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Junhui Wan,Junli Qin,Qinyue Cao,Ping Hu,Chunmei Zhong,Chunhua Tu 한국유전학회 2020 Genes & Genomics Vol.42 No.3
Background Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2) was induced in hypoxia and participated in cancer development. However, the role of PLOD2 in endometrial carcinoma remains unclear. Objective To explore the influences and regulation mechanism of PLOD2 in endometrial carcinoma under hypoxic condition. Methods The small interfering RNA (siRNA) targeting to PLOD2 and pcDNA3.1-PLPD2 were transfected to endometrial carcinoma cells to alter PLOD2 expression. Cell proliferation ability was determined by colony formation assay. Wound healing assay used to detect cell migration ability. Transwell invasion assay was used to detect cell invasion ability. Results PLOD2 and Hypoxia-inducible factor-1α (HIF-1α) were induced by hypoxia. Down-regulation of PLOD2 did not affect endometrial carcinoma cell proliferation ability, while inhibited cell migration, invasion under hypoxic condition. Besides, down-regulation of PLOD2 increased the levels of γ-catenin and E-cadherin and decreased levels of Fibronectin and Snail under hypoxic condition. Down-regulation of PLOD2 also inactivated Src and phosphoinositide 3-kinase (PI3K)/ protein kinase B (Akt) signaling under hypoxic condition. The promoting effects of PLOD2 overexpression on migration, invasion and epithelial-mesenchymal transition (EMT) of endometrial carcinoma cells were reversed by Akt inhibitor (MK2206) under hypoxic condition. Conclusion PLOD2 expression was increased in endometrial carcinoma cells under hypoxic condition. PLOD2 modulated migration, invasion, and EMT of endometrial carcinoma cells via PI3K/Akt signaling. PLOD2 may be a potential therapeutic target for endometrial carcinoma.
Nodule Rich Protein 2 modulates nodule number in Medicago truncatula
Junhui Yan,Xinwei Yang,Yawen Wang,Liangliang Yu,Li Luo 한국식물생명공학회 2021 Plant biotechnology reports Vol.15 No.1
Symbiotic nitrogen fxation is beneft to sustainable agriculture and global nitrogen cycle. Many small peptides were identifed as regulators involving in the interaction between rhizobia and legume. Here we reported Nodule Rich Protein 2 (MtNRP2) encoding a small peptide in Medicago truncatula, belonged to a group of nodule rich protein restricted in legume species. MtNRP2 expressed highly in root nodule and its promoter was active during the initiation and development of root nodule and lateral root. To investigate the function of MtNRP2 in nodulation, we generated MtNRP2-overexpression and MtNRP2- knockdown transgenic Medicago. MtNRP2-overexpression transgenic lines performed normal nodulation phenotype compared with vector control. However, in the MtNRP2-RNAi transgenic plants, the decrease of MtNRP2 expression lead to the increase of infection threads number (7 day post inoculation) and nodules number (3 week post inoculation); meanwhile, the expression of MtRGF3 and MtPUB1 was inhibited. These results suggested that MtNRP2 negatively regulated nodulation in Medicago truncatula.
CBS-dust 치환에 따른 고로슬래그 다량치환 시멘트 벽돌 품질에 미치는 영향
한준희 ( Han¸ Jun-hui ),한수환 ( Han¸ Soo-hwan ),김수호 ( Kim¸ Su-hoo ),윤치환 ( Yoon¸ Chi-whan ),한민철 ( Han¸ Min-cheol ),한천구 ( Han¸ Cheon-goo ) 한국건축시공학회 2021 한국건축시공학회 학술발표대회 논문집 Vol.21 No.2
This study examines the performance of CBS-Dust for the utilization of cement bricks as alkali stimulants for furnace slag replacement binders. It converts the CBS-Dust substitution rate and the excess slag substitution rate. According to the analysis, when replacing CBS-Dust with 65~70 % of BS substitution rate and 7.5~10 % of CBS-Dust, it shows excellent performance as an alkali stimulant of BS' potential hydrophobic reaction, and it is expected to be effective for secondary products of BS replaced in large quantities.
한준희 ( Han¸ Jun-hui ),후윈야오 ( Hu¸ Yun-yao ),임군수 ( Lim¸ Gun-su ),김수호 ( Kim¸ Su-hoo ),김종 ( Kim¸ Jong ),한민철 ( Han¸ Min-cheol ) 한국건축시공학회 2021 한국건축시공학회 학술발표대회 논문집 Vol.21 No.2
In this study, This is the result of thermal characteristics analysis to suggest an efficient method of using coal gasification slag(CGS) of byproduct from integrated gasification combined cycle(IGCC). In Specific Heat characteristics, CGS and CS showed similar values. Isothermal Conduction Calorimetry showed that the hydration reaction of cement was retarded when CGS was used. Therefore, it is expected that CGS will be used as an efficient alternative to reducing the hydration heat of mass concrete as a functional aggregate combination.
Junhui Zhang,Qun Chao,Bing Xu,Min Pan,Yuan Chen,Qiannan Wang,Ying Li 한국정밀공학회 2017 International Journal of Precision Engineering and Vol.18 No.7
When manufacturing axial piston pumps, mass difference of piston-slipper assembly is inevitable because of manufacturing precision limits. Small mass difference may not cause problems when the pump operates at low speeds, while it cannot be ignored at high speeds. One problem related to high speed is the cylinder block tilt resulting from the inertial effect of piston-slipper assembly. Recently, the speed of electro-hydrostatic actuator (EHA) pump in aircraft can reach more than 10,000 rpm. Therefore, mass difference of pistonslipper assembly should be taken into account in future EHA pump design. The main purpose of this paper is to investigate the effect of the mass difference of piston-slipper assembly on the cylinder block tilt in a high-speed EHA pump. A detailed set of relevant equations is developed to establish the relationship between the mass difference of piston-slipper assembly and cylinder block tilting moment. It is found that a tighter control over the mass difference of piston-slipper assembly should be guaranteed when it comes to high-speed EHA pumps.
Enriched finite element method for three-dimensional viscoelastic interfacecrack problems
Junhui Yang,Yongjun Lei,Junli Han,Shangyang Meng 대한기계학회 2016 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.30 No.2
The enriched finite element method is developed for three-dimensional problems of an interface crack between elastic and viscoelastic (including dissimilar viscoelastic) materials. According to the displacement fields of elastic interface crack, the displacement fields of viscoelastic interface crack are derived through the correspondence principle. By incorporating the displacement expressions into the displacement model of regular element, the incremental formulations of enriched element are derived. The stress intensity factor, and strain energy release rates can be solved based on the enriched degree of freedoms. A 3-D through interface crack at the center of jointed dissimilar viscoelastic plate subjected to remote tension and a quarter-circular viscoelastic interface corner crack subjected to uniform thermal loading was investigated using the enriched finite element method. It is shown that the present solutions are consistent with the analytical solutions, which indicates the present method is correct and efficient.
Distance Geometry-based Wireless Location Algorithms in Cellular Networks with NLOS Errors
( Junhui Zhao ),( Hao Zhang ),( Rong Ran ) 한국인터넷정보학회 2015 KSII Transactions on Internet and Information Syst Vol.9 No.6
This paper presents two distance geometry-based algorithms for wireless location in cellular network systems―distance geometry filtering (DGF) and distance geometry constraint (DGC). With time-of-arrival range measurements, the DGF algorithm estimates the mobile station position by selecting a set of measurements with relatively small NLOS (non-line-of-sight) errors, and the DGC algorithm optimizes the measurements first and then estimates the position using those optimized measurements. Simulation results show that the proposed algorithms can mitigate the impact of NLOS errors and effectively improve the accuracy of wireless location.
Junhui Zhu,Zhiwei Tan,Weijun Yang 한국고분자학회 2017 Macromolecular Research Vol.25 No.8
A series of conjugated metalloporphyrin polymers (MPP-AMnPs) were synthesized by using inexpensive, environmentally friendly and high-efficiency CuI/N,N-dimethyl glycine as catalytic system, and 5,10,15,20-mesotetra(4-aminophenyl) porphyrin manganese and p-dibromobenzene as building blocks. Scanning electron microscopy, N2 adsorption-desorption isotherms and scanning electron microscopy indicated that the polymers had large surface areas and homogeneous microporous structures. Thermogravimetric analysis showed that the polymers had remarkable thermostability. The catalytic performance of MPP-AMnP was tested by oxidizing cyclic ketones with dioxygen as oxidant. The conversion was high in a mild environment in l,2-dichloroethane solvent at 60 °C. Moreover, MPPAMnP remained stable in the reaction process and highly catalytically active after ten successive recycles.
LOU, JUNHUI,LEE, HEE,KIM, JEONG-JOO,CHO, SANG-HEE Gordon and Breach Science Publishers 2006 Integrated ferroelectrics Vol.80 No.-
<P>Ba 2 NaNb 5 O 15 (BNN) thin films were prepared by the ion beam sputter deposition (IBSD) process onto Pt(100)/TiO 2 /SiO 2 /Si substrate at annealing temperatures higher than 600°C. XRD and FE-SEM were used to investigate the crystallization behavior and microstructure of the films. Crystallization behavior and ferroelectric properties were studied in terms of deposition rate and annealing condition. It was found that the deposition rate strongly influenced the phase formation of the films, where the secondary phase was always observed if the deposition rate was high. However, single phase tungsten bronze BNN thin film was obtained when the deposition rate decreased to 22 Å/min. It was also found that the deposition rate affected the ferroelectric properties of BNN films. Crystallization started at about 600°C, and the well-developed diffraction patterns were obtained above 650°C if the annealing time was maintained to 30 minutes. The remanent polarization 2Pr and dielectric constant are about 2∼⃒4 &mgr;C/cm 2 and 100∼⃒200, respectively.</P>