폐경기 증후군 환자에서 Cyclofenil의 치료 효과

김덕윤,고은미,우정택,양인명,김진우,김영설,김광원,최영길 최신의학사 1992 最新醫學 Vol.35 No.10

입원 중인 베트남 참전 군인의 삶의 만족도와 관련된 요인

김애리,박종,김율,노희송,박광희,김은숙,김형철,홍강식,류소연,강명근,김기순 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.2

Background and Objectives: The aim of the study was to identify the factors associated with life satisfaction of hospitalized Vietnam veterans. Material and Methods: The data were collected from 200 hospitalized Vietnam veterans of 5 veterans hospitals in Korea from September 13 to 23, 2004. Information of general characteristics, health behavior, disease history, family function, depression and life satisfaction were collected by structured questionnaire. Results: The mean of life satisfaction was 21.48(±6.03), and the mean of depression was 53.10(±9.64). The prevalence of depression was mild depression 24.0%, moderate depression 43.5% and severe depression 25.0%. Depression was associated with life satisfaction and depression was higher, life satisfaction was lower. Family function and age were positively associated with life satisfaction, Conclusion: Life satisfaction was affected by depression and family function in hospitalized Vietnam veterans. Therefore, it was thought that psychosocial approaches such as improve depression and family function in care of hospitalized Vietnam veterans is required.

세포질내 정자주입법(ICSI)에 있어서 정자흡입 및 난자내 주입방법에 관한 연구

이택후,김항진,송건호,김대근,전상식,박윤규,서태광,전병균,류은경,이은숙,문진수,김광철 경북대학교 의학연구소 2000 경북대학교병원의학연구소논문집 Vol.4 No.1

Study on Method of Sperm Aspiration and Injection into an Oocyte in Intracytoplasmic Sperm Injection(ICSI) Immobilization of spermatozoa prior to intracytoplasmic sperm iniection(ICSI) sometimes results in crooked tail and this makes it difficult to aspirate sperm into an injection pipette tail first. Head-first sperm aspiration into an injection pipette avoid this problem due to the bigger size of the sperm head. The effect of head or tail-first sperm injection into an oocyte on fertilization cleavage, percentage of grade I embryos and development to blastocyst stage in ICSI program has been studied. A single living immobilized spermatozoa from oligoasthenozoospermic patient was injected into an oocyte head-first or tail-first according to the treatment. Eighteen hours after microinjection, oocytes ware inspected for survival and fertilization Fertilized oocytes with two pronuclei were cultured in 30μl drop of mHTF supplemented with 10% heat-inactivated follicular fluid(FF) at 37℃. On day 2. embryo transfer was performed with cleaved embryos. The remaining 2-8 cell stage embryos were co-cultured with BRL cells in mHTF + 10% FF for 72 hours and the developmental stage was observed. The data were analyzed by Analysis of Variance. A total of 164 oocytes from 36 cycles were assigned to earth treatment and ICSI was performed(88 head-first, tail-first). The rates of normal fertilization were 81.8% and 76.3% for head-first and tail-first, respectively. Of the fertilized oocytes, the percentage of cleaved embryos and the percentage of grade 1 embryo among cleaved embryos were 88.9% and 68.8%, 93.1% and 74.1% for head-first and tail-first, respectively. Of the 2-8 cell embryos cultured, 44.4%(16/36) and 50.0%(10/20) for head first and tail first, respectively developed to blastocyst stage. There were no differences in fertilization, cleavage, rates of grade 1 embryos, and development to blastocyst stage. In conclusion, head-first or tail-first sperm injection into an oocyte in ICSI program does not affect fertilization and subsequent embryo development to blastocyst stage in vitro.

사람 백혈병 암세포의 증식에 미치는 Berberine의 저해효과

김은영,김광혁 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Background : The isoquinoline alkaloid berberine is widely distributed in a variety of plants, especially in the genera Berberis and Coptis. The berberine, an alkaloid initially isolated from Chinese herbal medicine, has antibiotic activities against a variety of organisms including bacteria, viruses, fungi, protozoans, and chlamydia. Furthermore, berberine has shown a number of beneficial effects, including anti-tumor, anti-inflammation, and vasodilatory effects. Materials and Methods : In this work we have investigated the effects of berberine on cytotoxic activity against cancer cells. The direct cytotoxicity of berberine or berberine-combined chemotherapeutic agents for human leukemia cells K-562 was observed. Results: The effect of growth inhibition for cancer cells, K-562 was shown in the cytotoxicity test of berberine or berberine-combinated chemotherapeutic agents. Conclusion: These findings suggest that berberine shows tumor cell growth inhibition. These results show the probability of its usefulness for cancer therapy if more research results were accumulated.

백혈병환자의 정신병리

김은혜,한진희,김광수,유태열,김춘추 가톨릭 중앙의료원 가톨릭 암센터 1991 가톨릭 암센터 論集 Vol.5 No.1

인산염계 실리카 매몰재의 성분변화에 따른 티타늄의 주조특성

김광만,은진원,이상배,김경남 대한치과기재학회 1999 대한치과재료학회지 Vol.26 No.2

A large increase in the use of titanium in density is driven by the desire to take advantage of titanium's excellent biocompatibility and its high resistance to corrosion. The development of investments suitable for titanium castings is critical because their mechanical properties are greatly affected by the surface-reacted layer. The purposes of this study were to evaluate the characteristics of Titanium Vest Ⅱ(CO) and experimentally produced four phosphate- bonded SiO₂ investments(EA, EB, EC, ED). A great deal of attention was focused on the influence of investments, such as setting time, compressive strength, casting compatibility, casting defects, surface microhardness and interfacial zone of the cast titanium. The following results were obtained; 1. The setting time of all experimental groups were significantly shorter than control group(p<0.05). 2. Experimental groups were significantly greater than control group in compressive strength of 1hr and 2wks(p<0.05) and there was no significant difference among the experimental groups(->0.05). Compressive strength after 2wks was significantly greater than 1hr in all tested groups(p<0.05). 3. EA was showed the highest casting compatibility and CO the lowest. 4. There was no fin in the casting of all groups. There were small porosities in a dental x-ray inspection of EA. 5. CO was showed the highest microhardness at the distance of 50 ㎛ from the surface. 6. The interfacial zone was composed of four layers in all groups. There was irregular and thick layer in CO. According to these results, titanium is castable with experimentally produced phosphate-bonded SiO₂investments. In addition, there is room for further investigation of investment materials to improve the precise casting of titanium.

Emily Dickinson 시에 나타난 죽음의 고통과 시적 비전 : "Blank" 메타포를 중심으로 Pain of Death as Poetic Vision

김은영,김광선 명지대학교 인문과학연구소 2002 인문과학연구논총 Vol.24 No.-

In Dickinson's poems, pain is important element of death. She perceives death of consciousness in the breakdown of temporal sense by extreme pain. Dickinson's poems on pain are an attempt to blank time out and to create in its place. In its self-consuming totality, it is perception of death that hacks away consciousness to leave a bare nothing as blank. To be blank is the process that the self is translated from life into death of consciousness. Therefore blank as metaphor for death is regarded as nothing, but inner boundless space of consciousness, too. Also blank is the moment of Circumference. She contemplates the circumference of her own single brain, her own elevated spiritual and poetic circumference, and the circumference of time and eternity. In conclusion, relating to the blank metaphor, pain of death, is another means to poetic vision realizing immortality in a mere perceptual moment of death.

미생물을 이용한 Gellan Gum 생성의 Kinetic에 관한 연구

金春永,鄭奉佑,張光燁,李銀美 全北大學校 1992 論文集 Vol.34 No.-

Polysaccharides produced microbially, have shown themselves to be commercially significant. The reasons for the commercial exploitation of these microbial polysaccharides is because of their unique physical and consistant chemical properties and regularity of supply. Gellan gum is a recently discovered extracellular polysaccaride. This is an anionic heteropolysaccharide that forms viscous solutions and can under certain conditions, form thermoreversible gels with characteristics similar to those formed by both carrigeenan and agar. The aspect of Gellan gum produced by Pseudomonas elodea were investigated under various concentration of carbon sources and nitrogen sources. Sucrose and glucose are used as carbon source, and Bacto-peptone, Promosoy and (NH_4)_2SO_4 are used as nitrogen source. The maximum Gellan gum production was obtained in the culture medium 30.0g/L glucose, 0.6g/L Promosoy at pH 6.6, 37℃. The molecular weight of Gellan gum was 5 × 10 exp (5) which was determined by gel permeation chromatography.

건축벽체용 광택문양콘크리트의 성능평가에 관한 실험적 연구

김종원,김재은,차광석,조상영,정재욱,정상진 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2

Contemporary, architecture calls for a wide range of surface textures and treatments. A surface compatible with the architecture's design may vary from a glass-smooth finish to one requiring special sculptured ornamentation. These surfaces require many different types of form sheathing and lining. The purpose of study development new design form and made elaborateness shape. Easy to used in field that architecture finish material not used expect effective reduce of working hours, personnel expenses, architecture finish material, cost, through this study, we have figured out the best mix proportion for durability and gloss ability of glossing exposure concrete.

만성폐쇄성폐질환의 중증도와 폐고혈압 및 폐성심으로 진행과의 상관관계

김형호,박철진,이준,장광표,하성일,이재록,하재화,권세훈,권용운,윤성호,이승일 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.2

Background: From many previous studies, Pulmonary hypertension is the known independent predictive factor of the mortality in COPD. Also pulmonary hypertension is the major cardiovascular complication of COPD and is associated with the progression to cor pulmonale and poor prognosis. Author want to analyze the correlation between pulmonary hypertension and the severity of COPD which are classified by forced expiratory volume in one second, and the extent of progression to corpulmonale. Methods: Retrospectively we investigated the medical records of 118 patients with COPD who had pulmonary function test and echocardiogaphy more than one times during one-year follow-up (from June, 2005 to May, 2006) at respiratory division in chosun university hospital, and then 50 patients were enrolled in this study. We classified the severity from FEVl in pulmonary function test based on the GOLD guideline, also this was comparably analyzed with RVSP, RVIDd, Visual Grading from echocardiography. Results: 16 patients out of 50 were classified as moderate severity, 25 patients were severe, and 9 patients were very severe group. RVSP was higher in more severe groups than less severe groups but when it comes to pulmonary hypertension that RVSP is over 35 mmHg, there was no valid difference lies in those groups. As FEVl decreases RVSP and RVIDd increases, and observed relationship between RVSP which was classified as below 35 mm and above 35 mm groups and visual grading which was classified as normal and dilatated groups revealed valid correlation, Conclusion: As pulmonary function decreases, progression to pulmonary hypertension and cor pulmonale increases but there was no remarkable difference of prevalence in above moderate severity groups. 연구배경 폐고혈압은 이전의 많은 연구에서 만성폐쇄성폐질환에서 독립적인 사망의 예측인자로 알려져 있다. 또한 폐고혈압은 만성폐쇄성폐질환의 주요한 심혈관계 합병증이며, 폐성심으로의 진행 및 불량한 예후와도 관련되어 있다. 이에 저자는 폐고혈압과 1초간 노력성호기량으로 분류되는 만성폐쇄성폐질환의 중증도 및 폐성심으로의 진행 정도를 비교 분석하여 이들의 상관관계를 밝혀보고자 한다. 방법 2005년 6월부터 2006년 5월까지 1년 동안 본 병원 호흡기 내과에서 폐기능검사와 심장초음파 검사를 각각 1회 이상 시행한 적이 있는 118명에 한하여 의무기록을 후향적으로 조사하여 이 중에서 50명을 대상으로 하였다. 폐기능검사 시행 결과 얻은 1초간 노력성호기량을 바탕으로 GOLD guideline에 따라 중증도를 분류하였으며 이를 심초음파 시행 결과 얻은 우심실수축기압, 확장기말 우심실내부간격, 시각등급과 비교분석하였다. 결과 대상 환자 50명중 16명은 중등증, 25명은 중증, 9명은 최고중증 그룹으로 분류되었다. 우심실수축기압은 중증도가 높은 그룹에서 낮은 그룹에 비해 더 높게 나타났으나 폐고혈압에 해당하는 우심실수축기압이 35 mmHg이상인 환자에 있어사는 각 그룹간에 유의한 차이를 보이지 않았으며, 확장기말 우심실내부간격, 시각등급 또한 중증도와 유의한 차이를 보이지 안항ㅆ다. 1초간 노력성호기량이 감소함에 따라서는 우심실수축기압, 시각등급은 증가하였으며 우심실수축기압을 35mmHg 미만과 이상인 그룹으로, 시각등급을 정상과 확장이 있는 그룹으로 분류하여 비교한 결과에서는 유의한 상관관계를 나타냈다. 결론 폐기능이 감소할수록 페고혈압 및 폐성심으로의 진행이 증가하였으나 폐기능검사에서 중등도 이상의 그룹에서 유병률의 차이는 크지 않았다.