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      • KCI등재후보

        경기 북부지역에서 발생한 한국형 출혈열의 임상적 특성

        전성주(Seoung Ju Chun),전정수(Jung Su Chun),김재하(Jae Ha Kim),최두혁(Do Hyok Choi) 대한내과학회 1987 대한내과학회지 Vol.33 No.5

        N/A Korean hemorrhagic fever which was recognized for the first time in Korea near the Demilitarized Zone between North and South Korea in 1951 during Korea War have spread to the southern part of the Korean peninsula and several hundreds of cases are clinically and serologically diagnosed each year. However the Northern Part of Kyoung Ki Do is still remained as epidemic area. In recent years, we experienced 55 cases of Korean Hemorrhagic Fever in the northern part of Kyoung Ki Do during the period, 1984-1986, and we found different clinical patterns of Korean hemorrhagic fever from those reported earlier. Here we report the epidemiological and clinical observations with laboratory findings. 1) The disease was prevalent in adult male farmers and the epidemic seasons were fall and early winter. The epidemic areas of the disease are mainly Yang Ju, Yeoncheon and Pocheon. 2) Clinical pictures of Korean Hemorrhagic Fever were characterized by headache (76%), abdominal pain (69%), nausea & vomiting (67%), fever (56%) and myalgia & general aching (49%). 3) On physical examination, fever (56%), abdominal tenderness (36%), tachycardia (35%), hypotension (27%), petechia (24%), conjunctival injection (22%) and facial flushing and edema (16%) were found. 4) On laboratory examination, leukocytosis, thrombocytopenia, left shift of leukocyte, toxic granule, proteinuria, microscopic hematuria and increased specific gravity were found. Blood chemistry findings were characterized by increased BUN & creatinine, increased SGOT & SGPT, hyponatremia, increased LDH & FDP and hyperkalemia. 5) Clinical forms of typical hemorrhagic fever were as follows: Typical oliguric type 49%, typical nonoliguric type 21% and atypical type 29%. 6) Double infection to Leptospirosia was found in 8 cases.

      • KCI등재후보

        경기북부 지역의 Richettsia 질환에 관한 임상적 고찰

        전성주(Seoung Ju Chun),이기영(Kee Yeoung Lee),최두혁(Du Hyok Choi),양현억(Hyun Eog Yang) 대한내과학회 1989 대한내과학회지 Vol.36 No.4

        N/A Rickettsiosis is one of the most prevailng acute febrile diseases in the northern part of Kyoung Ki Do during harvest-time. We experienced 36 cases of rickettsiosis in this area during 1978. Herein we report the epidemiological and clinical observations with laboratory findings. 1) The disease was prevalent in adult female farmers and the epidemic seasons were fall and early winter. 2) The serologic test revealed a positive rate of 67% (24 cases) in R. tsutsugamushi and 33% (12 cases) in R. typhi and two cases were seropositive to Korean Hemorrhagic Fever. 3) Clinical pictures of Tsutsugamushi disease were characterized by fever (88%), chills (71%), headache (71 %) and abdominal pain (50%) but were less severe in R. typhi as fever in 83% of cases, chills 67% and headache 67%. 4) On physical examination, abdominal tenderness (54 %), fever (38%), CVA tenderness (29%), tachycardia (25 %) and eschar (13%) were found but were less severe in R. typhi as abdominal tenderness in 25% of cases, fever 25%, CVA tenderness 17% and tachycardia 17%. 5) On laboratory examination, a left shift of leukocytes, atypical lymphocytes, anemia, microscopic hematuria and proteinuria were found. Blood chemistry findings were characterized by increased SGOT & SGPT and increased CPK & LDH. The chest X-ray revealed interstitial pneumonia in nine cases (25%).

      • KCI등재후보

        경기 복부지역에서 발생한 렙토스피라병 15 예에 대한 임상적 관찰

        김재하,최두혁,윤석중,전성주 대한내과학회 1987 대한내과학회지 Vol.32 No.1

        Leptospirosis is an acute, systemic and zoonotic infectious disease caused by various serovars of Leptospira interrogans. It is known that there are clinical and epidemiological differences in different areas. We experienced 15 cases of Leptospirosis in the northern part of Kyoung Ki Do during autumn 1984 and 1985. Here we report the clinical and laboratory findings of the cases and the differences of findings according to specific areas and the summary of findings helpful for differentiating Leptaspirosis and other febrile illness such as Korean hemorrhagic fever and rickettsial diseases: 1) The disease was prevalent in adult male farmers working on the yard during harvest-time. Clinical pictures of Leptospirosis were characterized by fever (87%), headache(67%), myalgia (67%) and chills (53%). On physical examination, fever (67%), moist rale (60%), abdominal tenderness (53%), tachycardia (33%) and tachypnea (33%) were found. On laboratory examination, relative lymphopenia, atypical lymphocytes, proteinuria and microscopic hematuria were found. Blood chemistry findings were characterized by decreased serum cholesterol, and decreased serum HDL-cholesterol, hypoalbuminemia and increased SGOT, SGPT and LDH level. The abnormal chest X-ray findings were observed in 5 patients (33.3%); nodular acinar type (60%), massive confluent type (20%) and diffuse interstitial type (20%). 2) In comparison to other reported results in Won Ju and Chun Cheon area, the type of Leptospirosis in northern part of Kyoung Ki Do is mixed patterns of influenza form and pulmonary form with milder symptoms and signs than other areas. 3) Acute febrile illness during harvest-time in northern part of Kyoung Ki Do should be differentiated by Korean hemorrhagic fever and richettsial diseases by clinical manifestation, laboratory datas and serologic methods. Febrile period of Leptospirosis is longer than Korean hemorrhagic fever and serum levels of CPK, LDH are higher and proteinuria is milder than Korean hemorrhagic fever. The skin rash and pyuria is observed frequently in rickettsial diseases than Leptospirosis and Weil-Felix test is used in diagnosis of rickettsial diseases but false positive reaction is found in Leptospirosis and so complement fixation test and immunofluorescent test is required.

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