조직공정성과 조직후원인식의 관계에 관한 연구

정범구,김경재 충남대학교 경상대학부설 경영경제연구소 1997 경영논집 Vol.13 No.2

본 연구는 조직공정성과 조직후원인식의 상호관계를 알아보기 위해서 조직공정성과 조직후원인식의 개념과 이론을 정리하였고 연구모형과 가설을 통해서 실증분석결과를 제시하였다. 연구결과 조직공정성은 조직후원인식에 정적인 영향을 미치는 것으로 나타났고 조직공정성이 종속변수에 대하여 미치는 직접효과보다 조직후원인식을 매개로 하였을 때의 매개효과가 더 큰 것으로 나타났다.

인체 방광이행상피암에서 p53 발현의 의의

정재일,윤혜경 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

Objective: The aim of this study is to evaluate the prognostic significance of p53 expression and correlation with clinicopathologic parameters in transitional cell carcinoma of the urinary bladder Material and Method:. From Jan. 1st 1990 to Dec. 31st 1997, 37 cases of radical cystectomy for transitional cell carcinoma of urinary bladder were evaluated. Immunohistochemical stainings for p53 (DAKO) was done. More than 5% of positive p53 expression was regarded as positive. Statistical analysis between clinicopathologic parameters and p53 expression was performed. Results: Overall survival rate was 78%. Survival probability for grade and stage showed that high stage and high grade tumor were significantly lower than low grade and stage tumor(p<0.05). p53 expression was significantly increased in higher grade and high stage tumors, (p=0.003, p=0.05) But there is no correlation between p53 expression and survival. Conclusion: p53 expression by immunohistochemical staining in transitional cell carcinoma of urinary bladder were related with high stage and high grade tumor. But it was not independent prognostic factor.

Mycobacterium mageritense에 의한 당뇨병성 족부 감염증 1예

김충종,김낙현,김문석,김계형,전재현,박문석,박경운,박완범,박상원,김홍빈,김남중,오명돈,최강원 대한감염학회 2008 감염과 화학요법 Vol.40 No.6

Diabetic foot infection is one of the important complications in patients with advanced diabetes mellitus. Limb threatening infections such as osteomyelitis, abscess, and necrotizing fasciitis are frequently accompanied by the disease. Non-tuberculous mycobacterium (NTM) is a rare causative organism of diabetic foot infection. Thus, if one is not suspicious or meticulous, infection due to NTM will be easily overlooked and this will result in delayed diagnose and treat. Therefore, it is necessary to consider NTM as the causative organism if the wound does not respond to the conventional antibiotic treatment and the culture from the adequately obtained specimen reveals atypical acid-fast bacilli. We present a case of diabetic foot infection with osteomyelitis and abscess due to Mycobacterium mageritense, one of the rapid growing mycobacteria, that was successfully treated with surgical debridement and appropriate antibiotic treatment.

친수성 Polyvinylsiloxane 인상재의 putty와 light body의 결합강도

강재경,김경남,조리라,정경호 대한치과기재학회 2000 대한치과재료학회지 Vol.27 No.4

Polyvinylsiloxane is the most accurate and dimensionally stable material among the dental impression materials which replicate the teeth and oral tissues. There are two methods for taking impressions with the polyvinylsiloxane: one step simultaneous polymerization; and putty/wash two step reline technique. The purpose of this study was to evaluate tensile bond strength between putty and wash material under the conditions of contamination with saliva or water at taking impression by putty/wash technique. The materials used in this study were 4 hydrophilic polvinylysiloxane impression materials of putty and light body type(Perfect-F, Handae Chemical, Korea; Contrast, VOCO, Germany; Exaflex and Examix, GC, Japan; Express and Imprint Ⅱ, 3M, U.S.A.). First, putty material filled in one perforated metal mold with diameter of 15 ㎜ and height of 19 ㎜ was set, and it was bonded with light body material filled in other paired metal mold before setting. Tensile bond strength was measured at a cross-head speed of 300 ㎜/min by universal testing machine (Instron 6022, Instron Co., U.K.) after 10 minutes from the joining two mold in order to set completely. As results, tensile bond strength of Contrast, Examix and Perfect-F showed no significant difference with control group on contamination with saliva or water, and it showed cohesive failure in the light body. However, Imprint Ⅱ showed the highest strength among these tested materials and showed adhesive failure at 5 specimens in the case of contamination with saliva and 4 specimens with water. From the results of this study, each product use possible cross bond and the tensile bond strength of some materials showed lower value on contamination with saliva.

한국인 제1형 당뇨병에서 체도 세포질 항체의 양성률 : 항GAD항체, 항ICA512항체, 항phogrin항체의 조합 측정으로의 대체 가능성 Possible Replacement with Combined Measurement of Anti-GAD, Anti-ICA512, and Anti-phogrin Antibodies

김경아,김동준,정재훈,민용기,이문규,김광원,진동규,고경수,김상진,이명식 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.25 No.6

연구배경:최근 당뇨병의 분류를 새로 제정함에 있어 자가항체가 양성이면 임상형에 상관없이 제1형 당뇨병으로 분류하자는 제안이 나옴으로써 자가항체의 중요성은 더욱 커질 것으로 예상된다. 특히 우리나라와 같이 비비만형인 제2형 당뇨병이 많은 나라에서는 당뇨병의 병인 규명에 자가항체가 중요한 위치를 차지할 것으로 사료된다. 자가항체 중에서 전통적으로 측정되어온 췌도 세포질 항체(ICA)는 표준화하기 어렵고 기술적으로 제한점이 많으며 현실적으로도 췌장 공여자가 적은 점 등이 문제로 알려져 있다. ICA의 대응 항원들로는 GAD(glutamic acid decarboxylase), IA­2(islet­associaated antigen­2;ICA512), IA­2β(phogrin)등이 있다. 이러한 대응 항원에 대한 특이적인 자가항체의 측정은 ICA에 비해 표준화되었으며 최근에는 방사면역측정법(radioimmunoassay;RIA)키드까지 등장하여 손쉽고 정확히 이를 측정할 수 있게 되었다. 연구자들은 한국인 제1형 당뇨병에서 측정법이 표준화 되어 있는 항GAD항체 및 항ICA512항체 조합(combimation)의 조합으로 ICA의 측정을 대신할 수 있는지를 조사하였고 더 나아가 항phogrin항체의 조합 측정으로 임상적 유용성이 있는지 보고자 하였다. 방법: ICA는 면역조직화학 염색법을 이용하였다. 항 GAD항체는 상업화 된 키드(RSR??, United Kingdom)를 이용하였다. 항 ICA512항체와 항phogrin항체의 측정은 in vitro transcription&translation한 후 이를 이용해 방사면역 침전법을 이용하였다. 대상 환자로는 전형적 제1형 당뇨병 76명, 지진형 제1형 당뇨병 22명, 제2형 당뇨병 39명이었으며 각 군간의 연령은 각각 22.8±14.0, 37.9±13.9, 45.3±12.3세였다. 결과:1)전형적인 제1형 당뇨병에서는 ICA의 양성률이 30%, RIA조합만의(항GAD항체 또는 항 ICA512항체 또는 항phgrin항체 한가지에라도 양성인 경우)양성률이 57%이었다. 지진형 제1형 당뇨병에서는 각각 18%, 50%이었다. 제2형 당뇨병에서는 각각 7.7%, 5.1%이었다. 2)각 군에서 ICA가 양성인 군에서 RIA조합 양성률을 보면 전형적 제1형 당뇨병에서는 96%, 지진형 제1형 당뇨병에서는 100%에서 양성이었고 제2형 당뇨병에서는 RIA 조합 양성이 없었다. 각 군에서 ICA가 음성인 군에서도 RIA 조합시 전형적 제1형 당뇨병에서는 40%, 지진형 제1형 당뇨병에서는 39%에서 양성이었고, 제2형 당뇨병에서는 5.6%에서 양성이었다. 3)전형적 제1형 당뇨병에서 ICA가 양성인 군(n=23)에서 96%가 RIA조합 양성이었는데 이때 각각의 RIA유형을 보면 항GAD항체 양성이 87%였다. 한편 항 ICA512항체 양성이 48%, 항phogrin항체 양성이 44%이고 항GAD항체 도는 항ICA512항체 양성이 96%를 차지한다. 지진형 제1형 당뇨병에서는 ICA가 양성인 군(n=4)에서는 항 GAD항체 양성이 3명, 항ICA512항체 양성이 1명이었다. 따라서 기존의 ICA를 RIA조합으로 대체할 수 있을 것으로 사료되었는데 이때 항GAD항체와 항ICA512항체의 조합이 도움이 되겠고 항phogrin항체의 추가적인 검사는 일부의 환자에서만 도움이 되리라 사료된다. 4)이환 기간에 따라 ICA와 RIA조합을 비교시 ICA는 차이가 없었으나 RIA조합의 양성률은 지진형 제1형 당뇨병에서 4년 이상의 이환 기간이 지나면 그 이전보다 떨어졌다. 5)발병 연령에 따라 ICA와 RIA조합을 비교시 ICA 양성률이 전형적 제1형 당뇨병에서 15세 이전에 발병한 그룹에서 그 이후에 발병한 그룹보다 유의하게 높았다. 결론:이상의 결과를 요약하면 항GAD항체 및 항ICA512항체 측정의 조합은 ICA보다 민감도가 높아 기존의 ICA를 대체함은 물론 임상적 이용에서 현격한 우월성을 보이며, 성인에서 발병한 비전형적인 당뇨병의 분류에도 도움이 될 것으로 사료되었다. 추가적인 항phogrin항체의 측정은 임상적 유용성이 없었다. Background : Type 1 diabetes includes all forms of autoimmune-mediated and idiopathic beta-cell destruction leading to an absolute insulin deficiency. Evidence of an autoimune pathogenesis was assessed by studying cytoplasmic islet cell antibodies (ICA), antibodies to glutamic acid decarboxylase (GADA), antibodies reacting with an islet tyrosine phosphatase-related molecule referred to as ICA 512 (ICA 512A), or its homologue phogrin (phogrin-A). In comparison with ICA, the best validation to assess the risk of type 1 diabetes, shows that a combination of antibodies to GADA with ICA 512A has the power to detect a majority of ICA and 97 ~ 100% of subjects who progressed to overt diabetes. These findings suggest the possibility of replacing the laborious ICA test in the screening programs to identify subjects at risk of progressing to type 1 diabetes or for classifying the stage of diabetes at the time of diagnosis. Up to now, it is unclear whether these results are applicable to the slowly progressive type 1 diabetes that appears to be more prevalent in Asian than in western countries. The prevalence of combined autoantibody testing (1≥ of GADA, ICA512A, or phogrin-A) was investigated in the patients with type 1 diabetes (typical and slowly progressive) and type 2 diabetes, and compared with that of ICA which is a more laborious and insensitive test. Methods : The ICA assay was performed using immunoenzymatic staining of frozen human (blood group O) pancreatic sections with serial dilutions of serum samples with peroxidase-labeled protein A. For the GADA determination, commercially available GADA radiommunoassay kits utilizing the ^125I-labeled recombinant GAD65 (RSR®, United Kingdom) as an antigen was used. Either ICA512A or phogrin-A were detected by a radioligand-binding assay after in vitro transcription and translation using the clone ICA512bdc or phogrin c DNA. Serum was obtained from 76 patients with type 1 diabetes(mean age 45.3± 12.3 years). Typical and slowly progressive type 1 diabetes patients had the disease for between 4.0±4.6 and 10.1±9.5 years, respectively at the earliest serum sampling. Results: 1) In typicaltype 1 diabetes, 30% of patients tested positive for ICA and 57% for the combined autoantibody test. In type 2 diabetes, 7.7% and 5.1% tested positive, respectively. 2) Ninety-six percent of ICA-positive patients expressed one or more of the 3 auto-antibody specificities in typicaltype 1 diabetes. Among the 53 ICA-negative patients with typicaltype 1 diabetes, 40% had one or more of these auto-antibodies. In the slowly pregressive type 1 diabetes, 100% of the ICA-positive and 39% of the ICA-negative patients expressed one or more of the 3 autoantibody specificities. 3) Of the 23 patients with ICA-positive typical type 1 diabetes patients, 87% had a positive result for GADA, 48% FOR ICA512A, 44% for phogrin-A, and 96% for GADA or ICA512A. Of the 4 patients with ICA-positive slowly progressive type 1 diabetes, three had a positive result for GADA, and 1 for ICA512A. 4) When the prevalence of combined autoantibody testing was analyzed according to the duration of diabetes, the prevalence in patients tested within 4 years after the diagnosis and more than 4 years after the diagnosis was 61% and 52%, respectively in typical type 1 diabetes. Furthermore, that for the ICA was 37% and 21%, respectively. In the slowly progressive type 1 diabetes, the prevalence of combined auto-antibody testing was 88% and 25%, respectively (p<0.05), while that of ICA was 25% and 13%, respectively. 5) In typical type 1 diabetes, ICA were detected more frequently in patients younger than 15 years of age (48%) than in older patients (23%) (p<0.05), while the prevalence of combined auto-antibody testing -was not different according to the onset age(65% vs 53%). Conclusion : Combined autoantibody testing for GADA and ICA512A is more sensitive that ICA in type 1 diabetes. Therefore, it could replace the laborious ICA measurement and may be useful for discriminating the etiology of adult onset a typical diabetes(J Kor Diabetes Asso 25 :430~445, 2001).

中學校 學生들의 멘델유전에 관한 誤槪念 硏究

이경숙,이길재,정완호 한국교원대학교 과학교육연구소 1994 청람과학교육연구논총 Vol.4 No.1

Misconceptions of scientific concepts have been believed to be very persistent and difficult to be overcome through regular classroom activities. Therefore, it is important to find the misconceptions and cognitive structure of students. Mendelian genetics is an important and difficult topic for the student to learn. It is also difficult for the teacher to teach. Chromosome theory of inheritance and the concept of gene is the most important and difficult topics relate to mitosis/meiosis. The purpose of this research is a study of middle school students' understanding of the physical relationship of chromosome and genes. Particularly, this study is to establish new teaching strategy of the 3rd grade middle school students, by analyzing misconceptions of genetic continuity and to enhance their problem solving performance. Total 100 students were selected for this study from 2 different classes. They were all females. The test taken by students was open ended questionnaires. It was developed by Moll & Allen(1987) and it was modified for this study. Misconception was analyzed by personal interview. Each of the interviews was recorded and transcribed. Everything that students wrote and drew during the interviews, as well as the interview transcripts, were used to construct the data to be analyzed. The new instruction program "chromosome card game" used to reverse the misconceptions of Mendelian genetics, which were discovered in this study. The new instruction program was reviewed by having controlled experiment and treated additional study group. The results of this study are as follows: 1. Students have misconception on sister chromatids, the pairs of homologous chromosomes and gamete types. 2. According to the conceptual knowledge of chromosome and gene behavior, three types of chromosome model were suggested such as one-chromosome model, two-chromosome model and four-chromosome model. Many students can not construct the conceptual knowledge of genetics and meiosis. There is a tendency toward being mathematical rather than genetic in problem solving. 3. After the new instruction program was applied to the students, much enhanced study effect was discovered among experiment group. Based on above mentioned study, the classroom teachers must recognize the misconceptions some students have, and modify students' misconceptions, and increase the probability of meaningful learning.

학습조직 구축요인과 조직특성의 교육훈련 효과성 연구 : 콜센터 종사자를 중심으로

김경재,정범구,조장현 충남대학교 경영경제연구소 2008 경영경제연구 Vol.31 No.2

With the development of telecommunication technology, and with combination of computer and communication, a new field, which is called a customer care call center , has been created. In the past, the customer center was just passive in the way that their role was just answering to the customers' questions. However, now this has been changed to be active and positive for fulfill customers' satisfaction. Therefore, not only enterprises, but also public institutions and government agencies are having customer care centers as one of methods to maximize customer service. Also, the role of customer care center is extended to marketing activities. The actual proof study on training of call center employees and the transfer of the training to the work has been practiced for this research. The findings of this research are summarized as follows ; first, building factors of learning organization is positively associated with the transfer of training, second, organizational characteristics has moderating effects between building factors of learning organization and training effectiveness. 본 연구는 콜센터 종사자를 대상으로 학습조직 구축요인과 조직특성의 교육훈련 효과성 관계를 알아보기 위하여 학습조직구축요인, 조직특성, 교육훈련 효과성의 개념과 이론을 정리하였고, 연구모형과 가설을 통해 실증분석결과를 제시하였다. 연구결과 학습조직 구축요인이 교육훈련 효과성에 영향을 미치는 것으로 분석되었고, 양 관계에 있어서 조직특성이 부분적으로 조절효과가 있는 것으로 나타났다.

정보시대의 여성인권

백경재,김교정 숙명여자대학교 아시아여성연구소 2003 아시아여성연구 Vol.42 No.-

인권은 사람이 가지는 기본적인 권리로서 그 개념이 시대에 따라 진행·발전되고 있다는 인식 하에 정보시대의 여성인권의 개념과 발전양상을 연구하였다. 새로운 정보통신 기술을 기반으로 하는 정보사회가 여성인권을 침해할 수도 있고, 여성인권 문제 해결을 위한 좋은 수단이 될 수 있다는 두 가지 가능성을 열어두고 정보시대의 여성인권의 개념과 범위를 재정립하고자 했다. 정보시대에서의 기본적 인권으로 정보에 동등하게 접근할 수 있는 권리인 정보접근권리(The right to access information)와 자신의 생각을 자유롭게 표현하고 정보를 공유 또는 통신할 수 있는 권리를 통신권리(The right to communication)로 상정하고 이에 대한 개념과 범위를 밝히고자 하였다. 기본적인 여성인권과 관련하여 정보사회가 가지는 특수성으로 인한 여성인권을 침해하는 사례를 통하여 그 원인, 문제점을 살펴보고, 해결 방안을 모색하였다. 정보사회에서 여성 인권의 핵심요소라 할 수 있는 동등한 정보접근 권리와, 사이버 공간에서 자유로운 통신권리를 보장받기 위한 개인적, 사회적, 문화적 측면에서의 요구되는 노력을 구체화하였다. 세계인권선언에 기초한 글로벌 정보사회를 건설하기 위한 국제적 노력 속에서, 정보사회는 계속 진행, 구성중이다. 정보사회의 발전은 비단 정보통신기술의 발달만으로 이루어지는 것은 아니며, 역동적인 정보환경 속에서 사회에 대한 새로운 인식과 기존의 가치에 대한 다양한 시각에서의 해석이 요구된다. 여성의 인권 또한 시대의 변화에 따라 재정의되고, 다양하게 논의되고 발전할 수 있는 작업이 계속되어야한다. Human rights is a basic right for human and a developing concept, not completed one. The theme of the study is to identify the women human rights in the information age. International efforts for building global information society based on "Universal Declaration of Human Right" from gender perspective are studied. In line with the history of women human rights and the process of how women human rights has been developed and changed, the women human rights in the information age are formulated. By utilizing Information and Communication Technology(ICT), information society provides both positive and negative effect to human rights. The case of violating women human rights and the cases of solving the problem of women human rights due to the characteristics of information society have been investigated. The concepts and scope of women human rights in the information age are discussed and formulated. In our study, we identify the basic women rights in the information age as "the rights to access fo information" and "the right to communicate". And the factors for violating women human rights are identified and the strategies to solve this problem are recommended. To secure the women human rights to access to information and ICT and to communicate their freely in cyber space, the personal initiatives and challeges of information society and culture are needed. The information society is on going process and evolving concept. We learn to analyze the past values with a dynamic point of view in the new information environment. women human rights is the value that need to be re-analyzed and modify in the information society. In a course of preparing for the information society, women human rights have to be discussed continuously.

스포츠 참가자의 라이프스타일 특성과 서비스 만족의 관계

윤승원,정경회,이일재,박영표 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.1

The analysis of the customers' mind is crucial in the modern society where marketing strategy is very important for the satisfaction of the customers. the purpose of this study was investigating the relationship between lifestyle characteristics and service satisfaction of sports center customer. To achieve this purpose, the population of this study are the participants of the swimming pool, bowling center, fitness club and golf club among the commercial sports center in Jeonju, Jeollabugdo. They are chosen by the multi-stage stratified random sampling considering the events and region. The valid samples are 420 persons at last among 500 persons except the 80 persons whose validity are determined low. To analyze the data, frequency analysis, factor analysis, t-test, ANOVA, regression analysis and covariance structural analysis are used in this study. In this study, those following results are gathered by analysing the data through above approaches. First, According to the background variation of the sports participator; material service to income, personal service to educational level and occupation, systematic service to sex and educational level, there are significant service satisfactions. Second, Lifestyle characteristics of the sports participator influence on service satisfactions significantly; persuit of the trend, social contact, nervousness and individualism influence on personal service social contact, persuit of the trend, nervousness and sentimentalism on systematic service and the other variations on material service.

강원지역의 자원관리를 위한 지리정보시스템 개발

서백수,임길재,정영준,송화선,류창희,민경원,서희정 강원대학교 석재복합신소재제품연구센터 1997 석재연 논문집 Vol.2 No.-

강원도는 오랫동안 금속, 비금속, 석재 및 석탄과 같은 지하자원들을 공급하는 국내 주요생산지로 알려져 왔으나, 장기적인 채광과 비 계획적인 생산으로 인하여 매장량이 고갈되고 있으며, 대외적으로 생산 경쟁력 마저 잃어가고 있다. 이러한 문제점에 대한 해결방안의 일환으로 본 연구에서는 강원도내에 산재되어 있는 지하자원의 분포, 자원 생산시설 및 생산량, 경제성, 자원개발, 환경문제 등 자원관리에 필요한 제반사항을 수행할 수 있는 강원지역 자원 종합관리 GIS 시스템을 개발하였다. 이 시스템의 개발은 방대한 양의 정보 조사 및 저장, 오랜 개발기간, 많은 소요인력 및 개발 비용이 요구되기 때문에 본 연구에서는 조기에 자원관리 GIS 시스템을 개발하여 이와 관련된 생산 및 연구 분야에 조기에 적용할 수 있도록, 일차년도에는 현재 석재복합 신소재제품 연구센터의 집중적 연구대상 지역인 태백지역에 대한 탄광지역을 중심으로 자원 종합관리 GIS 시스템을 개발하였다. The Kangwon province has been well-known to be one of major underground resource producing districts which are mainly supplying metals, non-metals, stones, and coals. However, due to the long-term mining and unplanned production, the natural resource reserves have been rapidly drained and oversea production competition has been losing. In this study, we has developed a GIS system for regional resource management in the Kangwon province, which can operate, maintain, and manage the distribution of underground resources, resource production facilities, production and economic development, and environmental issues. The development of this system requires the collection, analysis, evaluation, and storage for a huge amount of research data, and in addition, the long period of time, the big research man power, and big development cost. Accordingly, to shorten the development period of time and to early apply itself to production, this stage of study has been intensively developed a regional resource GIS system for managing the mines scattered in the Tabak province, which is one of hottest RRC's research areas.