신장기능영상용 방사성의약품 Bz - MAG3 ( Benzoylmercaptoacetylglycylglycylglycine ) 의 키트화 및 체내분포

고창순(Chang Soon Koh),이명철(Myung Chul Lee),정준기(June Key Chung),이동수(Dong Soo Lee),김영주(Young Ju Kim),정재민(Jae Min Jeong),장영수(Young Soo Chang),조정혁(Jung Hyuk Cho) 대한핵의학회 1996 핵의학 분자영상 Vol.30 No.3

N/A The MAG3 is a tubular excreting radiopharmaceutical for renal image. We synthe-sized benzoyl MAG3 (Bz-MAG3) and made a kit for labeling with Tc-99m. We checked the labeling effeciency of Tc-99m labeled MAG3 and biodistribution. Labeling efficiency was checked by TLC- SG (acetonitrile/H2O=2/1). After injecting of 1 mCi of Tc-99M-MAG3 to ICR-mice, Tmax(min), T1/2(min) were obtained in the renogram. Sequencial images (30sec, 2min, 5min, 10min, 15min, 20min) of TC-99m-MAG3 were compared with those of commercial Tc-99m-DTPA (Du Pont Merck Pharmaceutical Co.) kit. 1) The Rf value of synthesized Tc-99m-MAG3 was 0.78 and labeling efficiency was 97.5±1.9% (n=10). 2) The dynamic images of the Tc-99m-MAG3 were better than those of the Tc-99m-DTPA. 3) The Tmax(min.) and T1/2(min.) of Tc-99m-MAG3 (n=10) were 1.5±0.5 (left), 1.4±0.4(right), and 4.3±1.4 (left), 4.8±2.0 (right), respectivel. The Tmax(min.) and T1/2(min.) of Tc-99m-DTPA (n=7) were 2.7±1.6 (left), 2.7±1.6 right), and 3.8±1.7 (left), 4.5±2.7 (right), respectively. The quaility of image and labeling efficiency of the synthesized Bz-MAG3 kit were excellent, that it was supposed to be used in routine clinical work.

Antioxidant Activity and Whitening Effect of Lindera erythrocarpa Extract

Min ?Chul Kang,Ryeo Kyeoung Ko,Ju-Yeop Lee,Haeng-Bum Kim,Bong-Seok Kim,Jong-Heon Han,Seong-Hyun An,Gi-Ok Kim 한국생물공학회 2008 한국생물공학회 학술대회 Vol.2008 No.10

Production of 5,8-dihydroxy-9(Z)-octadecenoic acid from oleic acid by whole recombinant cells of Aspergillus nidulans expressing diol synthase.

Seo, Min-Ju,Shin, Kyung-Chul,Jeong, Yeon-Ju,Oh, Deok-Kun Kluwer Academic Publishers 2015 Biotechnology letters Vol.37 No.1

<P>The optimal conditions for the production of 5,8-dihydroxy-9(Z)-octadecenoic acid (5,8-diHOME) from oleic acid by whole recombinant Escherichia coli cells expressing diol synthase from Aspergillus nidulans were 40 °C, pH 7.5, 10 % (v/v) dimethyl sulfoxide, 35 g cells l(-1), and 12 g oleic acid l(-1) at 250 rpm in a 250 ml baffled flask. Under these conditions, whole recombinant cells produced 5.2 g 5,8-diHOME l(-1) together with 1 g l(-1) of the intermediate 8-hydroperoxy-9(Z)-octadecenoic acid (8-HPOME) after 60 min. This corresponded to a conversion yield of 43 % (w/w), a volumetric productivity of 5.2 g l(-1 )h(-1), and a specific productivity of 148 mg g cells(-1 )h(-1). This is the first report of the biotechnological production of 5,8-diHOME from oleic acid.</P>

후두 미세수술 후 발생한 일시적인 설인신경 및 설하신경 장애 1예

정철우,주영민,박성철,최정섭 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.11

배추種子 發芽에 미치는 鹽素化炭化水素의 影響

尹昌柱,朴敏哲 聖心女子大學校 1981 論文集 Vol.12 No.2

Trichlorfon이 배추種子의 發芽에 미치는 影響을 調査하였다. 發芽率은 1g/ℓ이상의 濃度에서는 抑制되었으나 0.1g/ℓ이하의 濃度에서는 전혀 影響이 없었다. 줄기와 뿌리의 伸長生長은 0.01g/ℓ의 低濃度處理區에서는 큰 影響이 없었으나 그 이상의 濃度에서는 生長의 低下作用이 나타났고 生量의 變化도 伸長生長과 같은 傾向이 나타났으나 乾量에 있어서는 全般的으로 時間에 따라 減少하는 傾向을 보였다. 葉綠素는 모든 處理區에서 그 形成이 抑制되었으며 水分含量도 處理된 濃度에 反比例하여 增加하는 傾向이 있었으나 0.01g/ℓ의 處理區에서는 對照區와 큰 차이가 없었다. 蛋白質과 RNA는 0.1g/ℓ와 1g/ℓ의 處理區에서는 對照區와 0.01g/ℓ의 處理區에서 보다 더 낮은 含量을 보였다. The effects of Trichlorfon on the germination of chinese cabbage seeds were investigated. Trichlorfon inhibited the germination when seeds were treated at the concentrations of 1g/ℓor more, but made no difference at the concentrations of 0.1 and 0.01g/ℓ. Growth of shoot and root length was not affected by the treatment of Trichlorfon at 0.01g/ℓ, but was inhibited at 0.1 and 1g/ℓ. Chlorophyll formation was severely inhibited by Trichlorfon treatments. Fresh weights and water contents were in inverse proportion to the treated concentrations, but the water contents of control and 0.01g/ℓ didn't show any distinct difference. Contents of protein and RNA were lower in germinating seeds at the treated concentration of 0.1 and 1g/ℓthan at that of control and 0.01g/ℓ.

유리체강 내 트리암시놀론 주입으로 치유된 안유육종증 1예

박영철,정민규,최광주 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.3

Sarcoidosis is a granulomatous inflammation that is not made clear in its disease origin, If sarcoidosis involves the eye, systemic oral steroid is treated in general. The authors intend to report a case of completed cured ocular sarcoidosis using high dose steroid and intravitreal thamcinolone acetonide injection.

관절염으로 발현한 재발성 다발성 연골염 1례

엄민식,박원우,서승철,이진호,조주연,최혜영,이찬희,임소덕 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

Relapsing polychondritis is an uncommon multisystemic disease which is characterized by recurrent episodes of inflammation and progressive destruction of cartilaginous tissue. The cause of relapsing polychondritis is unclear and suspected to be autoimmune pathophysiology. It involves cartilage of nose, vertebra, trachea, peripheral joint as well as structures of eye, heart, blood vessels or inner ear. Auricular chondritis is present in almost all patients, and multiple arthritis, nasal chondritis, saddle nose, eye involvement, laryngotracheal involvement and skin manifestations are also present. We report a case of relapsing polychondritis presented a arthritis with review of literatures.

국가정보보호수준 측정 및 활용에 관한 연구

황철중,주용완,민경식,정경호 한국정보사회진흥원 2006 정보화정책 Vol.13 No.3

정보보호 수준을 측정하는 것은 매우 어려운 일로써 정보보호의 영역이 계속 확장됨에 따라 개념자체를 정의하기가 어렵고 아울러 다차원적인 요인을 포함하는 정보보호 지표 선정의 어려움, 시계열적인 통계 데이터 부족, 상이한 정보보호 지표를 하나의 지수로 통합하는 문제가 있기 때문이다. 그럼에도 불구하고 정보보호수준을 계량적으로 측정하기 위한 방법론으로 가장 적합한 것은 지수화하는 것이다. 이는 정책입안자나 정보보호 이해관련자들이 종합적인 측면에서 정보보호수준 목표를 결정하고 실행결과를 평가하는데 용이하기 때문이다. 본 연구의 목적은 정보보호정책 수립 및 평가의 기초 자료로 활용할 수 있는 지수를 산출하기 위한 종합적인 정보보호수준 평가지수 모델을 제시하고 지수를 산출하는데 있다. 지수산출결과, 정보보호수준은 2002년부터 2005년까지를 시계열적으로 보면 매년 평균 5.8%의 증가추세를 보이고 있다. 반면 역기능수준은 2003년 1.25 인터넷 대란으로 증가한 것을 제외하고 꾸준한 감소추세를 나타내고 있다. 특히 정보보호수준과 역기능수준이 발산하고 있어 정보보호정책이 유효하게 작용하고 있다고 판단되어진다.

농업인의 농업생산 역량 진단도구 개발

김진모,정철영,주대진,길대환,박종선,송민철 한국농업교육학회 2011 농업교육과 인적자원개발 Vol.43 No.4

급격하게 변화하는 환경에 대응할 수 있는 전문농업인을 체계적으로 육성해야하는 현 시점에서 농업인에게 실제적으로 요구되는 능력 및 역량을 표준화하고 농업인의 능력수준을 체계적으로 파악해야 할 필요성이 제기되고 있다. 이에 따라 본 연구는 농업생산 역량 진단도구 개발을 목적으로 하였다. 이를 위해 문헌 고찰, 전문가 협의회, 전문가 자문, 설문조사 등의 방법을 활용하여 23개 품목별 농업인의 성장단계 및 성취기준을 설정하고, 농업생산 역량모델을 개발한 후 이를 토대로 역량 진단도구를 개발하였다. 농업생산 역량모델은 직무분석 접근방법을 기반으로 하여 직무과제 분석을 실시하였고, 그 결과에 따라 역량 및 행동지표를 개발하였다. 역량 진단도구는 자가진단 방식으로 현재수준을 측정하도록 하였으며, 전문가 패널을 통해 설정한 개발목표 및 중요도와 비교할 수 있도록 구성하였다. 이 연구를 통해 도출된 주요 결과는 다음과 같다. 첫째, 농업인의 성장단계를 초보자, 준전문가, 전문가의 3단계로 규정하였다. 둘째, 농업인의 성장단계별 성취기준을 품목별로 설정하였다. 셋째, 23개 품목별 직무과제 분석을 통해 농업생산 역량모델을 개발하였다. 넷째, 품목별 역량모델의 행동지표를 활용한 문항개발을 통해 농업생산 역량 진단도구를 개발하였다. There are increasing needs to systematically foster professional farmers who can cope with the rapidly changing environment. Therefore, it is important to set competency standards for farmers and to systematically measure levels of farmers competencies. For this reason, the purpose of this study was to develop an assessment tool for farmers agriculture production competency. Through a literature review, council meetings, experts consultation and survey, we set developmental stages and achievement standards of farmers for 23 farming products, developed an agricultural production competency model, and finally developed an agricultural production competency assessment tool. A competency model for agricultural production was developed using job and task analysis, and competency behavioral indicators were developed according to the job analysis result. A competency assessment tool was made to measure farmers’present state of competency level by a self-assessment method and was designed to be able to compare themselves with developmental objectives and level of importance set by the expert panel. The result of this study is as follows: 1) Developmental stages of farmers were determined as three levels: beginners, semi-professionals and professionals; 2) Achievement standards for each developmental stage of farmers were set; 3) Agriculture production competency model was developed using job and task analysis for 23 farming products; 4) Assessment tool for agriculture production competency was developed by developing questionnaire items with competency behavioral indicators.

슬링(Sling) 시스템을 이용한 경부 안정화 운동

권재확,조미주,박민철,김선엽 대한정형물리치료학회 2002 대한정형도수물리치료학회지 Vol.8 No.2

Cervical pain is a rapid increase that is owing to a flexion-extension whiplash injury, unappropriated posture, chronical repetition injury from abdominal position of head and neck, excessive repeating work, chronical deficiency of excercise. Because of that is bring about muscle unbalance, tightness of cervical extensor muscle, weakness of cervical deep flexor muscles, instability of cervical region and reduction of proprioceptive sensor. Recent the role of muscle is more emphasized for preservation of sine stabilization. And cognition of integrated muscular system, importance for the operation and relation is increased to maintain stability of the motor system and pertinent function. Therefore we are going to introduce the sling exercise and stabilization exercise method for advanced efficient of cervical and upper limb and for the muscle strengthening to importance cervical stabilization through neurological program as control the reaction of cervical stabilization. Sling exercise therapy(SET) concept consists of a system of diagnosis and treatment. The system of diagnosis involves testing the muscle's tolerance through progressive loading in open and close kinetic chains. The SET system contains elements such as relaxation, increasing the range of movement, traction, training the stabilizing musculature, sensory-motor exercises, training in open and close kinetic chains, dynamic training of the mobilizing musculature, cardiovascular exercise, group exercise, personal exercise at home Sensory-motor training is an essential element of the SET concept. The emphasis is on closed kinetic chain exercise on an unstable surface, there by achieving optimum stimulation of the sensory-motor apparatus.