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      • KCI등재

        Current Status of Ginseng Cultivation and Soil Characteristics of Northeastern Three Provinces in China

        Park, Yang Ho,Kim, Jang Uk,Kim, Dong Hwi,Sonn, Yeon Kyu,Yun, Jin Ha,Moon, Huhn Pal,Cho, Soo Yeon 한국토양비료학회 2016 한국토양비료학회지 Vol.49 No.6

        This study was conducted to improve the continuous techniques for international competitiveness of ginseng industry to Korea-China FTA negotiation and conclusion, and provide the basic information for ginseng industry development of Korea. It was carried out the visiting of the northeastern three provinces (Jilin, Liaoling and Heilongjang) in China for 3-year from 2014 to 2016 and observed the farmers' fields of ginseng cultivation with soil environmental status. The types of ginseng cultivation could be observed in small scales of 0.5~3.0 ha, in middle scales of 4.0~10.0 ha and in large scales of 30~700 ha with the kinds of imhasam, Chinese ginseng, Korean ginseng and western ginseng. Also ginseng was cultivated in newly reclaimed land of forest in two types of direct seeding and transplanting of ginseng seedlings. The field beds of ginseng growing were covered with vinyl films in arch design of 100~130 cm height and vinyl was painted in spraying with blue, green and yellow colours for shading. It was investigated in status of the physico-chemical properties of soils. The physical information on the field soils were silt loam, loam and sandy loam in soil textures, and some plain in low slope, some alluvial fan or local valley in forest of land topography. Soil pH ranged within 5.0~5.2, soil EC was $0.93{\sim}3.78dS\;m^{-1}$, organic matter was $37{\sim}35g\;kg^{-1}$, nitrate nitrogen $63{\sim}490mg\;kg^{-1}$, available $P_2O_5$ $55{\sim}163mg\;kg^{-1}$, and in exchangeable cations, K was 0.30~0.98, Ca was 6.5~14.0, Mg was $1.1{\sim}5.3cmol_c\;kg^{-1}$ in ranges. Farmers used the fertilizer for ginseng cultivation in 10~11 t of compost, $200{\sim}400kg\;ha^{-1}$ of complex fertilizer and $750kg\;ha^{-1}$ of oil cakes. The northeastern three provinces of China can use the newly lands with large areas of ginseng cultivation in soil sickness by continuous cropping. and the soil basic fertility is batter than that of Korean in standard guide of ginseng cultivation soil.

      • KCI등재

        Current Status of Ginseng Cultivation and Soil Characteristics of Northeastern Three Provinces in China

        Yang Ho Park,Jang Uk Kim,Dong Hwi Kim,Yeon Kyu Sonn,Jin Ha Yun,Huhn Pal Moon,Soo Yeon Cho 한국토양비료학회 2016 한국토양비료학회지 Vol.49 No.6

        This study was conducted to improve the continuous techniques for international competitiveness of ginseng industry to Korea-China FTA negotiation and conclusion, and provide the basic information for ginseng industry development of Korea. It was carried out the visiting of the northeastern three provinces (Jilin, Liaoling and Heilongjang) in China for 3-year from 2014 to 2016 and observed the farmers’ fields of ginseng cultivation with soil environmental status. The types of ginseng cultivation could be observed in small scales of 0.5∼3.0 ha, in middle scales of 4.0∼10.0 ha and in large scales of 30∼700 ha with the kinds of imhasam, Chinese ginseng, Korean ginseng and western ginseng. Also ginseng was cultivated in newly reclaimed land of forest in two types of direct seeding and transplanting of ginseng seedlings. The field beds of ginseng growing were covered with vinyl films in arch design of 100∼130 cm height and vinyl was painted in spraying with blue, green and yellow colours for shading. It was investigated in status of the physico-chemical properties of soils. The physical information on the field soils were silt loam, loam and sandy loam in soil textures, and some plain in low slope, some alluvial fan or local valley in forest of land topography. Soil pH ranged within 5.0∼5.2, soil EC was 0.93∼3.78 dS m<SUP>-1</SUP>, organic matter was 37∼35 g kg<SUP>-1</SUP>, nitrate nitrogen 63∼490 mg kg<SUP>-1</SUP>, available P2O5 55∼163 mg kg-1, and in exchangeable cations, K was 0.30∼0.98, Ca was 6.5∼14.0, Mg was 1.1∼5.3 cmolc kg<SUP>-1</SUP> in ranges. Farmers used the fertilizer for ginseng cultivation in 10∼11 t of compost, 200∼400 kg ha<SUP>-</SUP>1 of complex fertilizer and 750 kg ha<SUP>-1</SUP> of oil cakes. The northeastern three provinces of China can use the newly lands with large areas of ginseng cultivation in soil sickness by continuous cropping. and the soil basic fertility is batter than that of Korean in standard guide of ginseng cultivation soil.

      • Mycophenolic Acid와 Rapamycin이 흰쥐 사구체 혈관간세포증식과 세포외기질 생성에 미치는 영향

        김명수,박제현,하헌주,허규하,서지연,김유선,김혜진,박기일 이화여자대학교 약학연구소 2004 藥學硏究論文集 Vol.- No.14

        Background: Excess proliferation and extracellular matrix (ECM) accumulation of mesenchymal cells such as vascular smooth muscle cells (VSMC) and glomerular mesangial cells cause chronic allograft nephropathy showing transplant vascular sclerosis and glomerulosclerosis. Mycophenolic acid (MPA) and rapamycin (RPM) are well known as strong inhibitors of VSMC proliferation, but their effects on the glomerular mesangial cells are not yet clearly understood. This study examined the effects of MPA or RPM on PDGF-induced proliferation and ECM accumulation in rat glomerular mesangial cells. Methods: Mesangial cells isolated from the glomeruli of Sprague-Dawley rats were cultured with DMEM containing 20% fetal bovine serum. Growth arrested and synchronized cells were administered with test drugs (MPA10 nM-10μM, RPM 0.1 nM-1μM) before the addition of PDGF 10 ng/mL. Cell proliferation was assessed by [³H]thymidine incorporation, collagen by [³H]proline incorporation, and fibronectin, ERK, and p38 MAPK by Western blot analysis. Results: PDGF increased mesangial cell proliferation by 4.64-fold. Compared to stimulated control, MPA above 500 nM and RPM above 10nM showed a significant inhibitory effect in a dose-dependent manner. The IC_(50) of MPA and RPM against PDGF-induced mesangial cell proliferation were around 500 nM and 100 nM, respectively. The collagen synthesis was also inhibited by MPA and RPM, but the fibronectin secretion was inhibited by MPA alone. The proliferation of mesangial cell correlated with activation of ERK and. p38 MAPK. MPA, but not RPM, inhibited ERK and p38 MAPK activation. Conclusion: This study demonstrated that MPA and RPM significantly inhibited PDGF-induced proliferation and ECM production in rat glomerular mesangial cells. The inhibitory effects of MPA, but not RPM, are correlated with ERK and p38 MAPK.

      • SCISCIESCOPUS

        Sodium–Metal Halide and Sodium–Air Batteries

        Ha,, Seongmin,Kim,, Jae‐,Kwang,Choi, Aram,Kim, Youngsik,Lee, Kyu Tae WILEY‐VCH Verlag 2014 ChemPhysChem Vol.15 No.10

        <P>Impressive developments have been made in the past a few years toward the establishment of Na-ion batteries as next-generation energy-storage devices and replacements for Li-ion batteries. Na-based cells have attracted increasing attention owing to low production costs due to abundant sodium resources. However, applications of Na-ion batteries are limited to large-scale energy-storage systems because of their lower energy density compared to Li-ion batteries and their potential safety problems. Recently, Na-metal cells such as Na-metal halide and Na-air batteries have been considered to be promising for use in electric vehicles owing to good safety and high energy density, although less attention is focused on Na-metal cells than on Na-ion cells. This Minireview provides an overview of the fundamentals and recent progress in the fields of Na-metal halide and Na-air batteries, with the aim of providing a better understanding of new electrochemical systems.</P>

      • Progastrin-releasing peptide as a diagnostic and therapeutic biomarker of small cell lung cancer

        오형주,( Ha Young Park ),( Tae Ok Kim1 ),( Chul Kyu Park ),( Hong Jun Shin ),( Hee Jung Ban ),( In Jae Oh ),( Yong Soo Kwon ),( Yu Il Kim ),( Sung Chul Lim ),( Young Chul Kim ),( Soo Hyun Kim ),( Myung G 대한결핵 및 호흡기학회 2015 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.120 No.-

        Background: Progastrin-releasing peptide (proGRP) is a recently identified biomarker of small cell lung cancer (SCLC). We aimed this study for evaluating the usefulness of automated proGRP measurement for diagnosis and treatment monitoring in patients with SCLC. Methods: From January 2011 to December 2013, plasma samples were prospectively collected from 452 [213 non-small cell lung cancer (NSCLC), 104 SCLC, 135 other diseases] patients visited for tissue diagnosis and tested by two-step automated immunoassay using the ARCHITECT proGRP assay kit (Abbott Diagnostics, USA). The cutoff level of proGRP was set at 63 pg/mL. Results: The mean proGRP was higher in SCLC (1823.0 ± 2684.0 pg/mL) than in NSCLC (61.0 ± 341.7 pg/mL) and other diseases (51.5 ± 222.6 pg/mL, p<0.001). The sensitivity of proGRP was 85.7% (90/105) in SCLC and 11.8% (25/212) in NSCLC. The specificity was 90.2%, positive predictive value was 72.5%, and negative predictive value was 95.4% in SCLC. The mean proGRP was higher in extensive disease (2158.1 ± 2980.6 pg/mL) than in limited disease (901.4 ± 1216.0 pg/mL, p=0.033). Among the 39 patients with SCLC could be followed, the mean proGRP levels of 23 responders were significantly decreased after chemotherapy (from 1651.5 ± 1386.4 pg/mL to 290.0 ± 524.8 pg/mL, p<0.001), whereas those of the 16 non-responders were not. (from 572.5 ± 790.3 pg/mL to 494.4 ± 610.9 pg/mL, p=0.583). Conclusion: Plasma proGRP could be a useful biomarker of SCLC for diagnosis and treatment monitoring. And the initial level may represent the tumor extent of SCLC.

      • 안지오텐신 변환효소 억제제와 안지오텐신 II 수용체 차단제 투여 후 발생한 급성 신부전과 폐부종으로 전원된 선천성 단일신 환자의 치료 1예

        백두현,김경진,홍성철,강석형,송하응,김혜인,김수현,오현정,강혜원,김서우,유민아,류동열,최규복,강덕희 이화여자대학교 의과대학 2010 EMJ (Ewha medical journal) Vol.33 No.1

        Blockers of renin-angiotensin system(RAS) including ACE inhibitor or ARB are one of the most frequently prescribed medications for the treatment of hypertension, heart failure and proteinuria. One of the major side effects of these RAS blockers is the deterioration of renal function, mainly due to a reduction of intraglomerular pressure. Therefore, close monitoring of renal function is recommended when RAS blockers are initially prescribed, especially for the patients with impaired renal function. We report a patient who was transferred to our hospital due to the sudden development of oliguria and dyspnea after treatment for hypertension with ACEi and ARB. She was finally diagnosed as RAS blocker-induced acute renal failure with pulmonary edema complicated on congenital solitary kidney. After hemodialysis and conservative treatment, her renal function was recovered with maintenance of normal urine output. Conclusion:This case highlights the necessity of the functional and structural evaluation of kidney to prevent the serious complication such as acute renal failure before the administration of ACEi and/or ARB.

      • KCI등재후보

        남산의 소나무림, 신갈나무림, 아까시나무림의 낙엽생산과 토양유기탄소 동태

        정헌모 ( Heon Mo Jeong ),김해란 ( Hae Ran Kim ),신동훈 ( Dong Hoon Shin ),이경미 ( Kyoung Mi Lee ),이승혁 ( Seung Hyuk Lee ),한영섭 ( Young Sub Han ),장래하 ( Rae Ha Jang ),이상경 ( Sang Kyeong Lee ),김태규 ( Tae Kyu Kim ),유영한 한국환경생물학회 2013 환경생물 : 환경생물학회지 Vol.31 No.2

        남산의 소나무림, 신갈나무림 그리고 아까시나무림에서 2008년 1월부터 2009년 12월까지의 월별 낙엽생산량과 토양의 유기탄소량을 조사하였다. 소나무림은 2008년과 2009년 모두 10월에 낙엽생산량이 가장 많았으며, 2008년 1월과 2009년 12월에 낙엽생산량이 가장 적었다. 신갈나무림은 2008년과 2009년 모두 11월에 낙엽생산량이 가장 많았으며, 2월에 낙엽생산량이 가장 적었다. 아까시나무림은 2008년 11월과 2009년 10월에 낙엽생산량이 가장 많았으며, 2008년 1월과 2009년 12월에 낙엽생산량이 가장 적었다. 이것은 한반도 중부에서 상록성의 소나무림이 낙엽성의 참나무숲 보다 더 일찍 낙엽이 진다는 것을 의미한다. 소나무림과 신갈나무림, 아까시나무림의 2년 평균의 낙엽생산량은 7.07, 6.36, 5.02 ton ha-1로 소나무가 가장 많았다. 소나무림과 신갈나무림, 아까시나무림의 2년 평균의 토양유기탄소량은 76.2, 68.6, 72.5 ton C ha-1로 소나무림에서 가장 많았다. 이처럼 소나무숲에서 높게 나타난 것은 남산에서 신갈나무나 아까시나무를 벌목하여 임목밀도가 줄었기 때문이다. The objective of this study was to estimate dynamics of litter production and soil organic carbon of Pinus densiflora forest, Quercus mongolica forest, and Rhobina pseudo-acasia forest at Mt. Nam as a part of Korea National Long-Term Ecological Research (KNLTER) from 2008 to 2009. Litter production of P. densiflora forest was the highest in October 2008, 2009 and the lowest in January 2008 and December 2009. Litter production of Q. mongolica forest was the highest in November and the lowest in February in 2008 and 2009. Litter production of R. pseudo-acacia forest was the highest in November in 2008 and October in 2009 and the lowest in January in 2008 and December in 2009. It means that leaves of P. densiflora forest shed earlier than deciduous oak forests in Korean central region. An average of litter production for 2 years was 7.07, 6.36, 4.66 ton ha-1 in P. densiflora forest, Q. mongolica forest, R. psuedo-acacia forest, respectively. An average of soil organic carbon matter for 2 years was 88.3, 76.5, 84.2 ton ha-1 in P. densiflora forest, Q. mongolica forest, R. psuedo-acacia forest, respectively.

      • KCI등재

        몬순기후와 복잡지형의 특성을 갖는 광릉 산림유역의 물과 탄소순환에 대한 교차규모 연구로부터의 교훈

        이동호 ( Dong Ho Lee ),김준 ( Joon Kim ),김수진 ( Su Jin Kim ),문상기 ( Sang Ki Moon ),이재석 ( Jae Seok Lee ),임종환 ( Jong Hwan Lim ),손요환 ( Yo Whan Son ),강신규 ( Sin Kyu Kang ),김상현 ( Sang Hyun Kim ),김경하 ( Kyong Ha Kim 한국농림기상학회 2007 한국농림기상학회지 Vol.9 No.2

        광릉 슈퍼사이트에서 대기와 식생간의 에너지와 물질교환 규명은 지형과 식생의 복잡성으로 인해 많은 기술적인 어려움에 직면하고 있다. 따라서 KoFlux 연구에서는 상호보완적인 다중 분야의 연구를 통해 이러한 어려움을 극복하기 위한 시도를 해 오고 있다. 본 논문에서는 현재 진행중인 KoFlux 연구의 예비결과 중 특히 광릉사이트에서의 물/탄소수지, 물과 탄소순환의 상호관련성 그리고 몬순기후하의 생태계에서 탄소순환에 미치는 수문학적 요인의 중요성에 대해 중점적으로 논의하고자 한다. 광릉낙엽활엽수림의 순생태생산량 (NEP)은 광범위한 생태학적 연구결과에 따르면 약 ~2.6 t C/ha/y로 예상된다. 이를 미기상 플럭스 관측 결과와 함께 고려할 때 광릉 산림은 탄소의 중요한 육상흡원으로서 기능함을 예상할 수 있다. 다양한 생태수문 관측에 의해 규명된 유역단위 물수지에 의하면 연단위 전체강수량의 약 30-40%가 증발산 (ET)에 해당함을 나타내고 있다. 광릉산림의 대표적인 수종인 졸참과 서어나무의 잎에서 얻어진 탄소 안정동위 원소 조성에 근거하여 계산된 식물 성장기간의 평균 물 이용효율(WUE)은 약 ~12 μmol CO2/mmol H2O에 해당된다. 얻어진 증발산량과 물이용효율은 유역단위의 생태계 생산량을 산출하는데 이용될 수 있다. 나이테 성장량과 토양호흡량의 연단위 변화는 강수량과 강수의 패턴에 의해 크게 영향을 받음을 보이고, 이는 몬순기후에 영향을 받는 동아시아 지역 생태계에서 탄소 순환과정이 수문학적 조건과 밀접한 상관관계를 가짐을 지시한다. 연구지역의 공간적 특성을 정량화하기 위해 관측지의 구조 및 기능적 단위를 규명하기 위한 연구가 진행되고 있고 이를 통해 서로 다른 시공간 규모에서 진행되고 있는 연구의 결과물을 체계적으로 연결 통합하고 나아가 보다 광역적인 규모에서 대표적인 물/탄소 수지를 산출하기 위한 연구가 시도되고 있다. KoFlux Gwangneung Supersite comprises complex topography and diverse vegetation types (and structures), which necessitate complementary multi-disciplinary measurements to understand energy and matter exchange. Here, we report the results of this ongoing research with special focuses on carbon/water budgets in Gwangneung forest, implications of inter-dependency between water and carbon cycles, and the importance of hydrology in carbon cycling under monsoon climate. Comprehensive biometric and chamber measurements indicated the mean annual net ecosystem productivity (NEP) of this forest to be ~2.6 t C ha-1 y-1. In conjunction with the tower flux measurement, the preliminary carbon budget suggests the Gwangneung forest to be an important sink for atmospheric CO2. The catchment scale water budget indicated that 30~40% of annual precipitation was apportioned to evapotranspiration (ET). The growing season average of the water use efficiency (WUE), determined from leaf carbon isotope ratios of representative tree species, was about 12 μmol CO2/mmol H2O with noticeable seasonal variations. Such information on ET and WUE can be used to constrain the catchment scale carbon uptake. Inter-annual variations in tree ring growth and soil respiration rates correlated with the magnitude and the pattern of precipitation during the growing season, which requires further investigation of the effect of a monsoon climate on the catchment carbon cycle. Additionally, we examine whether structural and functional units exist in this catchment by characterizing the spatial heterogeneity of the study site, which will provide the linkage between different spatial and temporal scale measurements.

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