김치유래 젖산균의 균체지방산 분석을 이용한 분류학적 연구

이정숙,정민철,김우식,이근철,김홍중,박찬선,이헌주,주윤정,이근종,안종석,박완,박용하,민태익 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.2

표준균주를 포함한 230여개의 김치유래 젖산균에 대한 균체지방산(FAMEs)을 분석하였다. FAMEs profiles는 Euclidian Distance 17.5에 의해 7개의 Major Cluster와 1개의 Single Cluster로 나뉘어졌다. 이중 A, B, C 및 Cluster는 Leuconostoc속으로 분석되어졌고, F는 Lactobacillus속으로 분석되어졌다. 그리고 E와 G cluster는 두개의 Genus가 혼재되어 나타났으며 보충적인 연구가 필요하다. 앞으로 김치유래 젖산균의 균체지방산 분석결과를 기반으로 한 데이타베이스에 95가지 탄소원을 이용하는 수치분류학적 접근방법 및 Pyrolysis Mass Spectrometry 등의 화학적 분석 방법과 분자친화적 연구를 통한 종합적 분류정보 체계가 갖추어지면 젖산균의 신속, 정확한 동정 및 연구에 활발히 이용되어질 것이다. Two hundreds and thirty lactic acid bacteria, mostly isolated from Kimchi, including type strains were sued for analysis of cellular fatty acids. The 230 test strains were recoverd in 7 major and 1 single clusters defined a Euclidian distance of 17.5. These aggregate taxa were equivalent to the genus Leuconostoc (aggregate group A, B, C and D), and the genera Leuconostoc and Lactobacillus (aggregate group G). It is concluded as evident that FAMEs (Fatty Acid Methyl Esters) profile of cell can be used as a criterion in classification of lactic acid bacterial from kimchi. Additional comparative taxonomic studies need to be carried out on well chosen representative strains to determine the most appropriate methods of value.

부신피질 자극호르몬 단독결핍 1례

박경식,이승현,최석영,박태규,이동화,이찬우,정성복,이인규 啓明大學校 醫科大學 1997 계명의대학술지 Vol.16 No.3

부신피질 자극호르몬 단독결핍은 국내에서 7례만이 보고된 희귀 질환이며 병인 및 경과 등 아직 불분명한 측면이 많다. 이는 질환지체의 희귀성도 있지만 치료후 자연경과에 대한 장기적인 추적검사가 이루어진 경우가 드물기 때문이기도 하다. 저자들은 비특이적인 전신증상을 주소로 내원한 폐경기후의 56세 여자 환자에서 자가면역질환의 증거없이 고프로릭틴혈증을 보인 부신피질 자극호르몬 단독결핍 1례를 경험하고 1년간의 부신피질호르몬 대치요법후 추적검사를 실시하였기에 문헌 고찰과 함께 보고하는 바이다. Isolated ACTH deficiency is a rare disorder which shows secondary adrenal insufficiency with normal states of other pituitary hormones. A 56-year-old postmenopausal woman complaining general weakness and intermittent mental confusion presented negligible serum cortisol and ACTH level with hyperprolactinemia and mild hyponatremia. Rapid ACTH stimulation test did not show significant increase of serum cortisol level. Combined pituitary stimulation test showed negligible response of cortisol and ACTH, and slightly decreased response of prolactin and gonadotropin. But the responses of TSH and GH were normal. There was no evidence of organic pituitary of hypothalamic lesion in brain MRI and antithyroid autoantibody was not detected in serum. After receiving 12 months of glucocorticoid replacement therapy, she skipped the medicine for 3 weeks and we performed follow-up endocrinologic tests. Serum ACTH and cortisol level was also negligible and prolonged ACTH simulation test showed normal response of serum cortisol. CRF stimulation test showed no response of serum ACTH. Basal prolactin level was decreased to near normal and combined pituitary stimulation test showed normal response of prolactin with slightly blunted response of TSH and GH. We concluded that the case was nonautoimmune origined isolated ACTH deficiency which was accompanied by hyperprolactinemia and resultant deficiency of gonadotropin, so we report this case with review of literatures.

구-막대 시스템에서 CDM을 사용한 강인한 제어기 설계

이호기,박용식,정찬수 崇實大學校 1999 論文集 Vol.29 No.1

All the controller design problem for linear time invariant dynamic system boils down to proper selecting the characteristic polynomials and numerator polynomials for concerned input-output relations. The propel selection of the characteristic polynomial is not so difficult, if only stability and response are to be satisfied, but it becomes complicated when robustness issue is added. The CDM could be a solution to this problem. CDM which is developed by Lipatov's conditions for stability and Kessler's standard form is easy to process of the controller design, especially it is more useful when the specifications are the settling time, rising time and overshoot. In this paper was used CDM design a simple but robust controller of the ball and beamsystem. The ball and beam system is highly nonlinear system. And it's linear transfer function used to design the controller. But CDM proved to be a solution to design even if there are some uncertainties like this linearized ball and beam system by simulations.

곁순의 화학적 방제가 연초식물의 생장량에 미치는 영향

이재흥,석영선,신주식,정찬문 충북대학교 엽연초연구소 2001 煙草硏究 Vol.18 No.-

This study was carried out to compare the effects of suckercides - Fatty alcohol(FA), Maleic hydrazide(MH) and Butralin - on the sucker control and growing characters of flue-cured tobacco leaves. Among the three suckercides, Butralin was treated at three different times, one day before topping, topping day and one day after topping, and at two different concentration, 1/30 and 1/60 water solution. The results are summarized as follows. Suckercide treated plot showed higher growth and weight of upper leaves than not-treated plots did. MH treated plot decreased numbers, fresh weight and dry weight of suckers compared to the other treated plots, and made the leaves shape narrow. The effect of Butralin on sucker control was lower than that of MH, but higher than that of FA. The yields when treated Butralin decreased compared to the yields when treated MH. Though there were no significant differences of yields and growing characters of leaves among the plots of three concentrations and two times of treating Butralin, it is recommended to apply 1/60 water solution of Butralin at topping time.

소세포 폐암의 갑상선전이 1예

장리라,최영식,박요한,문대성,김자경,김성은,최인수,유찬희,남성진 고신대학교 의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.3

Metastasis to the thyroid gland is usually considered uncommon. The most frequent sites of the primary tumor include the kidney, breast and lung. Its presence often indicates poor prognosis. Metastases represent the advanced stage of the tumors and fine needle aspiration cytology is and important way of diagnosis in thyroid metastasis. we experienced a case of Metastatic Small cell Lung Carcinoma to the Thyroid Gland. A 58-year-old man with Graves' disease diagnosed pulmonary nodule in the left upper lung field on his chest X-ray film. The patient's thyroid gland was diffusely swollen, and elastic to hard. A thyroid ultrasonography showed 1cm sized hypodense nodule on the left thyroid gland. The patient underwent a ultrasonography guided fine needle aspiration cytology of the mass. Cytological diagnosis was a metastatic small cell carcinoma. Then Chemotherapy was administered to the patient. The authors report this rare case of metastatic small cell lung carcinoma to the thyroid with literature review.

바이오안전성에 대한 세계적인 동향 : 유전자변형 생물체(LMO)를 중심으로

이이,정찬문,이학수,신주식 충북대학교 연초연구소 2006 煙草硏究 Vol.20 No.-

현대 분자생물학의 발달에 따른 유전자변형 생물체의 개발은 시간과 경제적으로 전통적인 육종의 한계를 많이 극복하고 있으며 세계적으로 유전자변형생물체의 개발이 빠른 속도로 진행되고 있다. 유전자의 변형에 따른 환경의 파괴, 인체에 대한 위해 가능성 때문에 바이오안전성의정서가 채택되는 등 세계적으로 바이오안전성에 대한 관심이 증가하고 있다. 바이오안전성은 유전자특성분석, 환경위해성평가, 인체위해성평가 등 3단계의 평가에 의해서 이루어지며 최종적으로 인체와 환경에 해를 끼칠 가능성이 있는 유전자변형생물체를 규제하기 위해서 이루어진다. 우리나라도 최근에 바이오안전성에 대한 관심이 증대되면서 바이오안전성 평가체계가 확립중이다. The development of molecular biology enabled us to overcome the restrictions of conventional breeding system and the number of genetically modified organisms are dramatically increasing. The possibility of the genetically modified organism's risk on human health and environment caused concerns on the biosafety. Biosafety test contains gene characteristics analysis, health safety test, and environmental risk test. The final aim of these tests is to prevent the commercialization of genetically modified organism which have possible risk on human health and environment. Biosafety evaluation system is being built in Korea.

원가시스템이 製造環境의 變化에 適應하고 있는가?: : A Case of Korean Manufacturing Firms 한국제조기업의 경우

이찬호,안태식 啓明大學校 會計情報硏究所 1995 會計情報리뷰 Vol.- No.1

제조환경의 변화에 따라 원가/관리회계시스템이 변화하여야 한다는 것은 국내외의 여러문헌에서 여러 학자들에 의하여 주장되어 오고 있다. 그러나 과연 원가시스템이 제조환경의 변화에 적응하고 있는가를 실증적으로 연구한 논문은 찾아보기 어렵다. 본 논문은 제조공정의 자동화, 생산제품의 다양화, 제품수명주기의 단축 등으로 대표되는 제조환경의 변화와 한국제조기업의 원가시스템의 설계변수와의 관계를 실증분석하되 표본수를 확대하고 분석에 포함되는 변수의 종류를 확대하여 연구결과의 일반화 가능성을 제고하고자 한다. 한국제조기업이 제조환경의 변화에 적응하여 원가시스템을 새롭게 재설계하고 있다고 보기 어려우며, 이것은 신원가시스템에로의 전환시 예상되는 조직의 저항에 대한 관리와 대규모의 투자재원의 조달등과 최고경영층의 강력한 의지가 없이는 신원가시스템으로의 변화가 불가능함을 간접적으로 시사하는 결과라 할 수 있다. Many researchers in cost/management accounting have addressed that cost/management accounting systems must adapt to the recent changes in manufacturing environment. However, there are few studies that provide empirical evidence on whether firms' costing systems are adjusting to the environmental changes. This paper provides an empirical analysis on the relationship between the variables that affect the design of costing systems of Korean manufacturing firms and the recent changes in manufacturing environment that are represented by factory automation, product variety, and short product life cycle. The results of this study indicated that firms' cost structures are adjusting to their factory automation and companies with highly automated production processes use more machine-hour-related allocation bases. It was expected that product variety would facilitate the adoption of more sophisticated costing systems to prevent cost distortions, and the shortening of product life cycle would decrease the usefulness of standard cost system and deemphasize the importance of low cost as a key success factor. However, the results of the study did not support those expectations. Based on the results of this study Korean manufacturing firms appear to not revising their costing systems commensurate to the changes in their operating environment. This finding implies that firms are not likely to adopt a new costing system unless there are top management's strong commitment to the transfer to the new system, financial sources for the transfer, and adequate management of organizational resistance against the transfer. The Effect of Accounting Information on the Distribution of Management Performance

회전원판 공법에서의 자산화 공정을 이용한 소규모 오·폐수처리

이찬기,류돈식 江原大學校 附設 環境硏究所 1998 環境硏究 Vol.15 No.-

The objective of this study is to solve the problems related to the effluent quality in RBC process: media clogging and the biomass sloughing. Three stage RBC with Autoxidation phase was operated along with the existing three stage RBC operation by varying the operational parameters in order to compare removal efficiencies of organics and nitrogen. The BOD removal efficiencies in the three stage RBC with Autoxidation phase were over 95% at a organic loading of 98.4g BOD/㎡/day The existing three stage RBC Process showed a 95% removal at a organic loading of 49.2g BOD/㎡/day, Suspended solids removal efficiency was between 61 and 70 percent in the Autoxidation Phase at 1st stage RBC by biomass sloughing, and that of the existing RBC was between 45 and 61 percent. Removal of ammonia-nitrogen determined by varying NH_(3)-N loading rate showed a 85.3~92.1 percent in the Autoxidation phase and a 67~76percent for the existing three stage RBC process. NO_(3)-N level in the effluent increased with decreasing influent loading. In the determination of the kinematic coefficient, area capacity constant(P) in the first stage Autoxidation phase of RBC was 39.9gBOD/㎡·day and half velocity constant(Ks) was 306mg/L. In the existing three stage RBC, they were 46.6gBOD/㎡·day and 467mg/L. respectively.

액체-고체 순환유동층의 상승관에서 액상의 점도가 고체체류량 및 열전달계수에 미치는 영향

이찬기,강석환,신광식,송평섭,강용,김상돈 한국화학공학회 2003 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.41 No.4

직경이 0.102 m이고 높이가 3.5 m인 액체-고체 순환유동층에서 액체의 점도가 고체입자의 체류량과 열전달계수에 미치는 영향을 검토하였다. 밀도가 2,500 kg/㎥인 유리구슬(d_(p)=1.0, 1.7, 2.1 또는 3.0 mm)과 CMC 용액(μ_(L)=0.96-38 mPas)을 각각 고체상과 액체상으로 사용하였다. 액체-고체 순환유동층에서 고체입자의 체류량은 액체의 유속이나 점도가 증가함에 따라 감소하였고 유동입자의 크기나 입자의 순환속도가 증가함에 따라 증가하였다. 액체-고체 순환유동층에서 열전달계수는 액체의 점도가 증가함에 따라 감소하였고 유동입자의 크기나 순환속도가 증가함에 따라 증가하였으나, 액체의 유속이 증가함에 따라서는 큰 변화가 없었다. 액체-고체 순환유동층에서 고체입자의 체류량과 열전달계수는 다음과 같이 실험변수와 무차원군에 의해 상관식으로 얻을 수 있었다. E_(S) = 0.783U^(-0.100)_(L)G^(0.164)_(S)d^(0.302)_(p)μ^(-0.036)_(L) h = 4349.3U^(0.010)_(L)G^(0.099)_(S)d^(0.151)_(p)μ^(-0.015)_(L) ◁그림삽입▷ Effects of liquid viscosity on the solid holdup and heat transfer coefficient have been investigated in the riser of a liquid-solid circulating fluidized beds, whose diameter is 0.102 m and 3.5 m in height. Glass beads (d_(p)=1.0, 1.7, 2.1 or 3.0 ㎜) whose density is 2,500 ㎏/㎥ and aqueous solutions of carboxymethy cellulose (CMC)(μ_(L)=0.96-38 mPas) have been used as the solid and liquid phase, respectively. It has been found that the solid holdup decreases with increasing liquid velocity or viscosity, but it increases with increasing solid particle size or solid circulation rate. The heat transfer coefficient decreases with increasing liquid viscosity but it increases with increasing particle size or solid circulation rate, however, it does not change considerablely with increasing liquid velocity. The solid holdup and heat transfer coefficient have been well correlated in terms of operating variables or dimensionless groups as fellow: ◁수식원문참조▷

地震 스펙트럼의 解析에 관한 硏究

이성재,하찬식 釜慶大學校 1996 釜慶大學校 論文集 Vol.1 No.2

This study deals with calculation of power spectral density and velocity response spectra of ground surface acceleration to estimate structural damage due to severe earthquake ground motions. These values are evaluated from velocity response characteristics of surface ground for an urban area. One type of earthquake and nine models of surface ground in an urban area supposed and combined in the present analysis. The summary of analytical results is as follow ; (1) Short distance earthquake (X=20Km, M=5.0) Peak power spectral density of ground surface acceleration is about 4∼8㎠/S³ and the maximum velocity response spectrum is (h=0.02) about 7∼8cm/s for period T=0.3∼0.5 seconds.