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( Sung Ha Lim ),( Eun Jung Kim ),( Chung Hyuk Lee ),( Gi Hyun Park ),( Kang Min Yoo ),( Sung Ju Nam ),( Kyong-oh Shin ),( Kyungho Park ),( Eung Ho Choi ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: The stratum corneum (SC) consists of corneocytes, intercellular lipids, and corneodesmosomes. Most of the previous studies have focused on a ceramide with a single chain fatty acid, not with diverse chain lengths. Objective: We evaluated whether a lipid mixture enriched by ceramide NP with fatty acids of diverse chain lengths can restore the skin barrier impaired by topical corticosteroid. Methods: 27 healthy adult males were recruited. Topical corticosteroid was applied on both the forearms and, either the test cream that contains a lipid mixture or a vehicle cream was applied on the left or right forearm, respectively. The functional parameters of the skin barrier, epidermal differentiation markers, hyaluronic acid synthase 3 (HAS3), cytokines, and the lipid profiles in the SC were analyzed. Results: The barrier recovery rate, SC integrity, and SC hydration were significantly improved in the test cream-applied site. Filaggrin and HAS3 levels were significantly higher, Interleukin-1α (IL-1α) levels were increased, and IL-2, IL-6, IL-10, and IL-13 levels decreased in the test cream-applied site. Lipid analysis showed that C18, C20, and total ceramide NP levels increased in the test cream-applied site. C16, C18, C20, C24, and total ceramide NP levels were elevated in the test cream-applied site after acute barrier disruption. Conclusion: A lipid mixture enriched by ceramide NP with fatty acids of diverse chain lengths could recover the barrier impaired by topical corticosteroid.
Monitoring Expression of bphC Gene from Ralstonia eutropha H85O Induced by Plant Terpenes in Soil
Jung, Kyung-Ja,Kim, Byung-Hyuk,Kim, Eungbin,So, Jae-Seong,Koh, Sung-Cheol The Microbiological Society of Korea 2002 The journal of microbiology Vol.40 No.4
A PCB degrader, Ralstonia eutropha H850 was shown to induce bphC gene encoding 2,3-dihydroxy-biphenyl-1,2-dioxygenase in a carvone-amended pure culture in our previous study (Park et al.,1999). The present study was carried out to examine how plant terpenes, as natural substrates, would cause an expression of a PCB degradative gene in soil that was amended with terpenes. The population of Ralstonia eutropha H850 was maintained at least around 10$\^$8/ (CFU/g fresh soil) in the soil amended with carvone or limonene in the presence of succinate as a growth substrate at 50 th day. The gene expression was monitored by RT-PCR using total RNA directly extracted from each soil and bphC gene primers. The bphC gene expression of the seeded strain H850 was observed in the soil amended with biphenyl (4 days) but not with succinate, carvone and limonene. These results indicate that terpenes widely distributed in nature could be a potential inducing substrate for effective PCB biodegration in the soil but their bioavailability and specific induction behavior should be taken into account before PCB bioremediation implementation.
Extrahepatic metastasis to the cavernous sinus of skull base in hepatocellular carcinoma
( Sang Jung Kim ),( Hyung Joon Kim ),( Hong Ju Moon ),( Jang Sik Mun ),( Hyun Woong Lee ),( Chang Hwan Choi ),( Jung Uk Kim ),( Jae Hyuk Do ),( Jae Kyu Kim ),( Sae Kyung Chang ) 대한간학회 2007 Clinical and Molecular Hepatology(대한간학회지) Vol.13 No.3(S)
The Influence of Transmission Reduction by Mask Haze Formation in ArF Lithography
Sung-Jin Kim,오혜근,안일신,Jai-Sun Kyoung,Jin-Back Park,Jung-Hyuk Cho,Seung-Wook Park,Sung-Hyuck Kim 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.2I
The line width has been gradually reduced to enhance the integration of semiconductor devices. As minimum line widths have shrunk, the exposure wavelength has also progressively shrunk. The exposure wavelengths have been reduced progressively from 436 nm to 365 nm to 248 nm and to 193 nm. This shrinkage of the exposure wavelength has caused some serious problems. One of the problems is the growth of defects in the reticle during the process. Such defects in the reticle are called haze. Haze is formed around the pellicle on the quartz side of the mask and on the chrome side of the mask. In this investigation, mask haze is intentionally formed on the backside of a mask by using 193 nm laser irradiation. The mask thickness is measured by using atomic force microscopy and spectroscopic ellipsometry. We investigated the simulated critical dimension value and the throughput by using Solid-E of Sigma-C for each mask. This paper will use simulations to describe the relationship between the transmittance and haze formation, the effect of haze on the process latitude, and throughput reduction due to haze formation. This study will lead to an understanding of the impact of possible limitations of haze transmission on the imaging performance of each mask.
Sang Min Park,Soo Youn Lee,Mi-Hyang Jung,Jong-Chan Youn,Darae Kim,Jae Yeong Cho,Dong-Hyuk Cho,Junho Hyun,Hyun-Jai Cho,Seong-Mi Park,Jin-Oh Choi,Wook-Jin Chung,Seok-Min Kang,Byung-Su Yoo 대한심장학회 2023 Korean Circulation Journal Vol.53 No.7
Most patients with heart failure (HF) have multiple comorbidities, which impact their quality of life, aggravate HF, and increase mortality. Cardiovascular comorbidities include systemic and pulmonary hypertension, ischemic and valvular heart diseases, and atrial fibrillation. Non-cardiovascular comorbidities include diabetes mellitus (DM), chronic kidney and pulmonary diseases, iron deficiency and anemia, and sleep apnea. In patients with HF with hypertension and left ventricular hypertrophy, renin-angiotensin system inhibitors combined with calcium channel blockers and/or diuretics is an effective treatment regimen. Measurement of pulmonary vascular resistance via right heart catheterization is recommended for patients with HF considered suitable for implantation of mechanical circulatory support devices or as heart transplantation candidates. Coronary angiography remains the gold standard for the diagnosis and reperfusion in patients with HF and angina pectoris refractory to antianginal medications. In patients with HF and atrial fibrillation, long-term anticoagulants are recommended according to the CHA2DS2-VASc scores. Valvular heart diseases should be treated medically and/or surgically. In patients with HF and DM, metformin is relatively safer; thiazolidinediones cause fluid retention and should be avoided in patients with HF and dyspnea. In renal insufficiency, both volume status and cardiac performance are important for therapy guidance. In patients with HF and pulmonary disease, beta-blockers are underused, which may be related to increased mortality. In patients with HF and anemia, iron supplementation can help improve symptoms. In obstructive sleep apnea, continuous positive airway pressure therapy helps avoid severe nocturnal hypoxia. Appropriate management of comorbidities is important for improving clinical outcomes in patients with HF.