White-Matter Hyperintensities and Lacunar Infarcts Are Associated with an Increased Risk of Alzheimer’s Disease in the Elderly in China

Shuai Ye,Shuyang Dong,Jun Tan,Le Chen,Hai Yang,Yang Chen,Zeyan Peng,Yingchao Huo,Juan Liu,Mingshan Tang,Yafei Li,Huadong Zhou,Yong Tao 대한신경과학회 2019 Journal of Clinical Neurology Vol.15 No.1

Background and Purpose This study investigated the contribution of white-matter hyperintensities (WMH) and lacunar infarcts (LI) to the risk of Alzheimer’s disease (AD) in an elderly cohort in China. Methods Older adults who were initially cognitively normal were examined with MRI at baseline, and followed for 5 years. WMH were classified as mild, moderate, or severe, and LI were classified into a few LI (1 to 3) or many LI (≥4). Cognitive function was assessed using the Mini Mental State Examination and the Activities of Daily Living scale. Results Among the 2,626 subjects, 357 developed AD by the end of the 5-year follow-up period. After adjusting for age and other potential confounders, having only WMH, having only LI, and having both WMH and LI were associated with an increased risk of developing AD compared with having neither WMH nor LI. Moderate and severe WMH were associated with an increased risk of developing AD compared with no WMH. Furthermore, patients with many LI had an increased risk of developing AD compared with no LI. Conclusions Having moderate or severe WMH and many LI were associated with an increased risk of developing AD, with this being particularly striking when both WMH and LI were present.

Peri-implantitis, systemic inflammation, and dyslipidemia: a cross-sectional biochemical study

Carlota Blanco,Antonio Liñares,Jose Dopico,Alex Pico,Tomás Sobrino,Yago Leira,Juan Blanco 대한치주과학회 2021 Journal of Periodontal & Implant Science Vol.51 No.5

Purpose: The aim of this study was to compare the inflammatory and lipid profile of patients with and without peri-implantitis. Methods: A cross-sectional biochemical study was carried out in which blood samples were collected from 16 patients with peri-implantitis and from 31 subjects with healthy implants. Clinical peri-implant parameters were obtained from all subjects. Levels of tumor necrosis factor-alpha and interleukin-10 (IL-10) were measured in serum. Lipid fractions, glucose and creatinine levels, and complete blood count were also assessed. Results: After controlling for a history of periodontitis, statistically significant differences between peri-implantitis patients and controls were found for total cholesterol (estimated adjusted mean difference, 76.4 mg/dL; 95% confidence interval [CI], 39.6, 113.2 mg/dL; P<0.001), low-density lipoprotein (LDL) cholesterol (estimated adjusted mean difference, 57.7 mg/dL; 95% CI, 23.8, 91.6 mg/dL; P<0.001), white blood cells (WBC) (estimated adjusted mean difference, 2.8×103/μL; 95% CI, 1.6, 4.0×103/μL; P<0.001) and IL-10 (estimated adjusted mean difference, −10.4 pg/mL; 95% CI, −15.8, −5.0 pg/mL; P<0.001). The peri-implant probing pocket depth (PPD) was modestly positively correlated with total cholesterol (r=0.512; P<0.001), LDL cholesterol (r=0.463; P=0.001), and WBC (r=0.519; P<0.001). A moderate negative correlation was observed between IL-10 and PPD (r=0.609; P<0.001). Conclusions: Otherwise healthy individuals with peri-implantitis showed increased low-grade systemic inflammation and dyslipidemia.

Alantolactone selectively suppresses STAT3 activation and exhibits potent anticancer activity in MDA-MB-231 cells

Chun, Jaemoo,Li, Rui-Juan,Cheng, Mao-Sheng,Kim, Yeong Shik Elsevier 2015 Cancer letters Vol.357 No.1

<P><B>Abstract</B></P> <P>The important goal of cancer drug discovery is to develop therapeutic agents that are effective, safe, and affordable. In the present study, we demonstrated that alantolactone, which is a sesquiterpene lactone, has potential activity against triple-negative breast cancer MDA-MB-231 cells by suppressing the signal transducer and activator of transcription 3 (STAT3) signaling pathway. Alantolactone effectively suppressed both constitutive and inducible STAT3 activation at tyrosine 705. Alantolactone decreased STAT3 translocation to the nucleus, its DNA-binding, and STAT3 target gene expression. Alantolactone significantly inhibits STAT3 activation with a marginal effect on MAPKs and on NF-κB transcription; however, this effect is not mediated by inhibiting STAT3 upstream kinases. Although SHP-1, SHP-2, and PTEN, which are protein tyrosine phosphatases (PTPs), were not affected by alantolactone, the treatment with a PTP inhibitor reversed the alantolactone-induced suppression of STAT3 activation, indicating that PTP plays an important role in the action of alantolactone. Finally, alantolactone treatment resulted in the inhibition of migration, invasion, adhesion, and colony formation. The <I>in vivo</I> administration of alantolactone inhibited the growth of human breast xenograft tumors. These results provide preclinical evidence to continue the development of alantolactone as a STAT3 inhibitor and as a potential therapeutic agent against breast cancer.</P> <P><B>Highlights</B></P> <P> <UL> <LI> STAT3 is a transcription factor that is a potent regulator of tumorigenesis. </LI> <LI> Alantolactone suppresses constitutive and inducible STAT3 tyrosine phosphorylation. </LI> <LI> Alantolactone inhibits NF-κB translocation to the nucleus. </LI> <LI> Alantolactone inhibits cell migration, invasion, adhesion, and colony formation. </LI> <LI> Alantolactone inhibits the tumor growth of MDA-MB-231 xenografts in mice. </LI> </UL> </P>

Clinical and Pathological Characteristics of Intraocular Cysticercosis

Juan-Juan Li,Li-Wei Zhang,Hua Li,Zhu-Lin Hu 대한기생충학열대의학회 2013 The Korean Journal of Parasitology Vol.51 No.2

Partially reduced SnO₂ nanoparticles anchored on carbon nanofibers for high performance sodium-ion batteries

Liu, Zhiming,Song, Taeseup,Kim, Joo Hyun,Li, Zhangpeng,Xiang, Juan,Lu, Tianchi,Paik, Ungyu Elsevier Inc. 2016 Electrochemistry Communications Vol.72 No.-

<P><B>Abstract</B></P> <P>One-dimensional (1-D) carbon nanofibers anchored with partially reduced SnO<SUB>2</SUB> nanoparticles (SnO<SUB>2</SUB>/Sn@C) were successfully synthesized through a simple electrospinning method followed by carbon coating and thermal reduction processes. The partially reduced Sn frameworks, combined with the carbon fibers, provide a more favorable mechanism for sodiation/desodiation than SnO<SUB>2</SUB>. As a result, SnO<SUB>2</SUB>/Sn@C exhibits a high reversible capacity (536mAhg<SUP>−1</SUP> after 50cycles) and an excellent rate capability (396mAhg<SUP>−1</SUP> even at 2C rate) when evaluated as an anode material for sodium-ion batteries (SIBs).</P> <P><B>Highlights</B></P> <P> <UL> <LI> The partially reduced Sn framework provides both favorable Na-ion diffusion dynamics and high specific capacity. </LI> <LI> The conductive Sn framework, bonded with carbon fiber, provides an efficient pathway for electron transport. </LI> <LI> The discrete SnO<SUB>2</SUB>/Sn nanoparticles provide sufficient space to accommodate the large volume expansion. </LI> <LI> The strategy of partial reduction may open up new ways to improve the electrochemical performance of metal oxides. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Well-designed Te/SnS₂/Ag artificial nanoleaves for enabling and enhancing visible-light driven overall splitting of pure water

Yan, Changzeng,Xue, Xiaolan,Zhang, Wenjun,Li, Xiaojie,Liu, Juan,Yang, Songyuan,Hu, Yi,Chen, Renpeng,Yan, Yaping,Zhu, Guoyin,Kang, Zhenhui,Kang, Dae Joon,Liu, Jie,Jin, Zhong unknown 2017 Nano energy Vol.39 No.-

<P><B>Abstract</B></P> <P>To produce hydrogen and oxygen from photocatalytic overall splitting of pure water provides a promising green route to directly convert solar energy to clean fuel. However, the design and fabrication of high-efficiency photocatalyst is challenging. Here we present that by connecting different nanostructures together in a rational fashion, components that cannot individually split water into H<SUB>2</SUB> and O<SUB>2</SUB> can work together as efficient photocatalyst with high solar-to-hydrogen (STH) energy conversion efficiency and avoid the use of any sacrificial reagent. Specifically, Te/SnS<SUB>2</SUB>/Ag artificial nanoleaves (ANLs) consist of ultrathin SnS<SUB>2</SUB> nanoplates grown on Te nanowires and decorated with numerous Ag nanoparticles. The appropriate band structure of Te/SnS<SUB>2</SUB> p-n junctions and the surface plasmon resonance of Ag nanoparticles synergistically enhance the quantum yield and separation efficiency of electron-hole pairs. As a result, Te/SnS<SUB>2</SUB>/Ag ANLs enable visible-light driven overall water-splitting without any sacrificial reagent and exhibit high H<SUB>2</SUB> and O<SUB>2</SUB> production rates of 332.4 and 166.2μmolh<SUP>−1</SUP>, respectively. Well-preserved structure after long-term measurement indicates its high stability. It represents a feasible approach for direct H<SUB>2</SUB> production from only sunlight, pure water, and rationally-designed ANL photocatalysts.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Te/SnS<SUB>2</SUB>/Ag ANLs heterostructure is prepared to catalyze overall water splitting. </LI> <LI> The catalyst show impressive H<SUB>2</SUB> and O<SUB>2</SUB> production rate under visible light. </LI> <LI> The structure and efficiency of catalyst shows no degradation after 10 days. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Digital Technology Facilitating the Fusion of Video Games and Films

Li Juan(이연) 한국엔터테인먼트산업학회 2019 한국엔터테인먼트산업학회논문지 Vol.13 No.4

오늘날의 미디어 환경은 매우 복잡해지고, 이전에는 볼 수 없었던 매체 형태가 점점 세상에 나타남으로써, 미디어 융합의 추세가 점점 뚜렷해지고 있다. 미디어 융합은 최극의 핫이슈로 이미 사람들의 생활방면에 스며있다고 말할 수 있다. 이 융합의 물결 속에서 영화와 전자 게임 사이에도 거대한 변화가 일어났다. 그들 사이의 리메이크 붐은 본래 전혀 다른 성격의 두 매체가 서로 교환해서 얻을 수 있는 거대한 경제효과를 보여주었다. 그들은 매체 융합이라는 이러한 새로운 환경에서 형식, 내용, 수법, 마케팅 등 여러 방면에서 참고와 융합을 진행했다. 영화와 전자게임의 융합이 어떤 방향으로 진행될지에 대해서는 많은 추측이 있지만, 이러한 추측의 내용은 모두 한계가 있다. 컴퓨터 가상현실 기술이 발전함에 따라 전자 게임은 인터넷과 함께 대중들에게 매우 리얼하게 시각, 청각, 촉각 등 방면의 요구를 만족시킬 수 있는 가상세계를 제공할 것이다. 그때가 되면 영화를 비롯한 각종 매체들이 전자 게임이 만들어 낸 가상세계에 철저히 녹아들 것이며 현재 진실세계에 존재하는 그러한 매체들처럼 가상세계의 하나의 원소가 될 것이다. Today"s media environment is becoming very complicated and the trend of media convergence is getting clearer. The convergence of media is the supreme hot issue. In this wave of convergence, there has also been a huge change between movies and electronic games. The remake boom between them showed a tremendous economic effect that can be achieved by exchanging two media of essentially different characteristics. As computer virtual reality technologies evolve, electronic games will provide a virtual world that can satisfy the demands of the visual, auditory, and tactile aspects very real to the public with the Internet. At that time, movies and other media will be thoroughly melted into the virtual world created by electronic games, and they will become an element of the virtual world as those media that exist in the truth world.

Association between Korean Traditional Fermented Vegetables (Kimchi) Intake and Weight Loss

Li-Juan Tan,Jiwon Jeong,Seok-Jae Oh,Jun-Mo Kim,Sangah Shin 한국식품영양과학회 2022 한국식품영양과학회 학술대회발표집 Vol.2022 No.10

Smartphone-based personalized blood glucose prediction

Juan Li,Chandima Fernando 한국통신학회 2016 ICT Express Vol.2 No.4

Effective blood glucose control is essential for patients with diabetes. However, individual patients may not be able to monitor their blood glucose level regularly because of all manner of real-life interference. In this paper, we propose a personalized diabetes prediction mechanism that leverages smartphone-collected patient data and population data to drive personalized prediction. Unlike existing predictive models, this model utilizes pooled population data and captures patient similarities, and eventually produces a personalized blood glucose prediction for an individual. We have implemented the proposed model as a mobile application and have performed extensive experiments to evaluate its performance. The experimental results demonstrate that the proposed prediction mechanism can improve the prediction accuracy and remedy the problem of sparse data in the existing approaches.

Dammarane-type triterpene oligoglycosides from the leaves and stems of Panax notoginseng and their antiinflammatory activities

Juan Li,Ru-Feng Wang,Yue Zhou,Hai-Jun Hu,Ying-Bo Yang,Li Yang,Zheng-Tao Wang 고려인삼학회 2019 Journal of Ginseng Research Vol.43 No.3

Background: Inflammation is widespread in the clinical pathology and closely associated to the progressof many diseases. Triterpenoid saponins as a key group of active ingredients in Panax notoginseng (Burk.)F.H. Chen were demonstrated to show antiinflammatory effects. However, the chemical structures ofsaponins in the leaves and stems of Panax notoginseng (PNLS) are still not fully clear. Herein, the isolation,purification and further evaluation of the antiinflammatory activity of dammarane-type triterpenoidsaponins from PNLS were conducted. Methods: Silica gel and reversed-phase C8 column chromatography were used. Furthermore, preparativeHPLC was used as a final purification technique to obtain minor saponins with high purities. MS, NMRexperiments, and chemical methods were used in the structural identifications. The antiinflammatoryactivities of the isolated saponins were assessed by measuring the nitric oxide production in RAW 264.7cells stimulated by lipopolysaccharides. Real-time reverse transcription polymerase chain reaction wasused to measure the gene expressions of inflammation-related gene. Results: Eight new minor dammarane-type triterpene oligoglycosides, namely notoginsenosides LK1-LK8 (1e8) were obtained from PNLS, along with seven known ones. Among the isolated saponins,gypenoside IX significantly suppressed the nitric oxide production and inflammatory cytokines includingtumor necrosis factor-a, interleukin 10, interferon-inducible protein 10 and interleukin-1b. Conclusion: The eight saponins may enrich and expand the chemical library of saponins in Panax genus. Moreover, it is reported for the first time that gypenoside IX showed moderate antiinflammatory activity.