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STIM1 negatively regulates Ca2? release from the sarcoplasmic reticulum in skeletal myotubes.
Lee, Keon Jin,Woo, Jin Seok,Hwang, Ji-Hye,Hyun, Changdo,Cho, Chung-Hyun,Kim, Do Han,Lee, Eun Hui Biochemical Society 2013 The Biochemical journal Vol.453 No.2
<P>STIM1 (stromal interaction molecule 1) mediates SOCE (store-operated Ca2? entry) in skeletal muscle. However, the direct role(s) of STIM1 in skeletal muscle, such as Ca2? release from the SR (sarcoplasmic reticulum) for muscle contraction, have not been identified. The times required for the maximal expression of endogenous STIM1 or Orai1, or for the appearance of puncta during the differentiation of mouse primary skeletal myoblasts to myotubes, were all different, and the formation of puncta was detected with no stimulus during differentiation, suggesting that, in skeletal muscle, the formation of puncta is a part of the differentiation. Wild-type STIM1 and two STIM1 mutants (Triple mutant, missing Ca2?-sensing residues but possessing the intact C-terminus; and E136X, missing the C-terminus) were overexpressed in the myotubes. The wild-type STIM1 increased SOCE, whereas neither mutant had an effect on SOCE. It was interesting that increases in the formation of puncta were observed in the Triple mutant as well as in wild-type STIM1, suggesting that SOCE-irrelevant puncta could exist in skeletal muscle. On the other hand, overexpression of wild-type or Triple mutant, but not E136X, attenuated Ca2? releases from the SR in response to KCl [evoking ECC (excitation-contraction coupling) via activating DHPR (dihydropyridine receptor)] in a dominant-negative manner. The attenuation was removed by STIM1 knockdown, and STIM1 was co-immunoprecipitated with DHRP in a Ca2?-independent manner. These results suggest that STIM1 negatively regulates Ca2? release from the SR through the direct interaction of the STIM1 C-terminus with DHPR, and that STIM1 is involved in both ECC and SOCE in skeletal muscle.</P>
Lee, Su-Hwan,Shin, Pyeong,Bae, Hui-Su,Lee, Jang-Hee,Oh, Yang-Yeol,Lee, Sang-Hun,Rho, Tae-Hwan,Song, Beom-Heon,Cho, Jae-Yeong,Lee, Kyoung-Bo,Lee, Keon-Hui,Park, Ki-Hoon 한국토양비료학회 2014 한국토양비료학회지 Vol.47 No.6
Newly reclaimed tidal land is known to be in low status of soil fertility. The incorporation of crop residue is an effective method to improve soil properties and fertility in reclaimed saline soils. The objective of this study was to evaluate the efficiency of rice straw (RS) application to improve physico-chemical properties of saline-sodic soil and its contribution to productivity of whole crop barley. Increasing rate of rice straw improved growth parameter related to yield of whole crop barley, which increased tiller number significantly (p<0.05).The yield increased by 15% (F.W) and 9% (D.W) in rice straw-amended plots. The content of soil organic matter (SOM) in the surface soil (0-20cm) with rice straw incorporation increased by 5~9% (RS 2.5~RS 7.5) compared to RS 0, in which the content of SOM decreased after two consecutive cultivations. Rice straw incorporation promoted soil physico-chemical properties and nutrient-availability of the test crop, as indicated in change in soil bulk density, porosity and increased nutrient uptake of plant. Especially, the P content and uptake of whole crop barley increased with increasing the rate of rice straw application. In conclusion, the rice straw application at rates of $5.0-7.5ton{\cdot}ha^{-1}$ in reclaimed saline soils effectively improved soil properties and crop productivity, which has potentials to reduce the loss of chemical fertilizers and facilitate the favorable condition for crop growth under adverse soil condition.
한국 청소년에서 물질 사용과 위험한 성 행동 사이의 연관성
이건희(Keon Hui Lee),김준원(Jun Won Kim),최태영(Tae Young Choi),윤서영(Seo Young Yoon),이종훈(Jong Hun Lee) 한국중독정신의학회 2020 중독정신의학 Vol.24 No.2
Objectives : This study aimed to investigate the association between substance use and risky sexual behavior in Korean adolescents. Methods : A cross-sectional survey using a self-administered questionnaire was conducted in 12-18 year-old adolescents in Korea in 2018. The data of 60,040 adolescents who participated in the survey were analyzed. Logistic regression was performed to investigate the association between substance use (alcohol use, tobacco use, and the use of other drugs) and risky sexual behavior (having sexual intercourse during adolescence, and having unprotected sexual intercourse), for males and females, separately. Results : The percentage of adolescents who had sexual intercourse was 5.3%. Among those who had sexual intercourse, 53.9% had unprotected sexual intercourse. Logistic regression analyses showed that all types of substance use were associated with having an early sexual debut and having unprotected sexual intercourse. Conclusion : The study showed that substance use, including alcohol use, tobacco use, and the use of other drugs, was associated with risky sexual behavior among Korean adolescents. Sexual health education and interventions are necessary for adolescents with a history of substance use.
Su-Hwan Lee,Hui-Su Bae,Yang-Yeol Oh,Sang-Hun Lee,Yeong-Joo Kim,Sun Kim,Jin-Hee Ryu,Kang-Ho Jung,Choong-Geun Lee,Jae-Hyeon Kim,Yeong-Doo Kim,Weon-Young Choi,Jae-Yeong Cho,Kyoung-Bo Lee,Keon-Hui Lee,Ki- 한국토양비료학회 2016 한국토양비료학회지 Vol.49 No.6
It is known that the poor soil fertility of newly reclaimed saline soils is due to the lack of organic matter and available mineral nutrients for crop production. The effect of green manuring with Sesbania aculeata in combination with five rates of urea-N treatments (N0. N25, N50, N75, N100) on the productivity of a subsequent whole-crop barley and the fertility of the reclaimed saline soil in Saemangeum was evaluated in the field during 2013-2014 growing season. Sesbania was grown during summer season (June to October). The amount of Sesbania incorporated was 16.2 Mg ha<SUP>-1</SUP>. Sesbania contributed to 393 kg N ha<SUP>-1</SUP> to the soils when ploughed down and incorporated before whole-crop barley cultivated. The performances of whole-crop barley following sesbania incorporation were significantly affected by a combination of Sesbania manuring and different N rates. The N fertilizer equivalence without N fertilizer following Sesbania was 42.6% (63.9 kgN ha<SUP>-1</SUP>), compared with N100(150 kg N ha<SUP>-1</SUP>) in fallow soils. The whole-crop barley yield responded to N fertilizer rates in both sesbaniaamended and fallow soil. The yield response to nitrogen rates in fallow soil was linear (Y=0.0586X+3.3011, R<SUP>2</SUP> =0.9534), whereas that in sesbania-amended soils was quadratic (Y= -0.001X<SUP>2</SUP>+0.1322X+5.7143, R<SUP>2</SUP>=0.9576). The yield of whole-crop barley in sesbania-amended with increasing N rates was increased up to SN75 (115 kgN) 10.3 Mg ha<SUP>-1</SUP>. Apparent N recovery (ANR) of whole-crop barely showed decreased with sesbania plus increasing rates of N fertilizer. Despite higher yield with sesbania manuring plus increasing N rates, the contributions of N from Sesbania with increasing N rates to whole-crop barley were decreased, whereas those from fertilizer increment due to excessively mineralized Nitrogen. Considering yield, ANR, N contribution from Sesbania and nitrogen fertilizer, the optimum N rate was N50 rate following sesbania incorporation.
Su-hwan Lee,Pyeong Shin,Hui-su Bae,Jang-Hee Lee,Yang-Yeol Oh,Sang-Hun Lee,Tae-Hwan Rho,Beom-Heon Song,Jae-Yeong Cho,Kyoung-Bo Lee,Keon-Hui Lee,Ki-Hoon Park 한국토양비료학회 2014 한국토양비료학회지 Vol.47 No.6
Newly reclaimed tidal land is known to be in low status of soil fertility. The incorporation of crop residue is an effective method to improve soil properties and fertility in reclaimed saline soils. The objective of this study was to evaluate the efficiency of rice straw (RS) application to improve physico-chemical properties of saline-sodic soil and its contribution to productivity of whole crop barley. Increasing rate of rice straw improved growth parameter related to yield of whole crop barley, which increased tiller number significantly (p<0.05).The yield increased by 15% (F.W) and 9% (D.W) in rice straw-amended plots. The content of soil organic matter (SOM) in the surface soil (0-20cm) with rice straw incorporation increased by 5~9% (RS 2.5~RS 7.5) compared to RS 0, in which the content of SOM decreased after two consecutive cultivations. Rice straw incorporation promoted soil physico-chemical properties and nutrient-availability of the test crop, as indicated in change in soil bulk density, porosity and increased nutrient uptake of plant. Especially, the P content and uptake of whole crop barley increased with increasing the rate of rice straw application. In conclusion, the rice straw application at rates of 5.0-7.5 ton·ha<SUP>-1</SUP> in reclaimed saline soils effectively improved soil properties and crop productivity, which has potentials to reduce the loss of chemical fertilizers and facilitate the favorable condition for crop growth under adverse soil condition.
Lee, Kwang‐,Ho,Kim, Sang‐,Mook,Jeong, Huisu,Pak, Yusin,Song, Hui,Park, Jeongpil,Lim, Keon‐,Hee,Kim, Jae‐,Hoon,Kim, Youn Sang,Ko, Heung Cho,Kwon, Il Keun,Jung, Gun‐,Young WILEY‐VCH Verlag 2013 ADVANCED MATERIALS Vol.25 No.23
<P><B>All‐solution‐processed transparent thin film transistors (TTFTs)</B> are demonstrated with silver grid source/drain electrodes, which are fabricated by printing and subsequent silver nanoparticles solution coating, which allows continuous processing without using high vacuum systems. The silver grid electrode shows a reasonable transmittance in visible range, moderate electrical conductance and mechanical strength. The TTFTs are employed to drive liquid crystal cells and demonstrate a successful switching operation.</P>