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( Hang Liu ),( Linan Xie ),( Jing Wang ),( Qiannan Guo ),( Shengnan Yang ),( Pei Liang ),( Chengshu Wang ),( Min Lin ),( Yuquan Xu ),( Liwen Zhang ) 한국미생물 · 생명공학회 2017 Journal of microbiology and biotechnology Vol.27 No.3
Beauveria bassiana infects a number of pest species and is known to produce insecticidal substances, such as the nonribosomal peptides (NRPs) beauvericin and bassianolide. However, most NRPs and their biological roles in B. bassiana remain undiscovered. To identify NRPs that potentially contribute to pathogenesis, the 21 predicted NRP synthetases (NRPSs) or NRPS-like proteins of B. bassiana ARSEF 2860 were primarily ranked into three functional groups: basic metabolism (7 NRPSs), pathogenicity (12 NRPSs), and unknown function (2 NRPSs). Based on the transcript levels during in vivo growth on diamondback moth (Plutella xylostella (Linnaeus)), half of the Group II NRPSs were likely to be involved in infection. Given that the metabolites biosynthesized by these NRPSs remain to be determined, our result underlines the importance of the NRPSome in fungal pathogenesis, and will serve as a guide for future genomic mining projects to discover functionally essential and structurally diverse NRPs in fungal genomes.
Junhui Zhang,Qun Chao,Bing Xu,Min Pan,Yuan Chen,Qiannan Wang,Ying Li 한국정밀공학회 2017 International Journal of Precision Engineering and Vol.18 No.7
When manufacturing axial piston pumps, mass difference of piston-slipper assembly is inevitable because of manufacturing precision limits. Small mass difference may not cause problems when the pump operates at low speeds, while it cannot be ignored at high speeds. One problem related to high speed is the cylinder block tilt resulting from the inertial effect of piston-slipper assembly. Recently, the speed of electro-hydrostatic actuator (EHA) pump in aircraft can reach more than 10,000 rpm. Therefore, mass difference of pistonslipper assembly should be taken into account in future EHA pump design. The main purpose of this paper is to investigate the effect of the mass difference of piston-slipper assembly on the cylinder block tilt in a high-speed EHA pump. A detailed set of relevant equations is developed to establish the relationship between the mass difference of piston-slipper assembly and cylinder block tilting moment. It is found that a tighter control over the mass difference of piston-slipper assembly should be guaranteed when it comes to high-speed EHA pumps.
Yu Fang,Yanqing Li,Xin Liao,Jie Deng,Qiannan Wang,Jingtao Liang,Bohua Yan 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.12
Depression, a prevalent psychiatric disorder, presents a serious health risk to humans. Increasing evidencesuggested that the gut microbiota and the 5-hydroxytryptamine (5-HT) pathway both contribute significantly to depression. This research aimed to investigate how Corydalis yanhusuo polysaccharides (CYP) could potentially alleviate depressioninduced by chronic unpredictable mild stress in mice, as well as its underlying mechanism. The sucrose preference test, tailsuspension test, and forced swimming test were employed to evaluate the behavior of mice. Enzyme-linked immunosorbentassay and PCR techniques were utilized to measure depression-related factors (dopamine [DA], 5-HT, norepinephrine [NE],brain-derived neurotrophic factor [BDNF], tryptophan hydroxylase 2 [TPH-2], 5-hydroxytryptophan [5-HTP], and tryptophanhydroxylase [TPH-1] levels). Hematoxylin and eosin staining and Nissl staining were conducted to observe histopathologicalchanges in the hippocampus, the differences in the diversity of gut flora between groups were analyzed using 16S rRNAsequencing, and gas chromatography–mass spectrometry metabolomics was utilized to evaluate short-chain fatty acid (SCFA)concentrations. The findings indicated that CYP treatment increased the sucrose preference index, decreased the immobilitytime, and improved neuropathological injury. In depressed mice, CYP improved the dysregulation of the gut microbiota, andincreased the SCFA levels. In addition, CYP enhanced the DA, 5-HT, NE, BDNF, and TPH-2 levels in the brain and theexpression of 5-HTP and TPH-1 in the colon, while SCFAs were positively correlated with these levels. In summary, ourstudy suggested that CYP may mitigate depression by ameliorating gut microbiota dysregulation, promoting the generation ofSCFAs, and activation of 5-HT signaling expression.