흰쥐 척수손상 후 운동회복 양식의 도식적 분석

김상수,김하용,심대무,송하헌,차상도,김종환 대한척추외과학회 1997 대한척추외과학회지 Vol.4 No.1

Objectives : To understand the motor recovery pattern after spinal cord injury, We designed the quantitative measuring method of locomotion recovery using computerized motion analysis combined with video recordings. Materials and Methods : Using computerized motion analysis technique, locomotions of the 10 cord-hemisected Sprague-Dawley rats on the treadmill were graphically analyzed. Patterns of foot trajectories were plotted on two dimensions before and after unilateral spinal cord hemisecion at T7 level. Result : Immediately following dorsal hemisection, patterns of foot trajectories altered dramatically. Walking speed, stride length and height of hindfoot movements were markedly reduced. Coordination of left and right hindlimb was also disrupted. Although the lesions were unilateral, locomotor behavior was distrubed bilaterally. However, by six weeks, stride length and coordination of hindlimbs returned to near normal but vertical movement of the hindlimb recovered very little. Forelimb-hindlimb coordination was also initially disrupted but partially returned within three weeks. Conclusion : Computerized motion analysis is a sensitive technique for the detection of minor motor deficits following nerve injuries.

경기 북부지역에서 발생한 한국형 출혈열의 임상적 특성

전성주(Seoung Ju Chun),전정수(Jung Su Chun),김재하(Jae Ha Kim),최두혁(Do Hyok Choi) 대한내과학회 1987 대한내과학회지 Vol.33 No.5

N/A Korean hemorrhagic fever which was recognized for the first time in Korea near the Demilitarized Zone between North and South Korea in 1951 during Korea War have spread to the southern part of the Korean peninsula and several hundreds of cases are clinically and serologically diagnosed each year. However the Northern Part of Kyoung Ki Do is still remained as epidemic area. In recent years, we experienced 55 cases of Korean Hemorrhagic Fever in the northern part of Kyoung Ki Do during the period, 1984-1986, and we found different clinical patterns of Korean hemorrhagic fever from those reported earlier. Here we report the epidemiological and clinical observations with laboratory findings. 1) The disease was prevalent in adult male farmers and the epidemic seasons were fall and early winter. The epidemic areas of the disease are mainly Yang Ju, Yeoncheon and Pocheon. 2) Clinical pictures of Korean Hemorrhagic Fever were characterized by headache (76%), abdominal pain (69%), nausea & vomiting (67%), fever (56%) and myalgia & general aching (49%). 3) On physical examination, fever (56%), abdominal tenderness (36%), tachycardia (35%), hypotension (27%), petechia (24%), conjunctival injection (22%) and facial flushing and edema (16%) were found. 4) On laboratory examination, leukocytosis, thrombocytopenia, left shift of leukocyte, toxic granule, proteinuria, microscopic hematuria and increased specific gravity were found. Blood chemistry findings were characterized by increased BUN & creatinine, increased SGOT & SGPT, hyponatremia, increased LDH & FDP and hyperkalemia. 5) Clinical forms of typical hemorrhagic fever were as follows: Typical oliguric type 49%, typical nonoliguric type 21% and atypical type 29%. 6) Double infection to Leptospirosia was found in 8 cases.

위장관선암에서 Secretory Component의 분포에 관한 연구

김도진,양승하,강상균 순천향대학교 1992 논문집 Vol.15 No.2

Secretory component(SC) is a portion of secretory IgA and acts as a specific receptor to IgA, This component has specificity in glandular epithelial cells only. Also this specificity maintain in adenocarcinoma of organs. Therefore, to understand the correlationship of SC along the differentiation of adenocarcinoma of various organs such as stomach, small and large intestine, and gallbladder, 57 cases were subjected(stomach 27 cases, small intestine 4 cases, large intestine 24 cases, and gallbladder 2 cases). And then performed immunoperoxidase stain by Avidin-Biotion-Comprex method using anti-SC serum, were performed then analyzed their histologic reaction. Results obtained are following as : 1. Rositive reaction of SC in adenocarcinoma of each organ showed 17(63%) of 27 cases in the stomach, 3(75%) of 4 cases in the small intestine, 18(75%) of 24 cases in the large intestine, and 1(50) of 2 cases in the gallbladder. 2. Positive reaction of SC showed difference along the dirrerentiation of the adenocarcinoma of the stomach, bearing 6(86% 0 of 7 well differentiated, all of 8 moderately differentiated and 3(25%) of 12 poorly differentiated cases. 3. In the adenocarcinoma of the large intestine, positive reaction of SC was 13(93%) of 14 cases in well differentiated form, 5(71)% of 7 cases in moderately differentiated, and 1(33%) of 3 cases in pooly differentiated form. 4. Adenocarcinoma of the small intestine showed positive reaction of SC all of well differentiatel form and 1(50%) of 2 cases of moderately differentiated form. Adenocarcinoma of the gallbladder showed positive reaction in 1 of moderately differentiated and negative reaction in 1 of poorly differentiated form. Above findings reveals that adenocarcinoma of each organs has almost simillar positivity rate of SC, but difference according to differentiation of the carcinoma.

교정용 각형선재에 부여된 torque가 브라켓에 발생시키는 모멘트에 관한 유한요소법적 분석

하도원,김영석,성재현 대한치과교정학회 2001 대한치과교정학회지 Vol.31 No.3

교정용 각형선재에 부여된 torque가 브라켓에 발생시키는 모멘트에 관한 유한요소법적 분석 본 연구의 목적은 교정치료의 마무리 단계에서 바람직하지 못한 순설측 경사를 가진 한 개 치아의 이동을 원할 때 브라켓 슬롯의 크기와 각형선재의 종류,크기에 따라 부여하여야 할 적절한 임상적 torque(SWA의 각형선재에서 나머지 편평한 부분과 이동을 위해 변형시킨 부분의 단면이 이루는 각도만큼의 torque)의 양을 구하고자 하는 것이다 임상적 torque는 play와 active torque(브라켓에 모멘트를 전달할 수 있는 torque)의 합으로 구성되는데, play는 수학적 공식을 이용하여 계산하였고 arrive torque는 컴퓨터를 이용한 삼차원 유한요소 법으로 구하였다. 유한요소모델은 일렬로 배열된 세 개의 브라켓과 여기에 삽입된 stainless steel, TMA, NiTi 이렇게3가지 종류의 교정용 각형선재로 구성된다. 양쪽의 브라켓을 일정한 각도로 비틀어서 가운데 브라켓에 발생하는 모멘트를 계산하였다. 선재의 크기는 많이 사용되는 각형선재인 .016" X .022", .017" X .022", .017" X .025", .018" X .025", .019" X .025" .020" X .025", .021" X .025"의7개로 디자인하였다. .018" 브라켓에는 .016" X .022", .017" X.022", .017" X .025" 선재를 삽입하여 실험하였고 .022" 브라켓에는 .016" X .022" 선재을 제외한 나머지 전재를 삽입하여 실험하였다. 실험으로 다음과 같은 결과를 얻었다. 1.삽입된 브라켓 슬롯의 크기에 상관없이 같은 크기와 재질의 교정용 각형선재에 같은 active torque를 가하면 동일한 모멘트가 발생하였다. 2.선재의 크기가 증가될 수록 동일한 active torque에 의해 발생되는 모멘트의 양은 증가하였다. 실험에 사용한 가장 굵은 선재인 .021" × .025" 선재는 동일한 재질의 가장 가는 .016" X .022" 전재에 비해 약 1.75배 더 큰 torsional stiffness를 가졌다. 3.선재의 재질에 따라서는 stainless steel, TMA, NiTi순으로 torsional stiffness가 감소하였는데 stainless steel에 비해 TMA는 0.35배, NiTi는 0.16배 였다. 4.브라켓간 거리의 증가와 발생되는 torsional stiffness는 반비례하였다 브라켓간 거리의 증가에 의해 감소되는 torsional stiffness의 비율은 선재의 재질과 상관이 있었고 크기에 따라서는 큰 차이가 없었다. 5.교정치료의 마무리 단계에서 이상적인 순설측 경사이동을 일으키는 임상적 torque의 공식과 값을 구하였다. (주요 단어 : 임상적 토오크, 액티브 토오크, 모멘트, 유한요소법) The purpose of this study was to investigate the ideal clinical torque(In the SWA rectangular wire, the torque by the angle between the plane part and twisted part to move the tooth) of the orthodontic rectangular wire which produce the proper labiolingual movement of the single tooth during finishing stage of the orthodontic treatment. The clinical torque is the sum of the play and the active torque which generates the moment at the bracket. The play is calculated by the formula and the active torque is calculated by the computer aided three-dimensional finite element method. The finite element model was consist of the three brackets which formed a row and 3 kinds of orthodontic rectangular wire(stainless steel, TMA, NiTi) which inserted in brackets. Both sides of the model were twisted and the moment generated in the center bracket was calculated. The sizes of seven wires which were used commonly were .016" X .022", .017" X .022", .017" X .025", .018" X .025", .019" X .025", .020" X .025", .021" X .025". In 018" bracket, 016" X .022", ,017" X .022", .017" X .025" wires were inserted and in 022" bracket, all the sizes of wires except .016" X .022" were inserted and tested. The following conclusion could be drawn from this study. 1.The moment generated on the same size of the wires by the same active torque were equal regardless of the bracket slot size. 2.The moment were increased with the size of the wires. The moment generated on the .021" X .025" wire was about 1.75 times as large as that on the .016" X .022" wire regardless of the material. 3.The moments were increased in the order of the NiTi, TMA, stainless steel. The moment of the TMA wire was 0.35 times as small as that of the stainless steel wire and the moment of the NiTi was 0.16 times as small as that of the stainless steel wire. 4.The moment was decreased as the interbracket distance was increased. 5.To get a desired moment with the specific size and material of the wire on the specific bracket slot, the formula and the results were displayed. Key words : Clinical torque, Active torque, Moment, Finite element method

폐장암에서 p53과 PCNA 표출에 관한 연구

김대중,양승하,정도영,강상균,김의한 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.1

To observe the expression of p53 protein and PCNA in lung carcinomas and to evaluate the correlationship between the two results, the author has been carried out immunohistochemical staining with mononuclear antibodies against p53 and PCNA. 64 cases of lung carcinomas used consist of 32 cases of squamous cell carcinomas, 18 cases of adenocarcinomas and 14 cases of small cell carcinomas, respectively. 1. p53 protein expression was seen in 16 cases out of 32 (50%) in squamous cell carcinoma, 7 cases out of 18 (39%) in adenocarcinoma and 10 cases out of 14 (71%) in small cell carcinoma. The positive rate of p53 is highest in small cell carcinoma. 2. p53 staining degrees showed that 3+ in 75% of squamous cell carcinoma, 1+ in 58% of adenocarcinoma and 1+ in 50% in small cell carcinma. were observed. The tumor cell composing of squamous cell carcinoma showed most strong staining to p53 protien. 3. PCNA labelling index showed higher index in p53(+) cases than p53(-) cases. The PCNA index of squamous cell carcinoma was highest and adenocarcinoma and small cell carcinoma in order. Above findings suggested that the PCNA index was related to p53 protein in tumor cells, but the PCNA index appeared to be influenced by the p53 protein content in tumor cells than whether the p53 protien was or not. So the growth rate of squamous cell carcinoma appeared to be most rapid than adenocarcinoma and small cell carcinoma.

판토마임과 음성언어의 동시 자극법이 발달지체 아동의 언어능력 향상에 미치는 효과

김경숙,권도하 대구대학교 2005 대구대학교 학술논문집 Vol.1 No.1

본 연구는 4명의 발달지체 아동의 언어능력 향상을 위해 판토마임과 음성언어의 동시 자극법의 효과를 제안하였다. 대상자는 PLS의 정상아동과 비교 하였을 때 1년 이상 발달상으로 지체된 아동들로써 20~28개월의 범위였다. 본 연구는 사전단계, 치료단계, 사후단계의 구성으로써 A-B설계를 이용하여 아동의 사전, 사후 단계에서 아동과 치료사의 놀이상황에서 구어샘플을 두 번 수집하여 언어의미관계, 평균발화길이, 의사소통행동평가를 분석하였다. 결과 첫째, 대상 아동 모두에게서 한 단어 의미관계의 비율이 낮아지고, 두 단어 및 세 단어의 의미관계의 발생은 증가되었다. 둘째, 대상 아동 모두 평균 발화길이는 감소하였다. 셋째, 의사소통 시작하기 행동이 높은 비율로써 나타났으며, 비언어 행동들은 감소하였고, 언어를 사용한 의사소통해동은 증가하였으며, 의사소통 반응에 있어 언어반응성의 정확성이 높아졌다. 이상으로, 판토마임과 음성언어의 동시 자극법을 이용한 치료가 언어능력 향상에 있어 효과적이었다고 나타났다. This study is intended for investigating the effects of simultaneous stimulation of pantomime and verbal language on the improvement of linguistic competence of 4 developmentally delayed children. The subjects are 20~28 months old who are developmentally retarded more than 1 year compared to normal children on PLS. This study utilized an A-B design with pre-test stage, treatment stage and post-test stage, and the change in (1) semantic relations of language, (2) mean length of utterance in morphemes and (3) communicative behaviors were analyzed by collecting twice the speech samples in unstructured play situation between pathologist and children in the stage of pre-test stage and post-test stage. The results showed the following: First, the rate of semantic relation of a word in expressive language was decreased in all subjects, and occurrence of two or three words was increased. Second, the mean length of utterance in morphemes in all the children increased. Third, the commencing communicative behavior showed in higher rate, non-liguistic behavior decreased with the increase of communicative behavior using language, and the accuracy of linguistic reaction out of the 'reaction to communication' became higher. In conclusion, the simultaneous stimulation using both the pantomime and the verbal language was effective in improving the linguistic compete.

폐결핵으로 오인된 SIADH를 동반한 편평상피 세포폐암 1예

김순제,류하근,김선두,이길도,박봉안,류주성,유재등,김인숙,신현준,문언수 대한노인병학회 1999 Annals of geriatric medicine and research Vol.3 No.4

그림카드를 활용한 이야기 꾸미기가 정신지체아동의 언어능력 증진에 미치는 효과

김선옥,권도하 대구대학교 2005 대구대학교 학술논문집 Vol.1 No.1

본 연구는 그림카드를 활용한 이야기 꾸미기 프로그램으로 3명의 정신지체 아동들에 대한 연구이다. 그리고 본 연구는 아동들의 어휘다양도, 이야기 발화길이, 및 이야기 순서 맞추기 효과를 알아보기 위한 연구이다. 본 연구는 실험 전 사전 평가, 실험 단계, 사후 평가, 및 유지단계의 과정을 통해 실시하였다. 본 연구의 실험은 2004년 8월~10월 걸쳐 주 2회, 16회기에 걸쳐 중재를 하고 일주일 전· 후로 사전 평가와 사후 평가를 실시하고 유지의 순서로 진행되었다. 결론은 다음과 같다. 첫째, 그림카드를 활용한 이야기 꾸미기 프로그램을 정신지체 아동의 언어지도에 적용한 결과 대상아동 모두에게서 총 낱말 수(NTW)와 다른 낱말 수(NDW)가 증가하는 효과가 있었다. 둘째, 그림카드를 활용한 이야기 꾸미기 프로그램을 정신지체 아동의 언어지도에 적용한 결과 대상아동 모두에게서 이야기 발화길이를 향상시키는데 효과가 있었다. 셋째, 그림카드를 활용한 이야기 꾸미기 프로그램을 정신지체 아동의 언어지도에 적용한 결과 이야기 순서 맞추기에서 대상아동1과 대상아동 3에서는 사후평가와 유지 시 향상을 보였으나 대상아동 2에 있어서 사후 평가 시에는 향상을 보였으나 유지에는 실패하였다. 이는 아동의 생활 연령과 사회연령이 어려서 전체적인 이야기 순서에 대한 이해도가 떨어져 유지되지 못한 것으로 생각된다. This study was a case study of teaching 3 mentally retarded children with story making program using picture cards, and it is to research the effect on their variety of vocabulary, length of story utterance, and ordering of the story sequence. This study was done through for steps namely pre-assessment before the experiment, experimental step, post-assessment were done before and after the experiment as well as maintenance. The results were as follows: First, the story making program using picture cards on the development of language ability of the mentally retarded children was effective in increasing NTW and NDW to all subjects. Second, the story making program using picture cards on the development of language ability of the mentally retarded children was effective in increasing the length of utterance. Finally, the story making program using picture cards on the development of language ability of the mentally retarded children was effective in increasing their pre- and post-assessment as well as maintenance on the subject child 1 and 3 in ordering the story sequence, but the subject child 3 failed maintain it even through he showed increase on post-assessment. it is regarded that it was because his living age and social age was too young to have comprehension and maintenance for his total story sequence ability.

롤러스케이트 선수의 운동상해발생과 예방에 대한 조사 연구

김동희,김도수,채양석,이하얀,김선호,조성채 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.1

The study was intended to research the fact of roller skate players injury. For the study, kinds and parts of injuries, skills to be hurted, facility, injured time, cause, remedy, mental response and protecting were investigated through 182 roller skate players. The results were as follows : 1. The injury body part was showed that leg was the highest and followed by knee and ankle. 2. In the cause of injury was showed as follows: skills on corner work, bank track with concrete, 200m distance. 3. In the general cause of injury was showed: chronic fatigue by over training. 4. In the treatment and participation period after injury outbreak were showed: treatment period was toward the inside 1 week and participation to play during the treatment. 5. To the injury prevention players responded warm up, and cool down and mental-concentration were needed. Supervisor, coach and players responded knee protector wearing was needed in elementary school players and helmet-chin protector wearing in general players. The game rule revision was not necessary and the agree and disagree for ground unity to resemble. Almost players to be like concrete ground.

캡슐내시경과 단일풍선 소장내시경으로 진단된 공장의 간질종양 1예

송도경,심기남,태정현,김경진,송명은,송하응,윤혜원,정가영,정정화 이화여자대학교 의과학연구소 2012 EMJ (Ewha medical journal) Vol.35 No.2

Gastrointestinal stromal tumors (GISTs) are common mesenchymal tumors that arise in the wall of the gastrointestinal tract. We report a case of obscure gastrointestinal bleeding due to a GIST of the jejunum successfully documented by videocapsule endoscopy (VCE) and single-balloon enteroscopy (SBE). A 36-year-old man with hematochezia was referred for further evaluation of no evidence of bleeding focus on esophagogastroduodenoscopy and colonoscopy. A VCE showed a suspicious ulcerative hyperemic mass that located in about 1 hour apart from duodenal second portion. SBE revealed a nonbleeding 4×2 cm mass with an ulcer at the proximal jejunum. The patient underwent laparoscopic resection without complication. Histological examination revealed a well circumscribed, dumbbell-shaped firm mass comprised of spindle cells. Immunohistochemical staining for CD 117 was diffusely positive, whereas staining for S-100, CD 34 and MIB-1 was all negative. It was confirmed to be a low-grade GIST at the proximal jejunum.