췌장 선방세포암 1예

이화정,지준호,박승찬,박정철,최은정,서혜진,이원식,이정림,배병조,손경락,이경희 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2

Acinar cell carcinoma is a rare tumor that represents 1~2% of al1 pancreatic cancers. Clinical and radiologic findings are inconclusive in this disease Acinar cell carcinoma is characterized by rapid progression and early metastasis, which lead to its poor prognosis. A 41-year-o1d man was admitted to our hospital for abdominal pain. Abdominal computed tomography (CT) and positron emission tomography-computed tomography (PET-CT) showed a splenic mass, which was being invaded by a pancreatic tail mass and which had increased ^(18)F-fluorodeoxyglucose (FDG) uptake Primary radical distal pancreatectomy and splenectomy were performed. Pathologic findings revealed an acinar cell carcinoma of the Pancreas The patient underwent a total gastrectomy three months later because of gastric recurrence Four months later, multiple hepatic metastases were discovered, and the patient underwent a left hepatectomy During treatment with capecitabine, there was no evidence of tumor progression for 14 months. We report a case of metastatic pancreatic acinar cell carcinoma, which did not progress for an extended period while the patient was being treated with capecitabme.

원발성 후복막 점액낭샘암종 1예

지준호,이화정,박승찬,박정철,최은정,서혜진,이원식,이정림,배병조,손경락,이경희 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2

Primary retroperitoneal mucinous cystadenocarcinoma is a very rare malignancy, and little is known concerning its Pathogenesis, optimal treatment, and prognosis. A 29-year-o1d pregnant woman (21 weeks) Presented with abdominal discomfort CA 19-9, CA 125, and CEA were normal Abdominal CT scanning revealed a 19x15x13 cm retropentoneal tumor Exploratory laparotomy and tumor excision were performed. Mucinous retropentoneal implants were removed as completely as possible Histologically, the tumor showed focal areas of capsular invasion, but free resection margins The uterus and both ovaries were normal in appearance No adjuvant therapy was pursued. Six months later, Peritoneal and bilateral ovarian metastases were discovered. Hence, we report the details of this case of primary retroperitoneal mucinous Cystadeno-carcinoma and present a review of the literature.

대장암 환자의 성격특성과 분노표현방식

손성은,유희정,서병선,김진천,한오수 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.3

연구목적 : 협조적이고 비주장적이며 인내심이 많고 부정적인 감정(특히 분노)을 잘 표현하지 않는 C형 성격 또는 1형 성격특성과 암 발병과의 관련성에 대해서는 일치된 결과가 없는 실정이다. 특히, 대장암 환자를 대상으로 이루어진 연구는 소수이며 분노의 억압 및 부정이 암 발생과 관련을 보였던 연구결과가 보고되었던 것과 대조적으로 공격적 적대감이 대장암 발생과 관련이 있다는 상반된 연구결과가 있다. 본 연구에서는 대장암 환자를 대상으로 1형 성격과 대장암 발병과의 관련성을 살펴보고, 분노의 경험과 표현 특성을 세분화하여 평가해서 암 발병과의 관련성을 밝혀 보고자하였다. 방 법 : 대장암 환자 35명과, 정상인 37명을 대상으로 Grossarth-Maticek의 성격-스트레스 검사 단축형중, 1형 성격을 반영하는 10문항과 Spielberger의 분노 검사 44문항을 이용하여 양군을 비교하였다. 자료 분석을 위해 환자 집단과 정상 집단 간 차이를 보고, 환자 집단과 정상 집단을 가장 잘 판별해줄 수 있는 변인을 찾기위해 판별분석을 실시하였다. 결 과 : 대장암 환자집단이 정상집단에 비해 분노 경험, 상태 분노, 분노 기질의 총점이 유의한 수준에서 높았고 그외의 다른 소척도나 1형 성격 스트레스 검사에 있어서는 유의한 차이는 나타나지 않았다. 판별분석 결과, 분노 기질 변인만 환자집단과 정상집단을 유의하게 판별하였다.(정준상관계수=.33, 판별율=65.8%). 결 론 : 평상시에 특별한 일 없이도 생리적 각성 상태를 동반하는 분노를 자주, 심하게 경험하는 특성과 대장암 발병이 관련성이 있음을 시사한다. Objectives : Although previous studies have suggested that Type 1 or Type C personality may be associated with the development of cancer, the results have not been consistent. There have been some evidences that repression, denial, or non-expression of anger are related with the incidence of colorectal cancer. However, according to the results of recent researches, aggressive hostility was related to the development of colorectal cancer. This study attempted to delineate psychological characteristics or personality patterns of the patients with colorectal cancer based on multidemensions of anger and Type 1 personality for cancer development. Method : The subjects were composed of 35 patients with colorectal cancer and 37 normal controls. Grossarth-Maticek personality questionnaire and the Spielberger state-trait anger expression inventory were administered. Results : In comparison with the normal control group, the colorectal cancer patient group showed significantly higher scores on anger experience, angry temperament and state anger but no significant differences on Type 1 personality scale and other subscales. In the discriminant analysis patients and control groups were classified by means of state anger, angry temperament, angry reaction, anger-in, anger-out and anger control variables. When angry temperament variable was selected as a discriminant variable, 65.8% of cases had been correctly classified. Conclusions : These results suggested the relationship between the disposition to experience and express anger without particular provocation and the development of cancer.

식사를 통한 N-Nitrosamine의 추정 섭취량 평가

신정혜,김연희,이수정,손미예,성낙주 한국식품영양학회 2002 韓國食品營養學會誌 Vol.15 No.1

단체급식소 12개소의 식단을 수거하여 각 메뉴별 및 1인분 식단별 NA 함량을 분석하였고 인공소화 기법을 활용하여 체내에서 생성 가능한 NA의 함량을 예측하였다. 육류와 어패류를 주재료로 요리된 메뉴들의 인공소화 전·후 NA 함량을 분석한 결과 멸치볶음에서 NDMA 함량이 흔적량 ~ 4.8 ㎍/kg으로 가장 높았고, 채소류를 주재료로 한 메뉴들에서는 불검출에서 흔적량의 NDMA가 정량되었으며, 인공소화 후에도 흔적량 이하로 정량되었다. 1인 분량의 식사를 수거하여 인공소화 전·후의 NA를 분석한 결과 NDMA는 인공소화 전 0.20 ~ 0.78 ㎍/kg의 범위였으나 인공소화 후에는 0.43 ~ 0.80 ㎍/kg으로 약간 증가하였다. 상기의 분석 결과를 기초로 하여 성인 1일 NA 섭취량을 계산한 결과 0.60 ~ 2.34 ㎍/day/person이며, 인공소화를 통한 체내에서의 생성량을 고려하면 최대 5.15㎍/day/person으로 추정된다. N-nitrosamine (NA) contents depending on simulated gastric digestion were analyzed with 12 kinds of diets collected from institutional food service those diets were estimated the total NA amounts including both intake from food directly and its endogenous formation in human body from simulated gastric digestion. NA was determined in dishes of meats, fished and vegetables before and after simulated gastric digestion. N-nitrosodimethylamine (NDMA) contents were from not detected(ND) to 4.8 ㎍/kg in dishes of meats and fishes. After digestion, its contents increased and the highest level was 3.0 ㎍/kg in panbroiled dried anchovy. In vegetable dishes, NDMA was detected as ND ~ trace before and after digestion. The contents of NDMA in diets collected from institutional food service were 0.20 ~ 0.78 ㎍/kg, 0.43 ~ 0.80 ㎍/kg before and after digestion, respectively. The average intake of Na per day to Korean, based on the above data, was 0.60 ~ 2.34 ㎍/day/person. The maximum daily intake of NA was reduced to 5.15 ㎍/day/person when considering NA amounts formed endogenously by simulated gastric digestion.

중국 성인 여성의 연령별 신체 계측치 비교 : 북경과 상해에 거주하는 여성을 중심으로 with the Focus on the Women Residing in Beijing and Shanghai

임순,손희순,석혜정 服飾文化學會 2003 服飾文化硏究 Vol.11 No.6

The purpose of this study is to look into the physical features for each residential area by the age, with the female subjects residing in Beijing and Shanghai. This would provide the specific information regarding the body types of Chinese adult women, and additionally it would assist the effective advancement into the Chinese local markets by serving as the basic data for the size development and fitting improvement of clothing products for Chinese women. The body measurements were made with 525 adult female subjects of 20 to 49 years of age, residing in Beijing and Shanghai, China. The number of measurements items was 79. The results are as follows: As they grew older, the women residing in Beijing and Shanghai all showed increases in the items of width, thickness, girth, and length, which are highly correlated with the physical obesity, while they did not show any differences by the age range in the item of height. Differences were also found in the tendency of the type distribution by the age range of Chinese adult women in each residential area. As they grew older, the women residing on Beijing showed increases in the distribution of Body type 2 and Body type 4, which clearly indicated the features of obesity. On the other hand, the women residing in Shanghai showed the almost similar distribution in their 20's and 30's, while those in their 40's showed a high frequency in Body type 2 than in Body type 4.

Effect of Ethanol Extract from Salvia miltiorrhiza on Cytochrome P450 1A1 and Ornithine Decarboxylase Activities

Yun-Hee Shon,Hyun-Jung Cho,Eun-Jung Jung,Mee-Kyung Kim,Kyung-Soo Nam 한국생명과학회 2006 한국생명과학회 심포지움 Vol.47 No.-

Molecular Mechanisms of Neurologic Disorders(Neurobiology) : Cancer chemopreventive activity of chitosan oligosaccharide

( Yun Hee Shon ),( Mee Kyung Kim ),( Jung Sun Jang ),( Eun Jung Jung ),( Kyung Soo Nam ) 한국생화학분자생물학회 (구 한국생화학회) 2008 생화학분자생물학회 춘계학술발표논문집 Vol.2008 No.-

Phase Ⅰ, phase Ⅱ 효소 및 ornithine decarboxylase에 미치는 해양심층수의 영향

손윤희(Yun-Hee Shon),김미경(Mee-Kyung Kim),장정선(Jung-Sun Jang),정은정(Eun-Jung Jung),남경수(Kyung-Soo Nam) 한국생명과학회 2008 생명과학회지 Vol.18 No.3

동해에서 취수한 해양심층수의 암예방 효능을 알아보고자 암발생 억제물질의 생화학적 표식자(biochemical markers)인 CYP 1A2 활성, phase II 효소인 QR과 GST의 활성, GSH 함량 및 ODC 활성에 미치는 영향을 살펴보았다. 해양심층수는 암의 개시단계(initiation)를 유발시키는 것으로 알려진 CYP 1A2 활성을 경도의존적으로 저해시켰다. 해양심층수를 Hepa 1c1c7 세포에 경도별(100∼1,000)로 처리하였을 때 phase II 생체 해독효소인 QR과 GST의 활성은 최대 20%의 증가를 나타내었고, 외부의 독성물질이나 대사산물로부터 세포를 보호하는 역할을 하는 GSH의 함량은 26∼40%의 증가를 나타내었다. 그리고 발암과정의 촉진/진행단계에 관여하는 ODC의 활성은 해양심층수의 경도 800과 1,000에서 20%와 35%의 저해율을 나타내었으며, 경도 1,000을 처리한 군에서는 양성대조군인 DFMO와 같은 저해율을 나타내었다. 그러므로 본 연구 결과에 의하면 동해 해양심층수는 발암과정과 관련된 개시 및 촉진/진행단계를 저해시켜 암예방 효능을 나타낼 것으로 사료된다. Deep sea water was tested for cancer chemopreventive activity by measuring the activities of β- naphthoflavone (β-NF)-induced cytochrome P 450 1A2 (CYP 1A2), quinone reductase (QR) and glutathione-S-transferase (GST), glutathione (GSH) levels, and ornithine decarboxylase (ODC) activity. The in vitro incubation of rat liver microsome with deep sea water (a hardness range of 100∼1,000) showed a hardness-dependent inhibition of CYP 1A2 activity. QR and GST activities were induced about 1.1∼1.2 fold with the treatment of deep sea water in murine hepatoma Hepa 1c1c7 cells. In addition GSH levels were increased 1.3∼1.4 fold in a hardness range of 100∼1,000. The deep sea water showed 20.3 and 35.0% inhibition of 12-O- tetradecanoylphorbol-13-acetate (TPA)-induced ODC activity at hardness 800 and 1,000, respectively. Therefore, deep sea water is worth further investigation with respect to cancer chemoprevention or therapy.

대형 주물공정 용접작업장의 건강 위해인자 및 환기 개선

정종현(Jong Hyeon Jung),정유진(Yu Jin Jung),이상만(Sang man Lee),이정희(Jung Hee Lee),손병현(Byung Hyun Shon),임현술(Hyun Sul Lim) 한국청정기술학회 2014 청정기술 Vol.20 No.2

이 연구에서는 대형 주물공정 용접작업장 근로자들의 건강보호 및 작업환경 개선을 위해 위해인자 조사 및 분석작업을 수행하였다. 또한, 대상 작업장의 작업환경을 개선하기 위해 측정 및 전산유체해석 모델링을 수행한 후 효과적인 환기방법을 제안하였다. 대형 주물공정 용접작업장 근로자들의 건강 위해인자를 조사한 결과, A사는 산화철분진, B사와 C사는 용접 흄, D사는 용접 흄과 산화철분진이 주오염원인 것으로 확인되었다. 작업자 호흡영역에서의 흄 농도는 0.05~4.37 mg/m<SUP>3</SUP>이었고, 용접작업장 공기 중 흄 농도는 0.13~7.54 g/m<SUP>3</SUP>이었다. 또한, 용접작업 시 최적의 환기방법을 제안하기 위해 측정 및 전산유체해석 모사를 수행한 결과, 배기공정의 경우에는 배기 덕트를 용접점에 근접시켜 국소배기를 실시하는 것이 효과적인 것으로 나타났다. 급기공정의 경우에는 개구부 끝 부분에서 급기를 하며 급기용 팬은 작업 공간 외부에 설치하는 것이 효과적일 것으로 나타났다. 향후 대형 주물공정 용접작업장의 터널형 반밀폐 공간에 대한 환기방법을 표준화한다면 주물산업 및 조선업 등에 종사하는 용접 근로자들의 건강보호 및 작업환경 개선에 매우 효과적일 것으로 판단된다. In this study we have examined the health risk factors and analyzing data of laborers working at the welding operation at large-sized casting process. In order to improve the working environment of workplace, an effective ventilation method was proposed after performing CFD (computational fluid dynamics) modeling and measurement of pollutants. As a result of examining the health risk factors of workers, oxidized steel dust is the main pollution source in the company A, welding fume in the companies B and C, and welding fume and oxidized steel dust in the company D. The fume concentration in the workers’ breathing zone was 0.051~4.37 mg/m<SUP>3</SUP>, and the fume concentration in the indoor air at the welding process was 0.13~7.54 mg/m<SUP>3</SUP>. From a result of CFD, a local exhaust with an exhaust duct adjacent to welding point was found to be most effective in case of the exhaust process. In case of air supply, we found that a desired location of air supply fan would be at the end of the opening. If a standardizing the ventilation system for tunnel-type semi-enclosed space at a large-sized casting process is introduced in welding work places in the future, it would be more effective to protect the health of welding workers working at the casting industry and shipbuilding industry and improve the work environment.

2단 활성슬러지 시스템을 이용한 저온에서 하수의 질소제거

정금희,손정희,박종복,이용희 ( Keum Hee Jung,Jung Hee Shon,Jang Bok Park,Yong Hee Lee ) 한국물환경학회 1998 한국물환경학회지 Vol.14 No.1

Nitrogen removal study of municipal wastewater was carried out in A City`s Wastewater Treatment Plant with dual sludge system. The dual sludge system consists of anoxic tank, oxic tank, and clarifier followed by Modified Ludzack-Ettinger(MLE) system. For nitrogen removal, methanol was used as an external carbon source in the anoxic tank. This process showed the effluent quality, achieving 81% of COD_(Cr), removal and 71% of total nitrogen removal. Influent wastewater contained 199∼548㎎/l of COD_(Cr), and 51∼83.8㎎/l of total inorganic nitrogen. The final effluent contained 42∼150㎎/l of COD-Cr and 11.2∼33.5㎎/l of total nitrogen. The specific denitrification rate and C/N ratio in the anoxic tank were 0.1∼0.34 (gNO₃-N/gVSS/d) and 3.06∼4.64 (gCOD consumed/gNO₃-N removed), respectively, at the range of 4∼14℃ of temperature.