Investigation of the Roles of Cyclooxygenase-2 and Galectin-3 Expression in the Pathogenesis of Premenopausal Endometrial Polyps

Esin Kasap,Serap Karaarslan,Esra Bahar Gur,Mine Genc,Nur Sahin,Serkan Güclü 대한병리학회 2016 Journal of Pathology and Translational Medicine Vol.50 No.3

Background: The pathogenesis and etiology of endometrial polyps has not been elucidated. In this study, we aimed to examine the pathogenic mechanisms of endometrial polyp development using immunohistochemistry. We evaluated the expression of galectin-3 and cyclooxgenase-2 (COX-2) during the menstrual cycle in premenopausal women with endometrial polyps or normal endometrium. Methods: Thirty-one patients with endometrial polyps and 50 healthy control patients were included in this study. The levels of expression of COX-2 and galectin-3 were studied by immunohistochemistry. Results: The percentage of COX-2–positive cells and the intensity of COX-2 staining in the endometrium did not vary during the menstrual cycle either in the control group or in patients with endometrial polyps. However, expression of galectin-3 was significantly lower in endometrial polyps and during the proliferative phase of the endometrium compared with the secretory phase. Conclusions: Our data suggests that the pathogenesis of endometrial polyps does not involve expression of COX-2 or galectin-3.

Recent advances in X-ray photoconductors for direct conversion X-ray image detectors

S.O. Kasap,M. Zahangir Kabir,J.A. Rowlands 한국물리학회 2006 Current Applied Physics Vol.6 No.3

Recent research on at panel X-ray image detectors has shown their potential for replacing existing X-ray lm/screen cassettes andcapturing X-ray images electronically, thus enabling the clinical transition to digital radiography. The present work examines the imagingproperties of a number of potential X-ray photoconductors for these new X-ray image detectors. The X-ray sensitivity is discussed interms of the absorption eciency, electronhole pair creation energy (ionization energy), and charge transport and trapping limitedattention to stabilized a-Se and HgI2, currently the most promising materials

Dependence of the electrical properties of stabilized a-Se on the preparation conditions and the development of a double layer X-ray detector structure

George Belev,Safa Kasap,J.A. Rowlands,David Hunter,Martin Yaffe 한국물리학회 2008 Current Applied Physics Vol.8 No.3,4

Stabilized a-Se lms deposited at suciently low substrate temperatures aren-like in which electrons can drift but holes are deeplytrapped. Such layers can be conveniently incorporated in a multilayer a-Se detector structure to block the injection of holes from thepositive electrode. We have shown that a simple double-layer detector structure based on a cold depositedn-layer (which is thenannealed) on which an i-like layer is grown can have dark current densities lower than 10. 10 Acm. 2 at a eld of 10 V/l m. The darkcurrent depends on the thickness of then-like layer. An a-Se X-ray detector for slot scanning was fabricated by having thein a-Se photo-conductor structure coated onto a CCD chip. The latter detector was shown to have excellent resolution with a modulation transfer func-tion remaining above 0.5 up to a spatial frequency of 11-14 lp mm-¹

Using machine learning for anomaly detection on a system-on-chip under gamma radiation

Wächter Eduardo Weber,Kasap Server,Kolozali Şefki,Zhai Xiaojun,Ehsan Shoaib,McDonald-Maier Klaus D. 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.11

The emergence of new nanoscale technologies has imposed significant challenges to designing reliable electronic systems in radiation environments. A few types of radiation like Total Ionizing Dose (TID) can cause permanent damages on such nanoscale electronic devices, and current state-of-the-art technologies to tackle TID make use of expensive radiation-hardened devices. This paper focuses on a novel and different approach: using machine learning algorithms on consumer electronic level Field Programmable Gate Arrays (FPGAs) to tackle TID effects and monitor them to replace before they stop working. This condition has a research challenge to anticipate when the board results in a total failure due to TID effects. We observed internal measurements of FPGA boards under gamma radiation and used three different anomaly detection machine learning (ML) algorithms to detect anomalies in the sensor measurements in a gamma-radiated environment. The statistical results show a highly significant relationship between the gamma radiation exposure levels and the board measurements. Moreover, our anomaly detection results have shown that a One-Class SVM with Radial Basis Function Kernel has an average recall score of 0.95. Also, all anomalies can be detected before the boards are entirely inoperative, i.e. voltages drop to zero and confirmed with a sanity check.

Impact of Prognostic Factors on Survival Rates in Patients with Ovarian Carcinoma

Arikan, Sevim Kalsen,Kasap, Burcu,Yetimalar, Hakan,Yildiz, Askin,Sakarya, Derya Kilic,Tatar, Sumeyra Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15

Purpose: The aim of the present study was to invesitigate the impact of significant clinico-pathological prognostic factors on survival rates and to identify factors predictive of poor outcome in patients with ovarian carcinoma. Materials and Methods: A retrospective chart review of 74 women with pathologically proven ovarian carcinoma who were treated between January 2006 and April 2011 was performed. Patients were investigated with respect to survival to find the possible effects of age, gravida, parity, menstruel condition, pre-operative Ca-125, treatment period, cytologic washings, presence of ascites, tumor histology, stage and grade, maximal tumor diameter, adjuvan chemotherapy and cytoreductive success. Also 55 ovarian carcinoma patients were investigated with respect to prognostic factors for early 2-year survival. Results: The two-year survival rate was 69% and the 5-year survival rate was 25.5% for the whole study population. Significant factors for 2-year survival were preoperative CA-125 level, malignant cytology and FIGO clinical stage. Significant factors for 5-year survival were age, preoperative CA-125 level, residual tumor, lymph node metastases, histologic type of tumor, malignant cytology and FIGO clinical stage. Logistic regression revealed that independent prognostic factors of 5-year survival were patient age, lymph node metastasis and malignant cytology. Conclusions: We consider quality registries with prospectively collected data to be one important tool in monitoring treatment effects in population-based cancer research.

X-ray induced effects in Sm3+-doped ZnO-P2O5 glass for radiation measurements

Go Okada,Hirokazu Masai,Aya Torimoto,Safa Kasap,Takayuki Yanagida 한양대학교 세라믹연구소 2016 Journal of Ceramic Processing Research Vol.17 No.3

We have studied X-ray induced effects on ZnO-P2O5 glass doped with Sm3+ ion. The glass was synthesized by a conventionalmelt-quenching method in an ambient atmosphere. We have investigated the following three different effects induced by Xrayirradiation in this glass, which can be used for radiation sensing applications. First, although the as-prepared glass sampleis highly transparent and homogeneous, upon irradiation with X-rays, the sample becomes slightly brownish due to anappearance of color centers induced by X-ray irradiation which can be measured as an optical absorption in the UV-Vis range. By utilizing the extent of absorption change by X-ray irradiation, it is possible to measure the incident radiation dose fromabout 0.5 to over 20 Gy. Second, with the Sm3+ ion included as a luminescent centre, the glass sample emits orange-red lightupon X-ray irradiation. The integrated light emission is proportional to the incident X-ray dose, hence it can be used as ascintillator plate for online radiation monitoring. The confirmed exposure dose detection range for this use is approximately1 -300 R. Last, when an irradiated sample is heated at elevated temperatures from 100 to 400 oC, it shows a thermallystimulatedluminescence (TSL). The emission intensity increases with the accumulated X-ray dose delivered prior to themeasurement, so our sample has a function to act as a TSL dosimeter as well. Over the radiation dose range we have tested,the X-ray induced effects above show linear response against the incident dose. The linear response is of particular importancefor dosimetry applications since it enables us to calibrate the response of sample to radiation dose with high accuracy.

Association Between Trp64arg Polymorphism of the β3 adrenoreceptor Gene and Female Sex in Obese Turkish Children and Adolescents

Yilmaz, Resul,Ates, Omer,Gul, Ali,Kasap, Tuba,Ozer, Samet,Ensari, Emel The Korean Society of Pediatric Gastroenterology 2019 Pediatric gastroenterology, hepatology & nutrition Vol.22 No.5

Purpose: The ${\beta}3-adrenergic$ receptor (ADRB3) is expressed in visceral adipose tissue and has been speculated to contribute to lipolysis, energy metabolism, and regulation of the metabolic rate. In this study, we aimed to investigate the association of polymorphism of the ADRB3 gene with the sex of children with obesity and related pathologies. Methods: ADRB3 gene trp64arg genotyping was conducted in 441 children aged 6-18 years. Among these subjects, 264 were obese (103 boys; 161 girls) and 179 were of normal weight (81 boys; 98 girls). In the obese group, fasting lipids, glucose and insulin levels, and blood pressure were measured. Metabolic syndrome (MS) was defined according to the modified World Health Organization criteria adapted for children. Results: The frequency of trp64arg genotype was similar in obese and normal weight children. In obese children, serum lipid, glucose, and insulin levels; homeostasis model assessment of insulin resistance (HOMA-IR) scores; and MS were not different between arg allele carriers (trp64arg) and noncarriers (trp64trp). In 264 obese children, genetic analysis results revealed that the arg allele carriers were significantly higher in girls than in boys (p=0.001). In the normal weight group, no statistically significant difference was found between genotypes of boys and girls (p=0.771). Conclusion: Trp64arg polymorphism of the ADRB3 gene was not associated with obesity and MS in Turkish children and adolescents. Although no relationships were observed between the genotypes and lipids, glucose/insulin levels, or HOMA-IR, the presence of trp64arg variant was frequent in obese girls, which can lead to weight gain as well as difficulty in losing weight in women.

Sensitivity of stabilized a-Se based X-ray photoconductors

M. Zahangir Kabir,M. Yunus,S.O. Kasap,O. Tousignant,H. Mani,P. Gauthier 한국물리학회 2006 Current Applied Physics Vol.6 No.3

A model explaining the ghosting mechanisms in amorphous selenium based X-ray image detectors is described by considering deeptrapping of charge carriers, trapped charges arising from previous exposures, trap lling eects, recombination between drifting andtrapped carriers, generation of X-ray induced new deep trap centers, space charge eects, carrier detrapping, and electric eld dependenttions, and the Poisson’s equation across the photoconductor for a pulse X-ray exposure by the nite dierence method. The numericalresults are compared with Monte Carlo simulations. The relative sensitivity decreases with increasing accumulative X-ray exposure anddecreasing applied electric eld. The sensitivity reduction at negative bias is greater than at positive bias. The theoretical model is tted toexperimental data. The comparison of the model with the experimental data reveals that the recombination between trapped and theoppositely charged drifting carriers, electric eld dependent charge carrier generation and X-ray induced new deep trap centers are mainly responsible for the sensitivity reduction in biased amorphous selenium based X-ray detectors.

Antifungal Activity of the Honeybee Products Against Candida spp. and Trichosporon spp.

Ayşe Nedret Koç,Sibel Silici,Filiz Kasap,Hatice Tuna Hörmet-Öz,Hikmet Mavus-Buldu,Barış Derya Ercal 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.1

Honeybee products (honey, royal jelly, pollen, and propolis) were evaluated for their ability to inhibit the growth of 40 yeast strains of Candida albicans, Candida glabrata, Candida krusei, and Trichosporon spp. The broth microdilution method was used to assess the antifungal activity of honeybee products against yeasts. Fluconazole was selected as the antifungal control agent. Using the broth microdilution method, minimal inhibitory concentration ranges with regard to all isolates were 5–80% (vol/vol), 0.06–1μg/mL, 0.002–0.25μg/mL, 0.006–0.1μg/mL, and 0.02–96μg/mL for honey, royal jelly, pollen, propolis, and fluconazole, respectively. The antifungal activities of each product decreased in the following order: propolis >pollen>royal jelly>>honey. This study demonstrated that honeybee products, particularly propolis and pollen, can help to control some fluconazole-resistant fungal strains.

Comparison of Myometrial Invasion and Tumor Free Distance from Uterine Serosa in Endometrial Cancer

Ozbilen, Ozlem,Sakarya, Derya Kilic,Bezircioglu, Incim,Kasap, Burcu,Yetimalar, Hakan,Yigit, Seyran Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.2

Background: We aimed to investigate whether the tumor free distance (the distance between the uterine serosa and the tumor at its deepest point) is useful in surgical staging and in predicting prognosis. Materials and Methods: Data from patients who underwent complete surgical staging for endometrial cancer between January 2006 and June 2011 were reviewed retrospectively. All demographic findings, surgical stages, histological type and grade, myometrial invasion, lymphovascular space invasion as well as abdominal cytology, cervical, adnexal, and omental involvement, and lymph node metastasis were recorded. The relations between myometrial invasion and tumor free distance from uterine serosa with prognostic factors were investigated. Results: Seventy patients were included in the study. Sixty-four (91.5%) had endometrioid type cancers and forty-four (62.9%) were grade 1. The deepest myometrial invasion was less than 1/2 in 42 patients (60%). In 18 patients (25.8%) lymphovascular invasion was noted. Eight (11.4%) were found to have cervical involvement, five (7.1%) had adnexal involvement and in 4 cases (5.7%) the peritoneal washings included malignant cells. Four patients had pelvic and one para-aortic node metastasis. We recognized that an invasion of more than 1/2 was correlated significantly with lymphovascular space involvement, histological grade, positive abdominal washing cytology, nodal and cervical involvement, but not with adnexal involvement. Tumor-free myometrial thickness was negative and statistically significant correlated with surgical stage, histological grade, lymphovascular space involvement, positive abdominal washing cytology, cervical and adnexal involvement. The importance of tumor-free myometrial thickness in determinating the lymphovascular space invasion was found to be highest in terms of sensitivity and specificity when crossing the ROC curve at 11 millimeters. Conclusions: Depth of myometrial invasion is more valuable for predicting lymph node metastasis than tumor-free myometrial thickness. The tumor-free myometrial thickness provides a better prediction for adnexal involvement.