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조동인(Dongin Cho),박창근(ChangKeun Park),박지영(Jiyoung Park),강진원(Jinwon Kang) 한국기술혁신학회 2019 한국기술혁신학회 학술대회 발표논문집 Vol.2019 No.5
현재 국제사회에서 논의되는 중요한 의제 중 하나로 기후변화 문제를 들 수 있다. 기후변화로 발생하는 영향을 지역수준에서 평가하고 그에 따른 적응대책을 적절하게 수립하기 위해서는 기후변화 대책에 대한 평가가 전제되어야 한다. 이를 위해 다양한 기후변화 적응대책 평가 방법론이 제안되고 있으나, 평가 관련 신뢰성 문제를 해결할 수 있는 방법론이 부족하다. 이와 같은 상황에서 본 연구의 목적은 기후변화에 따른 미래 예측 시 각 지역별 및 부문별 적응대책의 평가 결과를 활용하는데 신뢰성을 제공할 수 있도록 표준화된 신뢰도 평가체계 방법론을 제안하는 것이다. 본 연구는 다양한 정성적 혹은 정량적 방법과 함께 현실내재적 메커니즘을 활용하여 평가체계의 신뢰도 평가 모형을 개발 할 때, 신뢰도 평가가 탄력적으로 고려될 수 있도록 구성하였다. 본 연구에서 제안된 통합적 평가방법론의 신뢰도 평가체계는 기후변화로 인한 다양한 대응책 평가에 대해 신뢰도를 제공하기 때문에 평가된 결과를 기후변화 적응대책에 실질적으로 적용할 수 있는 근거가 될 것으로 기대한다. 이러한 신뢰도 평가모형은 향후 기후변화 대응책의 신뢰성을 표준화해서 국내 실정에 맞는 적응정책 신뢰도 평가가 가능하게 할 것이다. 또한 한국형 기후변화 적응대책 수립 및 평가 시 과학적 근거에 기반을 둔 신뢰성을 제공한다는 측면이 본 연구의 중요성을 강조한다. Climate change is one of most dominantly discussed issues in the world. Evaluating the effect of climate change at a regional level and setting up an appropriate adaptation policy for issues associated with climate change require a proper evaluation process on the climate change adaptation projects implemented already. Although various evaluation approaches to climate change adaptation programs have been proposed, it is rare to find a proper systematic approach to evaluating the reliability on climate change adaptation programs. Under the current situation on the system to evaluate climate change adaptation programs, the purpose of this study is to suggest a theoretical and standardized evaluation system on the reliability of climate change adaptation programs. The new approach suggested in this paper will be appropriate when requiring a confidence level for adaptation programs that are especially localized and categorized. Using various quantified and qualified evaluation methods with the inherent reality mechanism, we provide a conceptual framework to measure the reliability of climate change adaptation programs with the flexible adjustment process. Via the proposed framework, it is possible to provide the confidence level on the results collected from the evaluation systems and construct a standardized, system-wide assement procedure toward climate change adaptation policies. By applying this approach for a scientific evidence on the reliability of climate change adaptation policies, appropriate and efficient climate change adaptation programs will be properly prepared for and implemented in Korea.
Nanoconfinement-mediated Cancer Theranostics
Changsun Kang,Dongin Kim 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.1
Despite various therapeutic or diagnostic developments,cancer is still one of the most lethal diseases due toinsuffi ciently adequate treatments and the delay of the earlystage of disease detection. An image-guided drug deliverysystem (IGDDS), as a real-time noninvasive imagingassessment of therapeutic response, has the strong potentialto improve the diagnosis and treatment of cancer becauseits imaging property off ers the quantifi cation of nanomedicineat the intended disease sites, the possible assurance ofadequate treatment and elimination of undesirable delay ofearly-stage diagnosis due to low resolution. One of potentialmodality that overcomes these challenges could be thenanoconfi nement of gold (Au) nanoparticles within othernanoparticles called "Particle-in-Particle (PIP)", which is astrong candidate of cancer treatment because of its "theranostic(therapy + diagnostics)" advantages including imaging(e.g., CT) and therapeutic hyperthermia application. Inthis review, we will elaborate on the current application oftheranostic by nanoconfi nement. Then, we will narrow downthe gold nanoparticle-mediated theranostic application andits nanoconfi nement advantages. Finally, the future directionfor maximum nanoconfi nement mediated cancer therapy willbe included.
강인수(In-Su Kang),이승우(Seungwoo Lee),정한민(Hanmin Jung),김평(Pyung Kim),구희관(HeeKwan Goo),이미경(MiKyung Lee),성원경(Won-Kyung Sung),박동인(Dongin Park) 한국콘텐츠학회 2007 한국콘텐츠학회 종합학술대회 논문집 Vol.5 No.2_1
학술 정보에서 저자는, 실세계의 한 저자가 형태적으로 둘 이상의 저자명으로 출현할 수 있으며, 서로 다른 저자들이 동일한 저자명을 공유하기도 한다. 이는 각각 학술 정보에 대한 검색 및 탐색에 있어, 재현율과 정확률을 저하시키는 요인이다. 이 연구에서는 후자에 해당하는 저자의 동명이인 문제에 있어, 그 중의성 해소를 위한 자질의 특성에 집중하고자 한다. 최근까지, 저자 식별을 위한 자질로, 공저자, 논문 제목, 게재지명과 같은 서지 내적 자질과, 논문 원문 텍스트로부터 획득되는 전자메일주소, 소속기관, 논문의 토픽 등과 같은 서지 외적 자질이 사용되어 왔다. 그러나, 이러한 자질들이 저자 식별에 미치는 영향에 대한 비교 분석 연구는 찾아 보기 힘들다. 이 연구에서는, 한글 저자명에 대해 원문과 연계된 대용량 저자 식별 평가 셋을 구축하여, 동명 저자 중의성 해소에 있어 다양한 자질들의 특성을 비교한다. There exists a many-to-many mapping relationship between persons and their names. A person may have multiple names, and different persons may share the same name. These synonymous and homonymous names may severely deteriorate the recall and precision of the person search, respectively. This study addresses the characteristics of features for resolving homonymous author names appearing in citation data. As disambiguation features, previous works have employed citation-internal features such as co-authorship, titles of articles, titles of publications as well as citation-external features such as emails, affiliations, Web evidences. To the best of our knowledge, however, there has been no literature to deal with the influences of features on author disambiguation. This study analyzes the effect of individual features on author resolution using a large-scale test set for Korean.
Da-Hyun Kim,Seul Lee,Hyeok Gu Kang,박현우,이한웅,Dongin Kim,Dong-Hoon Yoem,Jin-Hyung Ahn,Eunsin Ha,Weon-Kyoo You,Sang Hoon Lee,김석준,전경희 생화학분자생물학회 2020 BMB Reports Vol.53 No.10
Notch signaling has been identified as a critical pathway in gastric cancer (GC) progression and metastasis, and inhibition of Delta-like ligand 4 (DLL4), a Notch ligand, is suggested as a potent therapeutic approach for GC. Expression of both DLL4 and vascular endothelial growth factor receptor 2 (VEGFR2) was similar in the malignant tissues of GC patients. We focused on vascular endothelial growth factor (VEGF), a known angiogenesis regulator and activator of DLL4. Here, we used ABL001, a DLL4/VEGF bispecific therapeutic antibody, and investigated its therapeutic effect in GC. Treatment with human DLL4 therapeutic antibody (anti-hDLL4) or ABL001 slightly reduced GC cell growth in monolayer culture; however, they significantly inhibited cell growth in 3D-culture, suggesting a reduction in the cancer stem cell population. Treatment with anti-hDLL4 or ABL001 also decreased GC cell migration and invasion. Moreover, the combined treatment of irinotecan with anti-hDLL4 or ABL001 showed synergistic antitumor activity. Both combination treatments further reduced cell growth in 3D-culture as well as cell invasion. Interestingly, the combination treatment of ABL001 with irinotecan synergistically reduced the GC burden in both xenograft and orthotopic mouse models. Collectively, DLL4 inhibition significantly decreased cell motility and stem-like phenotype and the combination treatment of DLL4/VEGF bispecific therapeutic antibody with irinotecan synergistically reduced the GC burden in mouse models. Our data suggest that ABL001 potentially represents a potent agent in GC therapy. Further biochemical and pre-clinical studies are needed for its application in the clinic.
조영진(Youngjin Cho),원준희(Junhee Won),박준영(Junyoung Park),강승천(Sungchun Kang),이동인(Dongin Lee) 한국자동차공학회 2008 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-
It is well known that two representative method to satisfy the EURO4 emission regulation. The one is the EGR system that reduces NOx in an engine by using EGR and PM by OPF. But this system has disadvantages of fuel efficiency and requirement for larger engine cooling capacity. The other is SCR system that reduces NOx in exhaust gas by dosing reagent (urea water solution) into exhaust gas. And the SCR system needs to decrease PM by optimization of fuel combustion. The SCR system has advantages of fuel efficiency and good durability of engine. Recently as the price of oil (diesel) goes up, the commercial vehicle drivers are more concerned about the fuel economy. So the European major manufacturer of commercial vehicle adopted the SCR system because of the above mentioned advantages. And this study focused on the development of EURO4 engine and commercial vehicle equipped with SCR system.
성인 여성의 비만여부에 따른 신체구성 및 경구당부하검사 비교
김기진,한승완,박주식,천우광,홍창배,안나영,강동인,오유진,이인규 대한스포츠의학회 2004 대한스포츠의학회지 Vol.22 No.1
This study analyzed the body composition and insulin sensitivity of OGTT(oral glucose tolerance test) following to obesity and abdominal fat area in adult women. Subjects were the range of 30~40 aged women, and was divided to 2 groups as obese group(n=11) and non-obese group(n=12) by BMI 25. Obese women showed a significant higher values of skinfold thickness and body circumference than non-obese women. Especially, obese women showed a stronger visceral obesity and abdominal obesity tendency as significant increase of abdominal fat and visceral fat area(100.22±39.32 ㎠) than non-obese women. In OGTT, obese women showed a significant increase of plasma glucose concentration as compare with non-obese group, although obese women showed an increase of plasma insulin concentration. Therefore, these results could be suggested that the significant increase of body fat and visceral fat area were correlated to the depression of insulin sensitivity.