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간내 담석과 동반된 간내 담도암에서의 p53과 Ki-ras의 발현
김명환,이성구,서동완,이승규,남승우,박능화,민영일,김연석,심기남,공경엽 대한소화기학회 1997 대한소화기학회지 Vol.30 No.5
Background/Aims: Hepatolithiasis or primary intrahepatic stones may be accompanied later by intrahepatic cholangiocarcinoma. This cancerous lesion is frequently associated with atypical hyperplastic epithelium that was suspected of being precancerous. To investigate the Ki-ras or p53 mutation may play a role in carcinogenesis, and to determine whether atypical hyperplastic epithelium may be precancerous, this study was performed in intrahepatic cholangiocarcinomas associated with hepatolithiasis. Methods: We examined 12 patients with intrahepatic cholangiocarcinomas associated with hepatolithiasis. Ki-ras point mutations were assessed by direct DNA sequencing. Expressions of p53 protein were immunohistochemically assessed. The overexpression of p53 and point mutation of Ki-ras were examined in normal, hyperplastic, atypical hyperplastic, and can- cerous tissues separately. Results: The expressions of p53 protein were detected in 4 (33%) of 12 cholangiocarcinomas and Ki-ras point mutations at codon 12 were found in 2 (17%) of 12 cholangiocarcinomas. In those two carcinoma cases which contained the mutant sequence of Ki-ras, the same point mutation from wild type GGT (glycine) to GAT (aspartic acid) was. found in the associated atypical hyperplastic epithelium. However, none of the normal and hyperplastic epithelium harbored Ki-ras or p53 mutations. Conclusions: The overexpression of p53 may play a part in the carcinogenesis of some intrahepatic cholangiocarcinomas associated with hepatolithiasis, whereas the role of Ki-ras mutations in those cases is dubious. However, Ki-ras point mutation at codon 12 may be responsible for either cancer or atypical hyperplastic epithelium associated with hepatolithiasis in certain cases, suggesting atypical hyperplastic epithelium may give rise to carcinoma.
수족냉증(手足冷症) 환자(患者)에 대(對)한 컴퓨터 적외선(赤外線) 체열촬영(體熱撮影)의 의의(意義)
조유경,오수완,조남희,김동묵,김진성,류봉하,박동원,류기원,Cho, Yu-Kyung,Oh, Su-Wan,Cho, Nam-Hee,Kim, Dong-Mook,Kim, Jin-Seong,Ryu, Bong-Ha,Park, Dong-Won,Ryu, Ki-Won 대한한방내과학회 1998 大韓韓方內科學會誌 Vol.19 No.2
To make a objective diagnosis of the syndrome of cold-limbs, We investigated the 20 patients with cold limbs and GI trouble and 20 normal people as a control group. And we compared the thermal difference between Chon-jung(CV17) and Chung-wan(CV12 中脘), Chon-jung(CV17) and Ki-hae(氣海 CV6) and we compared the thermal differences of No-gung(PE8 勞宮) and Yong-chon(湧泉 KI1), too. The results were as follows. 1. All 20 patients had GI trouble and cold limbs. They had the symptom-Indigestion(16 cases-80%) with heart burn, tympanites, abdominal distention, hiccup, belching. Beside that symptom they also had constipation(6 cases-30%), diarrhea(3 cases-15%), headache & dizziness(6 cases-30%). And some had the menstrual syndrome, chronic fatigue, palpitation, insomnia, edema, arthralgia. 2. The thermal difference of the palms between the patients group and the control group were $25.70^{\circ}C,\;25.82^{\circ}C$, but they were not significant. 3. The thermal difference of the soles between the patients group and the control group were $23.58^{\circ}C,\;24.42^{\circ}C$ and the significancy was P=0.020 so it was significant(P<0.05). 4. The thermal difference of the palms and Chon-jung(CV17) between the patients group and the control group were $1.08^{\circ}C,\;0.76^{\circ}C$, but they were not significant. 5. The thermal difference of the sales and Chon-jung(CV17) between the patients group and the control group were $3.01^{\circ}C,\;1.90^{\circ}C$ and the significancy was P=0.003 so it was significant(P<0.05). 6. The thermal difference of Chon-jung(CV17) and Chung-wan(CV12 中脘) between the patients group and the control group was $0.30^{\circ}C,\;0.62^{\circ}C$ and the significancy was P=0.793 so it was significant(P<0.05). 7. The thermal difference of Chon-jung(CV17) and Ki-hae(CV6 氣海) between the patients group and the control group was $0.53^{\circ}C,\;0.68^{\circ}C$, but they were not significant. From the above, I could find the significance of D.I.T.I to diagnose the cold-feet not the cold-hands and the thermal difference between the trunk and limbs was more significant on cold-feet than on cold-hand, either.
비젼 제어시스템에 사용된 카메라의 최적개수에 대한 실험적 연구
장완식,김선호,김기영,임호진,안힘찬 朝鮮大學校 機械技術硏究所 2002 機械技術硏究 Vol.5 No.2
The vision system model used for this study involves the six parameters that permits a kinds of adaptability in the relationship between the camera space location of manipulable visual cues and the vector of robot joint coordinates is estimated in real time. Also this vision control method requires the number of cameras to transform 2-D camera plane from 3-D physical space, and be used irrespective of location of cameras, if visual cues are displayed in the same camera plane. Thus, this study is to investigate the optimal number of cameras used for the developed vision control system according to the change of the number of cameras. This study is processed in the two ways : a) effectiveness of vision system model b) optimal number of cameras c) These results show the evidence of the adaptability of the developed vision control method using the optimal number of cameras.
이기덕,박완범,정혜승,강철인,김동민,김홍빈,오명돈,최강원 대한감염학회 2003 감염과 화학요법 Vol.35 No.5
에이즈 환자의 중추신경계 합병증으로 에이즈 바이러스 자체에 의한 합병증, 기회감염, 종양 등이 있다. 저자들은 전신긴장간대발작을 일으킨 31세 남자 에이즈 환자에 발생한 조류형결핵균 뇌수막염을 조직학적 및 미생물학적으로 증명하고, 항비결핵미코박테리아 약제를 고농도로 투여하여 치료하였다. 조류형결핵균 뇌수막염은 결핵성 뇌수막염으로 잘못 진단되면 치명적인 결과를 초래할 수 있으므로, 조직검사를 포함한 적극적인 검사가 필요하다. We report a case of Mycobacterium avium-intraceliuiarae meningoencephalitis found in a 31-year-old patient with AIDS and preexisting disseminated Mycobacterium avium-intracellularae infection. He had been taking highly active antiretroviral therapy and antimycobacterial medications when he developed generalized tonic-clonic seizure. Repeated workups including blood and cerebrospinal fluid examinations and magnetic resonance image (MRI) of the brain revealed nondiagnostic. The diagnosis was made by stereotactic brain biopsy of the nodule, which was detected 9 month after the first seizure attack in brain MRI. Acid-fast bacilli were observed on microscopic exam. Mycobacterium avium-intracellularae was isolated from the biopsy specimen.
고완기,문석환 제주한라대학 1997 論文集 Vol.21 No.-
This project satisfies several requests from users who want to use internet agent system with local information service model, and introduces new method which can analyze user's request and build an adaptable system. Because current web searching system has a general form, so that it can't regard for each person's various requests. This system can complement demerits which the users should check every unnecessary information and they can't gather and connect the consistent local information network system. Therefore, this project deals successfully with the general demerit of current web searching system for building of local information network system, performs electronic commerce or messaging with users perfectly. And this presents the example that builds the local total information management system which gives the very proper information to the users of local information system, and gives operation program of web-based local information management system that connects internet kiosk system for the internet network.