Hepatic Cirrhosis Occurring in a Young Woodchuck(Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus(WHV)

Kyu-shik Jeong,정원일,Jae-yong Chung,Mi-young An,Chae-yong Jung,Gyoung-jae Lee,Jong-soo Kang,Byeong-cheol Kang,Young-heun Jee,Bruce H Williams,Young-oh Kwon,Da-hee Jeong 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2

Cirrhosis Occurring in a Young Woodchuck (Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus (WHV)Da-hee Jeong, Won-il Jeong, Jae-yong Chung, Mi-young An, Chae-yong Jung, Gyoung-jae Lee1, Jong-soo Kang1, Byeong-cheol Kang2, Young-heun Jee3, Bruce H Williams4, Young-oh Kwon5 and Kyu-shik Jeong*College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea1Shinwon Scientific Co., LTD, Research Institute, Suwon, Korea2Clinical Research Institute, Seoul National University, Seoul 110-744, Korea3College of Veterinary Medicine, Jeju National University, Jeju 690-756, Korea

A New Sesame Variety, “Kangbaek” with Disease Resistance, Lodging Tolerence and High Yield

Kang-Bo Shim,Churl-Whan Kang,Suk-Bok Pae,Si-Kyu Lim,Yu-Young Lee,Duck-Yong Suh,Jae-Whan Rho,Jin Song,Dong-Whi Kim,Ho-Young Kim 한국육종학회 2005 한국육종학회지 Vol.37 No.5

A new sesame variety Kangbaek was developed from Yeongnam Agricultural Research Institute in 2004. Cros wasmade by lodging resistant SP9003-3 line to the F1with high yielding capacity, folowed by pedigree selection, yield test and RYT by the sesame breeding team at the National Insti-tute of Crop Science up to 2003. The variety showed higher disease resistance, especially phytophothra disease, and lodging resis-respectively. It's 1000 grains weight was about 2.54 g indicating 0.03 g heavier than that of Yangbaekkae, and it's oil content wasabout 52%. Kangbaek also contained total 7.65mg/g of such lignans as sesamin and sesamolin. The average yield of Kang-baek was 82 kg per 10a at the national-wide regional performance.

Organic Complementary Circuits: Remarkable Enhancement of Hole Transport in Top‐Gated N‐Type Polymer Field‐Effect Transistors by a High‐k Dielectric for Ambipolar Electronic Circuits (Adv. Mater. 40/2012)

Baeg, Kang‐,Jun,Khim, Dongyoon,Jung, Soon‐,Won,Kang, Minji,You, In‐,Kyu,Kim, Dong‐,Yu,Facchetti, Antonio,Noh, Yong‐,Young WILEY‐VCH Verlag 2012 Advanced Materials Vol.24 No.40

<P>On page 5433, Yong‐Young Noh, Antonio Facchetti, Kang‐Jun Baeg, and co‐workers report that high performance ambipolar complementary inverters and ring oscillators are provided by a remarkable enhancement of both hole injection and transport for n‐channel dominant N2200 OFETs. The significant enhancement of hole mobility in N2200 OTFTs is attributed to the strong dipoles in fluorinated high‐k gate dielectric blend of P(VDF‐TrFE):PMMA. </P>

지르코늄 합금 관의 임계좌굴 압력 산정을 위한 최소안전율

김형규(Hyung-Kyu Kim),김재용(Jae-Yong Kim),윤경호(Kyung-Ho Yoon),이영호(Young-Ho Lee),이강희(Kang-Hee Lee),강흥석(Heung-Seok Kang) 대한기계학회 2011 大韓機械學會論文集A Vol.35 No.3

얇은 관 탄성좌굴 공식의 불확실성을 고려하기 위해, 공식을 구성하는 파라미터인 튜브재료의 탄성계수, 푸아송 비, 튜브 두께 및 지름의 불확실성을 분석하였다. 본 연구는 원자로에서 연소되는 핵연료봉과 같이 사용 중 함몰을 엄격히 방지하고 있는 얇은 관의 설계신뢰도를 향상시키는 데에 중요하다. 분석 방법은 각각의 파라미터가 변화할 수 있는 범위를 충분히 포함할 수 있는 최소의 탄성좌굴 안전율을 구하고 이를 선형적으로 합하여 최종의 최소안전율을 구하였다. 최소 안전율에 가장 큰 영향을 미치는 파라미터는 관의 두께로 나타났다. 두께가 얇을수록 더 큰 최소안전율이 필요하며 예로 적용한 지르코늄 합금관의 경우, 두께가 0.254 와 0.87 ㎜ 일 때 최소안전율은 각각 1.547 과 3.487 로 나타났다. We consider the uncertainty in the elastic buckling formula for a thin tube. We take into account the measurement uncertainty of Young’s modulus and Poisson’s ratio and the tolerance of the tube thickness and diameter. Elastic buckling must be prohibited for a thin tube such as a nuclear fuel rod that must satisfy a self-stand criterion. Since the predicted critical buckling pressure overestimated that found in the experiment, the determination of the minimum safety factor is crucial. The uncertainty in each parameter (i.e., Young’s modulus, Poisson’s ratio, thickness, and diameter) is mutually independent, so the safety factor is evaluated as the sum of the inverse of each uncertainty. We found that the thickness variation greatly affects the uncertainty. The minimum safety factor of a thin tube of Zirconium alloy is evaluated as 1.547 for a thickness of 0.87 ㎜ and 3.487 for a thickness of 0.254 ㎜.

Zirconium 합금 관 임계좌굴 압력의 불확실성에 따른 최소안전율

김형규(Hyung-Kyu Kim),김재용(Jae-Yong Kim),윤경호(Kyung-Ho Yoon),이영호(Young-Ho Lee),이강희(Kang-Hee Lee),강흥석(Heung-Seok Kang) 대한기계학회 2010 대한기계학회 춘추학술대회 Vol.2010 No.11

Uncertainty of the elastic buckling formula of a thin tube is considered. The measuring uncertainty of Young’s modulus and Poisson’s ratio and the tolerance of the tube thickness and diameter are dealt with. The elastic buckling should be absolutely prohibited for a thin tube like a nuclear fuel rod that should satisfy a self-stand criterion. Since the predicted critical buckling pressure overestimated the actual one observed from an experiment, determination of the minimum safety factor is crucial. The uncertainty of each parameter (i.e., Young’s modulus, Poisson’s ratio, thickness and diameter) is mutually independent, so the safety factor is evaluated as the sum of the inverse of each uncertainty. It is found that the thickness variation strongly affects the uncertainty. The minimum safety factor of a thin tube of Zirconium alloy needs to be from 1.547 to 3.487 for the thickness of 0.87 and 0.254 ㎜, respectively.

유기용제의 위해도 평가 및 일부유기용제의 생물학적 폭로지표

강성규,이동배,이영수 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.1

This study was to estimate the total amount of domestic and imported organic solvents production. Potential hazard was evaluated through the amount and physical properties. According to his primary risk assessment, toluene, MEK and perchloroethylene were chosen to analyze the solvents in air and their metabolites in blood and urine for using in biological monitoring in the future. The results were as follws. 1. The amount of organic solvent consumption was about 3 million tons in 1989. Of all organic solvents, 70% were aromatic hydrocabons, 12% alcohols, 5% ketones, 3% aliphatic hydrocabons respectively. Xylene in aromatic hydrocabons, cyclohexane in aliphatic hydrocarbons, methanol in alcohols, acetone in ketones, and trichloroethylene in chlorinated hydrocarbons have been more frequently consumed. 2. Benzene was the most hazardous solvent followed by carbon tetrachloride, methanol, toluene, xylene and its derivatives, dichloromethane, chloroform, ethylene tetrachloride, cyclohexane and MEK. respectively. Of the chlorinated hydrocabons, all except methylchloroform were relatively, hazardous in this assessment. 3. The MEK in urine was a good indicator to pridice MEK exposure. The MEK in blood had high correlation with the MEK in urine. Both the blood and urine MEK were more specific when subjects were exposed to higher level. The urine and blood MEK corresponded to exposure of 200ppm MEK were 1.37mg/l and 2.83mg/l 4. The perchloroethylene in blood and trichloroactic acid in urine were good indicators to predict perchloroethylene exposure. Both the pechloroethylene in blood and trichloroacetic acid in urine were more specific when subjects were exposed to higher level. The perchloroethylene in blood and trichloroacetic acid in urine corresponded to exposure of 50ppm perchloroethylene were 1.43 mg/l and 2.56mg/l 5. The hippuric acid in urine and toluene in blood were good indicators to predict toluene exposure. The corrected hippuric acid with creatinine was more useful to exposure to toluene. The toluene in blood was more useful than the hippuric acid in urine, even if subjects were exposed to lower level. The hippuric acid in urine and toluene in blood corresponed to exposure of 100ppm toluene were 1.71g/g creatinine and 2.06mg/1.

복막유착의 원인 규명과 예방을 위한 실험적 연구

강대영,송규상,노승무,조준식,이태용 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1

Postoperative peritoneal adhesion is the most common cause of intestinal obstruction, and intestinal obstruction is one of the most difficult problems in abdominal surgery. In this experimental study for developing peritoneal adhesion model and its prevention, we divided rats into 5 groups; the talc powder treated group, the cotton-fluff treated group, the talc+fluff treated group, the ischemia group and the control group. There were 16 rats in each group. We made incisions on the midabdomen of the rats and administered talc powder, cotton fluff and talc powder+fluff into the peritoneal cavity respectively. In the ischemia group, we clamped the root of superior mesenteric artery for two minutes to induce ischemia on the small bowel of the rat. We counted the number of the peritoneal adhesive sites in peritoneal cavity on the 7th, 14th , 21st and 42nd postoperative day after peritoneal adhesion induced operation, and observed the characters of the adhesion state. The average number of the peritoneal adhesions were 1.25 per one rat in the talc powder group, 1.44 in the fluff group, 1.31 in the talc+fluff group and 1.31 in the ischemia group compared with 0.94 per one rat in the control group performed sham operation. 91.6% of the all adhesions were observed on the peritoneum of the previous incision sites and only 8.4% of the adhesions were adhered to the peritoneal surface of non-incision sites. The data of this study suggest that peritoneal injury and inflammatory reaction is the major cause of peritoneal adhesion. Also this study indicates that foreign bodies can develop peritoneal adhesion, but the effect is much lower than that of peritoneal injury with inflammatoty reaction.

원발성 간암종의 조직 발생에 대한 면역조직학적 연구

강대영,최정목,송규상,이헌영 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

To assess the utility of cytokeratin(CK) profile in the differential diagnosis of primary liver carcinomas(PLCs),we evaluated a series of needle biopsied specimens and surgically resected PLCs, comprising 30 pure hepatocellular carcinomas(HCCs) and 20 cholangiocarcinomas(CCs). The results are summarized as follows: 1) The pure hepatocellular carcinomas showed intense cytoplasmic expression of anti-cytokeratin (AE1/AE3);28/30 (93.3%). 2) The cholangiocarcinomas showed cytoplasmic expression of 2 types of CK(Anti-CK19,AE1/AE 3);14 of 20 (70.0%) of the CCs evidenced mature bile duct phenotype (CK 19), whereas 10 of 20 (50.0%) displayed the hepatocytic profile(AEl/AE3). 3) Nine of 30 HCCs also displayed the bile duct cell profile; high grade HCCs(8/20), and low grade HCCs(1/10). The above results show that a mixed biological phenotype can be found both among morphologically pure HCCs and peripheral CCs, suggesting that these two forms could share a common histogenesis.

III급 부정교합 어린이의 수완부 골성숙과 하악 3대구치 발육에 대한 연구

강근영,양규호,최남기,김선미 大韓小兒齒科學會 2008 大韓小兒齒科學會誌 Vol.35 No.2

본 연구는 I급 부정교합과 III급 부정교합 어린이의 수완부 골성숙 단계와 하악 제3대구치 발육을 비교 · 평가하고자 하였다. 이를 위해 전남대학교병원 소아치과에 내원한 환자들로 8세부터 15세 사이의 Angle I급 부정교합을 지난 남자 149명,여자 155명 그리고 Angle III급 부정교합을 지닌 남자 153명,여자 155명,총 612명을 대상으로 하였으며 골성숙 단계 평가를 위해 수완부 사진을 이용한 Fishman의 방법을 사용하였고 하악 제3대구치의 발육 단계를 평가하기 위해 Orthopantomogram을 이용한 Gat 등의 New Six-Developmental-Stage 방법으로 판독하여 다음과 같은 결과를 얻었다. 1. 골성숙 단계는 I급 부정교합과 III급 부정교합군 모두 전반적으로 여자가 남자보다 빠르나(p<O.05) 하악 제3대구치의 석회화 단계는 성별 차이가 없었다. 2. 남녀별 골성숙 단계와 하악 제3대구치의 석회화 단계는 I급과 III급 부정교합군 간에서 유의한 차이가 없었다. 3. I급 부정교합과 III급 부정교합군의 수완부 골성숙 단계와 하악 제3대구치 석회화 단계 사이의 상관관계는 두 군 모두 높은 상관성을 보였다(p<O.O1). 4. I급 부정교합과 III급 부정교합군의 하악 제3대구치 석회화 단계와 연령사이의 상관관계는 두 군 모두 높은 상관성을 보였다(p<O.O1). 이상의 결과로 수완부 골성숙도와 하악 제3대구치 발육은 I급 부정교합과 III급 부정교합군 간에 차이가 없었다. The purpose of this study was to investigate the relationship of the skeletal maturity of hand-wrist and the development of mandibular third molar in subjects with class I and class III malocclusion. The subjects used in this study were 304 children(149 boys, 155 girls) with class I malocclusions and 308 children(153 boys, 155 girls) with class III malocclusions, ranged from 8 to 15 years of age. Hand-wrist radiographs and panoramic radiographs were used to evaluate the stage of skeletal maturity and teeth development. Fishman s method for the skeletal maturity stages of the hand-wrist and new six-developmental-stage method for the calcification stages of mandibular third molars were analyzed. The results were as follows: 1. In subjects with class I and class III malocclusion, skeletal maturity of the hand-wrist occured earlier in females than in ma1es(p<0.05), while the calcification stages of mandibular third molars were no significant gender differences. 2. There were no significant differences between the groups, when comparing the skeletal maturity stages of the hand-wrist and the calcification stages of mandibular third molars between subjects with the class I and the class III malocclusion. 3. The correlation coefficients between the calcification stages of mandibular third molars and the skeletal maturity stages of the hand-wrist in subjects with class I and class III malocclusion showed a high interrelationship(p<0.01). 4. The correlation coefficients between the calcification stages of mandibular third molars and chronological age in subjects with class I and class III malocclusion showed a high interrelationship (p<0.01). As a result, there were no significant differences between class I and class III malocclusion group for skeletal maturity of the hand-wrist and third molar development.

Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.