted topical 5% imiquimod cream is an effective and safe treatment option for recalcitrant common warts of the children do not tolerate pain well.
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백강현,윤기영,최호정,정성목,이영원,조성환,박성준 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2011 動物醫科學硏究誌 Vol.18 No.1
Fine needle aspiration(FNA) cytology is considered as the diagnostic technique of choice in the assessment of swellen lymph nodes. The aim of this study is to determine the indication and diagnostic method of FNA of lymph node lesions performed at Veterinary Medicine Teaching Hospital of Chungnam National University. The records of 16 patients which had undergone FNA during the study period were retrieved. The cytological results were classified as lymphadenitis, lymphoid hyperplasia and lymphoma. Lymphoma cases were classified as B-cell origin and T-cell by immunophenotyping. The result of the FNA cytological diagnosis showed that nine (56%) of the patients were lymphoma, five (31%) of the patients were lymphoid hyperplasia and two (13%) of the patients were lymphadenitis.
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趙顯浩 부산대학교 과학교육연구소 1975 교사교육연구 Vol.2 No.2
This paper is to study the historical significance and attitude of our unique Tak Kwon Do in Korea. The contents of this paper is as follows: I. Introduction II. The spirit of Tak Kwon Do III. The historical perspective of Tak Kwon Do IV. The effective utilization of strength necessary for Tak Kwon Do V. Conclusion In particular, it was emphasized in Chapter IV that the creating factor of the scientific strength and the development of driving method of rational strength be important in order to enhance the techniques. In short, considering Korean reality, all Korean should not only re-recognize the nessity of Tak Kwon Do for the improvement of national physical standard but also for the sake of national defense regardless of sex.
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유동성 및 응축성 복합레진의 점탄성에 관한 유변학적 연구
조병훈,이인복,권혁춘,손호현,엄정문 대한치과보존학회 2000 Restorative Dentistry & Endodontics Vol.25 No.3
The purpose of this investigation was to observe the viscoelastic properties of five commercial flowable(Aeliteflo, Flow it, Revolution, Tetric flow, Compoglass flow) , three conventional hybrid(Z-100,Z-250,P-60) and two condensable(Synergy compact, SureFil) resin composites. A dynamic oscillatory shear test was done to evaluate the storage shear' modulus (G' ) , loss shear modulus(G") , loss tangent(tan δ) and complex viscosity(η* ) of the resin composites as a function of frequency dynamic frequency sweep test from 0.01 to 100 rad/s at 25℃ - by using Advanced Rheometric Exparusion SystemtARES) . To investigate the effect On the viscosity of resin composites of filler volume fraction, the filler weight % and volume % were measured by means of Archimedes' principle using a pyknometer. The results were as follows 1.The complex viscosity η* of flowable resins was lower than that of hybrid resins and significant differences were observed between brands. The complex viscosity η* of condensable resins was higher than that of hybrid resins. The order of complex viscosity η* at ω = 10 rad/s was as follows. Surefil, Synergy compact, P-60, Z-250, Z-100. Aeliteflo, Tetric flow, Compoglass flow, Flow it, Revolution. The relative complex viscosity of flowable resins compared to Z-100 was 0.04-0.56 but Surefil was 30.4 times higher than that of Z-100. 2.The storage shear modulus G' and the loss shear modulus G" of flowable resins were lower than those of hybrid resins but those of condensable resins were higher. The patterns of the change of loss tangent, tan δ of resin composites with increasing frequency were significantly different between brands.The phase angles,δ, ranged from 30.2-78.1˚at ω = 10 rad/s. 3.A11 composite resins represent pseudoplastic nature with increasing shear rate. 4.The complex shear modulus G* and the phase angle δ was represented by the frequency domain phaser form, G*( ω )= G* eIδ = G*〈 δ. The locus Of frequency domain phaser plots in a complex plane was a valuable method that represent the viscoelastic properties of composite resins. 5.There was no direct linear correlationship but a weak positive relation was observed between filler volume % or weight % and the viscosity of the resin composites.
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리스페달 정(리스페리돈 2㎎)에 대한 리스펜 정의 생물학적 동등성
조혜영,박은자,강현아,백승희,이석,박찬호,문재동,이용복 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.2
The purpose of the present study was to evaluate the bioequivalence of two risperidone tablets, Risperdal (Janssen Korea Co., Ltd) and Rispen (Myung In Pharm. Co., Ltd), according to the guidelines of Korea Food and Drug Administration (KFDA). The risperione release from the two risperidone formulations in vitro was tested using KP Ⅷ Apparatus Ⅱ method with various of dissolution media (pH 1.2, 4.0, 6.8 butter solution and water). Twenty four healthy male subjects, 23.33±2.10 years in age and 69.24±8.05 kg in body weight, were divided into two groups and a randomized 2×2 crossover study was employed. After one tablet containing 2 ㎎ as risperidone was orally administered, blood was taken at predetermined time intervals and the concentration of risperidone in serum were determined using HPLC method with UV detector. The dissolution profiles of two formulations were similar at all dissolution media. Besides, the pharmacokinetic parameters such as AUC_(t), C_(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_(t), C_(max) and untransformed T_(max). The results showed that the differences between two formulations based on the Risperdal were 0.20, -1.29 and -11.09% for AUC_(t), C_(max) and T_(max), respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) (e.g., log(0.90)∼log(1.03) and log(0.84)∼log(1.09) for AUC_(t) and C_(max), respectively). Thus, the criteria of the KFDA guideline for the bioequivalence were satisfied, indicating Rispen tablet and Risperdal tablet were bioequivalent.
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시클러 캡슐(세파클러 250㎎)에 대한 경보세파클러 캡슐의 생물학적동등성
조혜영,강현아,김세미,박찬호,오인준,임동구,문재동,이용복 한국약제학회 2005 Journal of Pharmaceutical Investigation Vol.35 No.1
The purpose of the present study was to evaluate the bioequivalence of two cefaclor capsules, Ceclor (Lilly Korea Co., Ltd.) and Kyongbocefaclor (Kyongbo Pharm. Co., Ltd.), according to the guidelines of the Korea Food and Drug Administration (KFDA). The release of cefaclor from the two cefaclor formulations in vitro was tested using KP VIII Apparatus II method with various dissolution media (pH 1.2. 4.0. 6.8 buffer solution and water). Twenty four healthy male subjects. 22.96±1.52 years in age and 67.03±7.90 kg in body weight, were divided into two groups and a randomized 2x2 cross-over study was employed. After one capsule containing 250 mg of cefaclor was orally administered, blood was taken at pre-determined time intervals and the concentrations of cefaclor in serum were determined using HPLC method with UV detector. The dissolution profiles of two formulations were similar at all dissolution media. In addition. the pharmacokinetic parameters such as AUC_(t), C_(max) and T _(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_(t). C_(max) and untransformed Tmaa. The results showed that the differences between two formulations based on the reference drug, Ceclor. were -1.90%, 2.68% and -7.60% for AUCt, C_(max) and T_(max), respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log 0.8 to log 1.25 (e.g., log 0.91-log 1.06 and log 0.92-log 1.18 for AU', and C_(max), respectively). Thus. the criteria of the KFDA bioequivalence guideline were satisfied, indicating Kyongbocefaclor capsule was bioequivalent to Ceclor capsule.
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원발성 위암조직에서 fragile histidine triad 유전자의 이상 발현에 대한 연구
조이현,이상한,우기민,송호연,조만희 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2
Background : The fragile histidine triad(FHIT) gene, located at human chromosome 3p14.2, has been shown to produce aberrant transcripts in a number of human cancers. Also, FHIT protein is supposed to have tumor suppressor function. Methods : To determine the role of the FHIT gene in gastric carcinoma, FHIT mRNA transcripts were examined in 16 primary adenocarcinomas by reverse transcription-polymerase chain reaction(RT-PCR). Expression of FHIT protein was measured by immunohistochemistry. Results : In this study, we found normal and abnormal RT-PCR products in 7 cases, and no transcript in one case. Positive immunostaining was observed in normal gastic gland, whereas FHIT immunoreactivity was significantly decreased or absent in most cases tested. Gastric cancer is thought to be develop from carcinogenic exposure, possibly accompanying with the high frequency of the FHIT gene abnormalities. Conclusion : The above results suggest that the FHIT gene can be a preferential target of environmental carcinogens, and the FHIT inactivation may play a role in the gastric carcinogenicity.
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신뢰성방법에 기초한 강교량의 잔존피로 수명 및 피로 위험도 평가
조효남,임종권,최현호 漢陽大學校 工學技術硏究所 1999 工學技術論文集 Vol.8 No.1
본 논문은 잔존피로수명 및 피로파괴 신뢰성해석 절차의 확립을 위해 피로신뢰성방법에 대한 기존 국내외 관련 연구에 대한 심도 깊은 고찰을 수행하였고 실온적인 평가방법을 제시하였다. 따라서 본 연구에서는 Miner 누적손상법칙에 기초한 S-N 피로해석이론 중에서 주로 확률적 S-N 방법과 Ang-Munse's방법에 대한 최근 평가 기술을 집중 고찰하였으며, 이를 실제 성수대교의 붕괴원인 규명에 적용해 봄으로써 그 타당성을 검증하였다. 또한 이를 위해서 성수대교의 붕괴 원인으로 추정되고 있는 핀연결 수직재의 피로응력범위의 보다 정확한 추정을 위하여 shell요소를 사용한 엄밀 국부 FEM해석이 수행되었다. This paper presents practical evaluation methods of the fatigue life and fatigue failure probability for the assessment based on all the available results of various field and labolatory tests. Therefore, both the probabilistic S-N approach and the well known Ang-Munse's fatigue reliability method based on linear damage-accumulation hypothesis, commonly known as Miner's rule, are used and demonstrated in order to verify it's appropriateness. A local FEM analysis using fine meshes shell elements is carried out for the more precise estimation of stress range of the vertical pin-connected hanger whose fatigue fracture triggered the collapse of the bridge.
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