고등급 이형성을 보인 편평톱니샘종

권경주,정성애,심기남,정정화,강석형,송도경,전승정,김혜인 이화여자대학교 의과학연구소 2012 EMJ (Ewha medical journal) Vol.35 No.1

Until recently, colorectal polyps were classified predominantly as hyperplastic or adenomatous. While adenomatous polyps are well-characterized precursor lesions of adenocarcinomas, hyperplastic polyps have been considered as benign lesion. However, some hyperplastic polyps with serrated morphology of the crypts have been recognized to have distinctive features and these polyps were termed ‘serrated adenomas’. Recent data show that sessile serrated adenomas (SSA) might be the precursors of serrated colonic cancers, underlining the necessity of identifying them. SSA is approximately 3% of all polyps, commonly appears as flat or sessile and yellowish due to mucus production. In the pathogenesis of SSA, progression to high grade dysplasia or early invasive carcinoma may be associated with serrated neoplasia pathway different from adenoma-carcinoma sequence. We report a case with a colon polyp diagnosed as sessile serrated adenoma with high grade dysplasia after endoscopic submucosal dissection.

금속이온 농도에 의한 IMI-O LB막의 전기전도도 특성

정상범,유승엽,권영수 동아대학교 정보기술연구소 2000 情報通信硏究所論文誌 Vol.8 No.1

Metal ion complex of poly(N- (2-4-imidazolyl)ethyl)maleimide-alt-1-octadecene (IMI-O) polymer used to confirm the possibility of molecular device made by Langmuir-Blodgett(LB) method. Electrical properties of the metal ion complex LB film were investigated using Metal/Insulator/Metal(MIM) structure. In the surface pressure-area(π-A) isotherms of IMI-O polymer, the surface pressure at collapse point has a difference due to the interaction between polymer and metal ions. And the complex between polymer and metal ions could be verified through the investigation by Raman spectroscopy. In the current-voltage(I-V) property, the conductivity change of IMI-O polymer complexes due to the kinds of metal ions couldn't be observed. However, the limiting area of molecules was changed by the concentration of the metal ions and the conductivity was increased with the occupied molecular area.

신경회로망 제어기를 이용한 PID 파라미터 추정에 관한 연구

權重東,裵銀敬,金恩基,全基英,李承桓,吳鳳煥,李勳九,金容珠,韓慶熙 明知大學校 産業技術硏究所 2006 産業技術硏究所論文集 Vol.25 No.-

In this paper, supposed to solve these problem to PID parameters controller algorithm using ANN. In the proposed algorithm, the parameters of the controller were adjusted to reduce by on-line system the error of the speed of IM. In this process, EBPA NN was constituted to an output error value of an IM and conspired an input and output. The performance of the self-tuning controller is compared with that of the PH) controller tuned by conventional method (Ziehler-Nichols). The effectiveness of the proposed control method is verified thought the Matlab Simulink and experimental results.

일개 소방서 소방관들의 외상후 스트레스 증상 및 관련요인

권순찬,송재철,이수진,김인아,고재우,류현철,김석현,김대호,정승아 大韓産業醫學會 2008 대한직업환경의학회지 Vol.20 No.3

목적: 본 연구에서는 일부지역 남자 소방관의 외상후 스트레스 증상과 관련요인을 분석하고 PTSD 고위험군의 빈도를 추정하고자 하였다. 방법: 서울 지역 한 소방서의 남자 소방대원 260명에게 설문지를 배포하였다. 그 중 한 가지 이상의 외상성 사건의 경험이 있고 IES-R-K 설문에 응답한 153명 중 우울증으로 의심되는 7명을 제외한 146명을 분석대상으로 하였다. 설문지는 일반적 특성과 작업관련 특성, IES-R-K 22문항,‘소방관과 응급구조사의 사건 스트레스인자’25개 문항을 포함하였다. 결과: 연구대상의 평균연령은 38.8(±6.8)세였으며 평균 근속기간은 12.0(±6.4)년이었다. 기혼이 118명 (80.8%)이었다. 근무형태별로는 상시주간이 20명(13.7%),격일근무가 126명(86.3%)이었다. 직능별로는 화재진압 46명(31.5%),구조 15명(10.3%),구급 26명(17.8%),운전 40명(27.4%),내근 19명(13.0%)이었다. IES-R-K 점수의 평균은 11. 3(±13.1)점이었으며 기혼자가 미혼자보다(p=0.005),24시간 격일근무자가 상시 주간근무자보다(p=0.032) 높았다. IES-R-K 점수 24/25점을 절단점으로 PTSD 고위험군의 빈도는 13.7% (20명)이었다. 외상성 사건 25개 중 경험한 종류수는 직능별로 구급과 구조에서 많았다.(p=0.000). PTSD 고위험군을 종속변수로 하고 나이와 교육수준을 보정한 다중로지스틱회귀분석에서 각각의 보정 비차비(95% CI)는 기혼 1.98(0.42∼9.30),근속년수 20년 이상 3.53(1.01∼12.38),24시간 격일근무 3. 31 (O.42∼26. 23),소방장 1.67(0.46∼6.09),외상성 사건을 경험한 종류수 2.18(0.79∼6.04)였다. 결론: 이 연구에서 서울지역의 일개 소방서에 근무하는 남자 소방관의 PTSD 고위험군의 빈도는 13.7%로 추정되어 일반인구집단의 PTSD 유병률에 비해 높은 것으로 나타났다. 외상성 사건에 무방비로 노출되어 있는 소방관들의 PTSD 위험군을 조기에 선별할 수 있는 간편한 자기기입식 설문지인 IES-R-K는 소방관의 PTSD를 조기에 개입하여 관리하는 효율적인 도구로 활용될 수 있을 것이다. 소방관들의 정신건강을 관리하고 개입이 필요한 정신질환을 조기에 발견하며 관리할 수 있는 체계적인 예방 및 관리 프로그램의 도입이 필수적이다. Objectives: To investigate the factors related with posttraumatic symptoms and to estimate the prevalence of posttraumatic disorder of urban male firefighters. Methods: From a study sample comprising 260 male firefighters from one fire station, the responses. from 146 who had experienced one or more traumatic events, responded to the 'Impact of Event Scale-Revised Korean version' (IES-R-K) and didn't show any evidence of depression were analyzed. We surveyed the firefighters using a self-administered questionnaire including general characteristics, job-related characteristics, IES-R-K, and a 'Firefighters and paramedics' incident stressor'. Results: The mean value of IES-R-K in this study was 11.3 and it was higher in the married firefighters than in the unmarried firefighters (p=0.005) and in the 24-hr shift workers than in the ordinary day shift workers (p=0.032). The frequency of posttraumatic stress disorder (PTSD) of the firefighters in this study using IES-R-K was 13.7%, with a cutoff point of 24/25. The overall number of experiences of 25 traumatic events was larger in emergency medical personnel and rescue workers than in other work functions (p=O.OOO). Conclusions: The prevalence of PTSD symptoms in firefighters was estimated to 13.7% using IES-R-K and was higher than the prevalence of PTSD in the general population. A program to manage the mental health and provide early detection for mental illness for firefighters is needed.

G4-48PyA 덴드리머 LB막의 금속이온 착체 효과

정상범,유승엽,권영수 동아대학교 정보기술연구소 2002 情報技術硏究所論文誌 Vol.9 No.2

Dendrimers represent a new class of synthetic macromolecules characterized by a regularly branched treelike structure. Peculiar features of the dendritic geometry are the large number of end groups as well as the shape persistence in higher generations, approaching spherical geometry. And one of the most peculiar characteristics of dendritic macromolecules is their controlled molecular structure and orientation, which means that they have a practical application in achieving a highly organized molecular arrangement. We attempted to fabricate a G4-48PyA dendrimer LB films containing 48 pyridinealdoxime functional end group that could form a complex structure with metal ions. Also, we investigated the surface activity of dendrimer films at sir-water interface. And we have studied the electrical properties of the ultra-thin dendrimer LB films. The electrical properties of the ultra-thin dendrimer LB films were investigated by studying the current-voltage characteristics of metal denrimer LB films/metal (MIM) structure. And rectifying behavior of the device was occurred in applied field.

정상 체중인 성인 남성에서 지방과다와 심혈관질환의 위험요인간의 관련성

권우성,김준수,채진욱,이근미,정승필,문용 영남대학교 의과대학 2003 Yeungnam University Journal of Medicine Vol.20 No.1

정상체중을 가진 성인 남성에서 지방과다(adiposity)와 심혈관계 질환의 위험요인과의 관련성을 알아보고자 하였다. 2001년 1월 3일부터 12월 31일까지 영남대 학교의료원에서 종합검진을 받은 만 28∼69세 성인 남성 129명을 대상으로 연령, 신체계측, 혈압, 공복 혈당, 혈청 지질대사치와 체성분 검사를 실시하였다. 체질량지수(BMI)가 18.5∼23 kg/㎡(76명)인 정상체중군과 23∼25 kg/㎡(53명)인 과체중군으로 분류하고, 체비방률, 체지방량과 위험인자들(수축기혈압, 이완기혈압, 공복시 혈당, 중성지방, 저밀도지단백, 고밀도지단백)의 상관관계를 분석하고, 정상체중군을 지방과다에 따라 3군으로 나누고, 각 군과 과체중군에서 심혈과 질환의 위험인자를 평가하였다. 정상체중의 제1군을 기준으로 제2, 3군과 과체중군의 위험인자 존재에 대한 비차비(odds ratio)를 조사하였다. 정상체중군에서 지방과다 변수들(adiposity variables: 체지방량, 체지방률)과 수축기 및 이완기 혈압, 저밀도지단백, 중성지방에서 유의한 상관관계가 있었다. (P<0.01). 나이를 보정하고 난 뒤 제1군을 기준으로 제3군(체지방율: 3.7, 체지방양: 4.7)과 과체중군(체지방율: 6.6, 체지방양 11.5)에서 위험인자에 대해 더 높은 비차비를 가졌다. 지방이 많은 정상체중의 성인남성은 적은 지방을 가진 성인 남성보다 심혈관 질환에서 더 높은 유병 위험도를 가졌다. 지방 측정은 정상체중군에서 심혈관계 질환의 위험인자외에 추가적인 정보를 제공할 수 있었다. Background: Most of all studies about the relation between the health risk and obesity are based on the European and American data. The purpose of this study is to examine the relation between adiposity and factors for cardio vacular disease (CVD) in normal weight individuals. Materials and Methods: Normal weight subjects with a body mass index (BMI) between 18.5 and 23 kg/㎡(76 subjects) and overweight subjects with a BMI between 23 and 25 kg/㎡ (53 subjects) were retained for this study. Normal weight subjects were divided into three group of each adiposity variable, then three group and the overweight group were evaluated for the presence of CVD risk factors and analyze the correlation coefficients between adiposity variables and risk factors controlled for age in normal weight, overweight groups. Using logistic regression analysis, the odds ratio (OR) for the prevalence of risk factors for each group of adiposity variables and the overweight group was estimated relative to the first group in normal weight subjects. Results: Systolic BP, diastolic BP, LDL cholestrol, HDL cholesterol, triglycerides in normal weight subjects were significantly correlated with all adiposity variables (P<0.01). Third group (3.7 for %fat and 4.7 for fat mass) of adiposity variables in the normal weight group and the overweight group (6.6 for %fat and 11.5 for fat mass) tended to have higher ORs compared to first group for risk factor variables. Conclusion: Normal weight subjects with elevated adiposity had higher prevalence of risk factors than normal weights subjects with less adiposity. Measuring of adiposity added additional information of cardiovascular disease risk factors in normal weight subjects.

실험동물에서의 내분비계 교란물질인 DEHP, DBP의 생체내 영향

정지윤,이성호,박영석,박병권,김병수,김상기,박창식,강경선,이영순 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10

The major protocol features of the rodent uterotrophic assay have been evaluated using a range of reference chemicals. The protocol variables considered include the selection of the test species and route of chemical administration, the age of the test animals, the maintenance diet used, and the specificity of the assay for estrogens. The rodents were ovariectomized under general anesthesia via bilateral flank incisions and randomly assigned to groups of 5 animals. This study investigated the estrogenic effects of phthalates, which are DEHP and DBP, suspected as endocrine disruptors. It is concluded that three daily subcutaneous administration of test chemicals, which are di-ethylhexyl phthalate(DEHP) and di-n-butyl phthalate(DBP), to 9 week-old rodents. The results revealed that DEHP & DBP show similar uterotrophic activity in the rat and the mouse, using subcutaneous administration. DEHP and DBP failed to affect any of these parameters, which are body weight, mammary gland, vaginal and uterus histopathology. but, DBP increased uterus weight to only one rat of 1.0 g/kg group. The results conform the need for rigorous attention to experimental design and criteria for assessing estrogenic activity.

정신병적 증상이 동반된 기면병 1예

홍승철,송정민,정종현,권용실,한진희,이성필 大韓神經精神醫學會 2003 신경정신의학 Vol.42 No.5

Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness, cataplexy, sleep paralysis, hypnagogic hallucinations and disrupted nocturnal sleep. We report a patient with a diagnosis of schizophrenia who was subsequently diagnosed as narcolepsy. A case of a 22-year-old woman with concomitant narcolepsy and psychotic symptoms was discussed from a perspective of the diagnosis and therapeutic challenges, particularly on pharmcological treatment dealing with issues raised by their coexistence.

반려동물의 기생충검사 이론 및 실제

이성호,박영석,박병권,김상기,정지윤,박수진,박창식,김병수 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10

The aim of this article is to improve human health and that of companion animals by improving the diagnosis and control of parasitic diseases. This is achieved by research into parasites of veterinary significance including zoonoses and the use of comparative systems to increase our understanding of some human parasitic diseases. We should promotes learning and teaching through knowledge and operates a diagnostic unit that offers a service to pet owner for indigenous and exotic parasitic diseases of companion animals. We must diagnose and treat them early. Zoonotic parasites are very important because many of animal parasites are zoonoses and give pain and death to human. Parasites are divided Protozoa, Helminthes and Arthropods. There are many protozoa, about 65,000 species. Arthropods are the vector of another diseases, such as virus, bacteria, protozoa and nematodes. Helminthes are composed of Trematoda, Cestoda, Nematoda and Acanthocephala. The target of Veterinary Parasitology is to recognize the characteristics of these parasites and subsequently diagnose, treat and control them. This article is intended to familiarize you with the essential facts and concepts of companion animal parasitology. Emphasis is placed on fecal sample techniques (comparison of fecal examination techniques; frequently found artifacts in fecal smears; direct Smear; zinc sulfate flotation; etc.) We recommend that the study be done to more references on animal parasites.

장기투석을 받은 만성 신부전 환자에서 발생한 종양에 관한 고찰

황정화,이혜경,홍현숙,박재성,김대호,권귀향,최득린,황승덕,이희발 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.2

The authors tried to evaluate tumor occurrence in long-term dialysis patients with chronic renal failure. Among 359 patients, 20 patients (about 5.6%) were diagnosed with malignancy during long-term dialysis from the period of 1983 to 1995 at our nephrology department. The ultrasonographic and computed tomographic findings including the clinical features of 20 patients that were retrospectively reviewed. The mean age of the patients was 53 (37-75)years old and the ratio of male to female was 9:1. Among the 20 cases, 7 cases of hepatoma (35%) were developed. Among them, urinary tract tumors such as renal and bladder cancer were developed in 4 (20%) and 2 (10%) of the cases. Other malignant tumors were lymphoma, stomach cancer, uterine cervical cancer, cholangiocarcinoma, lung cancer, meningioma, and acoustic neuroma one case of each (each of 5.3%). The most common tumor in patients with chronic renal failure, who were receiving long-term dialysis, was hepatoma and the second most common tumor was cancer of the urinary tract such as kidney and bladder.