간 세포암에서 VEGF, TGF-β1, b-FGF 발현의 의의

김성용,남충현,주종우,채만규,백무준,이문수,김형철,안현철,김홍수,김창진,김창호 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Purpose: Angiogenesis is important for the proliferation and the metastasis of solid tumors. The growth of a solid tumor is widely recognized to depend on the process of neovascularrozation. Without angiogenesis, tumors cease to grow beyond even a few milimeters in diameter. It has been shown that tumor vascular density is an independent prognostic marker in several types of human tumors and is known to correlate with poor prognosis. To date, many angiogenic factors have been identified, such as transforming growth factor-α(TGF-α), transforming growth factor-β(TGF-β), fibroblast growth factor family(FGF), vascular endothelial growth factor(VEGF), platelet derived endothelial cell growth factor(PD-ECGF), tumor necrosis factor-α(TNF-α), and angiogenin. Hepatocellular carcinoma(HCC) is the second most common tumor in Korean males and is known as a typical hypervascular tumor with frequent portal vein invastion. The authors identified the expreesion of VEGF, TGF-β1, and b-FGF in HCC specimens and evaluated the relationship between these growth factors and the clinicopathologic characteristics of HCC. Method: We reviewed the medical records of 30 patients who were diagnosed as hepatocellular carinoma treated with hepatic resection between January 1994 and December 1998 in Soonchunhyang University Chunan Hospital. The selection of the cases was decided according to the condition of paraffin block fixation. The prognostic factors such as age, sex, tumor size, concentration of serum α-fetoprotein, presence of liver cirrhosis, presence of tumor emboli in portal vein, TMN stage, amount of transfusion during the operation, hepatitis B virus(HBV) infection, and Edmonson-Steiner(E-S) grade were investigated. Relationship between the prognostic factors and the immunopathologic expression of the TGF-β1, b-FGF, and VEGF was examined. Result: Thirty patients (24 males, 6 females) were included in the current study. The patient's mean age was 50.6 years and the age ranged from 36 to 65 years. The mean size of the tumor was found to be 5.2cm. All the patients were follewed up for 7 to 63 months. Child's classification A patients were 23(76.7%)cases, B patients were 7(23.3%)cases, and C was none. Immunohistochemical staining of HCC tumor mass in VEGF expression patients were 17(56.7%), b-FGF expression patients were 10(33.3%), and TGF-β1 expression patients were 10(33.3%). VEGF expression or more than one positive expression among the three factors correlated with tumor size and the stage of HCC but did not correlated with other clinicopathological characteristics. TGF-β1 and b-FGF did not correlate with any clinicopathological characteristics. Conclusion: The results suggest that the expression of VEGF or more than one positive expression among the three factors in HCC cells may be a significant prognostic factor of HCC.

국가 대표급과 제주도 고교 대표급 수영선수들의 그랩 스타트의 운동학적 분석

김철원,김승곤,오만원,임상용,김성찬,이창준,남사웅,이세형,류재청,신석종,김세민 濟州大學敎 體育科學硏究所 1998 체육과학연구 Vol.4 No.-

The purpose of the study was to undertaken to analysis the Grab starting technique between national representive team(3) and Cheju's representive team(3) with 3D cinematography. The conclusions obtained were as follows: Cheju's showed more elapsed time than national representive team on starting block. and more vertical than horizontal direction of COG position, more concentrated vertical velocity & acceleration than forward direction. Therefore It is necessory for cheju's to train balanced trust force in horizontal and vertical direction in grab starting technique.

위절제술 환자의 표준진료지침 개발 및 적용 효과

김은희,김철규,이순교,김순덕,이혜옥,권정순,이경미,이민미,심순미,유용만,신종식,강은희,이상일,김병식,오성태,육정환,박수길 한국의료QA학회 2003 한국의료질향상학회지 Vol.10 No.2

Background : Gastric cancer is the most common malignant tumor in Korea. surgical operation is one of the major treatment modalities for gastric cancer patients. Therefore, gastrectomy is one of the most common procedures in General Surgery. There were variation in length of hospital stay and medical treatment for gastrectomy between three surgeons at Asan Medical Center. Clinical pathways have received considerable attention as a tool for recucing the medical practice variation, increasing the efficiency of care process, and improving the quality of care. The aim of this study was to evaluate the effect of a clinical pathway for gastrectomy in gastric cancer patients. Methods : The clinical pathway for gastrectomy was developed and implemented by a multidisciplinary group in Asan Medical Center. A computerized clinical pathway program was developed and revised after a pilot test. A total of 145 patients underwent gastrectomy by three surgeons at Asan Medical Center. We compared the length of hospital stay, patient satisfaction, and unplanned readmission rate between the pre-pathway group(n=67) and the post-pathway group(n=78). We also investigated the degree of satisfaction among the physicians and nurses who were main end-users of the clinical pathway. Results : The clinical pathway was applied to all target patients. The average length of hospital stay was shortened from 12.7days to 10.6days(p<0.01). The degree of patient satisfaction with the care process changed from 90.3% to 89.2% after the implementation of the clinical pathway, but the difference was of satistically significant(p=0.761). Unplanned readmission rate was 2.9% in the pre-pathway group. More than 90% of physicians and nurses answered that the clinical pathway had been a useful tool in their medical practice. Conclusions : The findings of the study demonstrated that implementation of the clinical pathway for gastrectomy produced substantial reduction in the length of hospital stay while improving the quality of patient outcomes. The computerized clinical pathway program can be used as one of the powerful patient management tools for reducing the practice variations and increasing the efficiency of care process in Korea hospital settings.

제 1형 신경섬유종증 환자에서 발생한 위장관 간질종양 1예

원경준,이준,변유미,조민근,한경택,김원,홍란,임성철,김경종,김영대,박찬국,김만우 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.2

Gastrointestinal stromal tumor (GIST) is the most common non-epithelial neoplasm arising in the gastrointestinal tract, but this tumor is rarely seen in association with type l neurofibromatosis (NFl) Generally, the majority of GISTs are isolated neoplasm and they are sporadically found in the stomach, but the GISTs in NFl patients are usually multiple and usually found in the small intestine. We report a case of multiple GISTs in the jejunum of a 63-year-old woman diagnosed as NFl accompanied by complication of gastrointestinal bleeding, In this case, Patient had multiple cafe-au lait spots and neurofibroma on skin and had freckling on axilla and groin, and then, we made a diagnosis of NFl. Gastrointestinal bleeding is controlled by resection of multiple GISTs. Generally, only 3-5% of all gastrointestinal bleeding comes from the small bowel. Causes of small intestinal bleeding are angiodysplasia, neoplasm, NSAIDs induced ulcer etc. but, If patients have NFl accompanied by complication of gastrointestinal bleeding, GISTs on small bowel must be considered.

중국 길림성 조선족의 민족 정체감에 관한 연구

이호영,이동근,신승철,김만권 大韓神經精神醫學會 1992 신경정신의학 Vol.31 No.2

The present study examined the structure and patterns of ethnic identity in a sample of Korean-Chinese parents and their adolescents residing in the Jilin Province in China. The ethnic identity of these participants(total :148 parents:100 adolesents:48) includes two major components : Korean identity and Chinese identity. Each of these components was measured in three different modalities : behavioral, affective and cognitive. The results are summarized as follow ; 1) Generational comparisons between Korean identity scores of parents and adolescents indicated similarities in the modalities of cognitive and behavioral identities. Both groups shared a Korean orientation manifested in their high level of Korean behavior and cognition. However, both groups also shared a relatively high level of Chinese identity. In summary, dual identity appeared to be preserved over time. The parents scored higher than the adolescents in their affective modality of Korean identity. Chinese identity was scored higher in the adolescents than korean identity in their affective modality. The generational comparisons indicated that the adolescents were acculturated in their affect than their parents. 2) Comparison of men and women in the strength of identity' component showed higher cognitive scores among the men. in Korean identity, compared with Chinese identity. Men were more identified with "Chinese" and "Korean" in the affective component of their identity.

신경인성 방광 1례에 대한 임상고찰

김만호,이지영,이정원,조충식,김철중 대전대학교 한방병원 2002 惠和醫學 Vol.11 No.1

From January 10th 2002 to February 17th 2002, the clinical study was carried out I case of patient in trouble with voiding difficulty such as urinary incontinence, enuresis and urinary frequency after the L₄-L_(5) HN P operation, who had been hospitalised in the Dept. of Internal Medicin e, Cheon-An Oriental Medical Hospital, Daejeon University. The results were as following 1. For this case, we could get the better result using Bo-Joong-lk-Gi-Tang(補中益氣湯) in the treating period. 2. We could get the effective result that the case of voiding difficulty after HNP operation and cerebral infarction by conservative therapy of oriental medicine such as acupuncture, moxibustion and herb medicine.

제주 우수 육상경기 선수들의 년중 훈련효과 분석 및 처방

김철원,임상용,김승곤,오만원,김성찬,이창준,남사웅,이세형,류재청 濟州大學敎 體育科學硏究所 1996 체육과학연구 Vol.2 No.-

The study was undertaken to analysis, evaluate, and prescribe t h e annual effect of training of periodically anaerobic and aerobic motor ability for Che-Ju representive team of elementary, middle and high school athletes. first. the performance can be obtained when it was prescribed proper training after analysis of physical fitness by each events. second, individually fitness. scientific analysis. prescription. proper management of athlete will be necessary to apply. In addition to physiology aspect, it is essential to consider sport biomechanics. sport psychology when we prescribe specific events and necessary approach in demension coach-athlete-researcher for individual.

골프스윙에서 볼의 비행거리에 미치는 요인분석 : 1번 드라이브를 중심으로 Focused on 1st driver

김철원,오만원,류재청 濟州大學敎 體育科學硏究所 1995 체육과학연구 Vol.1 No.-

The purpose of the study was to investigate factors influencing ball flight distance in 1st golf driving, and utilize the available training data investigated. The experimental method for the purpose was cinematography with 2 camera equipped front direction(#l camera) and rear direction(#2 camera) using air-ballon synchronization method. 1. physical fitness The characteristics of physical fitness was classified Zgroup, one(OMW, KJI) was superior power, muscular strength, normal blood pressure, the other(LHJ, LHJ) was not. 2. Temporal The elapsed total time from address to full followthrough in all subjects was mean 0.321 sec., 3 phases centering on impact was elapsed 0.132 ±O.OOsec(7.29%), 0.151 ±O.O32sec (7.87%), 0.183±0.057sec.(10.67%) in order of OMW, LHJ, KJI, KJH. The acceleration analysed was transferred with adequately suited timing to ball momentum obtained during downswing in OMW, decelerated centering impact the acceleration obtained during downswing, and the other 2 subjects was mid-level timing of the former 2subjects. 3. The horizontal displacement of COG was rear direction from address to backtopswing and front direction from topswing to followthrough. On considering COG displacement in rear or front, the most stable driving was in order OMW, KJH, KJI, LHJ. 4. The cocking range of foream-shift angle, topswing was in order OMW, KJI, KJH, LHJ, continuing followthrough was performed to ball flight direction on condition of uncocking from impact to followthrough in OMW, the others pulled instantly in just later impact. The shoulder-trunk mean angle was 136±3.94deg. in topswing, 18.65±3.10deg. in just before impact, 143.00±20.04deg. in followthrough considering the resulting, OMW showed the smaller degree, but the larger trunk twist to vertical axis while LHJ, KJH showed the contrast phenomenon. The trunk-thigh mean angle was 167.20±19.80deg., characteristics analysed divided into overextended(l86±2.16deg.) in OMW, overflexed(l41± 19.49deg) in LHJ and elbow flexion was mean 126.85±21.96deg, the range was in order of OMW, LHJ, KJI, KJH.in topswing and 64.60±10.87 deg in followthrough, the, elbow flexion range was the largest but the smallest in shaft-forearm incline in OMW while shaft-forearm incline was largest but largest flexion in LHJ. 5. Trunk Incline to vertical axis showed flexible followthrough in 25.20cm, 28.40cm of OMW, LHJ, but the others almost was not. 6. The rather high relation with muscular strength and Power factor showed rather high,and negative relation(r=-.92) with elbow flexion, with trunk incline(r=.84) in followthrough in correlation between ball flight distance and variables related with driving.

분자역학적 방법을 이용한 부산시내 대형건물 냉각탑수의 레지오넬라균의 형별 분류

김정만,정석훈,서대영,박은희,송은주,최재철,이은엽,장철훈 대한임상미샐물학회 2004 Annals of clinical microbiology Vol.7 No.1

운동소질지수와 일반운동능력과의 상관관계 연구

김상철,오만원 濟州大學敎 體育科學硏究所 1999 체육과학연구 Vol.5 No.-

This study is aimed to supply basic data for sports leaders to apply to Physical Education when it comes to teaching. selecting athletes and making their improvement in skill by looking into the correlation between McCloy's Motor Quotient, which was measured through the general motor capacity test, and the Six Fitness Factors that were classified by Cureton. T.K. In the research, Three Hypotheses were set in relation to the aim. First, there might be a positive correlation between the Motor Quotient and the variable of General Motor Ability. Second. each variable of the General Motor Ability might distinguish the group of Motor Ability Quotient. Third. the measurement of General Motor Ability might vary depending on the level of Motor Quotient. For this study 130 students among 153 students in the second grade of D high school. which is located in Cheju Province. were selected as subjects. Potential subjects that were physically or mentally handicapped. organ patients or athletes were not included. First. in order to find out the Motor Quotient. McCloy's General Motor Capacity Test was performed and the Classification. Sargent Jump. Iowa Brace Test. and Burpee tests were taken to measure the quotient. Second, for each factor of the 6 Fitness Factors such as muscular power, power. flexibility, balance, agility, and endurance, which were classified by Cureton. T.K . two sports activities were employed to measure the ability. In order to yield the results of measurement. Micro Software's SPSS win (ver7.5) was used. To make clear the correlation between the Motor Quotient and General Motor Ability. M(mean), SD (standard deviation), R(correlation) among the factors of General Motor Ability were evaluated. Stepwise multiple regression analysis was applied to examine the most suitable factors of Motor Quotient. One-way ANOVA analysis was applied to analyze difference measurement among Motor Quotient. And then Scheffe's test was used as post-verification. The conclusions based on these procedures and materials are as follows: 1. There is a positive correlation between the variables of Motor Quotient and General Motor Ability. The measurement of the activities for the test of General Motor Ability showed positive correlation in distance, frequency. weight. and time. 2 .The variables of General Motor Ability distinguish the Motor Quotient Group. Among the 14 General Motor Ability variables. standing broad jump's predictability was highest (54.6%). then back strength (8.8%). Sargent jump (3.5%). and closed-eyes foot balance (1.5%). 3. Depending on the level of Motor Quotient , there is a meaningful difference in General Motor Ability. Among 14 General Motor Ability variables. the result of the dispersed analysis in standing broad jump turned out statistically significant. In order to find out the specific difference between the groups. the Scheffe post-verification was used and the mid MQ group jumped well in standing broad jump than the low and mid MQ group. It revealed that 10 out of 14 general motor ability variables revealed that general ability is related to the motor quotient.