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Selection of Particle Beam vs. Photon Beam Radiation Therapy for HCC: Japanese Experience
( Hideyuki Sakurai ),( M Iizumi ),( S Shimizu ),( H. Numajiri ),( M. Mizumoto ),( K. Nakai ),( T. Okumura ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Radiation therapy (RT) using conventional fractionation has not been thought to be curative enough for hepatocellular carcinoma (HCC) and it has not been performed as a high priority in comparison to other standard treatments, such as surgery, percutaneous ablation and transcatheter approach. Because the liver is high sensitive to radiation, especially for patients with liver cirrhosis, non-irradiated normal liver volume must be preserved as much as possible when curative radiation is given for HCC. Since many technological progress has been made in radiation oncology in recent years, RTs are used as an important curative treatment option for liver cancer. Stereotactic body radiotherapy (SBRT), which is included in Japanese national health insurance system, is a technique to accurately concentrate doses three-dimensionally on the target with short-term irradiation of 1-2 weeks. This technique can be used for relatively small tumors less than 5 cm with about 90% local control. Recently, Hara K. et al. reported survival result of SBRT comparing radiofrequency ablation using propensity score analysis, and they concluded that SBRT appears to be an acceptable alternative treatment option for patients who are not candidates for RFA. In addition, in Japan, muticenter prospective study of SBRT for untreated solitary primary HCC, so called STRSPH study, is ongoing. Eligible patients are untreated solitary, Child-Pugh score ≦7, Diameter: 1-5cm, UICC 7th. T1, T2, T3bN0M0, performance status score of 0-2, and 20-85 year-old. The primary endpoint / number of cases of this study are 3-year overall survival / 60 cases. Particle beam therapy (PBT: proton beam therapy, heavy ion beam therapy) has unique character of radiation dose distribution, which is called Bragg peak. PBT can accumulate more dose to the target with minimizing normal liver dose. Primary liver tumor is an important indication that has been specified to be of the highest priority by the American Society for Radiology and Oncology (ASTRO). In fact, most of the studies on PBT for HCC are published by Japan, and rather highly evaluated abroad. Eighteen proton facilities and 6 heavy ion facilities are working now in Japan. The local control rate was approximately 90% and the 5-year survival rate was reported to be approximately 50%. According to the results of our hospital, PBT can control 90% of a large tumor of 10 cm or more. Clinical studies of PBT report favorable therapeutic effects, even for not only large tumors but also tumors in elderly patient. In addition, PBT has been clearly shown to play an important role in the treatment of HCC-related portal vein tumor thrombosis (PVTT). When applied as a curative treatment for bulky tumors with portal vein embolism, median survival time of 27 months has been obtained in our study. The clinical study comparing proton vs surgery, which is non-randomized trial using propensity score, is ongoing in Japan (JCOG1315C). Japanese Society for Radiation Oncology (JASTRO) defined identical rule for indication and treatment method in PBT for HCC, and the all data should be registered in the data-base since 2016. We are facing an aging society, although there are indications of surgery and other local treatment, the number of patients who choose curative radiation therapy due to aging and co-existing disease is increasing. But, the history of radical RT for HCC is still short, and sufficient consensus has not been obtained regarding the criteria for its therapeutic indication. RT may become an option for curative local treatment of HCC, but no specific role for RT has been described in the Japanese treatment guidelines. In the future, it is important to proceed with research to clarify the indication of curative radiation therapy, keeping in mind the comparison with other therapies.
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Nakai, Y.,Kimura, K.,Sato, M.,Inamoto, T.,Ogimoto, K. Asian Australasian Association of Animal Productio 1994 Animal Bioscience Vol.7 No.4
A total of 526 domestic and experimental animals in Miyagi prefecture, Japan were investigated for fecal carriage of Campylobacter jejuni and Campylobacter coli. C. jejuni was detected in chickens (8.2%), dogs (6.3%), pigs (4.3%), cattle (1.8%) and hamsters (1.4%). C. coli was only detected from pigs (20.7%). Drug susceptibility test was performed on 5 strains of C. jejuni isolated from chickens and 13 strains of C. coli isolated from pigs to tylosin (TS), thianphenicol (TP), carbadox (CDX), chroltetracyclin (CTC), vancomycin (VCM), cefoperazone (CPZ), latamoxef (LMOX), GM were highly effective and CTC, CP and PL were moderately effective against both C. jejuni and C. coli. TS and TPH were moderately effective against C. jejuni; however, they were less effective to C. coli. One strain of C. jejuni against CTC considered to be drug resistant. The results suggest that C. jejuni and C. coli can be controlled by several drugs effectively, although a drug resistant strain exists.
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Nakai, Y.,Ogimoto, K.,Kuwano, A.,Nakamura, K.,Kato, M. Asian Australasian Association of Animal Productio 1991 Animal Bioscience Vol.4 No.1
A mixed infection of Haemophilus paragallinarum (Hpg), Mycoplasma gallisepticum (MG) and M. synoviae (Ms) was detected in layers of a poultry farm in Iwate prefecture in Japan by pathological, serological and bacteriological investigation. Hpg strains were isolated from three of five birds investigated and all strains were identified to be type C. The Hpg isolates were more susceptible in vitro to a combination of sulfamonomethoxine and ormetoprim (Ektecin) than each of sulfamethoxasol, sulfamonomethoxine, oxytetracycline, tetracycline, streptomycin, erythromycin and thianphinicol. After a total of six days' medication of 1% feed additive Ektecin, symptoms of infectious coryza of hens in the farm almost disappeared and no Hpg was detected even from birds showing nasal discharge.
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Characteristics of Carrier-generated Field-effect Transistors with Pentacene/Vanadium Pentoxide
M. Minagawa,K. Nakai,A. Baba,K. Shinbo,K. Kato,F. Kaneko,이천 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.58 No.51
In this paper, the driving mechanism of carrier-generated organic field-effect transistors (OFETs) with pentacene and vanadium pentoxide (V_2O_5) layers is discussed. In this study, large on-currents were observed in an OFET with a 35-nm V_2O_5 layer. Devices with aluminum (Al)/pentacene/V_2O_5/Al layer structures were also prepared. These devices exhibited a large current density in spite of their high carrier injection barriers between each layer and the Al electrodes. Moreover, new absorption bands corresponding to the radical cation absorption of pentacene were observed within the absorption spectrum of the pentacene and V_2O_5 mixed layers. It was inferred that the charge transfer (CT) complexes that formed at the interface between the pentacene and V_2O_5 layers were dissociated by the applied gate voltage and that the generated holes contributed to driving the OFETs.
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THE COMBINATION EFFECT OF SULFAMETHOXAZOLE AND TRIMETHOPRIM AGAINST ANIMAL INTESTINAL BACTERIA
Nakai, Y.,Matsumoto, H.,Ogimoto, K. Asian Australasian Association of Animal Productio 1991 Animal Bioscience Vol.4 No.3
Combination effects of sulfamethoxazole (SMX) and trimethoprim (TMP) against nine gram positive bacterial strains and 43 gram negative bacterial strains which included 40 strains of animal intestinal bacteria were studied in vitro. Minimum inhibitory concentrations (MICs) of SMX and TMP alone and 20:1 (SMX : TMP) mixture (ST) were investigated by the method recommended by Ad Hoc Committee of the Japan Society of Chemotherapy for the Evaluation of Sensitivity Testing Methods for Sulfamethoxazole and Trimethoprim. MICs of ST were more potentiated than those of SMX alone in 8 of 9 gram positive strains and 40 of 43 gram negative strains. Especially, 38 strains of 40 intestinal bacteria showed significant susceptibility to ST as compared to SMX. These results suggest a strong synergistic activity of ST mixture against animal intestinal bacteria, The activity was considered to be comparable to those of other current antibiotics.
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Oxygen Vacancy and Magnetism of a Room Temperature Ferromagnet Co-doped TiO2
Ikuo Nakai,M. Sasano,K. Inui,T. Korekawa,H. Ishijima,H. Katoh,Y. J. Li,M. Kurisu 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.63 No.3
We report the local structure and the magnetic properties of a Co-doped TiO2 prepared by usingthe solid state reaction of milling with subsequent annealing. The Co-doped TiO2 shows a hysteresisbehavior in the magnetization curve at room temperature, which maintains the same rutile-typestructure as that of the starting material TiO2. The extended x-ray absorption fine structuremeasurement reveals that it contains some oxygen vacancies only around a Co atom which occupiesa Ti site. This supports the oxygen vacancy mediated ferromagnetic exchange mechanism.
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김지형,Dennis K. Gomez,Toshihiro Nakai,박세창 대한수의학회 2010 JOURNAL OF VETERINARY SCIENCE Vol.11 No.1
In order to evaluate the genetic variability of the causative agent of cold water disease (CWD), plasmid profiling was used to characterize Flavobacterium (F.) psychrophilum isolates (n = 169). Size analysis of plasmids in F. psychrophilum isolates (n = 128) from several fish species demonstrated that six kinds of plasmids were harbored, and ayu isolates had different profiles compared to other isolates. Moreover, multiple isolates (n = 41) from CWD outbreaks in 2002 to 2003 at a single ayu farm were examined to determine differences between isolates from successive outbreaks and showed different profiles by the sources of seedlings.
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Kim, J.H.,Gomez, D.K.,Nakai, T.,Park, S.C. Elsevier Scientific Pub. Co 2010 Veterinary microbiology Vol.140 No.1
In order to investigate methods for controlling systemic bacterial coldwater disease (CWD), bacteriophages that infect Flavobacterium psychrophilum were isolated by the enrichment method from pond water collected from Japanese ayu farms. The five phages isolated were classified as members of Myoviridae (PFpW-3, PFpC-Y), Podoviridae (PFpW-6, PFpW-7), and Siphoviridae (PFpW-8) and had highly variable patterns of infectivity for different F. psychrophilum isolates (n=128). The stability tests of the phages in different waters, pHs and temperatures were assessed, and the results indicated that none of the phages were affected by ayu farm conditions. Among the phages, PFpW-3 had high infectivity for F. psychrophilum isolated from ayu and other fish and demonstrated sufficient survivability in the stability tests. Thus, PFpW-3 and its indicator strain N2-3 were inoculated into cytophaga broth at different doses of multiplicity of infection (MOI) and proved to be efficient for the reduction of bacterial growth. This study may be the basis for a further evaluation of phage therapy in the treatment of CWD in Japanese ayu farms.
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